ORIGINAL_ARTICLE
Study of Neurodevelopmental Outcomes at 10-14 Months of Age Using Bayley Scale of Infant and Toddler Development in Asphyxiated Newborns with Hypoxic Ischemic Encephalopathy Treated with and without Therapeutic Hypothermia
Background: Therapeutic hypothermia has become an established protocol for all neonates with moderate to severe Hypoxic Ischaemic Encephalopathy (HIE). There are very few studies comparing the neurodevelopmental outcomes in asphyxiated neonates who received therapeutic hypothermia or did not. This study aimed to assess the neurodevelopmental outcomes of asphyxiated neonates with features of HIE at 10-14 months of age using Bayley Scale of Infant and Toddler Development III (BSID III) and to compare this outcome between neonates who received therapeutic hypothermia and those who did not. Methods: Term infants with HIE admitted in neonatal intensive care unit (NICU) at a tertiary referral hospital were followed up at 10-14 months of age from December 2013 to August 2015. Neurodevelopmental outcomes were assessed using BSID III. Results: A total of 76 neonates with birth asphyxia were admitted to NICU between December 2012 and August 2014. These neonates were followed up from December 2013 to August 2015, and 34 of them were included in the study. At10-14 months of age, 8 neonates (23.5%) had cognitive delay, 14 cases (41.17%) had motor delay, and 9 newborns (26.4%) had language delay using BSID III score of < 85 as cut off. Twenty (58.82%) infants had normal development in all 3 domains. Higher percentage of infants (73.68%) who received therapeutic hypothermia had normal BSID Score as compared to 40% of the neonates with normal BSID score (>85) who did not receive therapeutic hypothermia. Statistical analysis using Chi-square test showed P-value of 0.048 as statistically significant. Conclusion: Neurodevelopment assessment at 10-14 months of age using BSID III of asphyxiated neonates with HIE showed significantly better outcome in infants who received therapeutic hypothermia than those who did not.
https://ijn.mums.ac.ir/article_11892_1672c73856ba881b93793f5fef0f0c9f.pdf
2018-12-01
1
6
10.22038/ijn.2018.30065.1410
Bayley scale of infant development III
Hypoxic ischemic encephalopathy
Hypothermia
Neonates
Jayashree
Purkayastha
jayashreepurkayastha@yahoo.com
1
Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
LEAD_AUTHOR
Maitreyee
Dutta
mdatta_13@yahoo.co.in
2
Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
Leslie
Edward Lewis
3
Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
Ramesh
Bhat Y
4
Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
Joshua
Rajan X
5
Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
Gaurav
Ayappa
6
Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
1. World Health Organization. Perinatal mortality: a listing of available information. Geneva: World Health Organization; 1996.
1
2. National neonatal perinatal database India. Geneva: World Health Organization; 2003.
2
3. Haaland K, Loberg EM, Steen PA, Thoresen M. Posthypoxic hypothermia in newborn piglets. Pediatr Res. 1997; 41(4 Pt 1):505‑12.
3
4. Thoresen M, Penrice J, Lorek A, Cady EB, Wylezinska M, Kirkbride V, et al. Mild hypothermia after severe transient hypoxia‑ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res. 1995; 37(5):667‑70.
4
5. Edwards AD, Yue X, Squier MV, Thoresen M, Cady EB, Penrice J, et al. Specific inhibition of apoptosis after cerebral hypoxia-ischemia by moderate postinsult hypothermia. Biochem Biophys Res Commun. 1995; 217(3):1193-9.
5
6. Thomas N, George KC, Sridhar S, Kumar M, Kuruvilla KA, Jana AK. Whole body cooling in newborn infants with perinatal asphyxial encephalopathy in a low resource setting: a feasibility trial. Indian Pediatr. 2011; 48(6):445-51.
6
7. Gluckman P, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005; 365(9460):663-70.
7
8. Horn AR, Woods DL, Thompson C, Elis I, Kroon M. Selective cerebral hypothermia for post-hypoxic neuroprotection in neonates using a solid ice cap. S Afr Med J. 2006; 96(9 Pt 2):976-81.
8
9. Purkayastha J, Lewis LE, Bhat R, Anusha KM. Feasibility and safety of therapeutic hypothermia and short term outcome in neonates with hypoxic Ischemic encephalopathy. Indian J Pediatr. 2016; 83(2):175-7.
9
10. Zhou WH, Cheng GQ, Shao XM, Liu XZ, Shan RB, Zhuang DY, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxicischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr. 2010; 157(3): 367-72.
10
11. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson EJ, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005; 353(15): 1574-84.
11
12. Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis P. Cooling for newborns with hypoxicischaemic encephalopathy. Cochrane Database Syst Rev. 2007; 1:CD003311.
12
13. Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009; 361(14):1349-58.
13
14. American Academy of Paediatrics. Developmental surveillance and screening of infants and young children. Paediatrics. 2001; 108(1):192-6.
14
15. Sarnath HB, Sarnath MS. Neonatal encephalopathy following fetal distress. A clinical and Electroencephalographic study. Arch Neurol. 1976; 33(10): 696-705.
15
16. Jary S, Whitelaw A, Walløe L, Thoresen M. Comparison of Bayley-2 and Bayley-3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia. Dev Med Child Neurol. 2013; 55(11):1053-9.
16
17. Chalak LF, DuPont TL, Sánchez PJ, Lucke A, Heyne RJ, Morriss MC, et al. Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III. J Perinatol. 2014; 34(8):629-33.
17
18. Rutherford MA, Counsell SJ, Couran FM, Azzopaddi D, Edwards D, Renowden S, et al. Magnetic resonance imaging patterns of brain injury following hypothermia in neonates with Hyoxic ischaemic Encephalopathy. Paediatr Res. 2004; 4(351):583.
18
19. Rutherford M, Srinivasan L, Dyet L, Ward P, Allsop J, Counsell S, et al. Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome. Pediatr Radiol. 2006; 36(7):582-92.
19
20. Battin RM, Dezoete A, Gunn RT, Gluckmann DP, Gunn JA. Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia. Pediatrics. 2001; 107(3): 480-4.
20
21. Robertson CM, Finer NN. Long term follow up of term neonates with perinatal asphyxia. Clin Perinatol. 1993; 20(2):483-500.
21
ORIGINAL_ARTICLE
Current Practices Regarding Treatment of Neonatal Jaundice by Neonatal Care Practitioners in Nigeria
Background: Neonatal jaundice is a common medical condition encountered in the neonatal period in Nigerian hospitals. Its management is not homogenous among healthcare providers. Therefore, this study aimed at evaluating current practices related to the treatment of neonatal jaundice among doctors and nurses caring for neonates in Nigeria. Methods: Healthcare providers managing neonates in Nigeria were surveyed during annual general and scientific meetings of the Nigerian Society of Neonatal Medicine in 2017. In addition, the Paediatric Association of Nigeria’s mailing list was utilized to disseminate a self-administered, pretested and structured questionnaire to doctors and nurses involved in taking care of newborns in Nigeria. Results: The results of the study showed that local guidelines / protocols were highly applied by the respondents. The majority of the health care providers would screen newborns for neonatal jaundice before discharge. The practice of early discharge within 24 hours was rampant with a high frequency of late follow up at 6 weeks. Conclusion: The practices regarding management of neonatal jaundice among healthcare professionals in Nigeria vary with better practices observed in specialist cadres. Newborn discharge and follow-up practices also vary and are sub-optimal. Therefore, there is a need for more awareness creation on neonatal jaundice treatment among cadres of health care practitioners. This should be complimented with the development of a national guideline on the management of neonatal jaundice in Nigeria.
https://ijn.mums.ac.ir/article_11893_09a4d39e1b8b4673b805918910d99869.pdf
2018-12-01
7
14
10.22038/ijn.2018.31372.1435
Keywords: Health care practitioners
Neonatal Jaundice
Nigeria
Beatrice
Ezenwa
beatriceezenwa@yahoo.com
1
Department of Paediatrics, College of Medicine, University of Lagos, Nigeria Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria
LEAD_AUTHOR
Yeside
Akinbolagbe
yesidekush@yahoo.com
2
Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria
AUTHOR
Iretiola
Fajolu
iretifaj@yahoo.co.uk
3
Department of Paediatrics, College of Medicine, University of Lagos, Nigeria Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria
AUTHOR
Patricia
Akintan
akintanpatricia@yahoo.com
4
Department of Paediatrics, College of Medicine, University of Lagos, Nigeria Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria
AUTHOR
Luther
Agaga
agagaluther@gmail.com
5
College of Medicine, Lagos State University, Ikeja, Lagos
AUTHOR
Veronica
Ezeaka
6
Department of Paediatrics, College of Medicine, University of Lagos, Nigeria Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria
AUTHOR
1. Ogunfowora OB, Adefuye PO, Fetuga MB. What do expectant mothers know about neonatal jaundice? Int Electronic J Health Educ. 2006; 9:134-40.
1
2. Melton K, Akinbi HT. Neonatal jaundice. Strategies to reduce bilirubin-induced complications. Postgrad Med. 1999; 106(6):167-78.
2
3. Bhutani VK, Stark AR, Lazzeroni LC, Poland R, Gourley GR, Kazmierczak S, et al. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. Journal Pediatr. 2013; 162(3):477-82.
3
4. Brooks JC, Fisher-Owens SA, Wu YW, Strauss DJ, Newman TB. Evidence suggests there was not a “resurgence” of kernicterus in the 1990s. Pediatrics. 2011; 127(4):672-9.
4
5. Ebbesen F, Andersson C, Verder H, Grytter C, Pedersen-Bjergaard L, Petersen JR, et al. Extreme hyperbilirubinemia in term and near term infants in Denmark. ActaPaediatr. 2005; 94(1):59-64.
5
6. Van Praagh R. Diagnosis of kernicterus in the neonatal period. Pediatrics. 1961; 28:870-6.
6
7. Johnson LH, Bhutani VK, Brown AK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr. 2002; 140(4): 396-403.
7
8. Ransome-Kuti O. The problems of paediatric emergencies in Nigeria. Nig Med J. 1972; 2:62-70.
8
9. Udo JJ, Anah MU, Ochigbo SO, Etuk IS, Ekanem AD. Neonatal morbidity and mortality in Calabar, Nigeria: a hospital-based study. Niger J ClinPract. 2008; 11(3):285-9.
9
10. Iliyasu Z, Abubakar IS, Gajida AU. Magnitude and leading causes of in-hospital mortality at Aminu Kano Teaching Hospital, Kano, Northern Nigeria: a 4-year prospective analysis. Niger J Med. 2010; 19(4):400-6.
10
11. Ekwochi U, Ndu IK, Nwokoye IC, Ezenwosu OU, Amadi OF, Osuorah DI. Pattern of morbidity and mortality of new-borns admitted into the sick and special care baby unit of Enugu State University Teaching Hospital, Enugu state. Niger J ClinPract. 2014; 17(3):346-51.
11
12. Ogundare O, Omole O. The management of neonatal Jaundice in Nigeria. J ObafemiAwolowoUniv Med Students Assoc (IFEMED). 2008; 14(1):18-23.
12
13. Onyearugha CN, Onyire BN, Ugboma HA. Neonatal jaundice: prevalence and associated factors as seen in Federal Medical Centre Abakaliki, Southeast Nigeria. J Clin Med Res. 2011; 3(3):40-5.
13
14. Olusanya BO, Osibanjo FB, Mabogunje CA, Slusher TM, Olowe SA. The burden and management of neonatal jaundice in Nigeria: a scoping review of the literature. Niger J ClinPract. 2016; 19(1):1-17. 15. Mateo PC, Lee KS, Barozzino M, Sgro M. Management of neonatal jaundice varies by practitioner type. Can Fam Physician. 2013; 59(8):e379-86.
14
16. Adebami OJ. Factors associated with the incidence of acute bilirubin encephalopathy in Nigerian population. J Pediatr Neurol. 2011; 9(3):347-53.
15
17. Olusanya BO, Ogunlesi TA, Slusher TM. Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? Arch Dis Child. 2014; 99(12):1117-21.
16
18. Rennie JM, Sehgal A, De A, Kendall GS, Cole TJ. Range of UK practice regarding thresholds for phototherapy and exchange transfusion in neonatal hyperbilirubinaemia. Arch Dis Child Fetal Neonatal Ed. 2009; 94(5):F323-7.
17
19. Olusanya BO, Ezeaka CV, Ajayi-Obe EK, MukhtarYola M, Ofovwe GE. Paediatricians’ perspectives on global health priorities for new-born care in a developing country: a national survey from Nigeria. BMC Int Health Hum Rights. 2012; 12(1):9.
