<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Neonatology</title>
			<title_fa>مجله نوزادان ایران</title_fa>
			<short_title>IJN</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijn.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2251-7510</journal_id_issn>
			<journal_id_issn_online>2322-2158</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2022</year>
				<month>1</month>
				<day>1</day>
			</pubdate>
			<volume>13</volume>
			<number>1</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Serum KIM-1 and Cystatin Levels as the Predictors of Acute Kidney Injury in Asphyxiated Neonates</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa>تحقیقی اصیل</content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Asphyxia may lead to serious complications, among which acute kidney injury (AKI) is the most common. Early diagnosis of AKI can help prevent impaired acid-base, fluid, and electrolyte balance that may lead to life-threatening complications. This study aimed to evaluate the effect of kidney injury molecule-1 (KIM-1) and cystatin-C in the early diagnosis of AKI among asphyxiated neonates.
Methods: This case-control study was conducted on 45 asphyxiated neonates, 24 of whom were in the control group and 23 cases were in the case group. Creatinine (Cr), KIM-1, and cystatin-C were measured for participants within 8 h and 4 days after birth and compared between case and control groups.
Results: The mean level of Cr-Standardized KIM-1 measured within 8 h and 4 days after birth was significantly higher in the case group, compared to the control group (P-value&lt;0.05). The mean level of Cr-Standardized cysteine, only 4 days after birth, was significantly higher in the case group, compared to the control group (P-value&lt;0.05). A receiver operating characteristic (ROC) curve analysis demonstrated that between the two biomarkers with two measurements, the KIM-1 Cr-Standardized within 4 days had the highest area under the curve (AUC) (0.751, 95% CI: 0.597-0.905). Moreover, the results of ROC curve analysis showed that Cr-Standardized KIM-1 within 4 days after birth with a critical value of &gt;0.67 ng/ml allowed to predict kidney failure in newborns with 57.1‌% sensitivity and 86.4‌% specificity.
Conclusion: The findings of the present study show that high-specificity KIM-1 is a good biomarker for the early detection of acute renal failure in asphyxiated infants; however, similar expectations cannot exist with regards to cystatin-C for at least the first 8 h after birth.
 
 ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Acute kidney injury, Asphyxia, Cystatin-C, Kidney injury Molecule-1</keyword>
				<start_page>6</start_page>
				<end_page>12</end_page>
				<web_url>https://ijn.mums.ac.ir/article_19171.html</web_url>
			<author_list><author>
				<first_name>Mahryar</first_name>
				<middle_name></middle_name>
				<last_name>Mehrkesh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.mehrkash@yahoo.com</email>
				<code>82607</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, School of Medicine, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Behzad</first_name>
				<middle_name></middle_name>
				<last_name>Barekatain</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>b-barekatain@med.mui.ac.ir</email>
				<code>82608</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, School of Medicine, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alaleh</first_name>
				<middle_name></middle_name>
				<last_name>Gheisari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alaleh.gheissari@gmail.com</email>
				<code>82609</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, School of Medicine, Kidney Diseases Research Center, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mina</first_name>
				<middle_name></middle_name>
				<last_name>Ahmadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mina.ahmadi65@yahoo.com</email>
				<code>82610</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Armindokht</first_name>
				<middle_name></middle_name>
				<last_name>Shahsanai</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>armin.shahsanai@gmail.com</email>
				<code>82611</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Social Medicine, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>