Effect of Probiotics on Infantile Colic Using the Quadratic Inference Functions

Authors

1 Department of Biostatistics, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

2 Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

3 Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

Background: Infantile colic is defined as episodes of extreme and excessive crying due to unknown causes. Various results have been reported regarding the management of colic with probiotics in terms of effectiveness, with no side effects or health risks in the infants. The present study aimed to evaluate the effect of probiotics on the infants with colic using the quadratic inference functions (QIF).
Methods: This single-blind, randomized, clinical trial was conducted on 98 infants admitted to the pediatric gastroenterology clinic of Bu Ali Sina Hospital in Sari, Iran. The neonates were diagnosed with infantile colic by a pediatric gastroenterologist. Patients were randomly divided into two groups (49 subjects per each). In the control group, the infants received placebo, and in the case group, the neonates were administrated with BioGaia probiotic oral drops for 21 days. The QIF method was fitted to analyze the influential factors in the improvement of infantile colic.
Results: According to the QIF results in data analysis, mean duration of crying had a significant difference between the infants in the case and control groups (P<0.001). Moreover, time (first, second, and third week) was determined as a leading variable in the improvement of infantile colic (P=0.001).
Conclusion: According to the results of longitudinal data analysis, use of probiotics in the evolving gut could reduce infantile colic and improve the quality of life in the studied neonates

Keywords

References

1. Anabrees J, Indrio F, Paes B, AlFaleh K. Probiotics for infantile colic: a systematic review. BMC Pediatr. 2013; 13:186.
 2. Brazelton TB. Crying in infancy. Pediatrics. 1962; 29(4):579-88.
3. Illingworth RS. Crying in infants and children. Br Med J. 1955; 1(4905):75-8.
4. Savino F. Focus on infantile colic. Acta Paediatr. 2007; 96(9):1259-64.
5. Wessel MA, Cobb JC, Jackson EB, Harris GS Jr, Detwiler AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics. 1954; 14(5):421-35.
 6. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007; 119(1):e124-30.
 7. Barr RG, Kramer MS, Boisjoly C, McVey-White L, Pless IB. Parental diary of infant cry and fuss behaviour. Arch Dis Child. 1988; 63(4):380-7.
8. Barr RG. Colic and crying syndromes in infants. Pediatrics. 1998; 102(5 Suppl E):1282-6.
 9. de Weerth C, Fuentes S, Puylaert P, de Vos WM. Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics. 2013; 131(2):e550-8.
 10. Lehtonen L, Korvenranta H, Eerola E. Intestinal microflora in colicky and noncolicky infants: bacterial cultures and gas-liquid chromatography. J Pediatr Gastroenterol Nutr. 1994; 19(3):310-4.
 11. Savino F, Bailo E, Oggero R, Tullio V, Roana J, Carlone N, et al. Bacterial counts of intestinal Lactobacillus species in infants with colic. Pediatr Allergy Immunol. 2005; 16(1):72-5.
12. Hotel AC, Cordoba A. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Prevention. 2001; 5(1):1-59.
13. Connolly E, Mollstam B. Use of selected lactic acid bacteria for reducing infantile colic. Washington: United States Patent US; 2015.
 14. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007; 119(1):e124-30.
15. Diggle P, Heagerty P, Liang KY, Zeger S. Analysis of longitudinal data. 2nd ed. New York, USA: Oxford University Press; 2002.
 16. Fitzmaurice G, Davidian M, Verbeke G, Molenberghs G. Longitudinal data analysis. Florida: CRC Press; 2008.
17. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986; 73(1):13-22.
18. Crowder M. On consistency and inconsistency of estimating equations. Econometr Theor. 1986; 2(3):305-30.
19. Crowder M. On the use of a working correlation matrix in using generalized linear models for repeated measures. Biometrika. 1995; 82(2):407-10.
20. Qu A, Lindsay BG, Li B. Improving generalised estimating equations using quadratic inference functions. Biometrika. 2000; 87(4):823-36.
 21. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, doubleblind, placebo-controlled trial. J Pediatr. 2013; 162(2):257-62.
22. Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, doubleblind, placebo-controlled trial. Pediatrics. 2010; 126(3):e526-33.
 23. Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014; 348:g2107.
24. Chau K, Lau E, Greenberg S, Jacobson S, YazdaniBrojeni P, Verma N, et al. Probiotics for infantile colic: a randomized, double-blind, placebocontrolled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr. 2015; 166(1):74-8.
 25. Fallani M, Young D, Scott J, Norin E, Amarri S, Adam R, et al. Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics. J Pediatr Gastroenterol Nutr. 2010; 51(1):77-84.
26. Marques TM, Wall R, Ross RP, Fitzgerald GF, Ryan CA, Stanton C. Programming infant gut microbiota: influence of dietary and environmental factors. Curr Opin Biotechnol. 2010; 21(2):149-56.
 27. Akbarian Rad Z, Haghshenas Mojaveri M, Zahed Pasha Y, Ahmadpour-kacho M, Hajian K, Taghipoor Y. The effect of probiotic lactobacillus reuteri on reducing the period of restlessness in infants with colic. J Babol Univ Med Sci. 2015; 17(5):7-11.
Iranian Journal of Neonatology
Volume 8, Issue 3
September 2017
Pages 66-71

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