ORIGINAL_ARTICLE
Comparison of the Therapeutic Effects of Bubble CPAP and Ventilator CPAP on Respiratory Distress Syndrome in Premature Neonates
Background: Respiratory distress syndrome is one of the main complications associated with low birth weight, and a main cause of mortality in premature neonates. The present study aimed to compare the efficacy of ventilator continuous positive airway pressure (CPAP) and bubble CPAP in the treatment of respiratory distress syndrome (RDS) in premature neonates. Methods: This randomized controlled clinical trial was conducted on 119 neonates diagnosed with RDS, with the gestational age of 28-34 weeks and birth weight of 1000-2200 grams, who were admitted in the neonatal intensive care unit (NICU). Infants were allocated to two groups of ventilator CPAP (VCPAP) and bubble CPAP (BCPAP) therapy. Results: Mean weight, gestational age, and one-minute Apgar score were not significantly different between the two groups. However, duration of treatment with mechanical ventilation in the BCPAP group was significantly lower compared to the VCPAP group. In addition, frequency of complications had no significant difference between the two groups. Conclusion: In the treatment of RDS, duration of mechanical ventilation was lower in the BCPAP group compared to the VCPAP group in premature neonates
https://ijn.mums.ac.ir/article_9357_b547b2712c513ac7e2ffd06282cf6047.pdf
2017-09-01
1
5
10.22038/ijn.2017.18835.1215
Bubble CPAP
neonate
Oxygen therapy
respiratory distress syndrome
Mahmoud
Noori Shadkam
1
Premature Neonates Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Mojtaba
Movahedinia
ah.mehrparvar@yahoo.com
2
Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Zahra
Noori Shadkam
3
Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Amir Houshang
Mehrparvar
ah.mehrparvar@gmail.com
4
Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
LEAD_AUTHOR
1. Bellamy C. The state of the world’s children 1999. Geneva: United Nation Children’s Fund; 1999. P. 98-101.
1
2. Golestan M, Akhavan Karbasi S, Fallah R. Prevalence and risk factors for low birth weight in Yazd, Iran. Singapore Med J. 2011; 52(10):730-3.
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3. Golestan M, Fallah R, Akhavan Karbasi S. Neonatal mortality oflow birth weight infants in Yazd, Iran. Int J Reprod Biomed. 2008; 6(4):205–8.
3
4. Waldermar A. The high-risk infant. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BM, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier Health Sciences; 2011. P. 818-20.
4
5. Waldemar A. Respiratory distress syndrome. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BM, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier Health Sciences; 2011. P. 850-8.
5
6. Thomas E, Sherry E. Noninvasive respiratory support. In: Goldsmith JP, Karotkin EH, editors. Assisted ventilation of the neonate. 5th ed. Philadelphia: Saunders; 2011. P. 140-63.
6
7. Tagare A, Kadam S, Vaidya U, Pandit A, Patole S. A pilot study of comparison of BCPAP vs. VCPAP in preterm infants with early onset respiratory distress. J Trop Pediatr. 2010; 56(3):191-4.
7
8. Bahman-Bijari B, Malekiyan A, Niknafs P, Baneshi MR. Bubble-CPAP vs. Ventilatory-CPAP in preterm infants with respiratory distress. Iran J Pediatr. 2011; 21(2):151-8.
8
9. Courtney SE, Kahn DJ, Singh R, Habib RH. Bubble and ventilator-derived nasal continuous positive airway pressure in premature infants: work of breathing and gas exchange. J Perinatol. 2011, 3(1):44-50. 10. Kugelman A, Feferkon I, Riskian R, Chistyakov I, Kaufman B, Bader D. Nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure for respiratory distress syndrome: a randomized, controlled, prospective study. J Pediatr. 2007; 150(5):521-6.
9
11. Lee KS, Dunn MS, Fenwick M, Shennan AT. A comparison of underwater bubble continuous positive airway pressure with ventilatorderived continuous positive airway pressure in premature neonates ready for extubation. Biol Neonate. 1998; 73(2):69-75.
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12. Mohamadizadeh M, Asadi AR, Sadeghnia AR. Compare the effects of continuous positive airway pressure with two different methods to treat infants with respiratory distress syndrome. J Isfahan Med Sch. 2011; 29(146):901-11 (Persian).
11
13. Mazella M, Bellini C, Calevo MG, Campone F, Massocco D, Mezzano P, et al. A randomized control study comparing the infant flow driver with nasal continuous positive airway pressure in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2001; 85(2): F86-90.
12
14. Gupta S, Sinha SK, Tin W, Donn SM. A randomized controlled trial of post-extubation bubble continuous positive airway pressure versus infant flow driver continuous positive airway pressure in preterm infants with respiratory distress syndrome. J Pediatr. 2009; 154(5):645-50.
13
15. Koyamaibole L, Kado J, Qovu JD, Colquhoun S, Duke T. An evaluation of bubble-CPAP in a neonatal unit in a developing country: effective respiratory support that can be applied by nurses. J Trop Pediatr. 2006; 52(4):249-53.
14
ORIGINAL_ARTICLE
The Relationship between Cord Blood and Maternal Serum Zinc Levels and Birth Weight
Background: Examining the relationship between cord blood and maternal serum zinc levels and birth weight.Methods: A total of 127 infant-mother pairs were assigned to study (n = 58; with birth weight < 2500 g) and control (n = 69; with birth weight ≥ 2500 g) groups. Serum samples were collected from eligible mothers and cord blood of their low birth weight (LBW) or normal birth weight (NBW) healthy newborns. The inclusion criterion for the infant-mother pairs was lack of any medical complications. Serum zinc level was measured by using Inductively Coupled Plasma Mass Spectrometer method and the results were expressed in μg/dl. The two groups were compared in terms of maternal and cord blood serum zinc levels. Then, we evaluated their association with birth weight of neonates in both groups through Student’s t-test and one-way analysis of variance using SPSS.Results: The study protocol was reviewed and approved by the ethics committee of the Urmia University of Medical Sciences (Ir.umsu.rec.1393.108 1393/04/24). Participants were provided with detailed information about the study and were assured that confidentiality would be maintained at all times. Written consent was obtained prior to data collection.The mean age of the pregnant women was 26.1±5.8 years (age range: 18-40 years). The mean birth weight of the neonates in the two groups was 3275.9±552 kg. Pregnant women with serum zinc levels of higher than 70 μg/dl gave birth to neonates with birth weight higher than 3.5, whereas mothers with serum zinc levels of less than 60 μg/dl gave birth to infants with birth weight less than 3 kg (P=0.034). Mean serum zinc level in the cord blood of LBW group was 79.16±19.86 μg/dl, which was significantly lower than that in the NBW group (95.14±17.56 μg/dl; P<0.021). Similarly, mean maternal serum zinc level was 63.98±19.33 μg/dl in mothers who gave birth to LBW neonates, while it was 86.13±20.10 μg/dl in mothers with NBW neonates, indicating that serum zinc level was significantly lower in mothers with LBW infants than in those with NBW infants (P=0.017).Conclusion: Maternal and cord blood zinc concentrations were shown to be associated with birth weight of the newborns
https://ijn.mums.ac.ir/article_9358_3ba12ea795d2f2f0d40a9c2a9378a17e.pdf
2017-09-01
6
10
10.22038/ijn.2017.9996.1112
Low birth weight
Newborn
Pregnant
Serum zinc
Fariba
Nanbakhsh
1
Urmia University of Medical Sciences, Urmia, Iran
AUTHOR
fatemeh
Moghaddam Tabrizi
fmtabrizi@gmail.com
2
Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran
LEAD_AUTHOR
1. Lau C, Ambalavanan N, Chakraborty H, Wingate MS, Carlo WA. Extremely low birth weight and infant mortality rates in the United States. Pediatrics. 2013; 131(5):855-60.
1
2. MacDorman MF, Matthews TJ, Declercq E. Trends in out-of-hospital births in the United States, 1990- 2012. NCHS Data Brief. 2014; 144:1-8.
2
3. Etemad K, Yavari P, Mehrabi Y, Haghdoost A, Motlagh ME, Kabir MJ, et al. Inequality in utilization of in-patients health services in Iran. Int J Prev Med. 2015; 6:45.
