TY - JOUR ID - 13803 TI - Clinical Guideline Adaptation for Treatment of Neonatal Sepsis Based on Frequency of Microbial Agents JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Hosseini, Mohammad Bagher AU - Abdoli Oskouei, Shahram AU - Heidari, Fariba AU - Sadat Sharif, Amin AU - Salimi, Zakeiye AU - Sharif, Seyed Amir Abbas AD - Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AD - School of Medicine, Department of Community and Family Medicine, Tabriz University of Medical Sciences, Tabriz, Iran AD - School of Medicine, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran AD - Neonatal Intensive Care Unit, Alzahra Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Y1 - 2020 PY - 2020 VL - 11 IS - 1 SP - 1 EP - 11 KW - Antibiotic Treatment KW - Clinical Guideline KW - Microbial Agents KW - Neonatal sepsis DO - 10.22038/ijn.2019.38426.1605 N2 - Background: Sepsis is one of the most important causes of death in infants. The pattern of bacterial agents responsible for neonatal septicemia changes over time. The main aim of the present study was to provide a clinical guideline adapted for treatment of neonatal sepsis based on the frequency of microbial agents in the Neonatal Intensive Care Unit of Alzahra Hospital, Tabriz, Iran.Methods: The clinical guideline adaptation is conducted based on the ADAPTE Resource Toolkit for Guideline Adaptation (version 2.0) from December 2016 to January 2018. For data collection, the specialized websites were identified, then an internet search method was used for gaining clinical guidelines and medical literature databases. A panel was established with members of multi-specialties and the obtained guidelines were examined and evaluated. In the end, the final guideline was selected and translated.Results: Regarding the guideline, employing antibiotics should start when the neonate is < 35 weeks and premature rupture of membrane (PROM) happened < 18 h. Moreover, it could be employed when the neonate did not receive antibiotics, the gestational age (GA) is < 35 weeks with a PROM < 18 h or a GA < 37 weeks with a PROM ≥ 18 h. Conclusion: Implementation of the neonatal sepsis treatment guideline leads to a unified method of treatment, reduces the risk of antibiotic resistance, and decreases the mortality and morbidity associated with sepsis. UR - https://ijn.mums.ac.ir/article_13803.html L1 - https://ijn.mums.ac.ir/article_13803_1cb3a64f7341f00054b99cc85632ce8a.pdf ER -