%0 Journal Article %T The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia %J Iranian Journal of Neonatology %I Mashhad University of Medical Sciences %Z 2251-7510 %A Hashemian, Somayyeh %A Mohammadzadeh, Ashraf %A Farhat, Ahmadshah %A Ramezani, Mohammad %A Seyedi, Seyed Javad %D 2017 %\ 06/01/2017 %V 8 %N 2 %P 13-17 %! The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia %K Hyperbilirubinemia %K neonate %K Treatment %K Zinc sulfate %R 10.22038/ijn.2016.7777 %X Background: Approximately 60% of term neonates and 80% of preterm ones suffer from hyperbilirubinemia in theirfirst week of life. This study sought to characterize the therapeutic effect of oral zinc sulfate on neonatalhyperbilirubinemia.Methods: In this randomized, double-blind, placebo-controlled clinical trial, 70 term neonates with total serumbilirubin (TSB) level ≥ 20 mg/dl were enrolled. Thirty-four cases were treated with phototherapy and zinc (10 mg/day,single dose) as case, while the remainder received phototherapy plus placebo. TSB level was measured at the onset ofthe intervention, as well as 12, 24 and 48 h after the intervention and compared with each other.Results: The mean TSB levels were significantly lower in the zinc group after 12, 24 and 48 h (P=0.038, 0.005, 0.001,respectively). The mean durations of phototherapy in the case and control groups were 2.03±0.174 and 2.33±0.478days, respectively, being significantly less in the case group (P=0.002).Conclusion: This study revealed that oral zinc sulfate at a single dose of 10 mg/day diminished TSB level and durationof phototherapy. %U https://ijn.mums.ac.ir/article_8914_4a0c143cc91a13dcd87f27f05ce4fcd0.pdf