3
4. Moradi-Lakeh M, Vosoogh-Moghaddam A. Health sector evolution plan in Iran; equity and sustainability concerns. Int J Health Policy Manag. 2015; 4(10):637-40.
4
5. Moradi-Lakeh M, Namiranian N. Increasing trend of low birth weight in rural areas of iran: a warning. Iran J Pediatr. 2013; 23(1):123-4.
5
6. Erenel H, Mathyk BA, Sal V, Ayhan I, Karatas S, Koc Bebek A. Clinical characteristics and pregnancy outcomes of Syrian refugees: a case–control study in a tertiary care hospital in Istanbul, Turkey. Arch Gynecol Obstet. 2017; 295(1):45-50.
6
7. Linsell L, Malouf R, Morris J, Kurinczuk JJ, Marlow N. Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birthweight: a systematic review. Dev Med Child Neurol. 2016; 58(6):554-69.
7
8. Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013; 382(9890):427-51.
8
9. Prasad AS. Discovery of human zinc deficiency: its impact on human health and disease. Adv Nutr. 2013; 4(2):176-90.
9
10. Bradshaw J. The wellbeing of children in the UK. Bristol: Policy Press; 2016.
10
11. Moghaddam Tabrizi F, Saraswathi G. Maternal anthropometric measurements and other factors: relation with birth weight of neonates. Nutr Res Pract. 2012; 6(2):132-7.
11
12. Abass RM, Hamdan HZ, Elhassan EM, Hamdan SZ, Ali NI, Adam I. Zinc and copper levels in low birth weight deliveries in Medani Hospital, Sudan. BMC Res Notes. 2014; 7(1):386.
12
13. Gómez T, Bequer L, Mollineda A, González O, Diaz M, Fernández D. Serum zinc levels of cord blood: relation to birth weight and gestational period. J Trace Elem Med Biol. 2015; 30:180-3.
13
14. Jyotsna S, Amit A, Kumar A. Study of serum zinc in low birth weight neonates and its relation with maternal zinc. J Clin Diagn Res. 2015; 9(1):SC01-3.
14
15. King JC. Determinants of maternal zinc status during pregnancy. Am J Clin Nutr. 2000; 71(5):1334S-43.
15
16. Srivastava S, Mehrotra PK, Srivastava SP, Siddiqui MK. Some essential elements in maternal and cord blood in relation to birth weight and gestational age of the baby. Biol Trace Elem Res. 2002; 86(2):97-105.
16
17. Mori R, Ota E, Middleton P, Tobe-Gai R, Mahomed K, Bhutta ZA. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2012; 7:CD000230.
17
18. Shariati S, Yamini Y, Faraji M, Saleh A. On-line solid phase extraction coupled to ICP-OES for simultaneous preconcentration and determination of some transition elements. Microchim Acta. 2009; 165 (1-2):65-72.
18
19. Jelliffe DB. The assessment of the nutritional status of the community. Geneva, Switzerland: World Health Organization; 1966. P. 271.
19
20. Prasad AS. Essential and toxic element: trace elements in human health and disease. New York: Elsevier; 2013.
20
21. Wilson RL, Grieger JA, Bianco-Miotto T, Roberts CT. Association between maternal zinc status, dietary zinc intake and pregnancy complications: a systematic review. Nutrients. 2016; 8(10):E641.
21
22. Gernand AD, Schulze KJ, Stewart CP, West KP Jr, Christian P. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol. 2016; 12(5):274-89. 23. Crane JL, Cao X. Function of matrix IGF-1 in coupling bone resorption and formation. J Mol Med. 2014; 92(2):107-15.
22
24. Petry N, Olofin I, Boy E, Donahue Angel M, Rohner F. The effect of low dose iron and zinc intake on child micronutrient status and development during the First 1000 days of life: a systematic review and meta-analysis. Nutrients. 2016; 8(12):E773.
23
25. Zahiri Sorouri Z, Sadeghi H, Pourmarzi D. The effect of zinc supplementation on pregnancy outcome: a randomized controlled trial. J Matern Fetal Neonatal Med. 2016; 29(13):2194-8.
24
26. Jyotsna S, Amit A, Kumar A. Study of serum zinc in low birth weight neonates and its relation with maternal zinc. J Clin Diagn Res. 2015; 9(1):SC01-3.
25
27. Riley C, Rubarth LB. Identifying maternal risk factors and influence on fetal risk. neonatal advanced practice nursing: a case-based learning approach. New York: Springer Publishing Company; 2016.
26
28. Li Y, Liu QF, Zhang D, Shen Y, Ye K, Lai HL, et al. Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. Clin Nutr Res. 2015; 4(2):104-9.
27
29. Li G, Kong L, Zhou H, Kang X, Fang Y, Li P. Relationship between prenatal maternal stress and sleep quality in Chinese pregnant women: the mediation effect of resilience. Sleep Med. 2016; 25:8-12.
28
30. Ruiz-Núñez B, Pruimboom L, Dijck-Brouwer DJ, Muskiet FA. Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. J Nutr Biochem. 2013; 24(7):1183-201.
29
31. Ramakrishnan U, Young MF, Martorell R. Maternal nutrition and birth outcomes. Nutrition and health in a developing world. New York: Springer International Publishing; 2017. P. 487-502. 32. Λάγιου Π, Mucci L, Tamimi R, Kuper H, Λάγιου Α. Micronutrient intake during pregnancy in relation to birth size. Eur J Nutr. 2015; 44:52-9.
30
ORIGINAL_ARTICLE
Prophylactic Methylxanthines for Preventing Extubation Failure in the Preterm Neonates with the Gestational Age of ≤30 Weeks: A Randomized Controlled Trial
Background: Preterm neonates are at a high risk of respiratory depression at birth. Incidence of respiratory distress is reported in 60-80% of the neonates born with the gestational age of less than 28 weeks and 15-30% of the neonates with the gestational age of less than 32-34 weeks. The present study aimed to compare the incidence and risk of failed extubation in using caffeine and aminophylline in the preterm neonates with the gestational age of ≤30 weeks in the periextubation period.Methods: This single-centered, parallel, open-label, randomized controlled trial was conducted in a tertiary care referral hospital in India during June 2014-2016. Neonates with the gestational age of ≤30 weeks who were intubated for a minimum of 24 hours were enrolled in the study. Neonates with major anomalies, heart disease, and sepsis were excluded from the study. After the random allocation of the infants to treatment with the standard dose of caffeine citrate and aminophylline methylxanthine, intubation continued for seven consecutive days with or without non-invasive ventilatory support. As the primary objective, the incidence and risk of failed extubation were assessed. Secondary objective of the research was to compare the relative incidence of acute adverse effects, persistent apnea, and the associated morbidities.Results: Neonates treated by caffeine were at a higher risk of extubation failure (1.09 times) adjusted with birth weight (31.5% versus 21.4%; RR=1.09; 95% CI: 0.81-1.46; P=0.55), which was not statistically significant. In addition, risk of apnea within seven days and after seven days of methylxanthine therapy was 1.57 (95% CI: 0.95-2.61) and 1.10 (95% CI: 0.95-2.61) times higher in the neonates with caffeine treatment. Also, rate of tachycardia was high in the neonates treated by aminophylline, which was statistically significant (RR=0.27; 95% CI: 0.13-0.56; P<0.001). Duration of non-invasive ventilator support, length of admission in the neonatal intensive care unit, O2 requirement at discharge, death before hospital discharge, and the associated morbidities were similar between the groups.Conclusion: According to the results, the incidence and risk of extubation failure were clinically high in the caffeine-treated neonates. However, aminophylline administration could continue as a prophylactic agent in developing countries under medical supervision.
