Efficiency of Dimethicone and Symbiotic Approaches in Infantile Colic Management

Document Type : Original Article

Authors

1 Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Pediatrics, School of Medicine, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran

4 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Infantile colic (IC) (a frequent reason for infantile referral to pediatricians) is a common indiscoverable problem posing concerns for parents. Varieties of theories for the etiology of IC have been raised, and different therapeutic approaches have been recommended in this regard. This study aimed to assess and compare the efficiency of dimethicone versus symbiotic in the treatment of IC.
Methods: This randomized clinical trial was conducted on 149 infants with the diagnosis of IC based on the Wessel criteria from 2017 to 2018. The study population was randomly divided into two groups of Dimethicone (n=73) (five drops of dimethicone, three times a day for three weeks) and Symbiotic (n=76) (five daily drops of symbiotic for three weeks). Utilized symbiotic contained fructooligosacharide periodic and probiotic of 109CFU of Bifidobacterium lactis. Duration of an infant crying per day, numbers of crying per day, sleep duration per day, and number of defecation per day were obtained prior to the study and at the end of each week.
Results: There was no statistically significant difference between the groups regarding age, gender, and values of breastfeeding (P>0.05). Crying duration, numbers of crying, and sleep duration per day improved significantly in the dimethicone group (P<0.05) within the time as the symbiotic-treated group (P<0.05); however, the comparison of the two groups for IC treatment revealed no statistical differences (P>0.05).
Conclusion: The findings of the current study presented that dimethicone and symbiotic could successfully improve IC symptoms regarding crying times, as well as the duration and sleeping time per day. Comparison of these two remedies for IC treatment revealed no significant differences.
 
 

Keywords

References

  1. Kianifar H, Ahanchian H, Grover Z, Jafari S, Noorbakhsh Z, Khakshour A, et al. Synbiotic in the management of infantile colic: a randomised controlled trial. J Paediatr Child Health. 2014; 50(10):801-5.
  2. Mai T, Fatheree NY, Gleason W, Liu Y, Rhoads JM. Infantile Colic: new insights into an old problem. Gastroenterol Clin. 2018; 47(4):829-44.
  3. Rhoads JM, Fatheree NY, Norori J, Liu Y, Lucke JF, Tyson JE, et al. Altered fecal microflora and increased fecal calprotectin in infants with colic. J Pediatr. 2009; 155(6):823-8.e1.
  4. Wang B, Diorio C, Wang L, Huizinga J, Bienenstock J, Kunze W. Lactobacillus reuteri ingestion and IKCa channel blockade have similar effects on rat colon motility and myenteric neurones. Neurogastroenterol Motil. 2010; 22(1):98-107.e33.
  5. Eberl G, Lochner M. The development of intestinal lymphoid tissues at the interface of self and microbiota. Mucosal Immunol. 2009; 2(6):478-85.
  6. Balon AJ. Management of infantile colic. Am Fam Physician. 1997; 55(1):235-42.
  7. Lucassen P. Colic in infants. BMJ Clin Evid. 2010; 2010:0309.
  8. Metcalf TJ, Irons TG, Sher LD, Young PC. Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial. Pediatrics. 1994; 94(1):29-34.
  9. Sung V, Collett S, de Gooyer T, Hiscock H, Tang M, Wake M. Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. JAMA Pediatr. 2013; 167(12):1150-7.

10. Sung V, Collett S, de Gooyer T, Hiscock H, Tang M, Wake M. Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. JAMA Pediatr. 2013; 167(12):1150-7.

11. Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics. 2010; 126(3):e526-33.

12. Pfefferle PI, Prescott SL, Kopp M. Microbial influence on tolerance and opportunities for intervention with prebiotics/probiotics and bacterial lysates. J Allergy Clin Immunol. 2013; 131(6):1453-63.

13. Johnson JD, Cocker K, Chang E. Infantile colic: recognition and treatment. Am Fam Physician. 2015; 92(7):577-82.

14. Danielsson B, Hwang CP. Treatment of infantile colic with surface active substance (simethicone). Acta Paediatr. 1985; 74(3):446-50.

15. Savino F, Tarasco V. New treatments for infant colic. Curr Opin Pediatr. 2010; 22(6):791-7.

16. Wiberg JM, Nordsteen J, Nilsson N. The short-term effect of spinal manipulation in the treatment of infantile colic: a randomized controlled clinical trial with a blinded observer. J Manipulative Physiol Ther. 1999; 22(8):517-22.

17. Savino F, Cresi F, Pautasso S, Palumeri E, Tullio V, Roana J, et al. Intestinal microflora in breastfed colicky and non‐colicky infants. Acta Paediatr. 2004; 93(6):825-9.

18. Saavedra JM, Abi-Hanna A, Moore N, Yolken RH. Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety. Am J Clin Nutr. 2004; 79(2):261-7.

19. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007; 119(1):e124-30.

20. Savino F, Ceratto S. Advances in Infantile colic and the use of Probiotics. Functional Food Rev. 2012; 4(4):152-7.

21. Ben XM, Li J, Feng ZT, Shi SY, Lu YD, Chen R, et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol. 2008; 14(42):
6564-8.

22. Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child. 2006; 91(10):814-9.

23. Harb T, Matsuyama M, David M, Hill RJ. Infant Colic-what works: a systematic review of interventions
for breast-fed infants. J Pediatr Gastroenterol Nutr. 2016; 62(5):668-86.

24. Farid R, Ahanchian H, Jabbari F, Moghiman T. Effect of a new synbiotic mixture on atopic dermatitis in children: a randomized-controlled trial. Iran J Pediatr. 2011; 21(2):225-30.

25. Mugambi MN, Musekiwa A, Lombard M, Young T, Blaauw R. Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review. Nutr J. 2012; 11(1):81.

26. Vandenplas Y, Analitis A, Tziouvara C, Kountzoglou A, Drakou A, Tsouvalas M, et al. Safety of a new synbiotic starter formula. Pediatr Gastroenterol Hepatol Nutr. 2017; 20(3):167-77.

27. Heydarian F, Kianifar HR, Ahanchian H, Khakshure A, Seyedi J, Moshirian D. A comparison between traditional yogurt and probiotic yogurt in non-inflammatory acute gastroenteritis. Saudi Med J. 2010; 31(3):280-3.

28. Ahanchian H, Jones CM, Chen YS, Sly PD. Respiratory viral infections in children with asthma: do they matter and can we prevent them? BMC Pediatr. 2012; 12(1):147.

 

 

 


 

Iranian Journal of Neonatology
Volume 12, Issue 3
July 2021
Pages 25-31

Files

Share

How to cite

Statistics