18
20. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the new-born infant 35 or more weeks of gestation. Pediatrics. 2004; 114(1):297-316.
19
21. Dunbar A, Stewart H. NICE clinical guidelines. Br J Healthcare Assist. 2007; 1(7):329.
20
22. Olusanya BO, Ogunlesi TA, Kumar P, Boo NY, Iskander IF, de Almeida MF, et al. Management of late‑preterm and term infants with hyperbilirubinaemia in resource‑constrained settings. BMC Pediatr. 2015; 15:39.
21
23. Madlon-kay DJ. Evaluation and management of newborn jaundice by Midwest family physicians. J FamPract. 1998; 47(6):461-4.
22
24. National demographic and health survey. Macro, Calverton: National Population Commission and ORC; 2004.
23
25. Benahmed N, San Miguel L, Devos C, Fairon N, Christiaens W. Vaginal delivery: how does early hospital discharge affect mother and child outcomes? A systematic literature review. BMC Pregnancy Childbirth. 2017; 17(1):289.
24
26. Ezeaka VC, Ekure EN, Fajolu IB, Ezenwa BN, Akintan P. Mothers' perception of neonatal jaundice in Lagos, Nigeria: An urgent need for greater awareness. S Afr J Child Health. 2016; 10(4):227-30.
25
27. Catz C, Hanson JW, Simpson L, Taffe SJ. Summary of workshop, early discharge and neonatal hyperbilirubinemia. Pediatrics. 1995; 96(4 Pt 1):743-5.
26
28. Britton JR, Britton HL, Beebe SA. Early discharge of the term new-born: a continued dilemma. Paediatrics. 1994; 94(3):291-5
27
29. Lee KS, Perlman M, Ballantyne M, Elliot I, To T. Association between duration of neonatal hospital stay and readmission rate. J Pediatr. 1995; 127(5):758-66.
28
30. Gale R, Seidman DS, Stevenson DK. Hyperbilirubinemia and early discharge. J Perinatol. 2001; 21(1):40-3.
29
31. Lain SJ, Roberts CL, Bowen JR, Nassar N. Early discharge of infants and risk of readmission for jaundice. Pediatrics. 2015; 135(2):314-21.
30
32. de Almeida MF. When should we start phototherapy in preterm new-born infants? J Pediatr. 2004; 80(4):256-8.
31
33. Keren R, Tremont K, Luan X, Cnaan A. Visual assessment of jaundice in term and late preterm infants. Arch Dis Child Fetal Neonatal Ed. 2009; 94:F317-22.
32
34. Moyer VA, Ahn C, Sneed S. Accuracy of clinical judgment in neonatal jaundice. Arch PediatrAdolesc Med. 2000; 154(4):391-4.
33
35. Greco C,Arnolda G, Boo NY, Iskander IF, Okolo AA, Rohsiswatmo R, et al. Neonatal jaundice in Low and Middle-Income Countries: Lessons and future directions from the 2015 Don Ostrow Trieste yellow retreat. Neonatology. 2016; 110(3):172-80.
34
36. OteikwuOchigbo S, Venn I, Anachuna K. Prevalence of bilirubin encephalopathy in Calabar, South-South Nigeria: a five-year review study. Iran J Neonatol. 2016; 7(1):9-12.
35
37. Kolawole SE, Obueh HO, Okandeji-Barry OR. Prevalence of neonatal jaundice in Eku Baptist Community Hospital in Delta State Nigeria. J Public Health Epidemiol. 2016; 8(5):87-90.
36
ORIGINAL_ARTICLE
Effect of Antenatal Dexamethasone on Serum Umbilical Cord C-peptide and Glucose Levels in Term Neonates Delivered by elective Cesarean Section
Background: Antenatal steroid therapy recently has been considered for term and late preterm neonates delivered by Cesarean section (CS), with the aim of preventing adverse respiratory morbidity. The main aim of this study was to investigate the metabolic effects of antenatal dexamethasone on blood glucose (BG), homeostasis, and serum C-peptide level when administered to term fetuses. Methods: Umbilical cord blood C-peptide and BG were measured in singleton newborns of 37 weeks gestational age or older with planned CS; furthermore, the history of dexamethasone receiving was taken from mothers. Other parameters, such as, Apgar score, neonatal birth weight, BG follow-ups, and admission to the neonatal nursery were collected. Results: Totally, 117 mothers met the inclusion criteria, of whom 60 had received antenatal dexamethasone. This study demonstrated that babies treated with antenatal dexamethasone had a decrease in umbilical cord BG (P=0.001) and BG follow-up three hours after birth (P=0.001) compared to untreated group. However, there was no statistically significant difference in the BG measurements within both groups in the first 24 h post birth (P=0.14). Furthermore, no statistically significant difference was observed within the two groups regarding umbilical cord C-peptide measurements (P=0.08), birth weight (P=0.17), and the numbers of neonates that needed admission to the nursery (P=0.36). Conclusion: Although antenatal dexamethasone causes immediate mild BG homeostasis alterations in term newborns delivered by elective CS, its use is not associated with a statistically significant effect on serum umbilical cord C-peptide measurements, neonatal birth weight, and the rate of neonatal nursery admission.
https://ijn.mums.ac.ir/article_11894_07cbcc7d500f2bf44640f0a723d8212e.pdf
2018-12-01
15
21
10.22038/ijn.2018.34616.1510
Keywords: Antenatal dexamethasone
Blood glucose
Cesarean section
Cord blood C-peptide
Full-term infant
Ramadan
Mahmoud
ramadan.aboelhassan@yahoo.com
1
Pediatrics Department, Sohag Faculty of Medicine, Sohag University, Egypt
LEAD_AUTHOR
Magdy A
Mohamed
2
Department of Obstetrics and Gynecology, Faculty of Medicine, Sohag University, Egypt
AUTHOR
Shereen P
Aziz
3
Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt
AUTHOR
1. Liggins GC. Premature delivery of foetal lambs infused with glucocorticoids. J Endocrinol. 1969; 45(4):515-23.
1
2. Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics. 1972; 50(4):515-25.
2
3. Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2017; 3:Cd004454.
3
4. Hansen AK, Wisborg K, Uldbjerg N, Henriksen TB. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. BMJ. 2008; 336(7635):85-7.
4
5. Tita AT, Landon MB, Spong CY, Lai Y, Leveno KJ, Varner MW, et al. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Engl J Med. 2009; 360(2):111-20.
5
6. Srinivasjois R, Silva D. Antenatal steroid administration in medically uncomplicated pregnancy beyond 37 weeks of gestation for the prevention of neonatal morbidities prior to elective caesarean section: a systematic review and meta-analysis of randomised controlled trials. J Matern Fetal Neonatal Med. 2017; 30(10):1151-57.
6
7. Sotiriadis A, Makrydimas G, Papatheodorou S, Ioannidis JP. Corticosteroids for preventing neonatal respiratory morbidity after elective caesarean section at term. Cochrane Database Syst Rev. 2009; 4:CD006614.
7
8. Stutchfield P, Whitaker R, Russell I. Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial. BMJ. 2005; 331(7518):662.
8
9. Saccone G, Berghella V. Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials. BMJ. 2016; 355:i5044.
9
10. Nada AM, Shafeek MM, El Maraghy MA, Nageeb AH, Salah El Din AS, Awad MH. Antenatal corticosteroid administration before elective caesarean section at term to prevent neonatal respiratory morbidity: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016; 199:88-91.
10
11. Roberts D. Royal college of obstetricians and gynecologists. Antenatal corticosteroids to reduce neonatal morbidity and mortality. Green-top Guideline 7. London: Royal College of Obstetricians and Gynecologists; 2010.
11
12. Kirshenbaum M, Mazaki-Tovi S, Amikam U, Mazkereth R, Sivan E, Schiff E, et al. Does antenatal steroids treatment prior to elective cesarean section at 34-7 weeks of gestation reduce neonatal morbidity? Evidence from a case control study. Arch Gynecol Obstet. 2018; 297(1):101-7.
12
13. Sifianou P, Thanou V, Karga H. Metabolic and hormonal effects of antenatal betamethasone after 35 weeks of gestation. J Pediatr Pharmacol Ther. 2015; 20(2):138-43.
13
14. O'Rahilly S, Burnett MA, Smith RF, Darley JH, Turner RC. Haemolysis affects insulin but not C-peptide immunoassay. Diabetologia. 1987; 30(6):394-6.
14
15. Wu ZQ, Lu J, Xu HG. Hemolysis affects C-Peptide immunoassay. J Clin Lab Anal. 2016; 30(6):1232-5.
15
16. Sweet DG, Hadden D, Halliday HL. The effect of early feeding on the neonatal blood glucose level at 1- hour of age. Early Hum Dev. 1999; 55(1):63-6.
16
17. Althabe F, Belizán JM, McClure EM, HemingwayFoday J, Berrueta M, Mazzoni A, et al. A populationbased, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: the ACT cluster-randomised trial. Lancet. 2015; 385(9968):629-39.
17
18. Reynolds RM. Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis. Psychoneuroendocrinology. 2013; 38(1):1-11.
18
19. Moisiadis VG, Matthews SG. Glucocorticoids and fetal programming part 1: outcomes. Nat Rev Endocrinol. 2014; 10(7):391-402.
19
20. Dube MC, Morisset AS, Tchernof A, Weisnagel SJ. Cord blood C-peptide levels relate to the metabolic profile of women with and without gestational diabetes. Acta Obstet Gynecol Scand. 2012; 91(12): 1469-73.
20
21. Ahmad I, Beharry KD, Valencia AM, Cho S, Guajardo L, Nageotte MP, et al. Influence of a single course of antenatal betamethasone on the maternal-fetal insulin-IGF-GH axis in singleton pregnancies. Growth Horm IGF Res. 2006; 16(4):267-75.
21
22. Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol. 2012; 119(5):909-16.
22
23. Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, et al. Antenatal betamethasone for women at risk for late preterm delivery. N Engl J Med. 2016; 374(14):1311-20. 24. Davis EP, Waffarn F, Sandman CA. Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants. Dev Psychobiol. 2011; 53(2):175-83.
23
25. Alexander N, Rosenlocher F, Stalder T, Linke J, Distler W, Morgner J, et al. Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children. J Clin Endocrinol Metab. 2012; 97(10):3538-44.
24
26. Stutchfield PR, Whitaker R, Gliddon AE, Hobson L, Kotecha S, Doull IJ. Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial). Arch Dis Child Fetal Neonatal Ed. 2013; 98(3):F195-200.
25
27. Wapner RJ, Sorokin Y, Mele L, Johnson F, Dudley DJ, Spong CY, et al. Long-term outcomes after repeat doses of antenatal corticosteroids. N Engl J Med. 2007; 357(12):1190-8.
26
28. Leung TN, Lam PM, Ng PC, Lau TK. Repeated courses of antenatal corticosteroids: is it justified? Acta Obstet Gynecol Scand. 2003; 82(7):589-96.
27
29. Jobe AH, Wada N, Berry LM, Ikegami M, Ervin MG. Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. Am J Obstet Gynecol. 1998; 178(5):880-5.
28
30. Braun T, Husar A, Challis JR, Dudenhausen JW, Henrich W, Plagemann A, et al. Growth restricting effects of a single course of antenatal betamethasone treatment and the role of human placental lactogen. Placenta. 2013; 34(5):407-15.
29
31. Eriksson L, Haglund B, Ewald U, Odlind V, Kieler H. Health consequences of prophylactic exposure to antenatal corticosteroids among children born late preterm or term. Acta Obstet Gynecol Scand. 2012; 91(12):1415-21.