https://ijn.mums.ac.ir/article_9359_7225f1be155ab807ea3ead1ccd2af0a6.pdf
2017-09-01
11
18
10.22038/ijn.2017.23031.1281
Aminophylline
Caffeine
Extubation failure
Mechanical Ventilation
M
Shivakumar
1
Department of Pediatrics, 1st Floor, Woman and Child Block, Kasturba Medical College, Madhav Nagar, Manipal University, Manipal, Karnataka, India
AUTHOR
Muhammad
Najih
2
Pediatric Critical Care, Great Ormond Street Hospital for Children, NHS Trust Foundation, Royal College of Pediatrics and Child Health, Ilford, Greater London, United Kingdom, India
AUTHOR
Y
Ramesh Bhat
3
Department of Pediatrics, 1st Floor, Woman and Child Block, Kasturba Medical College, Madhav Nagar, Manipal University, Manipal, Karnataka, India
AUTHOR
Purkayastha
Jayashree
4
Department of Pediatrics, 1st Floor, Woman and Child Block, Kasturba Medical College, Madhav Nagar, Manipal University, Manipal, Karnataka, India
AUTHOR
Leslie Edward Simon
Lewis
leslielewis1@gmail.com
5
Department of Pediatrics, 1st Floor, Woman and Child Block, Kasturba Medical College, Madhav Nagar, Manipal University, Manipal, Karnataka, India
LEAD_AUTHOR
Asha
Kamath
aashakamat@gmail.com
6
Department of Community Medicine, Kasturba Medical College, Madhav Nagar, Manipal University, Manipal, Karnataka, India
AUTHOR
D
Shashikala
shifsoumi@gmail.com
7
Department of Pediatrics, 1st Floor, Woman and Child Block, Kasturba Medical College, Madhav Nagar, Manipal University, Manipal, Karnataka, India
AUTHOR
1. Holme N, Chetcuti P. The pathophysiology of respiratory distress syndrome in neonates. Paediatrics and child health. 2012; 22(12):507-12.
1
2. Miller JD, Carlo WA. Pulmonary complications of mechanical ventilation in neonates. Clin Perinatol. 2008; 35(1):273–81.
2
3. Venkatesh V, Ponnusamy V, Anandaraj J, Chaudhary R, Malviya M, Clarke P, et al. Endotracheal intubation in a neonatal population remains associated with a high risk of adverse events. Eur J Pediatr. 2011; 170(2):223–7.
3
4. Stefanescu BM, Murphy WP, Hansell BJ, Fuloria M, Morgan TM, Aschner JL. A randomized, controlled trial comparing two different continuous positive airway pressure systems for the successful extubation of extremely low birth weight infants. Pediatrics. 2003; 112(5):1031–8.
4
5. Danan C, Durrmeyer X, Brochard L, Decobert F, Benani M, Dassieu G. A randomized trial of delayed extubation for the reduction of reintubation in extremely preterm infants. Pediatr Pulmonol. 2008; 43(2):117–24.
5
6. Henderson-Smart DJ, Davis PG. Prophylactic methylxanthines for endotracheal extubation in preterm infants. Cochrane Database Syst Rev. 2010; (12):CD000139.
6
7. Davis PG, Henderson-Smart DJ. Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants. Cochrane Database Syst Rev. 2003; (2):CD000143.
7
8. Sant’Anna GM, Keszler M. Weaning infants from mechanical ventilation. Clin Perinatol. 2012; 39(3):543–62.
8
9. Sims ME, Rangasamy R, Lee S, Chung H, Cohen J, Walther FJ. Comparative evaluation of caffeine and theophylline for weaning premature infants from the ventilator. Am J Perinatol. 1989; 6(1):72–5.
9
10. Armanian AM, Badiee Z, Afghari R, Salehimehr N, Hassanzade A, Sheikhzadeh S, et al. Prophylactic Aminophylline for prevention of apnea at higherrisk preterm neonates. Iran Red Crescent Med J. 2014; 16(8):e12559.
10
11. Harris MC, Baumgart S, Rooklin AR, Fox WW. Successful extubation of infants with respiratory distress syndrome using Aminophylline. J Pediatr. 1983; 103(2):303–5.
11
12. Davis PG, Schmidt B, Roberts RS, Doyle LW, Asztalos E, Haslam R, et al. Caffeine for Apnea of Prematurity trial: benefits may vary in subgroups. J Pediatr. 2010; 156(3):382–7.
12
13. Steer PA, Flenady VJ, Shearman A, Lee TC, Tudehope DI, Charles BG. Periextubation caffeine in preterm neonates: a randomized dose response trial. J Paediatr Child Health. 2003; 39(7):511–5.
13
14. Supinski GS, Deal EC Jr, Kelsen SG. The effects of caffeine and theophylline on diaphragm contractility. Am Rev Respir Dis. 1984; 130(3):429–33.
14
15. Aranda JV, Turmen T. Methylxanthines in apnea of prematurity. Clin Perinatol. 1979; 6(1):87–108.
15
16. Shivakumar M, Jayashree P, Najih M, Lewis LES, Bhat Y R, Kamath A, et al. Comparative efficacy and safety of caffeine and aminophylline for apnea of prematurity in preterm (≤34 weeks) neonates: a randomized controlled trial. Indian Pediatr. 2017; 54(4):279-83.
16
17. Steer P, Flenady V, Shearman A, Charles B, Gray PH, Henderson-Smart D, et al. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2004; 89(6):F499-503.
17
18. Lane AJ, Coombs RC, Evans DH, Levin RJ. Effect of caffeine on neonatal splanchnic blood flow. Arch Dis Child Fetal Neonatal Ed. 1999; 80(2):F128-9.
18
19. Hoecker C, Nelle M, Poeschl J, Beedgen B, Linderkamp O. Caffeine impairs cerebral and intestinal blood flow velocity in preterm infants. Pediatrics. 2002; 109(5):784–7.
19
20. Schoen K, Yu T, Stockmann C, Spigarelli MG, Sherwin CM. Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity. Paediatr Drugs. 2014; 16(2):169–77. 21. Gannon BA. Theophylline or caffeine: which is best for apnea of prematurity? Neonatal Netw. 2000; 19(8):33–6.
20
22. Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, et al. Validation of the national institutes of health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005; 116(6):1353–60.
21
23. Kinsella JP, Greenough A, Abman SH. Bronchopulmonary dysplasia. Lancet. 2006; 367(9520): 1421–31.
22
ORIGINAL_ARTICLE
Evaluation of Immature Neutrophil Ratio and Calprotectin Level for the Diagnosis of Neonatal Sepsis
Background: Sepsis is defined as a systematic inflammatory reaction against infection. Despite the recent advances in medical and pediatric sciences, sepsis remains a significant life-threatening health issue. The main problem associated with this disorder is the nonspecific and non-discriminative symptoms of noninfectious diseases. The present study aimed to introduce diagnostic parameters of high sensitivity and specificity for neonatal sepsis.Methods: This case-control study was conducted in Mashhad, Iran during 2013-2015. Subjects included 40 septic neonates with confirmed diagnosis by a subspecialist of pediatrics and 40 neonates without clinical and laboratory findings of sepsis as the control group. Blood samples were collected from all the infants. In addition, differential white blood cell count of peripheral blood smear was performed, and immature/total neutrophil ratio (I/T) was calculated for all the PBS slides. Plasma calprotectin levels were also determined using the sandwich ELISA method.Results: Mean plasma concentration of calprotectin was 33190±23760 and 18980±13410 ng/ml in the septic and control groups, respectively. Moreover, mean I/T was 0.61±0.22 and 0.51±0.26 in the septic and control groups, respectively. The obtained results indicated that calprotectin levels and I/T were significantly higher in the septic group compared to the control group (P<0.05). Conclusion: According to the results, nucleated red blood cell count and calprotectin levels were the most specific parameters for the definite diagnosis of neonatal sepsis, while neutrophils had the highest sensitivity in this regard
https://ijn.mums.ac.ir/article_9360_74135c037750abf8fdbd3a0b88a39fc2.pdf
2017-09-01
19
24
10.22038/ijn.2017.19345.1220
calprotectin
ELISA
Immature neutrophils
Neonatal sepsis
NRBC
Seyyede Fatemeh
Shams
shams8869@yahoo.com
1
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hassan
Boskabadi
boskabadih@mums.ac.ir
2
Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Reza
Keramati
keramatimr@mums.ac.ir
3
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hossein
Ayatollahi
ayatollahihossein@yahoo.com
4
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Sepideh
Shakeri
5
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Maryam
Sheikhi
6
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Hadi
Sadeghian
sadeghianmh@mums.ac.ir
7
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. Arif SA, Ehsan A, Arif M, Hussain J, Bano R. Early diagnosis of neonatal sepsis through hematological and biochemical markers. Gomal J Med Sci. 2014; 11(2):178-82.
