TY - JOUR ID - 2012 TI - Neonatal Sepsis: An Update JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Kale, Anjali AU - jaybhaye, Deepali AU - Bonde, Vijay AD - Department of Pediatrics , Mahatma Gandhi Mission Hospital Aurangabad, 431001, Aurangabad, India AD - Department of Pharmacology, Mahatma Gandhi Mission Hospital Aurangabad, 431001, Aurangabad, India Y1 - 2014 PY - 2014 VL - 4 IS - 4 SP - 39 EP - 51 KW - Clinical Features KW - Diagnosis KW - MDR Neonatal Sepsis KW - Neonatal sepsis KW - Prevention DO - 10.22038/ijn.2013.2012 N2 - Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and ill-defined. Novel approaches in the diagnosis of neonatal sepsis include heart rate analysis on ECG, and colorimetric analysis of skin color. Although blood culture is the gold standard for the diagnosis of sepsis, culture reports are available only after 48-72 hours. In this era of multidrug resistance, it is mandatory to avoid unnecessary use of antibiotics to treat non-infected infants. Thus, rapid diagnostic test(s) that include Interleukien-6 (IL-6), neutrophil CD64 index, procalcitonin and nucleated RBC count– and differentiate the infected infants from the non-infected, particularly in the early neonatal period– have the potential to make a significant impact on neonatal care. The aim of this review is to specify the diagnostic criteria, treatment guidelines, and a summary of recent diagnostic tests of sepsis, along with the preventive measures. UR - https://ijn.mums.ac.ir/article_2012.html L1 - https://ijn.mums.ac.ir/article_2012_a454e2e397a441f2c9dbf551403f4a79.pdf ER -