30
ORIGINAL_ARTICLE
Effect of Bubble and Ventilator-derived Continuous Positive Airway Pressure on the Management of Respiratory Distress Syndrome in Premature Neonates
Background: In this study, we aimed to compare ventilator-derived and bubble continuous positive airway pressure (CPAP) in neonates with respiratory distress syndrome admitted to Neonatal Intensive Care Unit of Vali-e-Asr Hospital, Birjand, Iran, in 2014. Methods: This cohort study was conducted among 68 patients assigned into two groups. The neonates in group A (32 infants) were treated with bubble CPAP and those in group B (36 infants) were treated with a ventilator-derived CPAP. The protocol of treatment was applying CPAP with the positive end-expiratory pressure (PEEP) of 5-6 cm H2O and fraction of inspired oxygen equivalent to 30-40%, depending on the gestational age. In case of need for higher oxygen levels to maintain oxygen saturation of arterial blood (SpO2) (90-95%), surfactant was administered and additional PEEP was applied (up to 8 cm H2O). Data analysis was performed using independent t-test and Chi-squared in the SPSS software, version 18. Results: The duration of CPAP and oxygen therapy was 1.67±1.22 days and 3.57±2.67 days in group A and 2.09±1.53 days (P=0.21) and 4.67±3.74 days (P=0.16) in group B, respectively. There was a significant difference between the groups in terms of discharge weight and surfactant dosage (P=0.042 and P=0.007, respectively). Moreover, although the length of stay in hospital in the ventilation group was almost 4 days longer than the other group, there was no significant difference between the groups in this regard. Conclusion: There was no significant difference between bubble CPAP and ventilator-derived CPAP. Moreover, further studies with larger sample size are recommended.
https://ijn.mums.ac.ir/article_11895_f26e50e6090e9bba2de81c5de02ae574.pdf
2018-12-01
22
27
10.22038/ijn.2018.25855.1341
Keywords: CPAP
Bubble CPAP
Prematurity
RDS
Ventilator CPAP
Gholamreza
Faal
faalgh1@bums.ac.ir
1
Department of Pediatrics, Birjand University of Medical Sciences, Birjand, Iran
LEAD_AUTHOR
Fatemeh
Eghbal
naslesevomy@gmail.com
2
Department of Pediatrics, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
1. Wesenu M, Kulkarni S, Tilahun T. Modeling determinants of time-to-death in premature infants admitted to neonatal intensive care unit in Jimma University specialized hospital. Ann Data Sci. 2017; 4(3):361-81.
1
2. Bahman-Bijari B, Malekiyan A, Niknafs P, Baneshi MR. Bubble–CPAP vs. Ventilatory–CPAP in preterm infants with respiratory distress. Iran J Pediatr. 2011; 21(2):151-8.
2
3. Flannery DD, O’Donnell E, Kornhauser M, Dysart K, Greenspan J, Aghai ZH. Continuous positive airway pressure versus mechanical ventilation on the first day of life in very low-birth-weight infants. Am J Perinatol. 2016; 33(10):939-44.
3
4. Ladha K, Vidal Melo MF, McLean DJ, Wanderer JP, Grabitz SD, Kurth T, et al. Intraoperative protective mechanical ventilation and risk of postoperative respiratory complications: hospital-based registry study. BMJ. 2015; 351:h3646.
4
5. Shalish W, Kanbar LJ, Rao S, Robles-Rubio CA, Kovacs L, Chawla S, et al. Prediction of extubation readiness in extremely preterm infants by the automated analysis of cardiorespiratory behavior: study protocol. BMC Pediatr. 2017; 17(1):167.
5
6. Grassi A, Foti G, Laffey JG, Bellani G. Noninvasive mechanical ventilation in early acute respiratory distress syndrome. Pol Arch Intern Med. 2017; 127(9):614-20.
6
7. Chun J, Sung SI, Ho YH, Kim J, Park GY, Yoon S, et al. Prophylactic versus early rescue surfactant treatment in preterm infants born at less than 30 weeks gestation or with birth weight less than or equal 1,250 grams. J Korean Med Sci. 2017; 32(8):1288-94.
7
8. Dewez JE, van den Broek N. Continuous positive airway pressure (CPAP) to treat respiratory distress in newborns in low-and middle-income countries. Trop Doct. 2017; 47(1):19-22.
8
9. Gupta S, Sinha SK, Tin W, Donn SM. A randomized controlled trial of post-extubation bubble continuous positive airway pressure versus Infant Flow Driver continuous positive airway pressure in preterm infants with respiratory distress syndrome. J Pediatr. 2009; 154(5):645-50.
9
10. Sedkaoui K, Leseux L, Pontier S, Rossin N, Leophonte P, Fraysse JL, et al. Efficiency of a phone coaching program on adherence to continuous positive airway pressure in sleep apnea hypopnea syndrome: a randomized trial. BMC Pulm Med. 2015; 15(1):102.
10
11. Al-Mutairi FH, Fallows SJ, Abukhudair WA, Islam BB, Morris MM. Difference between continuous positive airway pressure via mask therapy and incentive spirometry to treat or prevent post-surgical atelectasis. Saudi Med J. 2012; 33(11):1190-5.
11
12. Polin RA, Sahni R. Newer experience with CPAP. Semin Neonatol. 2002; 7(5):379-89.
12
13. Sahni R, Schiaratura M, Polin RA. Strategies for the prevention of continuous positive airway pressure failure. Semin Fetal Neonatal Med. 2016; 21(3): 196-203.
13
14. Pillow JJ, Hillman N, Moss TJ, Polglase G, Bold G, Beaumont C, et al. Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs. Am J Respir Crit Care Med. 2007; 176(1):63-9.
14
15. Yadav S, Thukral A, Sankar MJ, Sreenivas V, Deorari AK, Paul VK, et al. Bubble vs conventional continuous positive airway pressure for prevention of extubation failure in preterm very low birth weight infants: a pilot study. Indian J Pediatr. 2012; 79(9):1163-8.
15
16. Kugelman A, Feferkorn I, Riskin A, Chistyakov I, Kaufman B, Bader D. Nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure for respiratory distress syndrome: a randomized, controlled, prospective study. J Pediatr. 2007; 150(5):521-6.
16
17. Goldsmith JP, Karotkin E. Assisted ventilation of the neonate. 5th ed. New York: Elsevier Health Sciences; 2010. P. 140-63.
17
18. Lee KS, Dunn MS, Fenwick M, Shennan AT. A comparison of underwater bubble continuous positive airway pressure with ventilator-derived continuous positive airway pressure in premature neonates ready for extubation. Neonatology. 1998; 73(2):69-75.
18
19. Mohammadizadeh M, Asadi AR, Sadeghnia AR. Compare the effects of continuous positive airway pressure with two different methods to treat premature infants with respiratory distress syndrome. J Isfahan Med Sch. 2011; 29(146):901- 11. (Persian)
19
20. Noori Shadkam M, Movahedinia M, Noori Shadkam Z, Mehrparvar AH. Comparison of the therapeutic effects of bubble CPAP and ventilator CPAP on respiratory distress syndrome in premature neonates. Iran J Neonatol. 2017; 8(3):1-5.
20
21. Mazzella M, Bellini C, Calevo MG, Campone F, Massocco D, Mezzano P, et al. A randomised control study comparing the Infant Flow Driver with nasal continuous positive airway pressure in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2001; 85(2):F86-90.
21
22. Lucking SE, Fields AI, Mahfood S, Kassir MM, Midgley FM. High-frequency ventilation versus conventional ventilation in dogs with right ventricular dysfunction. Crit Care Med. 1986; 14(9):798-801.
22
23. Tagare A, Kadam S, Vaidya U, Pandit A, Patole S. Bubble CPAP versus ventilator CPAP in preterm neonates with early onset respiratory distress--a randomized controlled trial. J Trop Pediatr. 2013; 59(2):113-9.
23
24. Morley CJ, Lau R, De Paoli A, Davis PG. Nasal continuous positive airway pressure: does bubbling improve gas exchange? Arch Dis Child Fetal Neonatal Ed. 2005; 90(4):F343-4.
24
25. Koti J, Murki S, Gaddam P, Reddy A, Reddy MD. Bubble CPAP for respiratory distress syndrome in preterm infants. Indian Pediatr. 2010; 47(2):139-43.
25
26. Tagare A, Kadam S, Vaidya U, Pandit A, Patole S. A pilot study of comparison of BCPAP vs. VCPAP in preterm infants with early onset respiratory distress. J Trop Pediatric. 2010; 56(3):191-4.
26
ORIGINAL_ARTICLE
Comparison of Maternal Serum and Umbilical Cord Blood Leptin Level in IUGR Neonates
Background: Gestational weight gain is an impressive factor in the fetal outcome. Intrauterine growth restriction (IUGR) is one of the most important problems during fetal period that may lead to many perinatal and long-term complications and growing neonatal morbidities and mortalities. The aim of the study was to ascertain the relationship between umbilical cord blood leptin concentration and fetal growth in neonates born with intrauterine growth restriction. Methods: Maternal serum and umbilical cord blood leptin concentration were measured by immune radiometric assay at term gestation. The study was conducted on 22 women with uncomplicated singleton pregnancies as control group (group A) and 22 women with fetal growth restriction in singleton pregnancies as case group (group B). All subjects had normal pregravid body mass index (BMI). Results: The results of the study showed that maternal serum leptin concentrations were significantly higher in group B comparing to group A (44ng/ml [28.9-58.2] vs. 24.6ng/ml [18.8-33.3]; P<0.001). However, umbilical cord blood leptin levels were significantly lower in group B comparing to group A (8.6 ng/ml [range 4.5-12.7] vs. 14.6 ng/ml [11.7-16.7]; P<0.001). Moreover, umbilical cord blood leptin levels were directly correlated with maternal BMI and neonatal birth weight in both groups. Conclusion: In growth-restricted fetuses at term, umbilical cord blood leptin concentrations were significantly lower than normal fetuses, suggesting that fetal adipose tissue is a major source for leptin production. Maternal serum leptin concentrations were higher in the presence of a growth restricted fetuses. This increas may be due to early hypoxia or an intrinsic placental mechanism, by which small placenta produces more leptin as a compensatory mechanism. Human recombinant leptin may have some roles in the treatment of IUGR fetuses in future.
https://ijn.mums.ac.ir/article_11896_c7d7d17282a710beb61604273696cc74.pdf
2018-12-01
28
32
10.22038/ijn.2018.29736.1403
Keywords: Adipose tissue
Intrauterine growth restriction
Leptin
Umbilical cord
hedieh
saneifard
h.saneifard@sbmu.ac.ir
1
Assistant Professor of Pediatric Endocrinology and Metabolism,ShahidBeheshti University of Medical Sciences. Tehran, IRAN
AUTHOR
Mitra
Radfar
2
Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Sedigheh
Shahrivar
3
Pediatrician, Tehran, Iran
AUTHOR
Marjan
Shakiba
4
Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Nooshin
Faraji
nooshin.f71@gmail.com
5
Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. Logan CA, Bornemann R, Koenig W, Reister F, Walter V, Fantuzzi G, et al. Gestational weight gain and fetal-maternal adiponectin, leptin, and CRP: results of two birth cohorts studies. Sci Rep. 2017; 7:41847.
1
2. Sumawan H, Purwara BH, Krisnadi SR. Low maternal leptin levels in preeclamptic women with fetal growth restriction. Open J Obstet Gynecol. 2013; 3(7):536.
2
3. Cunningham F, Leveno KJ, Bloom SL, Hauth JC, Gilstrap III L, Wenstrom K. Normal labor and delivery. Williams’s obstetrics. New York, NY: McGraw-Hill Professional; 2005. P. 410-40.
3
4. Ren RX, Shen Y. A meta-analysis of the relationship between birth weight and cord blood leptin levels in newborns. World J Pediatr. 2010; 6(4):311-6.
4
5. Kyriakakou M, Malamitsi-Puchner A, Militsi H, Boutsikou T, Margeli A, Hassiakos D, et al. Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers. Eur J Endocrinology. 2008; 158(3):343-8.
5
6. Taxvig C, Dreisig K, Boberg J, Nellemann C, Schelde AB, Pedersen D, et al. Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPARγ activation. Mol Cell Endocrinol. 2012; 361(1-2): 106-15.
6
7. Djiane J, Attig L. Role of leptin during perinatal metabolic programming and obesity. J Physiol Pharmacol. 2008; 59(Suppl 1):55-63.
7
8. Jaquet D, Leger J, Levy-Marchal C, Oury JF, Czernichow P. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab. 1998; 83(4):1243-6.
8
9. Pighetti M, Tommaselli GA, D'Elia A, Di Carlo C, Mariano A, Di Carlo A, et al. Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction. Obstet Gynecol. 2003; 102(3):535-43.
9
10. Helland IB, Reseland JE, Saugstad OD, Drevon CA. Leptin levels in pregnant women and newborn infants: gender differences and reduction during the neonatal period. Pediatrics. 1998; 101(3):E12. 11. Parizkova J. Impact of age, diet, and exercise on man's body composition. Ann N Y Acad Sci. 1963; 110(1):661-74.
10
12. Casabiell X, Pineiro V, Tome MA, Peino R, Dieguez C, Casanueva FF. Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J Clin Endocrinol Metab. 1997; 82(12): 4270-3.
11
13. Shekhawat PS, Garland JS, Shivpuri C, Mick GJ, Sasidharan P, Pelz CJ, et al. Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr Res. 1998; 43(3):338-43.