1
2. Samraj RS, Zingarelli B, Wong HR. Role of biomarkers in sepsis care. Shock. 2013; 40(5):358-65.
2
3. Umlauf VN, Dreschers S, Orlikowsky TW. Flow cytometry in the detection of neonatal sepsis. Int J Pediatr. 2013; 2013:1-6.
3
4. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013; 60(2):367-89.
4
5. Bhandari V. Effective biomarkers for diagnosis of neonatal sepsis. J Pediatr Infect Dis Soc. 2014; 3(3):234-45.
5
6. Resch B, Hofer N, Müller W. Challenges in the diagnosis of sepsis of the neonate: New York: Open Access Publisher; 2012.
6
7. Singh Laishram R, Devi Khuraijam R. Hematological and biological markers of neonatal sepsis. Iran J Pathol. 2013; 8(3):137-46.
7
8. Mussap M. Laboratory medicine in neonatal sepsis and inflammation. J Matern Fetal Neonatal Med. 2012; 25(Suppl 4):32-4.
8
9. van Herk W, El Helou S, Janota J, Hagmann C, Klingenberg C, Staub E, et al. PO-0253 use of infection markers for diagnostic and management of suspected neonatal early onset neonatal sepsis: an international survey. Arch Dis Childhood. 2014; 99(Suppl 2):A326-7.
9
10. Boskabad H, Moudi A, Parvini Z, Barati T. Evaluation of the cause and related factors of neonatal mortality in Qaem hospital 2010-2011. Iran J Obstet Gynecol Infertil. 2012; 14(7):21-6 (Persian). 11. Tappero E, Johnson P. Laboratory evaluation of neonatal sepsis. Newborn Infant Nurs Rev. 2010; 10(4):209-17.
10
12. Sandquist M, Wong HR. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Immunol. 2014 Oct;10(10):1349-56.Mally P, Xu J, Hendricks-Muñoz KD. Biomarkers for neonatal sepsis: recent developments. Res Rep Neonatol. 2014; 4:157-68.
11
13. Mally P, Xu J, Hendricks-Muñoz KD. Biomarkers for neonatal sepsis: recent developments. Res Rep Neonatol. 2014; 4:157-68.
12
14. Satar M, Ozlü F. Neonatal sepsis: a continuing disease burden. Turk J Pediatr. 2012; 54(5):449-57.
13
15. Abdel-Maaboud M, El-Mazary AA, Osman AM. Serum calprotectin as a diagnostic marker of late onset sepsis in full-term neonates. Egyp J Pediatr Allergy Immunol. 2014; 10(1):19-24.
14
16. Riskawa HK, Hilmanto D, Chairulfatah A. Serum calprotectin in preterm infants with and without sepsis neonatorum. J Indonesian Med Assoc. 2013; 62(4):125-9.
15
17. Decembrino L, De Amici M, Pozzi M, De Silvestri A, Stronati M. Serum calprotectin: a potential biomarker for neonatal sepsis. J Immunol Res. 2015; 2015:147973.
16
18. Stachon A, Bolulu O, Holland-Letz T, Krieg M. Association between nucleated red bloodcells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70. Shock. 2005; 24(1):34-9.
17
19. Ferber A, Fridel Z, Weissmann-Brenner A, Minior VK, Divon MY. Are elevated fetal nucleated red blood cell counts an indirect reflection of enhanced erythropoietin activity? Am J Obstet Gynecol. 2004; 190(5):1473-5.
18
20. Boskabadi H, Maamouri G, Tavakol Afshari J, Mafinejad S, Hosseini G, Mostafavi-Toroghi H, et al. Evaluation of serum interleukins-6, 8 and 10 levels as diagnostic markers of neonatal infection and possibility of mortality. Iran J Basic Med Sci. 2013; 16(12):1232-7.
19
21. Boskabadi H, Maamouri G, Sadeghian MH, GhayourMobarhan M, Heidarzade M, Shakeri MT, et al. Early diagnosis of perinatal asphyxia by nucleated red blood cell count: a case-control study. Arch Iran Med. 2010; 13(4):275-81.
20
22. Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatal. 2009; 33(3):130-7.
21
ORIGINAL_ARTICLE
Comparing the Hospital Costs of the Neonates Admitted to NICU of Amirkola Children's Hospital Before and After the Implementation of the Health Sector Reform in Iran
Background: The cost-effective strategies are of paramount importance in the improvement of neonatal health services. Regarding this, the present study aimed to evaluate the health sector reform of the Islamic Republic of Iran and its impact on hospital costs related to the admission of neonates in Amirkola Children's Hospital.Methods: This observational analytic study was conducted in 2015 to evaluate the hospital records of all neonates admitted to Amirkola Children's Hospital during late 2013 (before the implementation of health sector reform in Iran) and late 2014 (after the implementation of this reform).Results: According to the results, the number of the neonates admitted to this center has increased by 11% after reform. Furthermore, the mean total hospital cost and share of insurance organizations have elevated by 2.2 and 2.5 fold, respectively. Mean of the cost paid by the patients has reached to 2.7 million Rials, which has had a 33% decrease, compared to that of the pre-reform stage. Additionally, 5.8% of the total expenditures related to neonatal inpatient cares were paid out-of-pocket.Conclusion: As the findings of the present study indicated, the health sector reform in Iran has increased the rate of neonatal admission and decreased the amount of direct payment by the people.
https://ijn.mums.ac.ir/article_9361_c8f22e9002e85d9af952422534b19c24.pdf
2017-09-01
25
30
10.22038/ijn.2017.19518.1222
Children's hospital
Health sector reform
Neonatal care
Out-of-pocket payment
Yadollah
Zahed Pasha
yzpasha@gmail.com
1
Non-communicable Pediatric Research Center, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Simin
Mouodi
dr.mouodi@gmail.com
2
Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran
LEAD_AUTHOR
Mousa
Ahmadpour Kacho
s.mouodi@mubabol.ac.ir
3
Non-communicable Pediatric Research Center, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Zeinab
Hajitabar
zeynabhaji@gmail.com
4
Non-communicable Pediatric Research Center, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Tahere
Jahangir
zoya.t.jahangir@gmail.com
5
Non-communicable Pediatric Research Center, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Ali
Bijani
alibijani@yahoo.com
6
Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran
AUTHOR
1. Akseer N, Lawn JE, Keenan W, Konstantopoulos A, Cooper P, Ismail Z, et al. Ending preventable newborn deaths in a generation. Int J Gynaecol Obstet. 2015; 131(Suppl 1):S43-8.
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2. Economic UN, Council S. Millennium development goals and post-2015 development agenda. New York: UN Publications; 2013.
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3. Althabe F, Bergel E, Cafferata ML, Gibbons L, Ciapponi A, Alemán A, et al. Strategies for improving the quality of health care in maternal and child health in low and middle income countries: overview of systematic reviews. Paediatr Perinat Epidemiol. 2008; 22(Suppl 1):42-60. 4. Mangham-Jefferies L, Pitt C, Cousens S, Mills A, Schellenberg J. Cost-effectiveness of strategies to improve the utilization and provision of maternal and newborn health care in low-income and lowermiddle-income countries: a systematic review. BMC Pregnancy Childbirth. 2014; 14:243.
3
5. Kingkaew P, Werayingyong P, Aye SS, Tin N, Singh A, Myint P, et al. An ex-ante economic evaluation of the Maternal and Child Health Voucher Scheme as a decision-making tool in Myanmar. Health Policy Plan. 2015; 31(4):482-92.
4
6. Gupta RP, de Wit ML, McKeown D. The impact of poverty on the current and future health status of children. Paediatr Child Health. 2007; 12(8):667-72.
5
7. Velickovic V, Simovic A, Lazarevic G, Lazarevic M, Jakovljevic M. Improvements in Neonatal and Childhood Medical Care - Perspective from the Balkans. Front Public Health. 2015; 3:206.
