Clinical Guideline Adaptation for Treating Neonatal Sepsis Based on the Frequency of Microbial Agents

Document Type: Original Article


1 Pediatric Health Research Center, Department of Pediatrics and Neonatology, Tabriz University of Medical Sciences, Tabriz, Iran

2 Assistant Professor of Community and Preventive Medicine, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran


Background: Sepsis is one of the most important causes of death in infants. The pattern of bacterial agents responsible for neonatal septicemia changes over time. The aim of the present paper was to provide a clinical guideline adapted for treatment of neonatal sepsis based on the frequency of microbial agents in NICU of Alzahra hospital of Tabriz.
Methods & Materials: The clinical guideline adaptation is conducted based on the ADAPTE Resource Toolkit for Guideline Adaptation (ADAPTE, version 2) from December 2016 to January 2018. For data collection, first, the specialized websites were identified and then, an internet search method was used for gaining clinical guideline and medical literature databases. A panel was established with members of the multi-specialties and the obtained guidelines were examined and evaluated. In the end, the final guideline was selected and translated.
Results: Due to the guideline, employing antibiotics should be started when the neonate is