12
14. Duffield JA, Vuocolo T, Tellam R, McFarlane JR, Kauter KG, Muhlhausler BS, et al. Intrauterine growth restriction and the sex-specific programming of leptin and peroxisome proliferator-activated receptor γ (PPARγ) mRNA expression in visceral fat in the lamb. Pediatr Res. 2009; 66(1):59-65.
13
15. Palcevska-Kocevska S, Aluloska N, Krstevska M, Shukarova-Angelovska E, Kojik L, Zisovska E, et al. Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns. Srp Arh Celok Lek. 2012; 140(9- 10):595-9.
14
16. Marsoosi V, Mortazavi M. OP23. 03: comparison of leptin and adiponectin levels in maternal serum and venous umbilical cord blood between growth restricted and normal fetuses. Obstet Gynecol. 2009; 34(S1):136.
15
17. Pardo IM, Geloneze B, Tambascia MA, Pereira JL, Barros Filho AA. Leptin as a marker of sexual dimorphism in newborn infants. J Pediatr. 2004; 80(4):305-8.
16
18. Cetin I, Morpurgo PS, Radaelli T, Taricco E, Cortelazzi D, Bellotti M, et al. Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term. Pediatr Res. 2000; 48(5):646-51.
17
19. Nazem H, Sharifi F, Kazemi SA, Mousavinasab SN, Ghorovghi N, Boayni S, et al. Association of cord blood resistin with leptin, insulin, growth indices and fat levels in neonates of Mousavi Hospital of Zanjan in 2009. Zanjan Univ Med Sci J. 2011; 19(75):1-10.
18
20. Karakosta P, Georgiou V, Fthenou E, Papadopoulou E, Roumeliotaki T, Margioris A, et al. Maternal weight status, cord blood leptin and fetal growth: a prospective mother-child cohort study (Rhea study). Pediatr Perinat Epidemiol. 2013; 27(5):461-71.
19
21. Ali MA, Salman DA, Hallab HS. Neonatal and placental birth weight and its correlation with leptin level in maternal and cord blood. Iraqi Med J. 2017; 63(1):97-104.
20
ORIGINAL_ARTICLE
A Comparative Study of the Efficacy of Surfactant Administration through a Thin Intratracheal Catheter and its Administration via an Endotracheal Tube in Neonatal Respiratory Distress Syndrome
Background: The cornerstone of the treatment of respiratory distress syndrome (RDS) is respiratory support and surfactant replacement therapy. The administration of surfactant through a thin intratracheal catheter is one of the methods used to reduce one of the standard technique complications of a surfactant injection (Intubation-Surfactant-Extubation method [INSURE]). The aim of this study was to compare the effectiveness of this method on the treatment of RDS in neonates with one of the INSURE technique. Methods: In this double blind clinical trial, 104 neonates with RDS were randomly allocated to two groups, one group received surfactant via an endotracheal tube (INSURE) and the other received surfactant without intubation (SWI) via a thin intratracheal catheter. Subsequently the outcomes of the two groups were compared. Results: The incidence of hypoxemia during surfactant administration was significantly lower in the SWI group (11.5%) than in the INSURE group (28.8% , P< 0.05). no significant difference was observed in the need for intubation and mechanical ventilation during the first 72 hours of life, the duration of mechanical ventilation, the need for nasal continuous positive airway pressure (NCPAP), the need for oxygen, the incidence of bronchopulmonary dysplasia, intraventricular hemorrhage, pulmonary hemorrhage ,and death in the two groups. Conclusion: Administration of surfactant through a thin intratracheal catheter is a safe and easy technique. This method is as effective as the INSURE method in improving the outcomes of RDS treatment.
https://ijn.mums.ac.ir/article_11897_abe5f7dc3c5c94ca71bacfebe1aeaff3.pdf
2018-12-01
33
40
10.22038/ijn.2018.30057.1408
Keywords: Neonatal respiratory distress syndrome
Surfactant
Surfactant without intubation
Roya
Choupani
dr.choopani@yahoo.com
1
Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
LEAD_AUTHOR
Ghobad
Mashayekhy
dr.ghmashayekhy@yahoo.com
2
Department of Pediatrics, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Majid
Hmidi
3
Department of Pediatrics, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Soleiman
Kheiri
kheiri.soleiman@gmail.com
4
Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Marzieh
Khalili Dehkordi
5
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
1. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, et al. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants-- 2013 update. Neonatology. 2013; 103(4):353-68.
1
2. Ceylan A, Gezer S, Demir N, Tuncor O, Peker E, Kirimi E. The importance of administration of early surfactant and nasal continuous positive airway pressure in newborns with respiratory distress syndrome. Turk Pediatr Ars. 2014; 49(3):192-7.
2
3. Lista G, Castoldi F. Surfactant administration in spontaneous breathing with N-CPAP for RDS. Acta Biomed. 2014; 85(1):35-8.
3
4. Kribs A, Hartel C, Kattner E, Vochem M, Kuster H, Moller J, et al. Surfactant without intubation in preterm infants with respiratory distress: First multi-center data. Klin Padiatr. 2010; 222(1):13-7.
4
5. Baraldi E, Filippone M. Chronic lung disease after premature birth. N Engl J Med. 2007; 357(19): 1946-55.
5
6. Kribs A, Roll C, Gopel W, Wieg C, Groneck P, Laux R, et al. Nonintubated surfactant application vs conventional therapy in extremely preterm infants: a randomized clinical trial. JAMA Pediatr. 2015; 169(8):723-30.
6
7. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, et al. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants, 2010 update. Neonatology. 2010; 97(4):402-17.
7
8. Kribs A, Pillekamp F, Hunseler C, Vierzig A, Roth B. Early administration of surfactant in spontaneous breathing with nCPAP: feasibility and outcome in extremely premature infants (post menstrual age≤27 weeks). Pediatr Anesth. 2007; 17(4):364-9.
8
9. Bao Y, Zhang G, Wu M, Ma L, Zhu J. A pilot study of less invasive surfactant administration in very preterm infants in a Chinese tertiary center. BMC Pediatr. 2015; 15:21.
9
10. Dargaville PA, Aiyappan A, Cornelius A, Williams C, De Paoli AG. Preliminay evaluation of a new technique of minimally invasive surfactant therapy. Arch Dis Child Fetal Neonatal Neonatal Ed. 2011; 96(4):F243-8.
10
11. Mohammadizadeh M, Ardestani AG, Sadeghnia AR. Early administration of surfactant via a thin intratracheal catheter in preterm infants with respiratory distress syndrome: Feasibility and outcome. J Res Pharm Pract. 2015; 4(1):31-6.
11
12. Carlo WA, Ambalavanan N. Respiratory tract disorders. In: Kliegman RM, Stanton BF, Geme ST, Schor NF, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier; 2016. P. 848-67.
12
13. Kuipers MT, VanderPoll T, Schultz MJ, Wieland CW. Bench-to-bedside review: Damage associated molecular patterns in the onset of ventilatorinduced lung injury. Crit Care. 2011; 15(6):235.
13
14. Gopel W, Kribs A, Hartel C, Avenarius S, Teig N, Groneck P, et al. Less invasive surfactant administration is associated with improved pulmonary outcomes in spontaneously breathing preterm infants. Acta Paediatr. 2015; 104(3):241-6.
14
15. Aguar M, Cernada M, Brugada M, Gimeno A, Gutierrez A, Vento M. Minimally invasive surfactant therapy with a gastric tube is as effective as the intubation, surfactant, and extubation technique in preterm babies. Acta Paediatr. 2014; 103(6): e229-33.
15
16. Dargaville PA, Aiyappan A, De Paoli AG, Kuschel CA, Kamlin CO, Carlin JB, et al. Minimally-invasive surfactant therapy in preterm infants on continuous positive airway pressure. Arch Dis Child Fetal Neonatal Ed. 2013; 98(2):F122-6.
16
17. Kanmaz HG, Erdeve O, Canpolat FE, Mutlu B, Dilmen U. Surfactant administration via thin catheter during spontaneous breathing: randomized controlled trial. Pediatrics. 2013; 131(2):502-9. 18. Mirnia K, Heidarzadeh M, Hosseini MB, Sadeghnia A, Balila M, Ghogazadeh M. Comparison outcome of surfactant administration via tracheal catheterization during spontaneous breathing with InSurE. Med J Islamic World Acad Sci. 2013; 109(1007):1-6.
17
19. Heidarzadeh M, Mirnia K, Hoseini MB, Sadeghnia A, Akrami F, Balila M, et al. Surfactant administration via thin catheter during spontaneous breathing: randomised controlled trial in Alzahra hospital. Iran J Neonatol. 2013; 4(2):5-9.
18
20. Klebermass-Schrehof K, Wald M, Schwindt J, Grill A, Prusa AR, Haiden N, et al. Less invasive surfactant administration in extremely preterm infants: impact on mortality and morbidity. Neonatology. 2013; 103(4):252-8.
19
21. Lau CS, Chamberlain RS, Sun S. Less invasive surfactant administration reduces the need for mechanical ventilation in preterm infants: a metaanalysis. Glob Pediatr Health. 2017; 4:1-9.
20
22. Krajewski P, Chudzik A, Strzałko-Głoskowska B, Gorska M, Kmiecik M, Wieckowska K, et al. Surfactant administration without intubation in preterm infants with respiratory distress syndromeour experiences. J Matern Fetal Neonatal Med. 2015; 28(10):1161-4.
21
23. Dargaville PA. Innovation in surfactant therapy I: surfactant lavage and surfactant administration by fluid bolus using minimally invasive techniques. Neonatology. 2012; 101(4):326-36.
22
24. Gopel W, Kribs A, Ziegler A, Laux R, Hoehn T, Wieg C, et al. Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open- label, randomized, controlled trial. Lancet. 2011; 378(9803):1627-34.
23
25. Mehler K, Grimme J, Abele J, Huenseler C, Roth B, Kribs A. Outcome of extremely low gestational age newborns after introduction of a revised protocol to assist preterm infants in their transition to extrauterine life. Acta Paediatr. 2012; 101(12):1232-9.
24
26. Niemarrkt HJ, Kuypers E, Jellema R, Ophelders D, Hutten M, Nikiforou M, et al. Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution and lung compliance in spontaneously breathing preterm lambs. Pediatr Res. 2014; 76(2):166-70.
25
ORIGINAL_ARTICLE
Effect of Massage Therapy on Transcutaneous Bilirubin Level in Healthy Term Neonates: Randomized Controlled Clinical Trial
Background: Neonatal jaundice is a common condition in approximately 60% of term newborns during the first week after birth. Therefore, it is necessary to detect methods for the prevention of this problem.This study was conducted to evaluate the impact of massage therapy on transcutaneous bilirubin level in healthy term newborns. Methods: The present study was conducted on102 healthy term newborns. The newborns were randomly assigned to massage group and control group. The massage group received daily massage for five days from the first postnatal day while the control group received only routine neonatal care (without massage). In both groups, transcutaneous bilirubin level and frequency of defecation were the main studied variables. Results: The frequency of defecation in the massage group increased from 1.08 on the first day to 4.08 on the fifth day, whereas it increased from 0.865 on the first day to 2.731 on the fifth day in the control group, indicating a significant difference between the two groups (P<0.005). Moreover, transcutaneous bilirubin levels on the first and second days were not significantly different in both groups, while it was significantly lower during the third to fifth days in the massage group compared to that in the control group (P<0.005). Conclusion: The results of this study revealed that massage therapy could reduce transcutaneous bilirubin level and increase the frequency of defecation in healthy term neonates.
https://ijn.mums.ac.ir/article_11898_2d4a475badcddccf7bf6ff1bf7aa4cdd.pdf
2018-12-01
41
46
10.22038/ijn.2018.28906.1386
Keywords: Bilirubin
Jaundice
Massage
neonate
Homa
Babaei
homa_babaei@kums.ac.ir
1
Department of Neonatology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
LEAD_AUTHOR
Mazyar
Vakiliamini
2
Department of Neonatology, Dr. Kermanshahi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
1. Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2008; 358(9):920-8. 2. Martin RJ, Fanaroff AA, Walsh MC. Neonatal jaundice and liver disease. Fanaroff and martin's neonatalperinatal medicine: diseases of the fetus and infant. 10th ed. Philadelphia: Mosby Elsevier; 2015.
1
3. Kaplan M, Bromiker R, Hammerman C. Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? Neonatology. 2011; 100(4):354-62.