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8. Ahmadi A, Javadi A. Trends and determinants of infant mortality rate in Fars province during 2001- 2011. J Rafsanjan Univ Med Sci. 2015; 14(1):37-46 (Persian).
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9. Lawn JE, Kinney MV, Black RE, Pitt C, Cousens S, Kerber K, et al. Newborn survival: a multi-country analysis of a decade of change. Health Policy Plan. 2012; 27(Suppl 3):6-28.
8
10. Lamarche PA, Pineault R, Gauthier J, Hamel M, Haggerty J. Availability of healthcare resources, positive ratings of the care experience and extent of service use: an unexpected relationship. Health Policy. 2011; 6(3):46-56.
9
11. Cavallo MC, Gugiatti A, Fattore G, Gerzeli S, Barbieri D, Zanini R, et al. Cost of care and social consequences of very low birth weight infants without premature- related morbidities in Italy. Ital J Pediatr. 2015; 41(1):59.
10
12. Chuma J, Maina T. Catastrophic health care spending and impoverishment in Kenya. BMC Health Serv Res. 2012; 12:413. Zahed Pasha Y et al Neonatal Hospital Costs Before and After Health Sector Reform in Iran 30 Iranian Journal of Neonatology 2017; 8(3)
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13. Xu K, Evans DB, Carrin G, Aguilar-Rivera AM, Musgrove P, Evans T. Protecting households from catastrophic health spending. Health Aff (Millwood). 2007; 26(4):972-83.
12
14. The package of reports on monitoring of core health indicators in Islamic Republic of Iran. Tehran, Iran: The Academy of Medical Sciences, Islamic Republic of Iran; 2015. P. 209-19.
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15. Ministry of Health and Medical Education. Guidelines of health system reform plan. Executive version. Deputy of Health. Tehran: Iran: Ministry of Health and Medical Education; 2014 (Persian).
14
16. Health sector evolution programs report. 10th session of health sector evolution committee of the university in Amirkola Children’s Hospital. Babol, Iran: Babol University of Medical Sciences; 2014 (Persian).
15
17. Khayeri F, Goodarzi L, Meshkini A, Khaki E. Evaluation of the national health care reform program from the perspective of experts. J Client Cent Nurs Care. 2015; 1(1):37-46.
16
18. Khayeri F, Goodarzi L, Meshkini A, Khaki E. Assessment of the role of health system reform plan in franchise reduction for patients referred to university hospitals in Iran. J Client Cent Nurs Care. 2015; 1(2):71-6.
17
19. The news related to health sector evolution program. Kashan, Iran: Kashan University of Medical Sciences; 2014.
18
20. Khayeri F, Goodarzi L, Meshkini A, Khaki A. Reduction the amount paid by the patients admitted in hospitals. National congress in performance review of the 11th government in the field of health, Tehran, Iran; 2015. P. 13 (Persian).
19
21. Soleimani A, Forghani Dehnavi SS, Alahverdi S. The performance of the program "Reduction the amount paid by the patients" admitted in hospitals affiliated to Shahrekord University of medical sciences after implementation of health sector evolution program. National congress in performance review of the 11th government in the field of health, Tehran, Iran; 2015. P. 19-20 (Persian).
20
22. Lefevre AE, Shillcut SD, Waters HR, Haider S, EI Arifeen S, Mannan I, et al. Economic evaluation of neonatal care packages in a cluster-randomized controlled trial in Sylhet, Bangladesh. Bull World Health Organ. 2013; 91(10):736-45.
21
23. Flores-Huertaa S, Klünder-Klündera M, MartínezValverdeb S, Muñoz-Hernández O. An approximation to data on mortality and out-ofpocket expenses for medical attention of infants<2 years old affiliated with the Medical Insurance Siglo XXI. Boletín Med Hospital Infantil México. 2014; 71(5):271-6.
22
24. Lawn JE, Kinney MV, Black RE, Pitt C, Cousens S, Kerber K, et al. Newborn survival: a multi-country analysis of a decade of change. Health Policy Plan. 2012; 27(Suppl 3):6-28.
23
25. Oliaeemanesh A. Health insurances and their role in health system and health sector evolution program. Tehran, Iran: Ministry of Health and Medical Education; 2015 (Persian).
24
26. Bagheri Lankarani K, Ghahramani S, Honarvar B. Payment of the patients admitted in Shiraz after the first step of Health Sector Evolution program. National congress in performance review of the 11th government in the field of health, Tehran, Iran; 2015. P. 31 (Persian)
25
ORIGINAL_ARTICLE
Effect of the BASNEF Model on Maternal-Fetal Attachment in the Pregnant Women Referring to the Prenatal Clinics Affiliated to Shiraz University of Medical Sciences
Background: Prenatal attachment and positive adaptation with the concept of motherhood play a pivotal role in maternal and fetal health. The present study aimed to evaluate the effect of the beliefs, attitudes, subjective norms, and enabling factors (BASNEF) model on maternal fetal attachment in the pregnant women referring to prenatal clinics. Methods: This quasi-experimental study was conducted on 100 nulliparous women in their third pregnancy trimester (36-41 weeks), who referred to the selected prenatal clinics in Shiraz, Iran during 2011-2012. Intervention was performed based on the BASNEF model in six training sessions for 90 minutes. Data collection tools were the Cranley’s maternal-fetal attachment scale and BASNEF model. Data analysis was performed in SPSS version 18 using Pearson’s correlation-coefficient, independent t-test, and Chi-square at the significance level of 0.05.Results: After the intervention, a significant difference was observed in the mean score of maternal-fetal attachment in the intervention group compared to the control group (P<0.001). In addition, there was a significant positive correlation between the score of maternal-fetal attachment and enabling factors one month after the training in the intervention group (P=0.039). Conclusion: According to the results, training based on the BASNEF model could increase the maternal-fetal attachment in nulliparous pregnant women and improve the psychological health indicators of the neonates.
https://ijn.mums.ac.ir/article_9362_1e2c6184b019fe54fc895b34fa3bd7b7.pdf
2017-09-01
31
37
10.22038/ijn.2017.20521.1229
attachment
BASNEF Model
fetus
mothers
pregnancy
Marzieh
Akbarzadeh
1
Maternal-Fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Marzieh
Moattari
moattarm@sums.ac.ir
2
School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Maliheh
Abootalebi
maliheabootalebi@gmail.com
3
Department of Community Health Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
1. Chang HC, Yu CH, Chen SY, Chen CH. The effects of music listening on psychosocial stress and maternal--fetal attachment during pregnancy. Complement Ther Med. 2015; 23(4):509-15.
1
2. Akbarzadeh M, Rafiee B, Asadi N, Zare N. Comparative effect of attachment and relaxation training on perception of fetal movement and mother's anxiety in primiparous women: a randomized controlled study. Trends Med Res. 2016; 11(2):62-8.
2
3. Torshizi M. Different dimensions of maternal-fetal attachment behaviors and associated factors in pregnant women referred to health centers of Birjand, Iran, 2012. Iran J Obstet Gynecol Infertil. 2013; 16(72):13-21 (Persian).
3
4. Ustunsoz A, Guvenc G, Akyuz A, Oflaz F. Comparison of maternal-and paternal-fetal attachment in Turkish couples. Midwifery. 2010; 26(2):e1-9.
4
5. Colonnesi C, Draijer EM, Jan J M Stams G, Van der Bruggen CO, Bögels SM, Noom MJ. The relation between insecure attachment and child anxiety: a meta-analytic review. J Clin Child Adolesc Psychol. 2011; 40(4):630-45.
5
6. Sajjadi AS, Zahrakar K, Mohsenzadeh F, Karamnia M, Shokoohi YM, Alavinezhad S. Efficacy of maternal fetal attachment techniques on enhancing mother's attachment to the fetus. Dev Psychol. 2016; 12(47):281-8 (Persian).
6
7. Maas AJ, Vreeswijk CM, de Cock ES, Rijk CH, van Bakel HJ. “Expectant Parents”: study protocol of a longitudinal study concerning prenatal (risk) factors and postnatal infant development, parenting, and parent-infant relationships. BMC Pregnancy Childbirth. 2012; 12:46.
