Magnesium as a Prognostic Factor in Neonates with Respiratory Distress Syndrome

Document Type : Original Article

Authors

1 Maternal-Fetal and Neonatal Health Research Center, Vali-e Asr Hospital, Imam Khomeini hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

2 Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran

3 Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Magnesium (Mg) is a vital element which plays a significant role in the human body. Respiratory distress syndrome (RDS) is one of the most common problems in preterm neonates. The current study aimed to investigate the role of serum Mg level as a prognostic factor in neonates diagnosed with RDS.
Methods: This case-control study was performed in Vali-e-Asr Hospital, Tehran, Iran, for two years. A total of 100 preterm infants (50 cases, 50 controls) admitted to NICU were enrolled in this study. Demographic data, serum magnesium level, therapeutic interventions, and neonatal outcomes were investigated and the obtained data were analyzed using SPSS software. P-value less than 0.05 was considered significant.
Results: Of 100 neonates, 52% were male. The mean gestational age and birth weights were 33.4 ± 2.4 weeks and 2062 ± 72 gr, respectively. The findings revealed that the mean serum magnesium level in neonates with RDS was 2.02 ± 0.57 mg/dl, while it was 2.35 ± 0.67 mg/dl for neonates in the control group (P-value=0.001). Additionally, the calculated odds ratio of 2.38 indicated a correlation between reduced serum Mg levels and the occurrence of RDS.
Conclusion: The serum level of Mg among neonates with RDS was significantly lower, but the lower level of Mg was not associated with adverse outcomes in neonates.
 
 

Keywords

References

  1. Altura BM. Introduction: importance of Mg in physiology and medicine and the need for ion selective electrodes. Scand J Clin Lab Invest Suppl. 1994;54(sup217):5-9.
  2. Nabi-Afjadi M, Karami H, Goudarzi K, Alipourfard I, Bahreini E. The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection. Clin Mol Allergy. 2021;19(1):1-10.
  3. Ryan MF. The role of magnesium in clinical biochemistry: an overview. Ann Clin Biochem. 1991;28(1):19-26.
  4. Khalessi N, Mazouri A, Bassirnia M, Afsharkhas L. Comparison between serum magnesium levels of asphyxiated neonates and normal cases. Med J Islam Repub Iran. 2017;31:19.
  5. Mosayebi Z, Rahmani M, Behjati S, Kaviani Z, Movahedian AH. Alterations in Serum Magnesium Levels in Hyperbili-rubinemic Neonates Before
    and After Phototherapy. Iran J Neonatol. 2020;11(2):19-23.
  6. Ilves P, Blennow M, Kütt E, Mägi ML, Kudrjavtseva G, Lagercrantz H, et al. Concentrations of magnesium and ionized calcium in umbilical cord blood in distressed term newborn infants with hypoxic-ischemic encephalopathy. Acta Paediatr. 1996;
    85(11):1348–50.
  7. Thongprayoon C, Cheungpasitporn W, Srivali N, Erickson SB. Admission serum magnesium levels and the risk of acute respiratory failure. Int J Clin Pract. 2015;69(11):1303–8.
  8. Bae CW, Hahn WH. Surfactant Therapy for Neonatal Respiratory Distress Syndrome: A Review of Korean Experiences over 17 Years. J Korean Med Sci. 2009;24(6):1110-8.
  9. Sarici SU, Serdar MA, Erdem G, Alpay F, Tekinalp G, Yurdakök M, et al. Plasma ionized magnesium levels in neonatal respiratory distress syndrome. Biol Neonate. 2004;86(2):110–5.
  10. Fridman E, Linder N. Magnesium and broncho-pulmonary dysplasia. Harefuah. 2013;152(3):158-61.
  11. Aditiawarman, Salean JT, Sampurna MTA, Ernawati, Joewono HT. Comparison of short-term outcome and serum magnesium levels in premature infants of mothers after magnesium sulfate therapy. EurAsian J Biosci. 2020;14(1):1863-7.
  12. Mirzamoradi M, Behnam M, Jahed T, Saleh-Gargari S, Bakhtiyari M. Does magnesium sulfate delay the active phase of labor in women with premature rupture of membranes? A randomized controlled trial. Taiwan J Obstet Gynecol. 2014;53(3):309-12.
  13. Özlü F, Hacioğlu C, Büyükkurt S, Yapicioğlu H, Satar M. Changes on preterm morbidities with antenatal magnesium. Çukurova Med J. 2019;44(2):502-8.
  14. Klauser CK, Briery CM, Keiser SD, Martin RW, Kosek MA, Morrison JC. Effect of antenatal tocolysis on neonatal outcomes. J Matern Fetal Neonatal Med. 2012;25(12):2778–81.
  15. Elimian A, Verma R, Ogburn P, Wiencek V, Spitzer A, Quirk JG. Magnesium sulfate and neonatal outcomes of preterm neonates. J Matern Fetal Neonatal Med. 2002;12(2):118–22.
  16. Ilves P, Kiisk M, Soopõld T, Talvik T. Serum total magnesium and ionized calcium concentrations in asphyxiated term newborn infants with hypoxic-ischaemic encephalopathy. Acta Paediatr. 2000;89(6):680–5.
  17. Smith PB, Ambalavanan N, Li L, Cotten CM, Laughon M, Walsh MC, et al. Approach to infants born at 22 to 24 weeks’ gestation: relationship to outcomes of more-mature infants. Pediatrics. 2012;129(6):
    e1508-16.
  18. Dandinavar SF, D S, Ratageri VH, Wari PK. Prevalence of hypomagnesemia in children admitted to pediatric intensive care unit and its correlation with patient outcome. Int J Contemp Pediatr. 2019;6(2):462–7.
  19. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2019 Update. Neonatology. 2019;115(4):432–50.

 

Iranian Journal of Neonatology
Volume 14, Issue 4
October 2023
Pages 28-34

Files

Share

How to cite

Statistics