Electrocardiographic Parameters in Neonates with Hyperbilirubinemia in Northeast Iran

Document Type : Original Article


1 Department of Pediatrics, Hazrat-e- Rasool General Hospital, Iran University of Medical Science, Tehran, Iran

2 Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran

3 Golestan University of Medical Sciences, Golestan, Iran

4 Neonatal and Children Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran


Background: Hyperbilirubinemia, a common illness in neonates, imposes a risk of arrhythmia and sudden death, particularly during blood transfusions. The present study aimed to evaluate the electrocardiographic parameters in term newborns with hyperbilirubinemia in Gorgan, northeast Iran.
Methods: This cohort study was conducted on 101 term neonates admitted to our academic hospital with hyperbilirubinemia (direct bilirubin> 20 mg/dL). Those with sepsis, TORCH[(T)toxoplasmosis, (O)ther Agents, (R)ubella (also known as German Measles), (C)ytomegalovirus, and (H)erpes Simplex], congenital heart disease, polycythemia, and asphyxia were excluded. An electrocardiogram (ECG) was taken before the initiation of phototherapy, and heart rate, PR interval, QRS duration, QTc interval, and ST-T changes were recorded after every 8 h during the phototherapy.
Results: In this population of neonates with a mean age of 6.09±3.57 days, the results demonstrated that after 32 h of phototherapy, bilirubin decreased to less than 20 mg/dL. Following that, intensive phototherapy was replaced with the conventional method. Changes in ECG parameters were not significantly related to changes in bilirubin levels (P> 0.05).
Conclusion: As evidenced by the results of this study, there was no significant relationship between ECG parameters and serum level of bilirubin; nonetheless, changes in cardiovascular parameters along with bilirubin levels were remarkable.


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