2
4. Chen J, Sadakata M, Ishida M, Sekizuka N, Sayama M. Baby massage ameliorates neonatal jaundice in fullterm newborn infants. Tohoku J Exp Med. 2011; 223(2):97-102.
3
5. Dennery PA, Lorch S. Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development. Pediatrics. 2007; 120(1):247-8.
4
6. Newman TB, Maisels MJ. Evidence Insufficient to recommend melanoma surveillance following phototherapy for jaundice. Arch Dermatol. 2007; 143(9):1216-7.
5
7. Smith SL, Lux R, Haley S, Slater H, Beachy J, MoyerMileur LJ. The effect of massage on heart rate variability in preterm infants. J Perinatol. 2013; 33(1):59-64.
6
8. Kulkarni A, Kaushik JS, Gupta P, Sharma H, Agrawal RK. Massage and touch therapy in neonates: the current evidence. Indian Pediatr. 2010; 47(9):771-6.
7
9. Field T. Massage therapy. Med Clin North Am. 2002; 86(1):163-71.
8
10. Moyer-Mileur LJ, Haley S, Slater H, Beachy J, Smith SL. Massage improves growth quality by decreasing body fat deposition in male preterm infants. J Pediatr. 2013; 162(3):490-5.
9
11. Zhao H, Guan L, Shi G. The effects of infant touch on neonatal jaundice. Chin J Nurs. 2003; 10:772-3.
10
12. Guiping L. The influence of defecation and icterous of newborn children on touching. Heilongjiang Nurs J. 2002; 8(3):472-34.
11
13. Meng Z, Hua C, Chongyu Y. Observation of the effect of caress on defecation and jaundice of newborn. J Qilu Nurs. 2006; 12(6):449-514.
12
14. Semmekrot BA, Gerrits GP. Optimal breastfeeding to prevent hyperbilirubinaemia in healthy, term newborns. Ned Tijdschr Geneeskd. 2004; 148(41): 2016-9.
13
15. Volosovets ОP, Мarkevich VЕ, Tarasova ІV, Loboda АМ. Introduction to neonatology. 2nd ed. Tokyo: Medical Academy of Classical Learning; 1994. P. 639.
14
16. Dalili H, Sheikhi S, Shariat M, Haghnazarian E. Effects of baby massage on neonatal jaundice in healthy Iranian infants: a pilot study. Infant Behav Dev. 2016; 42:22-6.
15
17. Seyyedrasooli A, Valizadeh L, Hosseini MB, Asgari Jafarabadi M, Mohammadzad M. Effect of vamila massage on physiological jaundice in infants: a randomized controlled trial. J Caring Sci. 2014; 3(3):165-73.
16
18. Field T, Diego M, Hernandez-Reif M. Moderate pressure is essential for massage therapy effects. Int J Neurosc. 2010; 120(5):381-5.
17
19. Basiri-Moghadam M, Basiri-Moghadam K, Kianmehr M, JaniS. The effect of massage on neonatal jaundice in stable preterm newborn infants: a randomized controlled trial. J Pak Med Assoc. 2015; 65(6):602-6.
18
20. Lin CH, Yang HC, Cheng CS, Yen CE. Effects of infant massage on jaundiced neonates undergoing phototherapy. Ital J Pediatr. 2015; 41:94.
19
ORIGINAL_ARTICLE
Effects of Restrictive Fluid Management in Transient Tachypnea in Neonates
Background: The transient tachypnea is a common respiratory problem in the neonate. One of the significant issues in pathophysiology of this disorder is the delayed reabsorption of the fluid by the neonate’s lungs and the effusion of fluid in the lungs. The purpose of this study is to evaluate the effects of restrictive fluid management in transient tachypnea of the neonate. Methods: The present study was conducted on the neonates with the gestational age ≥ 34 weeks suffering from transient tachypnea during the first 6 h after birth. The amounts of total fluid in experimental and control groups were 50, 65 mL/kg and 65, 80 mL /kg for term and preterm neonates, respectively. In each group, a daily amount of 20 mL/kg fluid was added until 150 and 170 mL/kg for term and preterm newborns. Results: This study was carried out on 70 neonates, including 34 cases and 36 controls. The mean of hospitalization period in the experimental group was less than that of the control group. The mean period of respiratory support in the experimental group was less than that in the control group. Conclusion: The results of the present study revealed that the restrictive fluid management in the neonates with transient tachypnea might decrease the hospitalization period and the respiratory support period. Furthermore, it is a safe and effective method in treating transient tachypnea in neonates.
https://ijn.mums.ac.ir/article_11899_63a7fd385874f8d9b16648be75b5d80b.pdf
2018-12-01
47
52
10.22038/ijn.2018.27719.1371
Keywords: Respiratory support
Restrictive fluid management
Transient tachypnea in neonates
zahra
Akbarian rad
zhr_akbarian@yahoo.com
1
Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Mitra
Gorji Rad
2
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
AUTHOR
mohsen
haghshenas
matia.mojaveri@yahoo.com
3
Non-communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
LEAD_AUTHOR
1. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. New York: Elsevier Health Sciences; 2014.
1
2. Gupta N, Chawla D. Fluid restriction in the management of transient tachypnea of the newborn. New York: The Cochrane Library; 2015.
2
3. Zahed PY, Zeynalzadeh M, Taheri T, Baleghi M. Correlation between the mode of delivery with the risk of neonatal respiratory morbidity. J Babol Univ Med Sci. 2008; 10(4):30-6.
3
4. Dani C, Reali MF, Bertini G, Wiechmann L, Spagnolo A, Tangucci M, et al. Risk factors for the development of respiratory distress syndrome and transient tachypnoea in newborn infants. Italian Group of Neonatal Pneumology. Eur Respir J. 1999; 14(1):155-9.
4
5. Stroustrup A, Trasande L, Holzman IR. Randomized controlled trial of restrictive fluid management in transient tachypnea of the newborn. J Pediatr. 2012; 160(1):38-43.
5
6. Dehdashtian M, Aramesh MR, Melekian A, Aletayeb MH, Ghaemmaghami A. Restricted versus standard maintenance fluid volume in management of transient Tachypnea of newborn: a clinical trial. Iran J Pediatr. 2014; 24(5):575-80.
6
7. Kao B, Stewart de Ramirez SA, Belfort MB, Hansen A. Inhaled epinephrine for the treatment of transient tachypnea of the newborn. J Perinatol. 2008; 28(3):205-10.
7
8. Armangil D, Yurdakök M, Korkmaz A, Yiğit Ş, Tekinalp G. Inhaled beta-2 agonist salbutamol for the treatment of transient tachypnea of the newborn. J Pediatr. 2011; 159(3):398-403.
8
9. Kim MJ, Yoo JH, Jung JA, Byun SY. The effects of inhaled albuterol in transient tachypnea of the newborn. Allergy Asthma Immunol Res. 2014; 6(2):126-30.
9
10. Mohammadzadeh I, Akbarian-Rad Z, Heidari F, Zahedpasha Y, Haghshenas-Mojaveri M. The effect of inhaled salbutamol in transient of tachypnea of the newborn: a randomized clinical trial. Iran J Pediatr. 2017; 27(5):e9633.
10
11. Karabayir N. Intravenous furosemide therapy in transient tachypnea of the newborn. Pediatr Int. 2010; 52(5):851.
11
12. Lewis VE, Whitelaw A. Furosemide for transient tachypnea of the newborn. Cochrane Database Syst Rev. 2002; 1:21.
12
13. Yurdakok M, Ozek E. Transient tachypnea of the newborn: the treatment strategies. Curr Pharm Des. 2012; 18(21):3046-9.
13
ORIGINAL_ARTICLE
Comparison of Nasal Non-invasive Ventilation Methods in Preterm Neonates with Respiratory Distress Syndrome
Background: Humidified heated high flow nasal cannula (HHHFNC), nasal continuous positive airway pressure (NCPAP), and nasal intermittent positive pressure ventilation (NIPPV) are three nasal non-invasive ventilation methods. The purpose of this study was to compare these three methods in decreasing intubation and mechanical ventilation rate in preterm neonates with respiratory distress syndrome (RDS). Methods: This study was a randomized controlled study conducted on 160 neonates. The inclusion criteria for intubation in this study were persistent respiratory acidosis (arterial pH<7/2 or PCO2>60), hypoxemia, severe and repeated apnea episodes which did not respond to increasing respiratory rate and therefore required ventilation. Cranial Ultrasound was performed on the third day after birth. The data of all neonates were collected until the day of discharge and analyzed by SPSS (version 20) and statistical methods. Results: Based on the results,there was no significant difference among the three randomized methods. Out of all the cases, 72% of the neonates with NIPPV had successful non-invasive ventilation (35/53), compared to 73/6% in NCPAP (39/53) and 72/2% in HHHFNC (P=0/999). Similarly, there was no significant difference among the three methods in total ventilation time and the need for supplemental oxygen. Conclusion: The use of HHHFNC at birth in preterm neonates with RDS is safer than the other two methods. However, it is not more effective than the other two methods in the reduction of intubation rate.
https://ijn.mums.ac.ir/article_11903_5b70c1d5f00e5d32978a2e6c2061f8dc.pdf
2018-12-01
53
60
10.22038/ijn.2018.24544.1313
Keywords: Humidified heated high flow nasal cannula (HHHFNC)
Nasal continuous positive airway pressure (NCPAP)
Nasal intermittent positive pressure ventilation (NIPPV)
Preterm neonates
Respiratory distress (RDS)
ahmad
shahfarhat
farhata@mums.ac.ir
1
assistant professor, neonatologist, Neonatal Research Center, emam reza hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
AUTHOR
Ashraf
Mohammadzadeh
mohamadzadeha@mums.ac.ir
2
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Gholam Ali
Mamuri
3
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Reza
Saeidi
saeedir@mums.ac.ir
4
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Shadi
Noorizadeh
5
Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1. Manley BJ, Dold SK, Davis PG, Roehr CC. High-flow nasal cannulae for respiratory support of preterm infants: a review of the evidence. Neonatology. 2012; 102(4):300-8.
1
2. Kirpalani H, Millar D, Lemyre B, Yoder BA, Chiu A, Roberts RS, et al. A trial comparing noninvasive ventilation strategies in preterm infants. N Engl J Med. 2013; 369(7):611-20.
2
3. Ramanathan R. Nasal respiratory support through the nares: its time has come. J Perinatol. 2010; 30:S67-72.
3
4. Rangasamy R, Paz P, Binwal M. Non-invasive ventilation and surfactant therapy. J Pulmon Resp Med. 2013; 13:161-72.
4
5. Shoemaker MT, Pierce MR, Yoder BA, DiGeronimo RJ. High flow nasal cannula versus nasal CPAP for neonatal respiratory disease: a retrospective study. J Perinatol. 2007; 27(2):85-91.
5
6. Yoder BA, Stoddard RA, Li M, King J, Dirnberger DR, Abbasi S. Heated humidified high flow nasal cannula versus nasal CPAP for respiratory support in neonates. Pediatrics. 2013; 131(5):1482-90.
6
7. Frizzole M, Miller TL, Rodriguez ME, Zhu Y, Rojas J, Hesek A, et al. High flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol. 2011; 46(1):67-74. 8. Kubicka ZJ, Limauro J, Darnall RA. Heated humidified high flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure? Pediatrics. 2008; 121(1):82-8.
7
9. Frey B, Shann F. Oxygen administration in infants. Arch Dis Child Fetal Neonatal Ed. 2003; 88(2):84-8.
8
10. Woodhead DD, Lambert DK, Clark JM, Christensen RD. Comparing two methods of delivering high flow gas therapy by nasal cannula following endotraceal extubation: a prospective, randomized, masked, crossover trial. J Perinatol. 2006; 26(8):481-5.
9
11. Holleman-Duray D, Kuapie D, Weiss MG. Heated humidified high flow nasal cannula: use and a neonatal early extubation protocol. J Perinatol. 2007; 27(12):776-81.
10
12. Shoemaker MT, Pierce MR, Yoder BA, Digernomio RJ. High flow nasal cannula versus nasal CPAP for neonatal respiratory distress: a retrospective study. J Perinatol. 2007; 27(2):85-91.
11
13. Abdel Hady H, Shouman B, Aly H. Early weaning from CPAP to high flow nasal cannula in preterm infants is associated with prolonged oxygen requirement: a randomized control trial. Early Hum Dev. 2011; 87(3):205-8.
12
14. Compbell DM, Shah PS, Shah V, Kelly N. Nasal continuous positive airway pressure from high flow cannula versus infant flow for preterm infants. J Perinatol. 2006; 26(9):546-9.
