Document Type: Original Article
Neonatal Research Center, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Neonatal Research Center, School of Medicine, Ghaem Hospital, Mashhad University of Medical
Immunology Research Center, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Community Medicine Devision, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Objective: Asphyxia is a major cause of acute mortality and chronic neurologic disability in neonates. We sought to define the predictive values of serum concentrations of interleukin-1β in newborns with perinatal asphyxia to see if there is a relation between interleukin-1β (IL-1β) levels to the short term neurological deficit.
Methods: This was a prospective (case-control) study conducted between June 2007 and July 2008, at the Neonatal Intensive Care Unit, Ghaem Hospital, Mashhad, Iran. Serum IL-1β levels were measured at birth, 24 and 48 h post-partum in 38 consecutive uninfected neonates with perinatal asphyxia(blood pH< 7.2, low Apgar score , signs of fetal distress) and 41 randomly selected healthy newborns (normal infants free of a postnatal clinical event during the first weeks of life). Receiver-operating characteristic (ROC) curves were used for the determination of thresholds for the asphyxiated group versus healthy neonate group.
Results: A total of 79 infants were studied. Serum interleukin-1β concentrations in the infants who developed hypoxic-ischemic encephalopathy was 6 folds higher as compared to values in the normal infants (p< 0.006) and 5-folds higher compared to infants with asphyxia who did not subsequently develop hypoxic-ischemic encephalopathy (p< 0.006). There was also a significant relationship between serum IL-1Β and outcome at the time of discharge.
Conclusions: Serum levels of IL-1Β are increased substantially in neonates with asphyxia, and this is most pronounced in neonates with poorer prognosis.