Document Type : Original Article
Authors
1
Department of Community Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
2
Master of Genetics, Zabol University of Medical Sciences, Zabol, Iran
3
Department of Immunology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
4
Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran
5
Department of Internal Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
6
Department of Pediatrics, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
10.22038/ijn.2025.88224.2703
Abstract
Background: The study aimed to investigate the severity of Neonatal Abstinence Syndrome (NAS) complications in newborns in the eastern region of Iran.
Methods: The retrospective study was conducted among mothers and singleton live births between March 2022 and March 2023.
Results: Twenty-nine mothers (53.7%) used natural opioids (NO) and 25 (46.3%) synthetic opioids (SO). The highest number with the 20-30 age range. Of the newborns (NBs) from the NO, 31.03% were before 37 weeks. In contrast, in the SO, 88% were before 37 weeks (p < 0.05).
In the NO, 89.65% weighed < 2.5 kg. In contrast, 100% of those in the SO weighed > 2.5 kg. In SO exhibited crying for >10 minutes at a high. Additionally, SO had a high frequency of sleep (P<0.05). The SO showed a high frequency of metabolic disorders (P<0.05). The frequency of sneezing was high in the SO (P<0.05).
Nasal flaring was high in the SO (P<0.05). Respiratory rate index, defined as more than 60 breaths per minute and contraction> 60 breaths per minute, were high in the NO and SOs, respectively (P<0.05). Excessive sucking and poor nutrition were high in the NO, and SO, respectively (P<0.05).
The regurgitation index (grade 3), and loose stools and watery stools were high in the SO (P < 0.05).
Conclusion: While many studies exist, none have compared the effects of NO and SO on related symptoms. This study identified a significant correlation between the NB's gender and age at birth with the severity of NAS.
Keywords
)