13
15. Collins CL, Holberton JR, Bafield C, Davis PG. A randomized control trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in preterm infants. J Pediatr. 2013; 162(5):949-54.
14
16. Ramanathan R, Sekar KC, Rasmussen L, Bhatia J, Soll RF. Nasal intermittent positive pressure ventilation after surfactant treatment for respiratory distress syndrome in preterm infants<30 weeks’ gestation: a randomized, controlled trial. J Perinatol. 2012; 32(5):336-43.
15
17. Lee HS, Min SR. Comparison of effectiveness of nasal continuous positive airway pressure and nasal intermittent positive pressure ventilation for the initial treatment of preterm respiratory distress syndrome: a prospective pilot study. Neonatal Med. 2014; 21(3):158-65.
16
18. Menses J, Bhandari V, Alves JG. Nasal intermittent positive pressure ventilation vs nasal continuous positive airway pressure for preterm infants with respiratory distress syndrome. Arch Pediatr Adolesc Med. 2012; 166(4):372-6.
17
19. Armanian AM, Badiee Z, Heidari G, Feizi A, Salehimehr N. Initial treatment of respiratory distress syndrome with nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure: a randomized controlled trial. Int J Prev Med. 2014; 5(12):1543-51.
18
20. Moretti C, Luigi G, Fassi C, Gizzi C, Papoff P, Colarizi P. Nasal flow synchronized intermittent positive pressure ventilation to facilitate weaning in very low-birthweight infants: unmasked randomized controlled trial. Pediatr Int. 2008; 50(1):85-91.
19
ORIGINAL_ARTICLE
Effect of Phototherapy Treatment on Urinary Calcium Excretion in Neonates with Jaundice in Zahedan, Iran
Background: One of the recognized symptoms of phototherapy in neonates is hypocalcemia and hypercalciuria, and its etiology has not been identified yet. The present study investigated the recurrence of hypercalciuria among neonates with jaundice treated with phototherapy. Methods: This cross-sectional diagnostic examination was conducted on 100 newborns with jaundice treated with phototherapy in Ali-ibn-Abi-Talib hospital in Zahedan, Iran, during 2013 and 2014. In the present study, the subjects were collected in an accessible way after agreement and considering exclusion criteria. Calcium and creatinine (Ca/Cr) proportion in urinary tests of the neonates was estimated at the baseline and 24 h after the onset of phototherapy. The information was analyzed utilizing paired t-test. Results: The mean of gestational age was 38.5±2.5 weeks. Out of 100 cases, 53 newborns (53%) were male and 47 (47%) were female. The mean scores of birth weight was 2.52±0.59 kg and neonatal serum bilirubin level was 16.5±0.92 mg/dl. Ca/Cr ratios in neonates with jaundice were 0.28±0.21 and 0.40±0.34 before and after the phototherapy, respectively. Regarding that, the increase in Ca/Cr ratio was statistically significant (P<0.001). Hypercalciuria was not observed in the neonates before the phototherapy; however, it was noticed in 13 neonates after the phototherapy. Ca/Cr ratios in neonates with hypercalciuria and other newborns were 1.16±0.19 and 0.29±0.18, respectively. Furthermore, the difference between the two groups was statistically significant (P<0.001). Conclusion: Based on the results of this study, it was suggested that the neonates undergoing the phototherapy were at risk of hypercalciuria and the increased amount of urinary calcium excretion by means of phototherapy.
https://ijn.mums.ac.ir/article_11904_aa9ecbfe974be3067c367739d649348c.pdf
2018-12-01
61
65
10.22038/ijn.2018.29411.1395
Keywords: Hypercalciuria
Jaundice
Phototherapy
Mahmoud
Imani
arbabisarjou2007@gmail.com
1
Child and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
AUTHOR
Simin
Sadeghi-bojd
sisadegh@yahoo.come
2
Child and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
LEAD_AUTHOR
Fathmeh
Khonamani Falahati
3
Student of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
AUTHOR
Alireza
Ansari Moghadam
ansarialireza@yahoo.com
4
Department of Biostatistics and Epidemiology, Health School, Zahedan University of Medical sciences, Zahedan, Iran
AUTHOR
1. De Luca D. NICE guidelines on neonatal jaundice: at risk of being too nice. Lancet. 2010; 376(9743):771.
1
2. Kaplan M, Bromiker R, Hammerman C. Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? Neonatology. 2011; 100(4):354-62.
2
3. Dijk PH. Guideline 'prevention, diagnosis and treatment of hyperbilirubinemia in the neonate with a gestational age of 35 or more weeks'. Ned Tijdschr Geneeskd. 2009; 153:A93.
3
4. Hansen TW. Twists and turns in phototherapy for neonatal jaundice. Acta Paediatr. 2010; 99(8):1117-8.
4
5. Walsh S, Murphy J. Neonatal jaundice--are we overtreating? Iran Med J. 2010; 103(1):28-9.
5
6. Aycicek A, Erel O. Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy. J Pediatr (Rio J). 2007; 83(4):319-22.
6
7. Eghbalian F, Monsef A. Phototherapy-induced hypocalcemia in icteric newborns. Iran J Med Sci. 2015; 27(4):169-71.
7
8. Karamifar H, Pishva N, Amirhakimi GH. Prevalence of phototherapy-induced hypocalcemia. Iran J Med Sci. 2015; 27(4):166-8.
8
9. Sethi H, Saili A. Phototherapy induced hypocalcemia. Indian Pediatr. 1993; 30(12):1403-6.
9
10. Jain B, Singh H, Singh D, Toor NS. Phototherapy included hypocalcemia. Indian Pediatr. 1998; 35(6):566-7.
10
11. Hunter KM. Hypocalcaemia. In: Cloherty JP, Eichenwald CE, Stark AR, editors. Manual of neonatal care. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2004. P. 579-88.
11
12. Hakanson DO, Penny R, Bergstrom WH. Calcemic responses to photic and pharmacologic manipulation of serum melatonin. Pediatr Res. 1987; 22(4):414-6.
12
13. Hakanson DO, Bergstrom WH. Phototherapyinduced hypocalcemia in newborn rats: prevention by melatonin. Science. 1981; 214(4522):807-9.
13
14. Zecca E, Romagnoli C, Tortorolo G. Ineffectiveness of vitamin 25 (OH) D3 in the prevention of hypocalcemia induced by phototherapy. Pediatr Med Chir. 1983; 5(5):317-9.
14
15. Alizadeh-Taheri P, Sajjadian N, Eivazzadeh B. Prevalence of phototherapy induced hypocalcemia in term neonate. Iran J Pediatr. 2013; 23(6):710-1.
15
16. Hooman N, Honarpisheh A. The effect of phototherapy on urinary calcium excretion in newborns. Pediatr Nephrol. 2005; 20(9):1363-4.
16
17. Ehsanipour F, Khosravi N, Jalali S. The effect of hat on phototherapy-induced hypocalcemia in icteric newborns. Razi J Med Sci. 2008; 15(58):25-9.
17
18. Yadav RK, Sethi RS, Sethi AS, Kumar L, Chaurasia OS. The evaluation of the effect of phototherapy on serum calcium level. Peoples J Sci Res. 2012; 5(2):1-4.
18
19. Medhat FB. Assessment of phototherapy induced hypocalcaemia. [Doctoral Dissertation]. Egypt: Pediatrics in Cairo University; 2006.
19
20. Bahbah MH, ElNemr FM, ElZayat RS, Aziz EA. Effect of phototherapy on serum calcium level in neonatal jaundice. Menoufia Med J. 2015; 28(2):426.
20
21. Khan M, Malik KA, Bai R. Hypocalcemia in jaundiced neonates receiving phototherapy. Pak J Med Sci. 2016; 32(6):1449-52.
21
ORIGINAL_ARTICLE
Clinical Relevance of Faecal Calprotectin Level in Infantile Colic: A Cross-sectional Survey
Background: There is limited knowledge on the potential applicability of fecal calprotectin (f-CP) as an inflammatory screening parameter in infantile colic (IC). This study aimed to evaluate f-CP in neonates with IC as a useful diagnostic indicator regarding this condition. Methods: The present study was conducted on 100 cases, including 50 newborns with IC and 50 non-colicky neonates. The diagnosis of IC was fulfilled by the Wessel Criteria. The level of f-CP was determined by a specific enzyme-linked immunosorbent assay kit (Calprotectin ELISA, EuroImmun, Germany). The statistical analysis was performed in SPSS software (version 19). Results: Out of 100 neonates, 57 cases were male and 43 subjects were female. The age spectrum ranged from 19-90 days (40.4±15.9). Colicky newborns were slightly younger (P=0.06) with higher birth weight compared to the infants without colic (P<0.0001). The level of f-CP was significantly higher in colicky neonates (113.7±98.2 µg/g) than non-colicky cases (71.4±45.5 µg/g) (P=0.007). Overall, 37%, 30%, 26%, and 7% of the newborns showed f-CP levels<50, 50-100, 100-200, and >200 µg/g, respectively. There was a significant difference regarding the distribution of these f-CP categories between neonates with IC and the cases without IC (P=0.02). There were no significant correlations between the f-CP and newborn age, pregnancy age, present or birth weights, and number of pregnancies. Receiver operating characteristic analysis rendered an area under the curve of 0.642 (95% CI: 0.534-0.748) (P=0.01). At the cut-off value of 74 µg/g, f-CP showed sensitivity of 60% and specificity of 59% for the detection of IC. Conclusion: The results of this study revealed that the f-CP might be useful in the diagnosis of the IC.
https://ijn.mums.ac.ir/article_11905_ac09e440c18591fb8e874165781e3329.pdf
2018-12-01
66
71
10.22038/ijn.2018.29511.1399
Keywords: Calprotectin
Infantile colic
Intestinal inflammation
Leukocyte L1 antigen complex
Iraj
Shahramian
ir_buper@yahoo.com
1
Pediatric Ward, Amir Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Ali
Bazi
m.baziali@gmail.com
2
Zabol University of Medical Sciences
LEAD_AUTHOR
Alireza
Sargazi
3
Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Omolbanin
Sargazi Aval
omi.sargazi@gmail.com
4
Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Alireza
Dechal
alirezadechal75@gmail.com
5
Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Mostafa
Bazzi
mostafabz.1996@gmail.com
6
Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Masoud
Jahantigh
masoudjahantigh94@gmail.com
7
Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
1. Campeotto F, Butel MJ, Kalach N, Derrieux S, AubertJacquin C, Barbot L, et al. High faecal calprotectin concentrations in newborn infants. Archives of Disease in Childhood. 2004;89(4):F353-F5.
1
2. Aalto K, Lahdenne P, Kolho KL. Fecal calprotectin in juvenile idiopathic arthritis patients related to drug use. Pediatric Rheumatology. 2017;15.
2
3. Fagerberg UL, Loof L, Myrdal U, Hansson LO, Finkel Y. Colorectal inflammation is well predicted by fecal calprotectin in children with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr. 2005; 40(4):450-5.
3
4. Shams SF, Boskabadi H, Keramati MR, Ayatollahi H, Shakeri S, Sheikhi M, et al. Evaluation of Immature Neutrophil Ratio and Calprotectin Level for the Diagnosis of Neonatal Sepsis. Iranian Journal of Neonatology IJN. 2017;8(3):19-24.
4
5. Bremner A, Roked S, Robinson R, Phillips I, Beattie M. Faecal calprotectin in children with chronic gastrointestinal symptoms. Acta Paediatrica. 2005; 94(12):1855-8.
5
6. Fagerberg UL, Loof L, Lindholm J, Hansson LO, Finkel Y. Fecal calprotectin: A quantitative marker of colonic inflammation in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007; 45(4):414-20.
6
7. Hukkinen M, Pakarinen MP, Merras-Salmio L, Koivusalo A, Rintala R, Kolho KL. Fecal calprotectin in the prediction of postoperative recurrence of Crohn's disease in children and adolescents. Journal of Pediatric Surgery. 2016;51(9):1467-72.
7
8. Ellemunter H, Engelhardt A, Schuller K, Steinkamp G. Fecal Calprotectin in Cystic Fibrosis and Its Relation to Disease Parameters: A Longitudinal Analysis for 12 Years. J Pediatr Gastroenterol Nutr. 2017;65(4):438-42.
8
9. Khoshbaten M, Pishahang P, Nouri M, Lashkari A, Alizadeh M, Rostami-Nejad M. Diagnostic value of fecal calprotectin as a screening biomarker for gastrointestinal malignancies. Asian Pacific journal of cancer prevention : APJCP. 2014;15(4):1667-70.
