Hashemian, S., Mohammadzadeh, A., Farhat, A., Ramezani, M., Seyedi, S. (2017). The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia. Iranian Journal of Neonatology IJN, 8(2), 13-17. doi: 10.22038/ijn.2016.7777
Somayyeh Hashemian; Ashraf Mohammadzadeh; Ahmadshah Farhat; Mohammad Ramezani; Seyed Javad Seyedi. "The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia". Iranian Journal of Neonatology IJN, 8, 2, 2017, 13-17. doi: 10.22038/ijn.2016.7777
Hashemian, S., Mohammadzadeh, A., Farhat, A., Ramezani, M., Seyedi, S. (2017). 'The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia', Iranian Journal of Neonatology IJN, 8(2), pp. 13-17. doi: 10.22038/ijn.2016.7777
Hashemian, S., Mohammadzadeh, A., Farhat, A., Ramezani, M., Seyedi, S. The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia. Iranian Journal of Neonatology IJN, 2017; 8(2): 13-17. doi: 10.22038/ijn.2016.7777
The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia
1Department of Pediatric Endocrinology and Metabolism .Imam Reza Hospital , Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran
2Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Pharmaceutical and Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background: Approximately 60% of term neonates and 80% of preterm ones suffer from hyperbilirubinemia in their first week of life. This study sought to characterize the therapeutic effect of oral zinc sulfate on neonatal hyperbilirubinemia. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 70 term neonates with total serum bilirubin (TSB) level ≥ 20 mg/dl were enrolled. Thirty-four cases were treated with phototherapy and zinc (10 mg/day, single dose) as case, while the remainder received phototherapy plus placebo. TSB level was measured at the onset of the intervention, as well as 12, 24 and 48 h after the intervention and compared with each other. Results: The mean TSB levels were significantly lower in the zinc group after 12, 24 and 48 h (P=0.038, 0.005, 0.001, respectively). The mean durations of phototherapy in the case and control groups were 2.03±0.174 and 2.33±0.478 days, respectively, being significantly less in the case group (P=0.002). Conclusion: This study revealed that oral zinc sulfate at a single dose of 10 mg/day diminished TSB level and duration of phototherapy.
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