Infantile and Maternal Choriocarcinoma: A Case Report and Review of Literature

Document Type : Case Report


1 Associate Professor of Neonatology Depatrment of Neonatology , Children’s Medical Center, Tehran University of Medical Sciences , Tehran , Iran.

2 Associate Professor of Pediatric Cardiology Department of Pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran

3 Pediatrician, Children’s Medical Center, Tehran University of Medical Sciences , Tehran


Background: Choriocarcinoma is a rare highly malignant trophoblastic neoplasm. It can be preceded by any form of gestation including a complete or a partial mole, miscarriage and normal pregnancy. Simultaneous intraplacental choriocarcinoma involving both mother and infant is extremely rare. Hepatomegaly, anemia, elevated ßHCG is the diagnostic triad.
Here we report a 6 weeks old Afghan girl infant with intraplacental choriocarcinoma presented by severe anemia and widespread multiple metastatic lesions in liver, lung and brain with an elevated level of ßHCG .
According to rarity of the disease, rapid progression and the high mortality rate with delay in diagnosis and intervation , choriocarcinoma should be one of the differential diagnosis in severe infantile and maternal anemia without any antecedent reason. According to highly vascular and friable nature of tumor, biopsy can be dangerous for diagnosis. As choriocarcinoma secrets ßHCG, measurement of serum ßHCG is the most common method used to diagnose choriocarcinoma


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