Jaundice and factor VII deficiency in newborn

Document Type : Case Report


1 Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of pediatrics, school of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


Resistance to thyroid hormone is an uncommon condition. We report the clinical and laboratory findings of a case with both resistance to thyroid hormone and, a reduced capacity to produce and respond to thyroid hormone. RTH is a disorder characterized by elevated circulating thyroid hormones, state of non-suppressed pituitary TSH secretion and refractoriness to hormone action in peripheral tissues. Resistance to thyroid hormone might be an important additional diagnosis to consider in cases where thyrotropin remains persistently elevated.
 In this article we described an infant with RTH; her situation was diagnosed incidentally at birth with impaired hypothyroidism screening tests.



Jaundice is one of the most frequent referral symptoms to physician in newborn period. Sequestration of blood within body cavities including brain can result increased bilirubin production. But in intracranial hemorrhage (ICH) jaundice is rare or may be delayed after other clinical symptoms. This case is a rare presentation of factor VII deficiency which referred for jaundice secondary to ICH in newborn period.

Case report:

In May 25th of 2009 a boy was born with birth weight of 3012grams, birth length of 50cm, birth head circumference (HC) of 34cm. He presented with jaundice and vomiting in day 3 in Kashmar city of Khorasan Razavi province in northeast of Iran. He was treated with phototherapy for jaundice and packed red blood cells (PRBC) for anemia. Total bilirubin was 14.6 grams per dl, hemoglobin 9.3 grams per dl. After 3 days he began to increase head circumference, then was transferred to this university referral hospital for reexploration. On admission in hospital weight was 3150 grams and HC was 39 cm. On 8th day Brain sonography showed dilated third and bilateral ventricle, forth ventricle was normal and communicative hydrocephaly was seen. Axial brain CT scan (figure 1) showed ICH, hydrocephaly and hyperdencity of posterior fossa because of intracerebelar hemorrhage. Magnetic resonance imaging (MRI) showed hydrocephaly and hemorrhage.  He was second offspring and born with cesarean section. Apgar score was normal. He received complete vaccination and prophylactic plus VIT K on the first day of life. Mother has history of prolonged bleeding after teeth extraction and father had the history of spontaneous episthaxia. Vital signs of neonate were blood pressure 90 on 60 , temperature 36.8, respiratory rate 40 and pulse rate 140. In neurologic exam except for mild hypotonia everything was normal. The hemoglobin level was  9.3gr/dl , HCT 28%  ,  RBC 2.840000 in Micro liter, white blood cell count 8300/ul , Platelet count 316000 in Micro liter, G6PD  normal ,  Bilirobin (Total 14.2 mg gram/dl ,direct 0.2) Calcium 8.3, Sugar 163, blood culture negative, CRP negative. Liver and renal function test were within normal range. Coagulation parameters as follow: prothrombin time (PT) 26.3 seconds , activated partial thromboplastin time (aPTT) 38.9 seconds , fibrinogen  404 mg/dl (normal200-400 mg gram/dl), Factor VIII 111 %( normal 50-150%), Factor VII  3.3 %( normal 50-150%), Factor 1X  55% (normal  50-150%), Factor II  98% (normal 50-150%), Therapy for neonate was required as frequent fresh frozen plasma (FFP) and packed red blood cell (PRBC) transfusion. He always had prolonged PT with normal PTT for age. The neonate operated for ventriculoperitoneal shunt due to progressive increasing of head circumference. Parents were relative. Assessment family lab test showed, father PT 11.2 seconds and  F VII 97%,  mother PT 11.8 seconds and  F VII  85%,  brother   PT12.9 seconds and factor VII 73%. 


Axial brain CT scan of head at presentation showing an ICH.



Jaundice is observed during the first week of life in approximately 60% of term infants. This case is an unusual presentation of jaundice secondary to a fatal bleeding disorder. Although bleeding must be considered in any newborn with jaundice, ICH is neglected most of the times.

Neonatal bleeding disorders can present diagnostic and therapeutic challenges to the physicians. Early diagnosis of these hemorrhages can avoid significant long- term sequelae.

ICH is the most common reported bleeding complication in newborns with congenital FVII deficiency (1). Approximately 200 cases of true FVII deficiency have been reported. It occurs 1 in 500000 live births making it the less common cause of jaundice and bleeding disorders (1).  The condition is inherited as an autosomal recessive trait that produces sever deficiency in homozygote and mild deficiency without clinical manifestation in the heterozygote.

Patients with levels of>10 to 15 IU/dl rarely manifest bleeding (1). Patients with levels between 5 and 10 IU/dl tend to have milder symptoms such as epistaxis, gingival bleeding or genitourinary and gastrointestinal bleeding. Patients with levels

The delayed diagnosis of ICH in newborn is due to asymptomatic state of intracranial hemorrhage in some cases (4), indeed hemorrhage occurred in cerebellum. On the other hand it was secondary to delivery in rural and lacking of radiologic diagnostic procedure.  The diagnosis of factor VII F deficiency should be suspected in a patient with a history of bleeding when there is an isolated prolonged prothrombin time and normal PTT, but a diagnosis requires specific factor VII F deficiency assay by ELISA for confirmation.

Although jaundice always has a benign cause, it may be secondary to a fatal sequestration of blood such as brain hemorrhage due to coagulation factors deficiency.



We are thankful of our hematologist and neurosurgeon colleagues for consultation and also Najma Saberi for typing and Mojdeh Mahmoodi for data collection.

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