Association between the Maternal and Umbilical Cord Blood Vitamin D: A Cross-sectional Study

Document Type : Original Article

Authors

1 Department of Pediatrics, Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Nursing, Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Vitamin D has multifaceted effects on the mother’s health and fetus. Since its deficiency can cause numerous maternal and fetal complications, this study aimed to investigate the relationship between the maternal and umbilical cord blood vitamin D.
Methods: This cross-sectional study was conducted on 48 pregnant mothers and their 48 babies in Hafez Hospital, Shiraz, in 2021. First, 5cc the blood clot was taken from the mother and the baby's umbilical cord after delivery. Also, a checklist included the mother's age, pregnancy conditions, gender, weight, height, head circumference, age of baby teeth eruption, and the first and fifth minute Apgar score of their babies was filled. Data were analyzed using SPSS-26.
Results: The mean of vitamin D from the umbilical cord blood (35.95±11.97), and from mothers' serum (21.85±7.3); were correlated significant (r=0.80, P<0.001). The mean vitamin D serum level of mothers who received supplements during pregnancy (23.72±6.04) was higher than mothers who did not use them during pregnancy (8.29±19.45) (P<0.05). There was a significant relationship between the mother's vitamin D and umbilical cord vitamin D with the sprouting of the first milk tooth.
Conclusion: In this study, most mothers reported vitamin D deficiency, and their vitamin D levels were directly correlated to the umbilical cord vitamin D. These findings show the importance of monitoring the mother's vitamin D to indicate the vitamin D status of the fetus and encourage mothers to make effective use of sunlight and the enrichment food with vitamin D.
 

Keywords

References

  1. Whitfield GK, Remus LS, Jurubka PW, Zitzer H, Oza AK, Dang HT, et al. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol 2001;177(1-2):145-159.
  2. Charoenngam N, Holick MF. Immunologic effects of vitamin D on human health and disease. Nutrients. 2020;12(7):2097.
  3. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013;88(7):720-755.
  4. Abbaspour F, Gholami M, Sargeran K. Evaluating the associations between serum vitamin D levels and dental caries (ICDAS index) among dental students of Tehran university of medical sciences. J Dent Med. 2020;32(4):229-238.
  5. Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. Int J Mol Sci. 2017; 18(10):2170.
  6. Holtis BW. Assessment of vitamin D Nutriational and hormonal that is Important for skeletal and cellular health. Cur Opin Endocrinol Diabetes 2002;9:88-98.
  7. Tartagni M, Cicinelli MV, Tartagni MV, Alrasheed H, Matteo M, Baldini D, et al. Vitamin D supplementation for premenstrual syndrome-related mood disorders in adolescents with severe hypovitaminosis D. J Pediatr Adolesc Gynecol. 2016;29(4):357-361.
  8. Bahardoust M, Mousavi S, Ziafati H, Alipour H, Haghmoradi M, Olamaeian F, et al. Vitamin B12 deficiency after total gastrectomy for gastric cancer, prevalence, and symptoms: a systematic review and meta-analysis. Eur J Cancer Prev. 2024;33(3):208-216.
  9. Azami M, Badfar G, Shohani M, Mansouri A, Yekta-Kooshali MH, Sharifi A, et al. A meta-analysis of mean vitamin d concentration among pregnant women and newborns in Iran. Iran J Obstet Gynecol Infertil. 2017;20(4):76-87.
  10. Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013;5(1):51-108.
  11. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6S. 
  12. Palacios C, De-Regil LM, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol. 2016;164:148-155.
  13. Wierzejska R, Jarosz M, Klemińska-Nowak M, Tomaszewska M, Sawicki W, Bachanek M, et al. Maternal and cord blood vitamin D status and anthropometric measurements in term newborns at birth. Front Endocrinol (Lausanne). 2018;9:9.
  14. Barrett H, McElduff A. Vitamin D and pregnancy: An old problem revisited. Best Pract Res Clin Endocrinol Metab. 2010;24(4):527-539.
  15. BabazadehD, RazaviSA, Abd El-GhanyWA, CotterPF. Vitamin D deficiency in  farm  animals:  a  Farm Anim. Health Nutr. 2022; 1(1): 10-16.
  16. Moradzadeh K, Larijani B, Keshtkar A, Hossein Nezahad A, Rajabian R, Nabipoor. I, et al. Normal values of vitamin D and prevalence of vitamin D deficiency among Iranian population. Sci J Kurdistan Univ Med Sci. 2006;10(4):22-42.
  17. Sandoughi M, Kaykhaei MA. Evaluation and Treatment of vitamin D deficiency in Iranian Adults. A Narrative Review. Iran J Endocrinol Metab. 2021;23(1):60-71.
  18. Karatekin G, Kaya A, Salihoğlu O, Balci H, Nuhoğlu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63(4):473-477.
  19. Cetinkaya M, Cekmez F, Buyukkale G, Erener-Ercan T, Demir F, Tunc T, et al. Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 2015;35(1):39-45.
  20. Brooke OG, Butters F, Wood C. Intrauterine vitamin D nutrition and postnatal growth in Asian infants. Br Med J (Clin Res Ed). 1981;283(6298):1024.
  21. Barzegar M, Baradaran R, Gafarpour Sakha K, Mahbobi L, Shiva S, Ashrafi Hafez A; et al. Infantal Nutritional rickets and Mother's vitamin D status. Med J Tabriz Uni Med Sciences Health Services. 2007;29(3):33-37.
  22. Abbasian M, Chaman R, Amiri M, Ajami ME, Jafari-Koshki T, Rohani M, et al. Vitamin D deficiency in pregnant women and their neonates. Glob J Health Sci 2016;8 (9):54008
  23. Salek M, Hashemipour M, Aminoroaya A, Gheiratmand A, Kelishadi R, Ardestani P, et al. Vitamin D deficiency amount pregnant women and their newborns in Isfahan, Iran. Exp Clin Endocrinol Diabettes. 2008;116(6):353-356.
  24. Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O’beirne M, Rabi DM. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. Obstetric Anesthesia Digest. 2014;34(2):115-116.
  25. Aguilar-Cordero MJ, Lasserrot-Cuadrado A, Mur-Villar N, León-Ríos XA, Rivero-Blanco T, Pérez-Castillo IM. Vitamin D, preeclampsia and prematurity: A systematic review and meta-analysis of observational and interventional studies. Midwifery. 2020;87:102707.
  26. Karras SN, Wagner CL, Castracane VD. Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism. 2018; 86:112–123.
  27. Mojibian M, Soheilykhah S, Fallah Zadeh MA, Jannati Moghadam M. The effects of vitamin D supplementation on maternal and neonatal outcome: A randomized clinical trial. Iran J Reprod Med. 2015;13(11):687-696.
  28. Akhlaghi F, Vakili R, Khorasani E. Evaluation of umbilical cord vitamin D level and maternal factors effective on it in three hospitals of Emam Reza, Ghaem & Omol Banin during 2013-2014. Iran J Obstet Gynecol Infertil. 2015;17(134):1-7.
  29. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M; Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398-417.
  30. Jairam LS, Konde S, Raj NS, Kumar NC. Vitamin D deficiency as an etiological factor in delayed eruption of primary teeth: A cross-sectional study. J Indian Soc Pedod Prev Dent. 2020;38(3):211-215.
Iranian Journal of Neonatology
Volume 15, Issue 3
July 2024
Pages 17-23

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