Prenatal Ultrasound Diagnosis and Short-term Outcome of Congenital Malformations: Experience of the Maternity and Reproductive Health Hospital “Les Orangers” - Rabat, Morocco, between 2011-2016

Document Type : Original Article


1 Research team in congenital anomalies, Unit of Dysmorphology and Developmental Anomalies, Training in clinical epidemiology and medical-surgical sciences-Faculty of Medicine and Pharmacy Rabat-University Mohammed V - Rabat, Morocco

2 Laboratory of Biostatistics and Clinical and Epidemiological Research, Faculty of Medicine and Pharmacy of Rabat, University Mohammed V Rabat, Morocco



Background: The objective of our study to analyze the data of the prenatal diagnosis of congenital malformations at the maternity and reproductive health hospital "Les Orangers" in Rabat and to identify the main anomalies detected, their percentage and their short-term outcome.
Methods: This is a cross-sectional study conducted at the maternity and reproductive health hospital "Les Orangers" in Rabat, Morocco. The data was collected and reported on pre-established sheets and on the register of malformations of the hospital.
Results: A total of 245 cases of congenital malformations comprising 470 types of congenital malformations were recorded out of a total of 43,923 births over a period of five and a half years, giving a prevalence of 5.58 per thousand.
Prenatal diagnosis was made in a third of cases (33%), essentially during the 2nd-3rd trimester of pregnancy. The anomalies revealed by this antenatal diagnosis were dominated by urinary malformations in 70% and central nervous system anomalies in 67%, followed by other types of congenital anomalies in less than 40% of cases, while genetic problems were detected in 2.5%; this rate is underestimated since chromosomal abnormalities sometimes appear as syndromes, so that in some diseases, genetic changes are not separated from other abnormalities, and since more than half (50.7%) of cases presenting polymalformative syndromes not survived 77% of cases i.e. (48.5% of deaths and 28.5% of FDIU) and an etiological study was not carried out.
Conclusion: Antenatal ultrasound allows early detection and monitoring of the evolution of congenital malformations, and thus the possibility of ensuring early and adequate management of these anomalies from birth. In our context, it is necessary to develop a prenatal screening program for congenital anomalies and a network of reference centers for the management of these anomalies in order to improve their prognosis.


  1. Philippe Descamps. Prenatal diagnosis in practice. Masson. 2011. ISBN: 9782294709623

  1. Fetal ultrasounds for medical purposes and not medical: definitions and compatibility. Report Technological Assessment. High Authority of Health (HAS)/Procedure assessment service Professionals /26 April 2012.                                                

  1. World Health Organization, editor. International Statistical Classification of Diseases and related health problems: Alphabetical index. World Health Organization; 2004. Available from:
  2. Lelong N, Thieulin AC, Vodovar V, Goffinet F, Khoshnood B. Epidemiological surveillance and prenatal diagnosis of congenital anomalies in the Parisian population 1981-2007. Arch Pediatr. 2012;19(10):1030-1038.
  3. De Vigan C, Khoshnood B, Lhomme A, Vodovar V, Goujard J, Goffinet F. Prevalence and prenatal diagnosis of congenital malformations in the Parisian population: twenty years of surveillance by the Paris Registry of congenital malformations. J Gynecol Obstet BiolReprod 2005;34 (cahier 1): 8-16.
  4. Gilles Grange. Practical guide to obstetric and gynecological ultrasound. Under the aegis of the National College of French Gynecologists and Obstetricians. 2nd edition, 2016.
  5. Munim S, Nadeem S, Khuwaja NA. The accuracy of ultrasound in the diagnosis of congenital abnormalities. J Pak Med Assoc. 2006;56(1):16-18.
  6. Dulgheroff FF, Peixoto AB, Petrini CG, Caldas TMRDC, Ramos DR, Magalhães FO, et al. Fetal structural anomalies diagnosed during the first, second and third trimesters of pregnancy using ultrasonography: a retrospective cohort study. Sao Paulo Med J. 2019;137(5):391-400.
  7. Cedergren M, Selbing A. Detection of fetal structural abnormalities by an 11-14-week ultrasound dating scan in an unselected Swedish population. Acta Obstet Gynecol Scand. 2006;85(8):912-915.
  8. Weisz B, Pajkrt E, Jauniaux E. Early detection of fetal structural abnormalities. Reprod Biomed Online. 2005;10(4):541-553. 
  9. Taipale P, Ammälä M, Salonen R, Hiilesmaa V. Learning curve in ultrasonographic screening for selected fetal structural anomalies in early pregnancy. Obstet Gynecol. 2003;101(2):273-278. 
  10. Bardi F, Smith E, Kuilman M, Snijders RJM, Bilardo CM. Early Detection of Structural Anomalies in a Primary Care Setting in the Netherlands. Fetal Diagn Ther. 2019;46(1):12-19.