Serum Levels of Interleukin-10 as a Potential Indicator of Outcome in Premature Neonates with Respiratory Distress Syndrome

Document Type : Original Article

Authors

1 Department of Paediatric, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran Pediatric Diseases Research Center, Guilan University of medical sciences, Rasht, Iran

2 Department of Immunology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Abstract

Background: Respiratory distress syndrome (RDS) is one of the major causes of mortality in preterm newborns. Regarding the close association between inflammatory pathways and the occurrence of RDS, the present study aimed to determine the serum level of interleukin-10 (IL-10) in premature neonates with and without RDS.
Methods: In this case-control study, the serum level of IL-10 was assessed by immunoassay method in both groups of 30 premature neonates with RDS and 28 newborns without RDS as controls. Statistical analysis was conducted to compare potential variations among premature neonates with or without RDS.
Results: The mean level of IL-10 was significantly higher in neonates with RDS, compared to the non-RDS group (41.20±75.78 pg/ml versus 7.73±14.31 pg/ml, P=0.014, respectively). The IL-10 was significantly higher in non-survived neonates, compared to survived newborns (178.76±69.67 pg/ml vs. 6.81±4.06 pg/ml, P=0.0001). In multivariate linear regression analysis, the presence of RDS was associated with the increased level of serum IL-10 (Beta=1.038, P=0.001).
Conclusion: This study revealed that the increased serum levels of IL-10 in premature neonates with RDS might be considered an early indicator of fatal outcomes with high specificity.
 
 

Keywords

References

  1. Kelishadi R, Barekatain B. Comparison of serum triglyceride and cholesterol levels in premature neonates with or without respiratory distress syndrome (RDS). Int J Pediatr. 2021;2021:8893754.
  2. Barekatain B, Armanian A-M, Shahsanaei AD, Shokrani Chaharsoughi M. Association of cord blood total protein and albumin levels with respiratory distress syndrome. Iran J Neonatol. 2020;11(4):32-8.
  3. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, et al. European consensus guidelines on the management of respiratory distress syndrome - 2019 Update. Neonatology. 2019;115(4):432-50.
  4. Groene SG, Spekman JA, Te Pas AB, Heijmans BT, Haak MC, van Klink JMM, et al. Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins. EClinicalMedicine. 2021 ;32:100725.
  5. De Luca D, Cogo P, Kneyber MC, Biban P, Semple MG, Perez-Gil J, et al. Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps. Crit Care. 2021;25(1):75.
  6. Sweeney RM, McAuley DF. Prolonged glucocorticoid treatment in acute respiratory distress syndrome - Authors' reply. Lancet. 2017 15;389(10078):1516-7.
  7. Cardinal-Fernández P, Correger E, Villanueva J, Rios F. Acute Respiratory Distress: from syndrome to disease. Med Intensiva. 2016;40(3):169-75.
  8. Blondonnet R, Constantin JM, Sapin V, Jabaudon M. A pathophysiologic approach to biomarkers in acute respiratory distress syndrome. Dis Markers. 2016;2016:3501373.
  9. Ouyang W, O'Garra A. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation. Immunity. 2019;50(4):871-91.
  10. Jain D, Bancalari E. New developments in respiratory support for preterm infants. Am J Perinatol. 2019;36(S02):S13-S7.
  11. Bedke T, Muscate F, Soukou S, Gagliani N, Huber S. Title: IL-10-producing T cells and their dual functions. Semin Immunol. 2019;44:101335.
  12. Smart JM, Kemp AS. Ontogeny of T-helper 1 and T-helper 2 cytokine production in childhood. Pediatr Allergy Immunol. 2001;12(4):181-7.
  13. Blanco-Quirós A, Arranz E, Solis G, Villar A, Ramos A, Coto D. Cord blood interleukin-10 levels are increased in preterm newborns. Eur J Pediatr. 2000;159(6):420-3.
  14. Hammoud MS, Raghupathy R, Barakat N, Eltomi H, Elsori D. Cytokine profiles at birth and the risk of developing severe respiratory distress and chronic lung disease. J Res Med Sci. 2017;22:62.
  15. Jin X, Hu Z, Kang Y, Liu C, Zhou Y, Wu X, et al. Association of interleukin-10-1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population. Genet Test Mol Biomark. 2011 ;15(4):203-6.
  16. Capasso M, Avvisati RA, Piscopo C, Laforgia N, Raimondi F, de Angelis F, et al. Cytokine gene polymorphisms in Italian preterm infants: association between interleukin-10 -1082 G/A polymorphism and respiratory distress syndrome. Pediatr Res. 2007;61(3):313-7.
  17. Gong MN, Thompson BT, Williams PL, Zhou W, Wang MZ, Pothier L, et al. Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur Respir J. 2006;27(4):674-81.
  18. Beresford MW, Shaw NJ. Detectable IL-8 and IL-10 in bronchoalveolar lavage fluid from preterm infants ventilated for respiratory distress syndrome. Pediatr Res. 2002;52(6):973-8.
  19. Li Q, Qian G, Zhang Q, Gong J, Tang Z, Gao Z. [Changes of plasma interleukin-4, interleukin-10 and interleukin-13 in patients with acute respiratory distress syndrome]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi.Tuberc Respir Dis. 2002;25(11):661-4.
  20. Blanco-Quirós A, Arranz E, Solis G, Garrote JA, Mayo A. High cord blood IL-10 levels in preterm newborns with respiratory distress syndrome. Allergol Immunopathol. 2004;32(4):189-96.
  21. Pandey M, Chauhan M, Awasthi S. Interplay of cytokines in preterm birth. Indian J Med Res. 2017;146(3):316-27.
  22. Reyes-Lagos JJ, Peña-Castillo M, Echeverría JC, Pérez-Sánchez G, Álvarez-Herrera S, Becerril-Villanueva E, et al. Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor. Neuroimmunomodulation. 2017;24(3):162-70.
  23. Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, et al. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005;33(1):1-6.
  24. Liu CH, Kuo SW, Ko WJ, Tsai PR, Wu SW, Lai CH, et al. Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation. Sci Rep. 2017;7(1):1021.
Iranian Journal of Neonatology
Volume 13, Issue 2
April 2022
Pages 106-111

Files

Share

How to cite

Statistics