TY - JOUR ID - 19787 TI - Survival of Respiratory Failure within the First 72 Hours in Preterm Infants with Respiratory Distress Based on the Downes Score Assessment JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Iskandar, Wedi AU - Rachman, Hana Sofia AU - Galih, Vidi Permata AU - Indikurnia, Forestiera Qadriq AU - Hafizh, Muhammad Ghazy AD - Child Health Laboratory, Faculty of Medicine, Universitas Islam, Bandung, Indonesia. Al-Islam Hospital, Bandung, Indonesia AD - Child Health Laboratory, Faculty of Medicine, Universitas Islam, Bandung, Indonesia Al-Ihsan Regional General Hospital, Bandung, Indonesia AD - Al-Islam Hospital, Bandung, Indonesia AD - Medical Student, Faculty of Medicine, Universitas Islam, Bandung, Indonesia Y1 - 2022 PY - 2022 VL - 13 IS - 2 SP - 1 EP - 7 KW - Downes score KW - preterm infants KW - Respiratory failure DO - 10.22038/ijn.2022.59690.2133 N2 - Background: Respiratory distress in neonates is the most common condition of preterm infants receiving treatment in the neonatal intensive care unit. As a clinical assessment of respiratory distress, the Downes score can predict the risk of respiratory failure. The present study aimed to determine the survival of respiratory failure in the first 72 h in preterm infants with respiratory distress based on the Downes score assessment.Methods: A prospective cohort survival analysis was performed at three hospitals in Indonesia (Al-Islam Hospital, Bandung, Al-Ihsan Hospital, Bandung, and Cibabat Hospital, Cimahi) from April to July 2021. Subjects were infants aged 28-36 weeks, with respiratory distress based on the Downes score within the first 2, 6, 12, 24, 48, and 72 h after delivery. The analyzed variables included birth weight ([BW], <1500 vs. 1500-2500 g), gestational age ([GA], 28-32 vs. 32-37 weeks), and 5-min APGAR score (<7 vs. >7). Bivariate and multivariate analyses were conducted with Cox regression proportional hazard and the Kaplan-Meier estimate of survival rate was also performed. In addition, the adjusted hazard ratio (aHR) was calculated, and a P-value of less than 0.05 was considered statistically significant.Results: Of the 89 subjects who met the criteria, 20 (22.47%) experienced respiratory failure. The multivariate analysis including BW (aHR: 1.846, 95%CI: 0.570-5.979, P> 0.05), GA (aHR: 2.273, 95 %CI: 0.697-7.416, P>0.05), and the 5-min APGAR score (aHR: 2.049, 95%CI: 0.811-5.179, P>0.05) estimated the survival rate for respiratory failure at the age of 72 h at 74.7% (standard error: 0.05%).Conclusion: A GA of <32 weeks, a BW of <1500 g, and the condition of asphyxia simultaneously increased the aHR of respiratory failure, with an estimated survival rate of 74.7%.   UR - https://ijn.mums.ac.ir/article_19787.html L1 - https://ijn.mums.ac.ir/article_19787_f92180cb173cd4fabf71233dcd190642.pdf ER -