Correlations of Maternal Serum Zinc Levels with Cord Blood Procollagen Type 1-N Terminal Propeptide Levels and Anthropometric Measurements of Newborns

Document Type : Original Article

Authors

1 Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara/Universitas Sumatera Utara Hospital, Medan, North Sumatera, Indonesia

2 Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara/Universitas Sumatera Utara Hospital, Medan, North Sumatera, Indonesia

Abstract

Background: Zinc is an important micronutrient that is required for optimal fetal growth and development. Zinc deficiency during pregnancy may interfere with intrauterine fetal ossification. Fetal ossification can be measured with specific bone growth markers, such as procollagen type 1-N terminal propeptide (P1NP). This study aimed to investigate the mean maternal serum zinc levels and assess the correlations of maternal serum zinc levels with cord blood P1NP levels and anthropometric measurements of newborns.
Methods: This cross-sectional study was conducted at Universitas Sumatera Utara Hospital and other hospitals in Medan, Indonesia, from April to October 2019. The statistical populations were pregnant mothers and their newborns who met the inclusion criteria. The participants were selected using a consecutive sampling technique. Maternal serum zinc levels and cord blood P1NP levels were measured before delivery; moreover, anthropometric measurements were conducted in this study.
Results: A total of 42 subjects were included in this study with a mean maternal serum zinc level of 52.0±9.0 µg/dL. The proportion of pregnant mothers with low serum zinc levels was high (54.8%). According to the results, there was a significant correlation between maternal serum zinc levels and newborn birth weight (r=0.648) and length (r=0.656), as well as head circumference (r=0.578; P=0.001). There was also a significant and positive linear correlation between maternal serum zinc levels and cord blood P1NP levels (r=0.469; P=0.002).
Conclusion: The mean maternal serum zinc levels during pregnancy were below normal. There were positive significant correlations between maternal serum zinc levels and cord blood P1NP levels with anthropometric measurements of newborns.
 
 

Keywords

References

  1. Ashworth A. Nutrition, food security and health. In: Nelson textbook of pediatrics. Kliegman RM, Stanton BF, Geme JW 3rd, Schor NF, Behrman RE, editors. 20th ed. Philadelphia: Elsevier; 2016. P. 295-306.
  2. Terrin G, Canani RB, Di Chiara M, Pietravalle A, Aleandri V. Conte F, et al. Zinc in early life: a key element in the fetus and preterm neonate. Nutrients. 2015; 7(12):10427-46.
  3. Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: an integrative review. J Res Med Sci. 2013; 18(2):144-57.
  4. Caulfield LE, Zavaleta N, Shankar AH, Merialdi M. Potential contribution of maternal zinc supplemen-tation during pregnancy to maternal and child survival. Am J Clin Nutr. 1998; 68(2 Suppl):499S-508S.
  5. Seriana I, Yusrawati, Lubis G. Serum zinc level at term pregnancy and newborn anthropometry. Indones J Obstet Gynecol. 2015; 3(4):190-95.
  6. Merialdi M, Caulfield LE, Zavaleta N, Figueroa A, Costigan KA, Dominici F. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth. Am J Clin Nutr. 2004; 79(5):826-30.
  7. King JC. Determinants of maternal zinc status during pregnancy. Am J Clin Nutr. 2000; 71(5 Suppl):
    1334S-43S.
  8. Gebreselassie SG, Gashe FE. A systematic review
    of effect of prenatal zinc supplementation on birthweight: meta-analysis of 17 randomized controlled trials. J Health Popul Nutr. 2011; 29(2):134-40.
  9. Priyana A. Peran pertanda tulang dalam serum pada tatalaksana osteoporosis. Univ Med. 2007; 26(3):
    153-59.

10. Veselá PK, Kaniok R, Bayer M. Markers of bone metabolism, serum leptin levels and bone mineral density in preterm babies. J Pediatr Endocrinol Metab. 2016; 29(1):27-32.

11. Yamaga A, Taga M, Hashimoto S, Ota C. Comparison of bone metabolic markers between maternal and cord blood. Horm Res. 1999; 51(6):277-9.

12. Vasikaran S, Cooper C, Eastell R, Griesmacher A, Morris HA, Trenti T, et al. International osteoporosis foundation and international federation of clinical chemistry and laboratory medicine position on bone marker standards in osteoporosis. Clin Chem Lab Med. 2011; 49(8):1271-4.

13. Hotz C, Peerson JM, Brown KH. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data (1976-1980). Am J Clin Nutr. 2003; 78(4):756-64.

14. Pathak P, Kapil U, Dwivedi SN, Singh R. Serum zinc levels among pregnant women in a rural block of Haryana state, India. Asia Pac J Clin Nutr. 2008; 17(2):276-9.

15. Raimi OG, Falade OA, Folorunso OS, Lawal AK. Zinc and iron levels in pregnancy: a review. Pak J Food Sci. 2012; 22(2):53-60.

16. Karimi A, Bagheri S, Nematy M, Saeidi M. Zinc deficiency in pregnancy and fetal neonatal outcomes and impact of the supplements on pregnancy outcomes. Iran J Neonatol. 2012; 3(2):77-83.

17. Wijaksono AW, Rasyid R, Mariko R. Hubungan kadar zink dan kenaikan berat badan ibu hamil dengan berat badan ibu hamil dengan berat badan bayi lahir di RSUD Curup Kabupaten Rejang Lebong provinsi Bengkulu. Majalah Kedokteran Andalas. 2019; 42(2): 56-61.

18. Wang H, Fang Hu Y, Hao JH, Chen YH, Su PY, Wang Y, et al. Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Sci Rep. 2015; 5:11262.

19. Awaddalah SM, Abu-Elteen KH, Elkarmi AZ, Qaraein SH, Saleem NM, Mubarak MS. Maternal and cord blood serum levels of zinc, cooper, and iron in healthy pregnant Jordanian women. J Trace Elemen in Exper Med. 2004; 17(1):1-8.

20. Donangelo CM, King JC. Maternal zinc intakes and homeostatic adjustments during pregnancy and lactation. Nutrients. 2012; 4(7):782-98.

21. Brown KH, Wuehler SA, Peerson JM. The importance of zinc in human nutrition and estimation of the global prevalence of zinc deficiency. Food Nutr Bull. 2001; 22(2):113-25.

22. Mahomed K, Bhutta K, Middleton P. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2007; 2:CD000230.

23. Chaffee B, Kinga J. Effect of zinc supplementation on pregnancy and infant outcomes: a systematic review. Paediatr Perinat Epidemiol. 2012; 26(01):
118-37.

24. Moonga BS, Dempster DW. Zinc is a potent inhibitor of osteoclastic bone resorption in vitro. J Bone Miner Res. 1995; 10(3):453-7.

25. Bayer M. Reference values of osteocalcin and procollagen type I N-propeptide plasma levels in a healthy Central European population aged 0-18 years. Osteoporos Int. 2014; 25(2):729-36.

26. Choi JS, Park I, Lee SJ, Ju HJ, Lee H, Kim J. Serum procollagen type I N-terminal propeptide and osteocalcin levels in Korean children and adolescents. Yonsei Med J. 2019; 60(12):1174-80.

27. Berger PK, Pollock NK, Laing EM, Chertin V, Bernard PJ, Grider A, et al. Zinc supplementation increases procollagen type 1 amino-terminal propeptide in premenarcheal girls: a randomized controlled trial. J Nutr. 2015; 145:2699-704.

 

 


 

Iranian Journal of Neonatology
Volume 12, Issue 2
April 2021
Pages 8-13

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