7
8. Brandon AR, Pitts S, Denton WH, Stringer CA, Evans HM. A history of the theory of prenatal attachment. J Prenat Perinat Psychol Health. 2009; 23(4):201-22.
8
9. Yercheski A, Mahon NE, Yercheski TJ, Hanks MM, Cannella BL. A meta-analytic study of predictors of maternal-fetal attachment. Int J Nurs Stud. 2009; 46(5):708-15.
9
10. van Bakel HJ, Maas AJ, Vreeswijk CM, Vingerhoets AJ. Pictorial representation of attachment: measuring the parent-fetus relationship in expectant mothers and fathers. BMC Pregnancy Childbirth. 2013; 13:138.
10
11. Magee SR, Bublitz MH, Orazine C, Brush B, Salisbury A, Niaura R, et al. The relationship between maternal-fetal attachment and cigarette smoking over pregnancy. Matern Child Health J. 2014; 18(4):1017-22.
11
12. Kuo PC, Bowers B, Chen YC, Chen CH, Tzeng YL, Lee MS. Maternal-foetal attachment during early pregnancy in Taiwanese women pregnant by in vitro fertilization. J Adv Nurs. 2013; 69(11):2502-13.
12
13. Maddahi MS, Dolatian M, Khoramabadi M, Talebi A. Correlation of maternal-fetal attachment and health practices during pregnancy with neonatal outcomes. Electron Physician. 2016; 8(7):2639-44.
13
14. Young R. The importance of bonding. Int J Childbirth Educ. 2013; 28(3):11-7.
14
15. Parsa P, Saiedzadeh N, Roshanai G, Masoumi SZ. The effect of training on maternal-fetal attachment (MFA) in Nulliparous women: a randomized clinical trial. Nasim Danesh. 2016; 24(1):24-30 (Persian).
15
16. Pillitteri A. Maternal & child health nursing: care of the childbearing & childrearing family. Philadelphia: Lippincott Williams & Wilkins; 2010. P. 1778.
16
17. Shahnazi H, Bee Koon P, Abd Talib R, Lubis SH, Ganjali Dashti M, Khatooni E, et al. Can the BASNEF model help to develop self-administered healthy behavior in Iranian youth? Iran Red Crescent Med J. 2016; 18(3):e23847.
17
18. Hubley J. Understanding behavior: the key to successful health education. Trop Doct. 1988; 18(3):134-8.
18
19. Amiri A, Rkhshany F, Farmanbar R. The effect of educational program based on BASNEF model on healthy lifestyle of taxi drivers in Langroud. J Health Chimes. 2014; 1(4):45-54 (Persian).
19
20. Sharifirad GR, Golshiri P, Shahnazi H, Barati M, Hasanzadeh A, Charkazi AR, et al. The impact of educational program based on BASNEF model on breastfeeding behavior of pregnant mothers in Arak. Arak Med Univ J. 2010; 13(1):63-70 (Persian).
20
21. Cranley MS. Development of a tool for the measurement of maternal attachment during pregnancy. Nurs Res. 1981; 30(5):281-4.
21
22. Jamshidimanesh M, Astaraki L, Behboodi Moghadam Z, Taghizadeh Z, Haghani H. Maternal-fetal attachment and its associated factors. J Hayat. 2012; 18(5):33-45 (Persian).
22
23. Taavoni S, Ahadi M, Ganji T, Hosseini FA. Comparison of maternal fetal attachment between primgravidas and multigravidas women with past history of fetal or neonatal death. Iran J Nurs. 2008; 21(53):53-61.
23
24. Likis FE. Prenatal education: enduring and essential. J Midwifery Womens Health. 2009; 54(6):429.
24
25. Hosseinian S, Yazdi SM, Alavinezhad S. The Effectiveness of fetal attachment training program on maternal- fetal relationship and mental health of pregnant women. Quart J Child Ment Health. 2016; 2(4):75-87 (Persian).
25
26. Abasi E, Tafazoli M. The effect of training attachment behaviors on primipara maternal fetal attachment. Sci J Hamadan Nurs Midwifery Facul. 2009; 17(12):35-45 (Persian).
26
27. Akbarzadeh M, Toosi M, Zare N, Sharif F. Effect of learning attachment behaviors on anxiety and maternal fetal attachment in first pregnant women. Evid Based Care. 2011; 1(1):21-34 (Persian).
27
28. Saastad E, Israel P, Ahlborg T, Gunnes N, Frøen JF. Fetal movement counting--effects on maternal-fetal attachment: a multicenter randomized controlled trial. Birth. 2011; 38(4):282-93. 29. Mehrabian F, Valipour R, Kasmaei P, Atrkar Roshan Z, Mahdavi Roshan M. The effect of education based on BASNEF model on promoting of nutritional behavior to prevent iron deficiency anemia. J Holistic Nurs Mideifery. 2014; 25(79):89-98.
28
30. Akbarzadeh M, Bahmani N, Moatari M, PourAhmad S. The impact of the BASNEF educational programme on breastfeeding behavior in Iran. Br J Midwifery. 2013; 21(4):276-84.
29
31. Zendehtalab H, Vaghei S, Emamimoghadam Z. Effect of intervention based on BASNEF model on quality of life in patients with type 2 diabetes. Evid Based Care. 2013; 3(1):7-16 (Persian).
30
32. Baghdari N, Sadeghi Sahebzad E, Kheirkhah M, Azmoude E. The effects of pregnancy-adaptation training on maternal-fetal attachment and adaptation in pregnant women with a history of baby loss. Nurs Midwifery Stud. 2016; 5(2):e28949.
31
33. Kwon MK, Bang KS. Relationship of prenatal stress and depression to maternal-fetal attachment and fetal growth. J Korean Acad Nurs. 2011; 41(2):276-83.
32
34. Taffazoli M, Aminyazdi SA, Shakeri MT. The relationship between maternal-fetal attachment and mother-infant attachment behaviors in primiparous women referring to Mashhad health care centers. J Midwif Reprod Health. 2015; 3(2):318-27.
33
35. Charkazi A, Miraeiz SZ, Razzaghnejad A, Shahnazi H, Hasanzadeh A, BadlehMT. Breastfeeding status during the first two years of infants’ life and its risk factors based on BASNEF model structures in Isfahan. J Educ Health Promot. 2015; 2:9.
34
ORIGINAL_ARTICLE
Risk Factors and Neurological Outcomes of Neonatal Hypernatremia
Background: Hypernatremia might lead to neurological and developmental disabilities. This study aimed to determine the frequency, risk factors, and one-year neurological prognosis of hypernatremia in newborns. The findings of the present study may assist the prevention of hypernatremia mortality and complications.Methods: This cross-sectional study was conducted on all neonates admitted to the neonatal ward and the Neonatal Intensive Care Unit (NICU) of Bahrami Children's Hospital, Tehran, Iran from September 2013 to September 2014. All the newborns, who were diagnosed with hypernatremia (serum sodium>150 mEq/L) were included in this study. The data were collected using a form, which included clinical symptoms and risk factors for neonatal hypernatremia in addition to the laboratory data. Additionally, the patients were subjected to the developmental examination for one year. Another form was used during the follow-up period to collect all the relevant data.Results: A total of 1,923 newborns were examined in the present study. The results demonstrated that 74 (3.8%) neonates had sodium levels of >150 mEq/L. Furthermore, jaundice was found to be the most prevalent presentation of hypernatremia, which was reported in 57% of the admitted neonates. Additionally, weight loss was the most common observation on the follow-up examinations. Neonates admitted at older ages (>7 days) had higher sodium levels (160.71±8.98 mEq/L). There were 18 neonates with seizures before or during the hospitalization and 19 (25.7%) cases showed abnormal development during the one-year follow-up. Moreover, a statistically significant relationship was observed between the abnormal development and the presence of seizure (OR: 2.543, CI: 1.358-4.763).Conclusion: The findings of the current study demonstrated the critical role of weighing the newborns 72-96 h after birth and monitoring for jaundice in the prevention of the neonatal hypernatremia. Furthermore, seizures in these patients were associated with an increased risk of future developmental problems; however, more studies are required in this regard
https://ijn.mums.ac.ir/article_9363_0d201fb6e43eb292fad886d9d43a5ef5.pdf
2017-09-01
38
43
10.22038/ijn.2017.20577.1231
Hypernatremia
Neurologic manifestations
Newborn
Outcome assessment
Risk factors
Kamyar
Kamrani
arianamiri90@yahoo.com
1
Department of Pediatrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Jalaleddin
Amiri
mana2261@yahoo.com
2
Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Nahide
Khosroshahi
3
Department of Pediatrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
zahra
sanaei
zahrasanaei58@yahoo.com
4
Department of Community Medicine, Education Development Office, Hamadan University of Medical Sciences, Hamadan, Iran
LEAD_AUTHOR
1. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. New York: Elsevier Health Sciences; 2014.
