Coarse Tremor as the Only Sign of Perinatal Hemorrhagic Stroke: A Case Report

Document Type : Case Report

Authors

1 Neonatal Research Center, Shiraz University of Medical Science, Shiraz, Iran

2 Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Tremor which is the most common abnormal movement in the neonatal period might be a benign condition or the result of pathologic events and is divided into two subtypes, namely fine tremor and coarse tremor. Fine tremor is usually benign and results from some metabolic disturbance, such as hypoglycemia. On the other hand, coarse tremor is an indicator of brain insult and should be regarded as a central pathology comparable to intracranial hemorrhage and hypoxic-ischemic encephalopathy and requires further evaluations. Stroke is one of the most important associated pathologies that are readily missed in the neonatal period. The possibility of stroke should be suspected in all newborns in the presence of coarse tremor.
Case report: Here, we will present a newborn with perinatal hemorrhagic stroke who was in good condition after birth with Apgar score of 9 and normal vital signs, birth weight, head circumference, length, and primitive reflexes; however, he had coarse tremor in both upper extremities in physical examination as the only sign of the hemorrhagic stroke.
Conclusion: It is recommended that neonates with coarse tremor be investigated more carefully to rule out the structural brain pathology.

Keywords


1. Paddock M, Demetriou A, Nicholl R. Are we considering neonatal stroke early enough in our differential diagnosis? J Neonatal Perinatal Med. 2014; 7(4):293-9.
2. Huntsman RJ, Lowry NJ, Sankaran K. Nonepileptic motor phenomena in the neonate. Paediatr Child Health. 2008; 13(8):680-4.
3. Armentrout DC, Caple J. The jittery newborn. J Pediatr Health Care. 2001; 15(3):147-9.
4. Gelfand AA, Glass HC, Marco EJ, Ferriero DM. Focal clonic seizures suggest stroke in a newborn. Neurol Bull. 2010; 2(1):7-11.
5. Gleason CA, Juul SE. Avery's diseases of the newborn e-book. New York: Elsevier Health Sciences; 2017.
6. Hagberg H, Edwards AD, Groenendaal F. Perinatal brain damage: the term infant. Neurobiol Dis. 2016; 92:102-12.
7. Joseph S, Angelis D, Bennett R, Kola B, Hughes A. Variability in clinical presentation of neonatal stroke: report of four cases. Case Rep Neurol Med. 2017; 2017:5215686.
8. Pulver M, Juhkami K, Loorits D, Ilves P, Kuld J, Õiglane-Šlik E, et al. Symptomatic neonatal arterial ischemic stroke with prenatal and postnatal neuroimaging. Child Neurol Open. 2017; 4:23290 48X17730460.
9. Gacio S, Muñoz Giacomelli F, Klein F. Presumed perinatal ischemic stroke: a review. Arch Argent Pediatr. 2015; 113(5):449-55.
10. Wang LW, Huang CC, Yeh TF. Major brain lesions detected on sonographic screening of apparently normal term neonates. Neuroradiology. 2004; 46(5):368-73.
11. Chang YC, Lee CY, Chen CH, Ku YC, Wang JD. Cyanosis as a signal of perinatal stroke: findings at ultrasound and MRI. Iran J Pediatr. 2015; 25(3):e533.
12. Walkinshaw SA. Fetal choroid plexus cysts: are we there yet? Prenat Diagn. 2000; 20(8):657-62.
13. Demasio K, Canterino J, Ananth C, Fernandez C, Smulian J, Vintzileos A. Isolated choroid plexus cyst in low-risk women less than 35 years old. Am J Obstet Gynecol. 2002; 187(5):1246-9.