New Insight into the Effect of Phototherapy on Serum Magnesium Level


1 Pediatric Growth Disorders Research Center, Department of Pediatrics, School of Medicine, 17 Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran

2 School of Medicine, Guilan University of Medical Sciences, Rasht, Iran


Background: Jaundice is one of the most common findings in the neonatal period. In almost all the cases, neonatal jaundice occurs due to the elevated level of unconjugated bilirubin. Evidence is scarce regarding the association between magnesium and bilirubin levels in neonatal hyperbilirubinemia. The present study aimed to investigate serum magnesium levels before and after phototherapy.
Methods: This observational study was conducted on 65 neonates with jaundice, who were admitted to 17 Shahrivar Hospital of Rasht, Iran during September 2011-2012. Neonates with total serum bilirubin level of >20 mg/dL underwent phototherapy with 12 lamps. Magnesium levels were measured before and 24 hours after phototherapy. Data analysis was performed in SPSS version 19 using descriptive statistics (mean and standard deviation) and paired t-test at 95% confidence interval, and P-value of less than 0.05 was considered statistically significant.
Results: In total, 65 neonates, including 37 boys (56.9%) and 28 girls (43.1%), were enrolled in the study. Mean magnesium level was significantly higher before phototherapy (2.07±0.33) compared to after phototherapy (1.81±0.27) (P<0.0001).
Conclusion: According to the results, mean magnesium level was significantly higher before phototherapy compared to after phototherapy. However, physiological characteristics of magnesium were not assessed. It seems that the findings of the present study could lay the groundwork for further investigation in this regard.


1. Badeli HR, Sharafi R, Sajedi SA. The effect of clofibrate on neonatal hyperbilirubinemia in uncomplicated jaundice. Iranian Journal of Pediatrics. 2008;18(1):20-4.
2. Qaisiya MAH. Unconjugated Bilirubin mediated oxidative stress, ER stress, and activation of Nrf2 pathway. 2014.
 3. Mehta Y, Shitole C, Setia MS. Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis. Iranian journal of pediatrics. 2016;26(1).
 4. Khosravi N, Aminian A, Taghipour R. Total serum magnesium level in icteric neonates before and after phototherapy. Tehran University of Medical Sciences. 2011;69(7).
 5. Imamoglu E, Gursoy T, Karatekin G, Ovali F. Effects of antenatal magnesium sulfate treatment on cerebral blood flow velocities in preterm neonates. Journal of Perinatology. 2014;34(3):192-6.
6. Dalili S, Rezvany SM, Medghalchi A, Mohammadi H, Dalili H, Mirzanejad M, Gholamnezhad H, Amirhakimi A. Congenital hypothyroidism: a review of the risk factors. Acta Medica Iranica. 2012 Nov 1;50(11):735.
 7. Karamizadeh Z, Dalili S, Sanei-far H, Karamifard H, Mohammadi H, Amirhakimi G. Does congenital hypothyroidism have different etiologies in Iran?. Iranian journal of pediatrics. 2011 Jun;21(2):188.
8. Karamifar H, Dalili S, Karamizadeh Z, Amirhakimi G, Dalili H. Autoimmune polyglandular syndrome type 2: an unusual presentation. Acta Medica Iranica. 2010;48(3):196-7.
9. Dalili S, Mohtasham-Amiri Z, Rezvani SM, Dadashi A, Medghalchi A, Hoseini S, Gholami-Nezhad H, Amirhaki A. The prevalence of Iodine Deficiency Disorder in two different populations in Northern Province of Iran: a comparison using different indicators recommended by WHO. Acta Medica Iranica. 2012 Dec 1;50(12):822.
10. Ilves P, Kiisk M, Soopold T, Talvik T. Serum total magnesium and ionized calcium concentrations in asphyxiated term newborn infants with hypoxic‐ ischaemic encephalopathy. Acta Paediatrica. 2000;89(6):680-5.
11. Engel RR, Elin RJ. Hypermagnesemia from birth asphyxia. The Journal of pediatrics. 1970;77(4):631-7. 12. Sarici SU, Serdar MA, Erdem G, Alpay F. Evaluation of plasma ionized magnesium levels in neonatal hyperbilirubinemia. Pediatric research. 2004;55(2):243-7.
 13. Okhravi T, Eslami ST, Ahmadi AH, Nassirian H, Najibpour R. Evaluation of Auditory Brain Stems Evoked Response in Newborns With Pathologic Hyperbilirubinemia in Mashhad, Iran. Iranian Red Crescent medical journal. 2015;17(2).
 14. Naylor DE, Liu H, Niquet J, Wasterlain CG. Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiology of disease. 2013;54:225-38.
 15. Wong RJ, Stevenson DK, editors. Neonatal hemolysis and risk of bilirubin-induced neurologic dysfunction. Seminars in Fetal and Neonatal Medicine; 2015: Elsevier.
 16. Imani M, Rezaee-pour M, Mohamdi M, Shiri M, Noroozifar M, Mahmodi N. Study of relationship between total Magnesium and total bilirubin levels in neonates' sera before and after phototherapy. Razi Journal of Medical Sciences. 2012;19(100):54-61.