Association of Using Oxytocin during Labor and Breastfeeding Behaviors of Infants within Two Hours after Birth


1 Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

2 Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Neonatal Intensive Care Unit, Shahid Beheshti Hospital, Isfahan, Iran

4 Department of Midwifery, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran

5 Nursing and Midwifery Care Research Centre, faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran


Background: Opioids are used to relieve pain during labor and may affect the neurobehavioral conditions of infants. However, effects of using drugs, such as oxytocin, as a routine component of pre- and post-delivery care on the breastfeeding behaviors of newborns remain unclear. The present study aimed to investigate the association between the maternal use of oxytocin during labor and breastfeeding behaviors of neonates within two hours after birth.
Methods: This descriptive-analytical study was conducted on 160 women selected via convenience sampling. The participants were assigned to two groups of oxytocin administration (n=70) and physiologic delivery (n=90). Data were collected using demographic questionnaires and infant breastfeeding assessment tool (IBFAT). IBFAT was completed by the researcher through observing the behaviors of infants during breastfeeding after birth. Data analysis was performed in SPSS version 20, using descriptive and analytical statistics, including independent t-test, correlation-coefficients, and analysis of variance.
Results: Mean age of the mothers in the oxytocin administration and physiologic delivery groups was 26.9±5.9 and 27.8±5.5 years, respectively. Breastfeeding was significantly stronger in the infants whose mothers had physiologic delivery compared to the group administered with oxytocin during labor.
Conclusion: According to the results, use of oxytocin during labor directly weakens the breastfeeding of neonates. Therefore, it seems necessary to inform and prepare women for physiologic delivery during pregnancy


1. Gholamitabartabari M, Heidarzadeh M, Sattarzadeh N, Kooshavar H. Performing and evaluation of breast feeding education program on exclusive breastfeeding and growth induce of preterm infant of 4 month after birth. J Babol Univ Med Sci. 2011; 13(2):57-62 (Persian).
2. Gaffari V, Vahidshahi K, Parviniejad N. Assessment of mother's attitude and knowledge toward exclusive breastfeeding, Sari. J Jahrom Univ Med Sci. 2009; 7(1):53-60 (Persian).
3. Vahidi AA, Eranmanesh E. Breastfeeding and medication. J Kerman Univ Med Sci. 2011; 18(2):194-206.
4. Szabo AL. Intrapartum neuraxial analgesia and breastfeeding outcomes: limitations of current knowledge. Anesth Analg. 2013; 116(2):399-405.
 5. Maury S. Breastfeeding information & guideline: a manual for breastfeeding support in pediatric & neonatal units. Trans: Saadvandian S, Tahery M. Mashhad: Sokhan Gostar; 2007. P. 22-70 (Persian).
6. Kamalifard M, Heidarzadeh M, Ghoujazadeh M, Mohammadi M. The effect of kangaroo mother care on exclusive breast feeding in nulliparous. Nurs Midwifery J. 2010; 5(17):12-8 (Persian).
7. Reynolds F. The effects of maternal labor analgesia on the fetus. J Best Pract Res Clin Obstet Gynecol. 2010; 24(3):289-302.
8. Montgomery A, Hale TW; Academy Of Breastfeeding Medicine. ABM clinical protocol #15: analgesia and anesthesia for the breastfeeding mother, revised 2012. Breastfeed Med. 2012; 7(6):547-53.
 9. Wilson MJ, MacArthur C, Shennan A. The effect of epidural analgesia on breast feeding: analysis of a randomized controlled trial. Int J Obstet Anesth. 2009; 18(1):S7.
10. Reynolds F. Labour analgesia and the baby: good news is no news. Int J Obstet Anesth. 2011; 20(1):38-50.
11. Nissen E, Widstrom AM, Lilja G, Matthiesen AS, Uvnas-Moberg K, Jacobsson G, et al. Effects of routinely given pethidine during labour on infants’ developing breastfeeding behaviour. Effects of dosedelivery time interval and various concentrations of pethidine/norpethidine in cord plasma. Acta Paediatr. 1997; 86(2):201-8.
 12. Riordan J, Gross A, Angeron J, Krumwiede B, Melin J. The effect of labor pain relief medication on neonatal suckling and breast feeding duration. J Hum Lact. 2000; 16(1):7-12.
13. Radzyminski S. The effect of ultra-low dose epidural analgesia on newborn breast feeding behaviours. J Obstet Gynecol Neonatal Nurs. 2003; 32(3):322-31.
 14. Safarabadi Farahani T, Ali Akbar M, Taavoni S, Haghani H. The effect of kangaroo contact on duration of exclusive breastfeeding and success of lactation among primiparous women at Shahid Akbar-Abadi hospital in Tehran. Iran J Nurs. 2009; 22(59):60-70.
15. Brimdyr K, Cadwell K, Widstrom AM, Svensson K, Neumann M, Hart E, et al. The association between common labor drugs and suckling when skin-to-skin during the first hour after birth. Birth. 2015; 42(4):319-28.
16. Akbas M, Akcan AB. Epidural analgesia and lactation. Eurasian J Med. 2011; 43(1):45-9.
17. Jordan S. Infant feeding and analgesia in labour: the evidence is accumulating. Int Breastfeed J. 2006; 1:25.
18. Olza Fernandez I, Marín Gabriel M, Malalana Martínez A, Fernández-Cañadas Morillo A, López Sánchez F, Costarelli V. Newborn feeding behavior depressed by intrapartum oxytocin: a pilot study. Acta Paediatr. 2012; 101(7):749-54.
 19. Wiklund I, Edman G, Andolf E. Cesarean section on maternal request: reasons for the request, selfestimated health, expectations, experience of birth and signs of depression among first-time mothers. Acta Obstet Gynecol Scand. 2007; 86(4):451-6.
 20. Dozier AM, Howard CR, Brownell EA, Wissler RN, Glantz JC, Ternullo SR, et al. Labor epidural anesthesia, obstetric factors and breastfeeding cessation. Matern Child Health J. 2013; 17(4):689-98.
21. Wiklund I, Norman M, Uvnäs-Moberg K, RansjöArvidson AB, Andolf E. Epidural analgesia: breastfeeding success and related factors. Midwifery. 2009; 25(2):e31-8.
 22. Jordan S, Emery S, Watkins A, Evans JD, Storey M, Morgan G. Associations of drugs routinely given in labour with breastfeeding at 48 hours: analysis of the Cardiff Births Survey. BJOG. 2009; 116(12):1622-9.
 23. Garcia-Fortea P, Gonzalez-Mesa E, Blasco M, Cazorla O, Delgado-Ríos M, González-Valenzuela MJ. Oxytocin administered during labor and breastfeeding: a retrospective cohort study. Matern Fetal Neonatal Med. 2014; 27(15):1598-603.
 24. Lind JN, Perrine CG, Li R. Relationship between use of labor pain medications and delayed onset of lactation. J Hum Lact. 2014; 30(2):167-73.