9
10. Ataee P, Afrasiabi V, Nikkhoo B, Sani MN, Rahehagh R, Ghaderi E, et al. Relationship Between Fecal Calprotectin and Upper Endoscopy Findings in Children With Upper Gastrointestinal Symptoms. Iranian Journal of Pediatrics. 2017(In Press).
10
11. Campeotto F, Baldassarre M, Butel MJ, Viallon V, Nganzali F, Soulaines P, et al. Fecal Calprotectin: Cutoff Values for Identifying Intestinal Distress in Preterm Infants. J Pediatr Gastroenterol Nutr. 2009;48(4):507-10.
11
12. Savino F TV, Lingua C, Moja L, Ricceri F. Pain-relieving agents for infant colic. The Cochrane Library. 2012.
12
13. Shahramian I, Moradi M, Afshari M, Delaramnasab M, Sargazi A, Ebrahimi M, et al. Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial. International Journal of Pediatrics. 2017;5(12):6529-37.
13
14. Rhoads JM, Fatheree NY, Norori J, Liu YY, Lucke JF, Tyson JE, et al. Altered Fecal Microflora and Increased Fecal Calprotectin in Infants with Colic. Journal of Pediatrics. 2009;155(6):823-U284.
14
15. Rosso C, Caviglia GP, Pellicano R. Usefulness of fecal calprotectin determination in pediatric intestinal diseases. Minerva Pediatrica. 2016;68(6):478-86.
15
16. Biskou O, Gardner-Medwin J, Mackinder M, Bertz M, Clark C, Svolos V, et al. Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis. J Pediatr Gastroenterol Nutr. 2016;63(5):E112-E5.
16
17. Kapel N, Campeotto F, Kalach N, Baldassare M, Butel MJ, Dupont C. Faecal Calprotectin in Term and Preterm Neonates. J Pediatr Gastroenterol Nutr. 2010;51(5):542-7.
17
18. Josefsson S, Bunn TK, Domellof M. Fecal calprotectin in very low birth weight infants. J Pediatr Gastroenterol Nutr. 2007;44(4):407-13. 19. Domellof M. Fecal calprotectin: An indicator of NEC in VLBW infants? Pediatric Research. 2004;56(3):476-.
18
20. Lee YM, Min CY, Choi YJ, Jeong SJ. Delivery and feeding mode affects fecal calprotectin levels in infants < 7 months old. Early Human Development. 2017;108:45-8.
19
21. Li F, Ma JQ, Geng SS, Wang JL, Ren F, Sheng XY. Comparison of the different kinds of feeding on the level of fecal calprotectin. Early Human Development. 2014;90(9):471-5.
20
22. Polycarpou E, Zachaki S, Papaevangelou V, Tsolia M, Kyriacou A, Kostalos C, et al. Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates. Journal of Perinatology. 2013;33(2):141-6.
21
23. Savino F, Castagno E, Calabrese R, Viola S, Oggero R, Miniero R. High Faecal Calprotectin Levels in Healthy, Exclusively Breast-Fed Infants. Neonatology. 2010; 97(4):299-304.
22
24. Dorosko SM, MacKenzie T, Connor RI. Fecal Calprotectin Concentrations Are Higher in Exclusively Breastfed Infants Compared to Those Who Are Mixed-Fed. Breastfeeding Medicine. 2008;3(2): 117-U25.
23
25. Moussa R, Khashana A, Kamel N, Eisharqawy SE. Fecal calprotectin levels in preterm infants with and without feeding intolerance. Jornal De Pediatria. 2016;92(5):486-92.
24
26. Heida A, Holtman GA, Lisman-van Leeuwen Y, Berger MY, van Rheenen PF. Avoid Endoscopy in Children With Suspected Inflammatory Bowel Disease Who Have Normal Calprotectin Levels. J Pediatr Gastroenterol Nutr. 2016;62(1):47-9.
25
27. Bukulmez A, Dogru O, Kundak AA, Oztekin O, Koken R, Melek H, et al. The Effect of Phototherapy on Fecal Calprotectin Levels. American Journal of Perinatology. 2013;30(3):215-8.
26
28. Oswari H, Prayitno L, Dwipoerwantoro PG, Firmansyah A, Makrides M, Lawley B, et al. Comparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula. Journal of Paediatrics and Child Health. 2013;49(12):1032-9.
27
29. Ho TTB, Groer MW, Luciano AA, Schwartz A, Ji M, Miladinovic BS, et al. Red blood cell transfusions increase fecal calprotectin levels in premature infants. Journal of Perinatology. 2015;35(10):837-41.
28
30. Indrio F, Baldassarre ME, Francavilla R, Marucco AC, Menolascina A, Polimeno L, et al. Effect of unconjugated bilirubin on intestinal permeability and fecal calprotectin in healthy term newborns. Pediatric Research. 2005;58(2):375-.
29
31. Kolho KL, Alfthan H, Hamalainen E. Effect of Bowel Cleansing for Colonoscopy on Fecal Calprotectin Levels in Pediatric Patients. J Pediatr Gastroenterol Nutr. 2012;55(6):751-3.
30
ORIGINAL_ARTICLE
A Comparative Study of the Effects of Mint Tea Bag, Mint Cream, and Breast Milk on the Treatment of Cracked Nipple in the Lactation Period: A Randomized Clinical Trial Study
Background: The results of the previous studies on the effects of mint on cracked nipple are contradictory. The purpose of the present study was to compare the effects of mint tea bag, mint cream and breast milk on the healing of cracked nipple during lactation. Methods: This study was a clinical trial with a control group , pre and post-test design conducted in health centers of Hamadan University of Medical Sciences, Hamadan, Iran from 2016 to 2017.Samples were divided into three groups (n=72 subjects in each group). Interventions were performed at least 4 times a day for 14 days after the start of treatment. Data were collected through the cracked nipple measuring checklist, the amount of wound and demographic questionnaire before the intervention and on 4, 8, and 14 days after the intervention. Data analysis was conducted using descriptive and inferential statistics in SPSS software (version 21). Results: There was a decreasing trend in the mean score of crack pain on days 0-14 in the groups of mint cream, mint tea, and breast milk after the intervention; however, there was a statistically significant difference in the breast milk group (P<0.001). Moreover, with regard to within group comparison, there was a decreasing trend with a significant difference in the mean score of wound in three groups before the intervention (P<0.001) and on the fourth day after the intervention (P= 0.003). Conclusion: The results of the present study indicated that breast milk was more effective than mint cream and mint tea in the treatment of cracked nipple.
https://ijn.mums.ac.ir/article_11906_97d0c78c0dc8f3ad8fa8e554515b8b9f.pdf
2018-12-01
72
79
10.22038/ijn.2018.30078.1409
Keywords: Cracked nipple
Mint cream
Mint tea
Tayebeh
Gharakhani Bahar
1
Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Khodayar
Oshvandi
2
Mother and Child Care Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Seyedeh
Zahra Masoumi
zahramid2001@yahoo.com
3
Mother and Child Care Research Center, Department of Midwifery, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran
LEAD_AUTHOR
Younes
Mohammadi
4
Modeling of Non-communicable Diseases Research Center, Department of Epidemiology, School of public Health, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Shirin
Moradkhani
5
Medicinal Plants and Natural Products Research Center, Department of Pharmacognosy and Pharmaceutical Biotechnology, School of pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Farzin
Firozian
6
Medicinal Plants and Natural Products Research Center, Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
1. Ahmadi M, Moosavi SM. Evaluation of occupational factors on continuation of breastfeeding and formula initiation in employed mothers. Global J Health Sic. 2013; 5(6):166-71.
1
2. Parsa S, Zanozi A. Maternity and child health. Tehran: Janghalban; 2017.
2
3. Anatolitou F. Human milk benefits and breastfeeding. J Pediatr Neonat Individual Med. 2012; 1(1):11-8.
3
4. Sankar MJ, Sinha B, Chowdhury R, Bhandari N, Taneja S, Martines J, et al. Optimal breastfeeding practices and infant and child mortality: a systematic review and meta-analysis. Acta Paediatr. 2015; 104(467):3-13.
4
5. Bland KI, Copeland EM, Klimberg V, Gradishar WJ. The breast: comprehensive management of benign and malignant diseases. 5th ed. Philadelphia: Saunders; 2009.
5
6. Lawrence RA, Lawrence RM. Breastfeeding a guide for the medical profession. 8th ed. New York: Elsevier Health Sciences; 2015.
6
7. Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: a systematic review. J Obstet Gynecol Neonatal Nurs. 2005; 34(4):428-37.
7
8. Amir LH. Managing common breastfeeding problems in the community. BMJ. 2014; 348:g2954.
8
9. Kent JC, Ashton E, Hardwick CM, Rowan MK, Chia ES, Fairclough KA, et al. Nipple pain in breastfeeding mothers: incidence, causes and treatments. Int J Environ Res Public Health. 2015; 12(10):12247-63.
9
10. Danforth DN. Danforth's obstetrics and gynecology. Philadelphia: Lippincott Williams & Wilkins; 2008.
10
11. Cunningham FG, Leveno K, Bloom S, Spong C, Dashe J, Hoffman B, et al. Williams obstetrics. New York: McGraw-Hill; 2014.
11
12. Ghosh V, Saranya S, Mukherjee A, Chandrasekaran N. Antibacterial microemulsion prevents sepsis and triggers healing of wound in wistar rats. Colloids Surf B Biointerfaces. 2013; 105:152-7.
12
13. Saeidi R, Tafazoli M, Gholami M, Mazloom R. New treatment for nipple soreness in breastfeeding mothers: a clinical trial study. Iran J Neonatol. 2015; 6(2):40-51.
13
14. Kent J, Ashton E, Hardwick CM, Rowan MK, Chia ES, Fairclough KA, et al. Nipple pain in breastfeeding mothers: incidence, causes and treatments. Int J Environ Res Public Health. 2015; 12(10):12247-63.
14
15. Shanazi M, Farshbaf Khalili A, Kamalifard M, Asghari Jafarabadi M, Masoudin K, Esmaeli F. Comparison of the effects of lanolin, peppermint, and dexpanthenol creams on treatment of traumat ic nipples in breastfeeding mothers. J Caring Sci. 2015; 4(4):297-307.
15
16. Sangestani G, Khatiban M, Pourolajal J, Oshvandi K. Influence of doula on the primiparous parturients' anxiety in the delivery ward. Hayat. 2014; 19(4): 48-60.
16
17. Maury S. Breastfeeding information & guideline a manual for breastfeeding support in pediatric & neonatal units. Trans: Saadvandian S, Tahery M. Mashhad, Iran: Sokhan Gostar Publication; 2007. P. 22-70.
17
18. Izetbegovic S, Alajbegovic J, Mutevelic A, Pasagic A, Masic I. Prevention of diseases in gynecology. Int J Prev Med. 2013; 4(12):1347-58.
18
19. Stoll K, Kornelsen J. Midwifery care in rural and remote British Columbia: a retrospective cohort study of perinatal outcomes of rural parturient women with a midwife involved in their care, 2003 to 2008. J Midwifery Womens Health. 2014; 59(1):60-6.
19
20. Berman AJ, Snyder S, Mn BJ. Kozier & Erb's fundamentals of nursing. London: Pearson Education UK; 2015.
20
21. Purwaningsih AA, Rahayu HS, Wijayanti K. Effectiveness of warm compress and cold compress to reduce laceration perineum pain on primiparous at Candimulyo Magelang 2015. IJRMS. 2017 Jan 26;3:24-9.
21
22. Linari S, Castaman G. Clinical manifestations and management of Gaucher disease. Clin Cases Mineral Bone Metab. 2015; 12(2):157.
22
23. Dambolena JS, López AG, Rubinstein HR, Zygadlo JA. Effects of menthol stereoisomers on the growth, sporulation and fumonisin B1 production of Fusarium verticillioides. Food Chem. 2010; 123(1): 165-70.
23
24. Singh R, Shushni MA, Belkheir A. Antibacterial and antioxidant activities of Mentha piperita L. Arabian J Chem. 2015; 8(3):322-8.
24
25. Tyagi AK, Malik A. Antimicrobial potential and chemical composition of Mentha piperita oil in liquid and vapour phase against food spoiling microorganisms. Food Control. 2011; 22(11):1707-14. 26. Farhangi GJ, Farahpour M, Mohammadi NM. Histopathological evaluation of the effect of Mentha piperita essential oil on cutaneous wound healing in rats infected with C. albicans. J Comparative Rathobiol Iran. 2015; 11(4):1453-61.
