Correlation between Lead in Maternal Blood, Umbilical Cord Blood, and Breast Milk with Newborn Anthro-pometric Characteristics

Document Type: Original Article

Authors

1 Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran

3 Department of Pediatrics, Valiasr Hospital, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Midwifery, Iran University of Medical Sciences, Tehran, Iran

Abstract

Background: Breast milk can be a source of toxic material, along with the transfer of nutrients needed for infant growth. This study was conducted to measure the level of lead in maternal and neonatal blood and breast milk in Tehran, Iran.
Methods: In this cross-sectional study, 150 mothers and their infants were studied. Samples of maternal blood, fetal umbilical cord blood, breast milk, and amount of lead measured by atomic absorption method were collected. Correlations between lead levels and demographic characteristics of mother and infants were assessed.
Results: The mean levels of lead in maternal and neonatal blood and breast milk were 9.79±4.31, 8.29±4.83, and 8.65±3.67 μg/dl, respectively. The different levels of lead were associated with cord blood, maternal blood, and breast milk. No significant relationship was found between lead levels and neonatal parameters (i.e., weight, height, and head circumference). The Spearman's correlation also showed the association between different levels of lead with cord blood, maternal blood, and breast milk. Linear regression also did not show any relationship between lead levels in cord blood, milk, and mother blood with newborn growth parameters.
Conclusion: The present study failed to find a significant correlation between lead and newborn birth parameters. In our study, lead levels in maternal blood, breast milk, and cord blood were lower, compared those of the previous years in Iran; however, it needs to decrease, because lead even at very low concentrations may also have adverse effects.

Keywords


1. Örün E, Yalçın SS, Aykut O, Orhan G, Morgil GK, Yurdakök K, et al. Breast milk lead and cadmium levels from suburban areas of Ankara. SciTotal Environ. 2011;409(13):2467-72.
2. Gürbay A, Charehsaz M, Eken A, Sayal A, Girgin G, YurdakökM, et al. Toxic metals in breast milk samples from Ankara, Turkey: assessment of lead, cadmium, nickel, and arsenic levels. Biol Trace Elem Res. 2012;149(1):117-22.
3. Dorea JG. Mercury and lead during breast-feeding. Br J Nutr. 2004;92(1):21-40.
4. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, Romieu I, Peterson KE, Aro A, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology. 2003; 14(2):206-12.
5. Dooyema CA, Neri A, Lo YC, Durant J, Dargan PI, Swarthout T, et al. Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010. Environ Health Perspect. 2011;120(4):601-7.
6. Karrari P,Mehrpour O, Abdollahi M. A systematic review on status of lead pollution and toxicity in Iran; Guidance for preventive measures. Daru. 2012;20(1):2.
7. Koyashiki GA, Paoliello MM, Tchounwou PB. Lead levels in human milk and children's health risk: a systematic review. Rev Environ Health. 2010; 25(3):243-54.
8. Koyashiki GA, Paoliello MM, Matsuo T, de Oliveira MM, Mezzaroba L, Carvalho M, et al. Lead levels in milk and blood from donors to theBreast Milk Bank 

in Southern Brazil. Environ Res. 2010;110(3): 265-71.
9. Mortada WI, Sobh MA, El-Defrawy MM. The exposure to cadmium, lead and mercury from smoking and its impact on renal integrity. Med Sci Monit. 2004;10(3):CR112-6.
10. Winiarska-Mieczan A. Cadmium, lead, copper and zinc in breast milk in Poland. Biol Trace Elem Res. 2014;157(1):36-44.
11. Soleimani S, Shahverdy MR, Mazhari N, Abdi K, Gerayesh Nejad S, Shams S, et al. Lead concentration in breast milk of lactating women who were living in Tehran, Iran. Acta Med Iran. 2014;52(1):56-9.
12. Farhat A, Mohammadzadeh A, Balali-Mood M, Aghajanpoor-Pasha M, Ravanshad Y. Correlation of blood lead level in mothers and exclusively breastfed infants: a study on infants aged less than six months. Asia Pacific J Med Toxicol. 2013; 2(4):150-2.
13. Schnur J, John RM. Childhood lead poisoning and the new Centers for Disease Control and Prevention guidelines for lead exposure. J Am Assoc Nurse Pract. 2014;26(5):238-47.
14. Ettinger AS, Wengrovitz AM. Guidelines for the identification and management of lead exposure in pregnant and lactating women. Atlanta: National Center for Environmental Health; 2010.
14. Ettinger AS, Roy A, Amarasiriwardena CJ, Smith D, Lupoli N, Mercado-García A, et al. Maternal blood, plasma, and breast milk lead: lactational transfer and contribution to infant exposure. Environ Health Perspect. 2013;122(1):87-92.
15. Meyer PA, Brown MJ, Falk H. Global approach to reducing lead exposure and poisoning. Mutat Res. 2008;659(1-2):166-75.
16. Rahimi E, Hashemi M, Baghbadorani ZT. Determination of cadmium and lead in human milk. Int J Environ Sci Technol. 2009;6(4):671-6.
17. Nishioka E, Yokoyama K, Matsukawa T, Vigeh M, Hirayama S, Ueno T, et al. Evidence that birth weight is decreased by maternal lead levels below 5 μg/dl in male newborns. Reprod Toxicol. 2014;47:21-6.
18. Atabek ME, Kurtoglu S, Pirgon O, Uzum K, Saraymen R. Relation of in utero lead exposure with insulin-like growth factor-I levels and neonatal anthropometric parameters. Int J Hyg Environ Health. 2007; 210(1):91-5.
19. Vigeh M, Yokoyama K, Ramezanzadeh F, Dahaghin M,Sakai T, Morita Y, et al. Lead and other trace metals in preeclampsia: a case–control study in Tehran, Iran. Environ Res. 2006;100(2):268-75.