1
2. Boskabadi H, Anvarifar F, Nourizadeh N. Could neonatal hypernatremia dehydration influence hearing status? Iran J Otorhinolaryngol. 2014; 26(74):13-8.
2
3. Habibi M, Abourazzak S, Babakhouya A, Boubou M, Atmani S, Tizniti S, et al. Severe hypernatremic dehydration associated with cerebral venous and aortic thrombosis in the neonatal period. BMJ Case Rep. 2012; 2012:720114426.
3
4. Suliman OS. Dying for milk: a neonate with severe hypernatremia associated with inadequate breast feeding. Sudan J Paediatr. 2015; 15(2):55-62.
4
5. Trachtman H. Cell volume regulation: a review of cerebral adaptive mechanisms and implications for clinical treatment of osmolal disturbances: II. Pediatr Nephrol. 1992; 6(1):104-12.
5
6. Breuning-Boers JM, van Dommelen P, van Wouwe JP, Verkerk PH. Weight loss, serum sodium concentration and residual symptoms in patients with hypernatremic dehydration caused by insufficient breastfeeding. Ned Tijdschr Geneeskd. 2006; 150(16):904-8.
6
7. Koklu E, Gunes T, Ozturk MA, Kose M, Kurtoglu S, Yuksel F. A review of 116 cases of breastfeedingassociated hypernatremia in rural area of central Turkey. J Trop Pediatr. 2007; 53(5):347-50.
7
8. Moritz ML, Manole MD, Bogen DL, Ayus JC. Breastfeeding-associated hypernatremia: are we missing the diagnosis? Pediatrics. 2005; 116(3): e343-7.
8
9. Unal S, Arhan E, Kara N, Uncu N, Aliefendioğlu D. Breast-feeding-associated hypernatremia: Retrospective analysis of 169 term newborns. Pediatr Int. 2008; 50(1):29-34.
9
10. Uras N, Karadag A, Dogan G, Tonbul A, Tatli MM. Moderate hypernatremic dehydration in newborn infants: retrospective evaluation of 64 cases. J Matern Fetal Neonatal Med. 2007; 20(6):449-52.
10
11. Bolat F, Oflaz MB, Güven AS, Özdemir G, Alaygut D, Doğan MT, et al. What is the safe approach for neonatal hypernatremic dehydration? A retrospective study from a neonatal intensive care unit. Pediatr Emerg Care. 2013; 29(7):808-13.
11
12. Boskabadi H, Maamouri G, Ebrahimi M, GhayourMobarhan M, Esmaeily H, Sahebkar A, et al. Neonatal hypernatremia and dehydration in infants receiving inadequate breastfeeding. Asia Pac J Clin Nutr. 2010; 19(3):301-7.
12
13. van Dommelen P, Boer S, Unal S, van Wouwe JP. Charts for weight loss to detect hypernatremic dehydration and prevent formula supplementing. Birth. 2014; 41(2):153-9.
13
14. Ibinda F, Zarnack H, Newton CR. Sodium disturbances in children admitted to a kenyan hospital: magnitude, outcome and associated factors. PloS One. 2016; 11(9):e0161320.
14
15. Zaki SA, Mondkar J, Shanbag P, Verma R. Hypernatremic dehydration due to lactation failure in an exclusively breastfed neonate. Saudi J Kidney Dis Transpl. 2012; 23(1):125-8.
15
16. Boskabadi H, Akhondian J, Afarideh M, Maamouri G, Bagheri S, Parizadeh SM, et al. Long-term neurodevelopmental outcome of neonates with hypernatremic dehydration. Breastfeed Med. 2017; 12(3):163-8.
16
17. Ergenekon E, Unal S, Gücüyener K, Soysal SE, Koç E, Okumus N, et al. Hypernatremic dehydration in the newborn period and long‐term follow up. Pediatr Int. 2007; 49(1):19-23.
17
18. Basiratnia M, Pishva N, Dehghani A. Prevalence of breastfeeding–associated hypernatremia among hospitalized hyperbilirubinemic neonates. Iran J Neonatol. 2014; 5(2):12-6.
18
ORIGINAL_ARTICLE
Association of Using Oxytocin during Labor and Breastfeeding Behaviors of Infants within Two Hours after Birth
Background: Opioids are used to relieve pain during labor and may affect the neurobehavioral conditions of infants. However, effects of using drugs, such as oxytocin, as a routine component of pre- and post-delivery care on the breastfeeding behaviors of newborns remain unclear. The present study aimed to investigate the association between the maternal use of oxytocin during labor and breastfeeding behaviors of neonates within two hours after birth.Methods: This descriptive-analytical study was conducted on 160 women selected via convenience sampling. The participants were assigned to two groups of oxytocin administration (n=70) and physiologic delivery (n=90). Data were collected using demographic questionnaires and infant breastfeeding assessment tool (IBFAT). IBFAT was completed by the researcher through observing the behaviors of infants during breastfeeding after birth. Data analysis was performed in SPSS version 20, using descriptive and analytical statistics, including independent t-test, correlation-coefficients, and analysis of variance.Results: Mean age of the mothers in the oxytocin administration and physiologic delivery groups was 26.9±5.9 and 27.8±5.5 years, respectively. Breastfeeding was significantly stronger in the infants whose mothers had physiologic delivery compared to the group administered with oxytocin during labor.Conclusion: According to the results, use of oxytocin during labor directly weakens the breastfeeding of neonates. Therefore, it seems necessary to inform and prepare women for physiologic delivery during pregnancy
https://ijn.mums.ac.ir/article_9369_4f8b6f98090bde1ace4c372b60602001.pdf
2017-09-01
48
52
10.22038/ijn.2017.18301.1209
Breastfeeding behaviors in infants
labor
Oxytocin
Physiologic delivery
Mehri
Abdoulahi
z.hemate@gmail.com
1
Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
zeinab
hemati
z_hemate@nm.mui.ac.ir
2
Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
LEAD_AUTHOR
Fatemeh Sadat
Mousavi Asl
3
Neonatal Intensive Care Unit, Shahid Beheshti Hospital, Isfahan, Iran
AUTHOR
Masoumeh
Delaram
masoumehdelaam@yahoo.com
4
Department of Midwifery, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Mahboobeh
Namnabati
namnabat@nm.mui.ir
5
Nursing and Midwifery Care Research Centre, faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
1. Gholamitabartabari M, Heidarzadeh M, Sattarzadeh N, Kooshavar H. Performing and evaluation of breast feeding education program on exclusive breastfeeding and growth induce of preterm infant of 4 month after birth. J Babol Univ Med Sci. 2011; 13(2):57-62 (Persian).
1
2. Gaffari V, Vahidshahi K, Parviniejad N. Assessment of mother's attitude and knowledge toward exclusive breastfeeding, Sari. J Jahrom Univ Med Sci. 2009; 7(1):53-60 (Persian).
2
3. Vahidi AA, Eranmanesh E. Breastfeeding and medication. J Kerman Univ Med Sci. 2011; 18(2):194-206.
3
4. Szabo AL. Intrapartum neuraxial analgesia and breastfeeding outcomes: limitations of current knowledge. Anesth Analg. 2013; 116(2):399-405.
4
5. Maury S. Breastfeeding information & guideline: a manual for breastfeeding support in pediatric & neonatal units. Trans: Saadvandian S, Tahery M. Mashhad: Sokhan Gostar; 2007. P. 22-70 (Persian).