25
27. Masoumi SZ, Parsa P, Darvish N, Mokhtari S, Yavangi M, Roshanaei G. An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan. Iran J Reprod Med. 2015; 13(8):513.
26
28. Bolol-haghighi N, Masoumi SZ, Kazemi F. Effect of massage therapy on duration of labour: a randomized controlled trial. Journal of clinical and diagnostic research: JCDR. 2016 Apr;10(4): QC12- QC15.
27
29. Oshvandi K, Shiri FH, Safari M, Fazel MR, Salavati M, Tehrani TH. Effect of pre-warmed intravenous fluid therapy on prevention of postoperative shivering after Caesarean section. Hayat. 2011;17(4):5-15.
28
30. Tafazoli M, Ebrahimi A, Mohammad Zadeh A, Esmaili H. Effect of breastfeeding technique modification on prevention of nipple sore. Iran J Obstet Gynecol Infertil. 2015; 17(138):10-7.
29
31. Storr GB. Prevention of nipple tenderness and breast engorgement in the postpartal period. J Obstet Gynecol Neonatal Nurs. 1988; 17(3):203-9.
30
32. Thabet HA, Mourad MA, Alahadal AM, Alsenany S, Alsaif A. Prevention of nipple cracks with peppermint water versus breast milk in lactating primiparous women. Life Sci J. 2013; 10(4):2010-7. 33. Eshgizade M, Moghaddam MB, Moghaddam HM, Mahmoudian A, Mesbah M. Comparison of the effect of olive oil, aloe vera extract and breast milk on healing of breast fissure in lactating mothers: a randomized clinical trial. Qom Univ Med Sci J. 2016; 10(3):19-27.
31
34. Pugh LC, Buchko BL, Bishop BA, Cochran JF, Smith LR, Lerew DJ. A comparison of topical agents to relieve nipple pain and enhance breastfeeding. Birth. 1996; 23(2):88-93.
32
35. Akbari SA, Alamolhoda SH, Baghban AA, Mirabi P. Effects of menthol essence and breast milk on the improvement of nipple fissures in breastfeeding women. J Res Med Sci. 2014; 19(7):629.
33
36. Mohammadzadeh A, Farhat A, Esmaeily H. The effect of breast milk and lanolin on sore nipples. Saudi Med J. 2005; 26(8):1231-4.
34
37. Melli MS, Rashidi MR, Nokhoodchi A, Tagavi S, Farzadi L, Sadaghat K, et al. A randomized trial of peppermint gel, lanolin ointment, and placebo gel to prevent nipple crack in primiparous breastfeeding women. Med Sci Monitor. 2007; 13(9):CR406-11.
35
38. Kazemirad M, Khodakarami N, Salamzadeh J, Nasiri N, Kazemi M, Moattar F. Comparison of calendit-e cream versus expressed breast milk. Adv Nurs Midwifery. 2013; 23(80):5380.
36
39. Lavergne NA. Does application of tea bags to sore nipples while breastfeeding provide effective relief? J Obstet Gynecol Neonatal Nurs. 1997; 26(1):53-8.
37
40. Walker M. Are there any cures for sore nipples? Clin Lactation. 2013; 4(3):106-15.
38
ORIGINAL_ARTICLE
Conservative Management in a Ventilated Preterm Neonate with Pneumopericardium, Pleural Effusion, and Pulmonary Collapse: A Case Report
Background: Neonatal pneumopericardium (PPC) is a rare clinical condition usually associated with other air leak syndromes. It increases morbidity and mortality due to cardiac tamponade. Case report: A preterm male neonate weighing 1260 g was born with the gestational age of 28 weeks. Cardiopulmonary resuscitation was routinely performed without any medical therapy. The newborn was transferred to the neonatal intensive care unit due to marked respiratory distress with tachypnea and cyanosis. Pulse oximetry showed oxygen saturation of 70%. A whiteout of the lung and air-bronchogram pattern was found on the chest X-ray. The arterial blood gases demonstrated PH=7.14, PCo2=51 mmHg, Po2=36 mmHg, bicarbonate=15.8 mg. The neonate was intubated with a tracheal tube size 2.5 and mechanical ventilation was initiated with 90% fraction of inspired oxygen (FiO2), PIP=14 cmH2O, and PEEP=4 cmH2O. After intubation, the newborn received two doses of surfactant. On the third day, patent ductus arteriosus was established and appropriate treatment was performed. After five days, the chest X-ray was repeated due to increasing respiratory distress and an increasing FiO2, which revealed a pneumopericardium with right-sided pleural effusion and left upper lobe collapse. Afterwards, pleurocentesis was performed. Left ventricular ejection fraction (65%) was preserved and no evidence of cardiac tamponade was observed. Serial chest X-ray and echocardiography were performed daily. After the next seven days, the chest radiograph demonstrated a complete resolution of the pneumopericardium, pleural effusion, and lung collapse. Conclusion: The present case study presented a preterm neonate suffering from pneumopericardium along with pleural effusion and lung collapse. Despite the complexity, the PPC was asymptomatic and eventually resolved without pericardiocentesis.
https://ijn.mums.ac.ir/article_11907_ec05e10c167fc01f30bb2b2dc5c6fb67.pdf
2018-12-01
80
83
10.22038/ijn.2018.31594.1440
Keywords: Air leak syndrome
Pneumopericardium
Preterm
respiratory distress syndrome
Yazdan
Ghandi
y.ghandi@arakmu.ac.ir
1
Amirkabir Hospital, School of Medicine, Department of Pediatrics, Pediatric Cardiology Arak University of Medical Sciences, Arak, Iran
LEAD_AUTHOR
Niloofar
alsadat Motamedi
2
Amirkabir Hospital, School of Medicine, Department of Pediatrics, Pediatric Cardiology Arak University of Medical Sciences, Arak, Iran
AUTHOR
1. Burt TB, Lester PD. Neonatal pneumopericardium. Radiology. 1982; 142(1):81-4.
1
2. Suresh P, Tagare A, Kadam S, Vaidya U, Pandit A. Spontaneous pneumopericardium in a healthy fullterm neonate. Indian J Pediatr. 2011; 78(11):1410-1.
2
3. Hook B, Hack M, Morrison S, Borawski-Clark E, Newman N, Fanroff A. Pneumopericardium in very low birth weight infants. J Perinatol. 1995; 15(1):27-31.
3
4. Roychoudhury S, Kaur S, Soraisham AS. Neonatal pneumopericardium in a non ventilated term infant: a case report and review of the literature. Case Rep Pediatr. 2017; 2017:3149370.
4
5. Mansfield P, Graham CB, Beckwith JB, Hall DG, Sauvage LR. Pneumopericardium and pneumomediastinum in infants and children. J Pediatr Surg. 1973; 8(5):691-98.
5
6. Heckmann M, Lindner W, Pohlandt F. Tensionpneumopericardium in a preterm infant without mechanicalventilation: a rare cause of cardiac arrest. Acta Paediatr. 1998; 87(3):346-8.
6
7. Karadžić R, Antović A, Ilić G, Kostić-Banović L. Pneumopericardium: a possible rare cause of neonatal death. Med Biol. 2007; 14(2):98-100.
7
8. Shaireen H, Rabi Y, Metcalfe A, Kamaluddeen M, Amin H, Akierman A, et al. Impact of oxygenconcentration on time to resolution of spontaneous pneumothorax in term infants: a population based cohort study. BMC Pediatr. 2014; 14(1):208.
8
ORIGINAL_ARTICLE
Osteopetrosis Presenting with Neonatal Thrombocytopenia: A Case Report
Background: Osteopetrosisis an inherited and rare bone disease, characterized by the impairment ofbone modeling and remodeling and the failure of osteoclasts to resorb bone. It also results in skeletal fragility despite increased bone mass, and may cause hematopoietic insufficiency, disturbed tooth eruption, nerve entrapment syndromes, and growth impairment. The infantile form of the disease is the most severe one with a poor prognosis. If untreated, it will result in death by the first decade of life. Case report: A term 10-day-old female neonate with a birth weight of 2850 grams delivered by caesarian section was reported without a history of parents' consanguinity from a healthy, gravida 2, para 1, abort 1 mother with no complication during pregnancy. The newborn admitted to the neonatal ward due to diffuse petechiae, purpura on the skin, and periorbital ecchymosis (raccoon eyes), without any other abnormal significant signs and symptoms. In laboratory findings except for frequent low platelet count as low as 10000-25000, there wasn’t any other abnormalities. Other coagulative tests were within normal ranges. In addition to antibiotics for probable sepsis, platelet transfusion was considered as the treatment, and due to the lack of proper response to the treatment, with suspicious of alloimmune thrombocytopenia, two courses of IV IgG were administered. Eventually, the persistent thrombocytopenia in spite of mentioned treatment led to further investigation , and finally osteopetrosis was diagnosed by the result of brain CTS. The patient was discharged from the hospital with a moderate thrombocytopenia while she needed frequent platelet transfusion. Eventually with bone marrow transplantation, the sign and symptoms of the disease subsided. Conclusion: In persistent and unjustifiable neonatal thrombocytopenia, diagnosis of osteopetrosis should be considered.
https://ijn.mums.ac.ir/article_11908_4f33e0408abc0c1ccf2babac93abf7d3.pdf
2018-12-01
84
87
10.22038/ijn.2018.32097.1445
Keywords: Neonates
Osteopetrosis
Thrombocytopenia
Mohammad
Kazemian
1
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
Minoo
Fallahi
2
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Science, Tehran, Iran
LEAD_AUTHOR
Seyed Hossein
Fakhraee
3
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
Samin
Alavi
4
Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Naeeme
Taslimi Taleghani
5
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
Sara
Sani
6
Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
1. Watchko JF. Common hematologic problems in the newborn nursery. Pediatr Clin North Am. 2015; 62(2):509-24.
1
2. Ulusoy E, Tüfekçi Ö, Duman N, Kumral A, İrken G, Ören H. Thrombocytopenia in neonates: causes and outcomes. Ann Hematol. 2013; 92(7):961-7.
2
3. Olgaç A, Tümer L, Boyunağa Ö, Kızılkaya M, Hasanoğlu A. Diagnostic dilemma: osteopetrosis with superimposed rickets causing neonatal hypocalcemia. J Trop Pediatr. 2015; 61(2):146-50.
3
4. Verma P, Kadam S, Umarji HR, Surya V. A rare case report of intermediate osteopetrosis and review of literature. J Cleft Lip Palate Craniofacial Anomalies. 2014; 1(2):127.
4
5. Moscatelli I, Löfvall H, Schneider Thudium C, Rothe M, Montano C, Kertész Z, et al. Targeting NSG mice engrafting cells with a clinically applicable lentiviral vector corrects osteoclasts in infantile malignant osteopetrosis. Hum Gene Ther. 2017; 29(8):938-49.
5
6. Palagano E, Slatter MA, Uva P, Menale C, Villa A, Abinun M, et al. Hematopoietic stem cell transplantation corrects osteopetrosis in a child carrying a novel homozygous mutation in the FERMT3 gene. Bone. 2017; 97:126-9.
6
7. Peterson JA, McFarland JG, Curtis BR, Aster RH. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. Br J Haematol. 2013; 161(1):3-14.
7
8. El-Sobky TA, Elsobky E, Sadek I, Elsayed SM, Khattab MF. A case of infantile osteopetrosis: the radio clinical features with literature update. Bone Rep. 2015; 4:11-6.
8
9. Sobacchi C, Schulz A, Coxon FP, Villa A, Helfrich MH. Osteopetrosis: genetics, treatment and new insights into osteoclast function. Nat Rev Endocrinol. 2013; 9(9):522-36.
9
10. Patil K, Mahima VG, Raina A, Mutneja P. Osteopetrosis: a case report. Int J Med Dent Case Rep. 2016; 2:1-3.
10
11. Morovvati S, Amirpour Amraii S, Zahed Shekar Abi H, Shahbazi N, Ranjbar R. Osteopetrosis; a report of two Iranian patients with autosomal recessive inheritance pattern. Int J Mol Cell Med. 2012; 1(3):173-7.
11
12. Uzun H, Keskin EY, Şenses DA, Erdem A, Dikici B, Kocabay K. A rare cause of neonatal hypocalcemia: malignant infantile osteopetrosis. Turkish J Med Sci. 2009; 39(3):457-60.
12
13. Engiz O, Kara S, Bagrul D, Lahr G, Alioglu B, Arikan I, et al. Infantile malignant osteopetrosis: a rare cause of neonatal hypocalcemia. J Pediatr Endocrinol Metab. 2012; 25(11-12):1205-7.
13