Effects of Maternal Immune System Status on Neonate’s Immune System

Document Type : Original Article


1 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz,Ahvaz, Iran

2 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz,Ahvaz, Iran

3 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz ,Iran. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

4 Department of Histology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran


Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.
Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate’s humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study.
Results: The spleen’s mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P≤0.05) in the anti-sheep red blood cells antibody titer.
Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate’s immune responses, spleen, liver, and thymus development.


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