Evaluation of External Genital Anomalies and the Underlying Factors in Male Newborns

Document Type : Original Article

Authors

1 M.D, student research committee, Emergency Department, Arak University of medical science, Arak, Iran.

2 Kidney Transplantation Fellowship, Assistant Professor, Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran

3 Neonatology Fellowship, Assistant Professor, Department of Pediatrics, Urmia University of Medical Sciences, Urmia, Iran

4 M.D, Urmia University of Medical Sciences, Urmia, Iran

5 BSc of Midwifery, Urmia University of Medical Sciences, Urmia, Iran

6 MSc of Epidemiology, Urmia University of Medical Sciences, Urmia, Iran

Abstract

Background: External genital anomalies are the most common congenital disorders in male infants with unknown etiology in the majority of cases. According to recent reports, incidence rate of these anomalies is rising in different countries. This study aimed to evaluate the prevalence of external genital anomalies and possible underlying factors in male newborns.
Methods: This cross-sectional study was conducted on all the male neonates born in Motahari Hospital of Urmia during October 2009-June 2010. Neonatal screening results and demographic data were recorded separately in a questionnaire for each neonate. Data analysis was performed in SPSS V.20 using descriptive statistics (mean, frequency, percentage, and standard deviation) and Chi-square test to evaluate the correlations between quantitative variables.
Results: In this study, external genital anomalies were identified in 83 male neonates (8.3%). Moreover, 59 infants (5.9%) had cryptorchidism, 18 (1.8%) had hypospadias and 12 infants (1.2%) had microphallus. Moreover, a significant correlation was observed between the incidence of cryptorchidism and maternal comorbidities, low birth weight, prematurity, maternal gestational hypertension, and diabetes mellitus.
Conclusion: According to the results of this study, cryptorchidism is the most prevalent external genital anomaly in male newborns, followed by hypospadias. Occurrence of these anomalies is associated with several risk factors, such as prematurity, low birth weight, maternal diseases (e.g., diabetes and hypertension), and use of medications during pregnancy. In addition, cryptorchidism had a significant correlation with smoking habits, and further studies with larger sample sizes are required in this regard.
 

Keywords

References

  1. Aho MO, Tammela OK, Somppi EM, Tammela TL. Sexual and social life of men operated in childhood for hypospadias and phimosis. Eur Urol. 2000; 37(1):95–100.
  2. Jiwani A, Marseille E, Lohse N, Damm P, Hod M, Kahn JG. Gestational diabetes mellitus: results from a survey of country prevalence and practices. J Matern Fetal Neonatal Med. 2012; 25(6):600–10.
  3. Carmichael SL, Shaw GM, Nelson V, Selvin S, Torfs CP, Curry CJ. Hypospadias in California: trends and descriptive epidemiology. Epidemiology. 2003; 14(6):701–6
  4. Wisborg K, Kesmodel U, Bech BH, Hedegaard M, Henriksen TB. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: prospective study. BMJ. 2003; 326(7386):420.
  5. Duguid A, Morrison S, Robertson A, Chalmers J, Youngson G, Ahmed SF; Scottish Genital Anomaly Network. The psychological impact of genital anomalies on the parents of affected children. Acta Paediatr. 2007; 96(3):348-52.
  6. Preiksa RT, Zilaitiene B, Matulevicius V, Skakkebaek NE, Petersen JH, Jørgensen N, et al. Higher than expected prevalence of congenital cryptorchidism in Lithuania:a study of 1204 boys at birth and 1 year follow-up. Hum Reprod. 2005; 20(7):1928-32.
  7. Leung AK, Robson WL. Hypospadias: an update. Asian J Androl. 2007; 9(1);16-22.
  8. Carmichael SL, Shaw GM, Nelson V, Selvin S, Torfs CP, Curry CJ. Hypospadias in California: trends and descriptive epidemiology. Epidemiology. 2003; 14(6):701-6.
  9. Fisch H, Golden RJ, Libersen GL, Hyun GS, Madsen P, New MI, et al. Maternal age as a risk factor for hypospadias. J Urol. 2001; 165(3):934-6.

10. Ahmed SF, Dobbie R, Finlayson AR, Gilbert J, Youngson G, Chalmers J, et al. Prevalence of hypospadias and other genital anomalies among singleton births, 1988-1997, in Scotland. Arch Dis Child Fetal Neonatal Ed. 2004; 89(2):149-51.

11. Bin-Abbas B, Conte FA, Grumbach MM, Kaplan SL. Congenital hypogonadotropic hypogonadism and micropenis: effect of testosterone treatment on adult penile size why sex reversal is not indicated. J Pediatr. 1999; 134(5):579-83.

12. Shiva S, Hoseinian MH. Study on External Genital Anomalies in Newborn Babies. Iran J Pediatr. 2008; 18(Suppl 1):3-8.

13. Sebastian Calderón J, Zarante I. Congenital urological anomalies: epidemiological description and associated risk factors in Colombia 2001-2004, Arch Esp Urol. 2006; 59(1):7-14

14. Weidner IS, MÃller H, Jensen TK, Skakkebaek NE. Risk factors for cryptorchidism and hypospadias. J Urol. 1999; 161(5):1606-9.

15. Carmichael SL, Shaw GM, Nelson V, Selvin S, Torfs CP, Curry CJ. Hypospadias in California: trends and descriptive epidemiology. Epidemiology. 2003; 14(6):701-6.

16. Boisen KA, Chellakooty M, Schmidt IM, Kai CM, Damgaard IN, Suomi AM, et al. Hypospadias in a cohort of 1072 danish boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age. J Clin Endocrinol Metab. 2005; 90(7):4041-6.

17. Martinez-Frias ML, Prieto D, Prieto L, Bermejo E, Rodríguez-Pinilla E, Cuevas L. Secular decreasing trend of the frequency of hypospadias among newborn male infants in Spain. Birth Defects Res A Clin Mol Teratol. 2004; 70(2):75-81.

18. Chong JH, Wee CK, Ho SK, Chan DK. Factors associated with hypospadias in Asian newborn babies. J Perinat Med. 2006; 34(6):497-500.

19. Aberg A, Westbom L, Kallen B. Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Dev. 2001; 61(2):85-95.

20. Hussain N, Chaghtai A, Herndon CD, Herson VC, Rosenkrantz TS, McKenna PH. Hypospadias and early gestation growth restriction in infants. Pediatrics. 2002; 109(3):473-8.

21. Sweet RA, Schrott HG, Kurland R, Culp OS. Study of the incidence of hypospadias in Rochester, Minnesota, 1940-1970, and a case-control comparison of possible etiologic factors. Mayo Clin Proc. 1974; 49(1):52-8.

22. Abdollahi S, Bahlooli A. The study of congenital external genitalia anomalies in 2000 newborn boys. Iran J Urol. 1995; 5-6(2):65-7.

 

 

 

 

 

 

 

 

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