Clinical Features in Infants Younger Than 2 Months of Age Hospitalized with Laboratory-Confirmed COVID-19

Document Type : Original Article

Authors

1 Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

2 Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

3 Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

4 Student Committee Research, Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Babol, Iran

5 1. Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

Abstract

Background: A limited number of studies described the clinical aspects of the new coronavirus outbreak in the infant population. This study was conducted to describe the clinical features and laboratory findings in infants younger than 2 months of age hospitalized with confirmed coronavirus disease 2019 (COVID-19) infection.
Methods: This observational retrospective cohort study included all infants aged <2 months, admitted to two pediatric state hospitals, north of Iran, between February 19, 2020, and January 1, 2021, with confirmed COVID-19 infection. The patients whose pharyngeal or rectal specimens examined for coronavirus disease using a real-time polymerase chain reaction (RT-PCR) assay was positive, were included in the research. All patients were followed until they were discharged from the hospital.
Results: Totally, 13 infants with an age range from 1 to 50 days have been recognized. More than one-third of the study patients (38.5%) have been hospitalized immediately after birth. Dyspnea and gastrointestinal symptoms were the most typical manifestations of the patients. One patient had positive RT-PCR results in cerebrospinal fluid examination
Conclusion: The median length of stay in the hospital was seven days. More than 90% of infants younger than 2 months of age hospitalized with confirmed COVID-19 infection are expected to be cured.
 
 

Keywords

References

  1. Zachariah P, Johnson CL, Halabi KC, Ahn D, Sen AI, Fischer A, et al. Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (covid-19) in a children’s hospital in New York City, New York. JAMA Pediatr. 2020; 174(10):e202430-e.

    1. Shereen M, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020; 24:91-8.
    2. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395(10226):809-15.
    3. Xu L, Yang Q, Shi H, Lei S, Liu X, Zhu Y, et al. Clinical presentations and outcomes of SARS-CoV-2 infected pneumonia in pregnant women and health status
      of their neonates. Sci Bull (Beijing). 2020; 65(18):1537-42.
    4. Ryan GA, Purandare NC, McAuliffe FM, Hod M, Purandare CN. Clinical update on COVID-19 in pregnancy: A review article. J Obstet Gynaecol Res. 2020; 46(8):1235-45.
    5. Lopes de Sousa ÁF, Félix de Carvalho HE, de Oliveira LB, Schneider G, Camargo ELS, Watanabe E, et al. Effects of COVID-19 infection during pregnancy and neonatal prognosis: what is the evidence? Int J Environ Res Public Health. 2020; 17(11):1-17.
    6. Heald-Sargent T, Muller WJ, Zheng X, Rippe J, Patel AB, Kociolek LK. Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19). JAMA Pediatr. 2020; 174(9):902-3.
    7. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020; 109(6):1088-95.
    8. Mehta NS, Mytton OT, Mullins EWS, Fowler TA, Falconer CL, Murphy OB, et al. SARS-CoV-2 (COVID-19): What do we know about children? A systematic review. Clin Infect Dis. 2020; 71(9):2469-79.
    9. Cui X, Zhao Z, Zhang T, Guo W, Guo W, Zheng J, et al. A systematic review and meta-analysis of children with Coronavirus Disease 2019 (COVID-19). J Med Virol. 2020; 93(2):1057-69.
    10. Topjian A, Aziz K, Kamath-Rayne BD, Atkins DL, Becker L, Berg RA, et al. Interim Guidance for Basic and Advanced Life Support in Children and Neonates With Suspected or Confirmed COVID-19. Pediatrics. 2020:e 20201405.
    11. Patel NA. Pediatric COVID-19: Systematic review of the literature. Am J Otolaryngol. 2020; 41(5):1-10.
    12. Mantovani A, Rinaldi E, Zusi C, Beatrice G, Saccomani MD, Dalbeni A. Coronavirus disease 2019 (COVID-19) in children and/or adolescents: a meta-analysis. Pediatr Res. 2020; 89(4):733-7.
    13. American Academy of Pediatrics. FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19. 2020. https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/faqs-management-of-infants-born-to-covid-19-mothers/
    14. Amatya S, Tammy EC, Gandhi CK, Glass KM, Kresch MJ, Mujsce DJ, et al. Management of newborns exposed to mothers with confirmed or suspected COVID-19. J Perinatol. 2020; 40(7): 987-96.
    15. Salvatore CM, Han JY, Acker KP, Tiwari P, Jin J, Brandler M, et al. Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study. Lancet Child Adolesc Health. 2020; 4(10):721-7.
    16. Fore HH. A wake-up call: COVID-19 and its impact on children's health and wellbeing. Lancet Global Health. 2020; 8(7):861-2.
    17. Abdi M. Coronavirus disease 2019 (COVID-19) outbreak in Iran: Actions and problems. Infect Control Hosp Epidemiol. 2020; 41(6):754-5.
    18. Mahmoudi S, Mehdizadeh M, Shervin Badv R, Navaeian A, Pourakbari B, Rostamyan M, et al. . The Coronavirus Disease 2019 (COVID-19) in Children: a study in an Iranian Children’s Referral Hospital. Infect Drug Resist. 2020; 13:2649-55.
    19. Jalali SF, Ghassemzadeh M, Mouodi S, Javanian M, Akbari Kani M, Ghadimi R, et al. Epidemiologic comparison of the first and second waves of coronavirus disease epidemics in Babol, North of Iran. Caspian J Intern Med. 2020; 11(0):544-50.
    20. Habersaat KB, Betsch C, Danchin M, Sunstein CR, Böhm R, Falk A, et al. Ten considerations for effectively managing the COVID-19 transition. Nat Hum Beha. 2020; 4(7):677-87.
    21. Baker T, Greiner J, Maxwell-Schmidt E, Lamothe P, Vesonder M. Guidelines for frontlinehealth care staff safety for COVID-19. J Prim Care Community Health. 2020; 11:1-10.
    22. Akbarian-Rad Z, Haghshenas Mojaveri M, Bouzari Z, Sadeghi F, Yahyapour Y, Naeimi Rad M, et al. Neonatal outcomes in pregnant women infected with COVID-19 in Babol, North of Iran: A retrospective study with short term follow-up. Infect Dis Obstet Gynecol. 2021; 2021:1-5.
    23. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, et al. European consensus guidelines on the management of respiratory distress syndrome - 2019 Update. Neonatology. 2019; 115(4):432-50.
    24. Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C. Epidemiological and Clinical characteristics of covid-19 in children: a systematic review and meta-analysis. Front Pediatr. 2020; 8:1-12.
    25. Zimmermann P, Curtis N. Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections. Arch Dis Child. 2020; 2020:1-11.

     27.Dhochak N, Singhal T, Kabra SK, Lodha R. Pathophysiology of COVID-19: Why Children Fare Better than Adults? Indian J Pediatr. 2020; 87(7):537-46.

    1. 28. Sinaei R, Pezeshki S, Parvaresh S, Sinaei R. Why COVID-19 is less frequent and severe in children: a narrative review. World J Pediatr. 2021; 17(1):10-20.
    2. Bwire GM. Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women? SN Compr Clin Med. 2020; 2(7):874-876.
    3. Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021; 224(1):35-53.

    31.  Centeno-Tablante E, Medina-Rivera M, Finkelstein JL, Rayco-Solon P, Garcia-Casal MN, Rogers L, et al. Transmission of SARS-CoV-2 through breast milk and breastfeeding: a living systematic review. Ann N Y Acad Sci. 2021; 1484(1):32-54.

Iranian Journal of Neonatology
Volume 13, Issue 3
July 2022
Pages 70-74

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