Evaluation of Hematological Parameters and Characteristics of Preterm Infants Born at  32 Weeks’ Gestation with Retinopathy of Prematurity

Document Type : Original Article

Authors

1 Sakarya University Education and Research Hospital, Sakarya, Turkey

2 Sakarya Adatıp Hospital, Sakarya, Turkey

10.22038/ijn.2025.85848.2652

Abstract

Background: To investigate the possible effect of hematological parameters and other risk factors on the development of retinopathy of prematurity (ROP) in preterm infants born at 32 weeks’ gestational age (GA) and older.
Methods: Infants having a birth weight (BW) above 1250 g and born at 32–35 weeks’ GA with any stage of ROP disease were included in the study, while infants without ROP and born at 32–35 weeks’ GA were randomly selected to form the control group (non-ROP group). Complete blood cell count (CBC) parameters obtained on the first day of preterms’ life were analysed, and delivery type, cause of preterm birth, total number of births and smoking status during pregnancy were recorded. Infant-related factors, such as the GA at birth, BW) and total time spent in NICU were also recorded, and all parameters were compared between groups.
Results: In total, 50 preterm infants were included in the study, 20 in the ROP group and 30 in the control group (non-ROP). No significant differences in hematological parameters were found between groups, though red blood cell (RBC) transfusion was found to be more common in the ROP group (p: 0.03).
Conclusion: There were no statistically significant differences in hematological parameters measured on the infants’ first day of life following preterm birth at 32–35 weeks’ GA and a 1250 g BW. Therefore, RBC transfusion may be a risk factor for ROP development in late preterm infants.
 

Keywords

References

  1. Chung SH, Bae CW. Improvement in the survival rates of very low birth weight infants after the establishment of the Korean Neonatal Network: Comparison between the 2000s and 2010s. J Korean Med Sci. 2017;32 (8):1228-1234.
  2. Hartnett ME. Retinopathy of prematurity: Evolving treatment with anti-vascular endothelial growth factor. Am J Ophthalmol. 2020;218:208-13.
  3. Dericioğlu V, Butur S, Celiker H, Şahin Ö. Incidence, risk factors and screening evaluation of retinopathy of prematurity in high birthweight infants: A Large cohort study in Turkey. Ophthalmic Epidemiol. 2022;29(1):78-84.
  4. Bas AY, Demirel N, Koc E, Ulubas Isik D, Hirfanoglu İM, Tunc T; TR-ROP Study Group. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. Br J Ophthalmol. 2018;102(12):1711-1716.
  5. Padhi TR, Rath S, Jalali S, Pradhan L, Kesarwani S, Nayak M, et al. Larger and near-term baby retinopathy: a rare case series. Eye (Lond). 2015;29(2):286-289.
  6. Gonçalves E, Násser LS, Martelli DR, Alkmim IR, Mourão TV, Caldeira AP, et al. Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service. Sao Paulo Med J. 2014;132(2):85-91.
  7. Owen LA, Morrison MA, Hoffman RO, Yoder BA, DeAngelis MM. Retinopathy of prematurity: A comprehensive risk analysis for prevention and prediction of disease. PLoS One. 2017;12(2):e0171467.
  8. Alajbegovic-Halimic J, Zvizdic D, Alimanovic-Halilovic E, Dodik I, Duvnjak S. Risk factors for retinopathy of prematurity in premature born children. Med Arch. 2015;69(6):409-413.
  9. Akyüz Ünsal Aİ, Key Ö, Güler D, Kurt Omurlu İ, Anık A, Demirci B, et al. Can complete blood count parameters predict retinopathy of prematurity? Turk J Ophthalmol. 2020;50(2):87-93.
  10. Niranjan HS, Bharath Kumar Reddy KR, Benakappa N, Murthy K, Shivananda S, Veeranna V. Role of hematological parameters in predicting retinopathy of prematurity (ROP) in preterm neonates. Indian J Pediatr. 2013;80(9):726-730.
  11. Lubetzky R, Stolovitch C, Dollberg S, Mimouni FB, Salomon M, Mandel D. Nucleated red blood cells in preterm infants with retinopathy of prematurity. Pediatrics. 2005;116(5):e619-622.
  12. Freitas AM, Mörschbächer R, Thorell MR, Rhoden EL. Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study. Int J Retina Vitreous. 2018;4:20.
  13. Schaffer DB, Palmer EA, Plotsky DF, Metz HS, Flynn JT, Tung B, et al. Prognostic factors in the natural course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology. 1993; 100(2):230-237.
  14. Gilbert C, Fielder A, Gordillo L, Quinn G, Semiglia R, Visintin P, et al. International NO-ROP Group. Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implications for screening programs. Pediatrics. 2005;115(5):e518-525.
  15. Akçakaya AA, Yaylali SA, Erbil HH, Sadigov F, Aybar A, Aydin N, et al. Screening for retinopathy of prematurity in a tertiary hospital in Istanbul: incidence and risk factors. J Pediatr Ophthalmol Strabismus. 2012;49(1):21-25.
  16. Gunay M, Celik G, Tuten A, Karatekin G, Bardak H, Ovali F. Characteristics of severe retinopathy of prematurity in infants with birth weight above 1500 grams at a referral center in Turkey. 2016;11(8):e0161692.
  17. Akdogan M, Ustundag Y, Cevik SG, Dogan P, Dogan N. Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity. Indian J Ophthalmol. 2021;69(8):2182-2187.
  18. Hu YX, Xu XX, Shao Y, Yuan GL, Mei F, Zhou Q, et al. The prognostic value of lymphocyte-to-monocyte ratio in retinopathy of prematurity. Int J Ophthalmol. 2017;10(11):1716-1721.
  19. Zhu Z, Hua X, Yu Y, Zhu P, Hong K, Ke Y. Effect of red blood cell transfusion on the development of retinopathy of prematurity: A systematic review and meta-analysis. PLoS One. 2020;15(6):e0234266.
  20. Şahinoğlu Keşkek N, Gülcan H, Yılmaz G, Akkoyun İ. Impact of platelet count in retinopathy of prematurity. Turk J Ophthalmol. 2020;50(6):351-355.
  21. Parrozzani R, Nacci EB, Bini S, Marchione G, Salvadori S, Nardo D, et al. Severe retinopathy of prematurity is associated with early post-natal low platelet count. Sci Rep. 2021;11(1):891.
  22. Çömez A, Yurttutan S, Seringec Akkececi N, Bozkaya A, Köküsarı G, Evgin İ, et al. Red cell distribution width and its association with retinopathy of prematurity. Int Ophthalmol. 2021;41(2):699-706.
  23. Stutchfield CJ, Jain A, Odd D, Williams C, Markham R. Foetal haemoglobin, blood transfusion, and retinopathy of prematurity in very preterm infants: a pilot prospective cohort study. Eye (Lond). 2017;31(10):1451-1455.
  24. Lim ZD, Pheng E, Min ETL, Van Rostenberghe H, Shatriah I. Comparison of mean platelet counts in preterm infants with and without retinopathy of prematurity. Int J Environ Res Public Health. 2021;18(7):3783.
  25. Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF. Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol. 2018;63(5):618-637.
Iranian Journal of Neonatology
Volume 16, Issue 4
October 2025
Pages 6-11

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