5
6. Kamalifard M, Heidarzadeh M, Ghoujazadeh M, Mohammadi M. The effect of kangaroo mother care on exclusive breast feeding in nulliparous. Nurs Midwifery J. 2010; 5(17):12-8 (Persian).
6
7. Reynolds F. The effects of maternal labor analgesia on the fetus. J Best Pract Res Clin Obstet Gynecol. 2010; 24(3):289-302.
7
8. Montgomery A, Hale TW; Academy Of Breastfeeding Medicine. ABM clinical protocol #15: analgesia and anesthesia for the breastfeeding mother, revised 2012. Breastfeed Med. 2012; 7(6):547-53.
8
9. Wilson MJ, MacArthur C, Shennan A. The effect of epidural analgesia on breast feeding: analysis of a randomized controlled trial. Int J Obstet Anesth. 2009; 18(1):S7.
9
10. Reynolds F. Labour analgesia and the baby: good news is no news. Int J Obstet Anesth. 2011; 20(1):38-50.
10
11. Nissen E, Widstrom AM, Lilja G, Matthiesen AS, Uvnas-Moberg K, Jacobsson G, et al. Effects of routinely given pethidine during labour on infants’ developing breastfeeding behaviour. Effects of dosedelivery time interval and various concentrations of pethidine/norpethidine in cord plasma. Acta Paediatr. 1997; 86(2):201-8.
11
12. Riordan J, Gross A, Angeron J, Krumwiede B, Melin J. The effect of labor pain relief medication on neonatal suckling and breast feeding duration. J Hum Lact. 2000; 16(1):7-12.
12
13. Radzyminski S. The effect of ultra-low dose epidural analgesia on newborn breast feeding behaviours. J Obstet Gynecol Neonatal Nurs. 2003; 32(3):322-31.
13
14. Safarabadi Farahani T, Ali Akbar M, Taavoni S, Haghani H. The effect of kangaroo contact on duration of exclusive breastfeeding and success of lactation among primiparous women at Shahid Akbar-Abadi hospital in Tehran. Iran J Nurs. 2009; 22(59):60-70.
14
15. Brimdyr K, Cadwell K, Widstrom AM, Svensson K, Neumann M, Hart E, et al. The association between common labor drugs and suckling when skin-to-skin during the first hour after birth. Birth. 2015; 42(4):319-28.
15
16. Akbas M, Akcan AB. Epidural analgesia and lactation. Eurasian J Med. 2011; 43(1):45-9.
16
17. Jordan S. Infant feeding and analgesia in labour: the evidence is accumulating. Int Breastfeed J. 2006; 1:25.
17
18. Olza Fernandez I, Marín Gabriel M, Malalana Martínez A, Fernández-Cañadas Morillo A, López Sánchez F, Costarelli V. Newborn feeding behavior depressed by intrapartum oxytocin: a pilot study. Acta Paediatr. 2012; 101(7):749-54.
18
19. Wiklund I, Edman G, Andolf E. Cesarean section on maternal request: reasons for the request, selfestimated health, expectations, experience of birth and signs of depression among first-time mothers. Acta Obstet Gynecol Scand. 2007; 86(4):451-6.
19
20. Dozier AM, Howard CR, Brownell EA, Wissler RN, Glantz JC, Ternullo SR, et al. Labor epidural anesthesia, obstetric factors and breastfeeding cessation. Matern Child Health J. 2013; 17(4):689-98.
20
21. Wiklund I, Norman M, Uvnäs-Moberg K, RansjöArvidson AB, Andolf E. Epidural analgesia: breastfeeding success and related factors. Midwifery. 2009; 25(2):e31-8.
21
22. Jordan S, Emery S, Watkins A, Evans JD, Storey M, Morgan G. Associations of drugs routinely given in labour with breastfeeding at 48 hours: analysis of the Cardiff Births Survey. BJOG. 2009; 116(12):1622-9.
22
23. Garcia-Fortea P, Gonzalez-Mesa E, Blasco M, Cazorla O, Delgado-Ríos M, González-Valenzuela MJ. Oxytocin administered during labor and breastfeeding: a retrospective cohort study. Matern Fetal Neonatal Med. 2014; 27(15):1598-603.
23
24. Lind JN, Perrine CG, Li R. Relationship between use of labor pain medications and delayed onset of lactation. J Hum Lact. 2014; 30(2):167-73.
24
ORIGINAL_ARTICLE
Results of Screening for Neonatal Metabolic Diseases in Mashhad City, Iran (2015)
Background: Neonatal screening is a preventive medical measure to screen infants shortly after birth for treatable metabolic disorders and endocrinopathies. The present study aimed to evaluate and compare the accuracy of laboratory samples in the screening programs for metabolic diseases in Mashhad city, Iran with international guidelines.Methods: This observational study was conducted on all the patients referring to the health centers of Mashhad, Iran during two weeks. In total, 220 infants were enrolled in the study and divided into three groups of health center 1, 2, and 3. A checklist was prepared based on the international guidelines to evaluate the neonatal screening procedures.Results: In total, 220 neonates aged 3-14 days (90 girls and 130 boys) were enrolled in this study. Mean weight and height of the neonates was 3215.90±485.12 grams and 49.85±2.04 centimeters, respectively. In all the cases, mode of nutrition was breastfeeding, and sampling was performed within 36 hours after birth. Neonates had no history of corticosteroid administration, catecholamine administration, parenteral nutrition, and blood transfusion. Heels of the neonates had no contact with the filter paper, and the samples were dried away from direct sunlight and heat. Two of the health centers used disinfectants and dried the heels of infants afterwards prior to drawing the samples. Conclusion: According to the results, the studied health centers followed the protocol properly. However, two of the health centers used disinfectants in such way that we were not sure whether the heels of the neonates were dried completely
https://ijn.mums.ac.ir/article_9370_71d692aac1859c34c5836c16fa74352a.pdf
2017-09-01
53
57
10.22038/ijn.2017.17082.1198
Health centers of Mashhad
Metabolic diseases
Neonatal screening
Fatemeh
Keykhaei
1
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mahla
Arabpour
2
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Keyhan
Gonoody
gonoodik1@mums.ac.ir
3
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Samaneh
Ayoubi
4
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ahmad
Shah Farhat
farhata@mums.ac.ir
5
Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
abdolreza
norouzy
norouzya@mums.ac.ir
6
Department of Biochemistry and Nutrition, Endoscopic and Minimally Invasive Surgery and Cancer Research Centers, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. Panel NIoHCD. National institutes of health consensus development conference statement: phenylketonuria: screening and management, October 16–18, 2000. Pediatrics. 2001;108(4):972-82.
1
2. Senemar S, Ganjekarimi H, Fathzadeh M, Tarami B, Bazrgar M. Epidemiological and clinical study of Phenylketonuria (PKU) disease in the National Screening Program of Neonates, Fars province, Southern Iran. Iranian Journal of Public Health. 2009;38(2):58-64.
2
3. Liu SG, Phase M. Implementing the 4 ‘A’s Test: Detecting delirium in acutely admitted older adults in a London Teaching Hospital.
3
4. Harms E. Richtlinien zur Organisation und Durchführung des Neugeborenenscreenings auf angeborene Stoffwechselstörungen und Endokrinopathien in Deutschland. PerinatalMedizin. 1997; 9(3):91-4.
4
5. Bundesausschuss G, Vorsitzende D. Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Richtlinie Methoden vertragsärztlicher Versorgung in Anlage I" Anerkannte Untersuchungs-oder Behandlungsmethoden" und in Anlage II" Methoden, die nicht als vertragsärztliche Leistungen zu Lasten der Krankenkassen erbracht werden dürfen": Akupunktur. Bundesanzeiger; 2006.
5
6. Moyer VA, Calonge N, Teutsch SM, Botkin JR. Expanding newborn screening: process, policy, and priorities. Hastings Center Report. 2008;38(3):32-9.
6
7. Gaviglio A, Dunker D. Newborn Screening Parental Options-Minnesota Dept. of Health. 2003. 8. Committee NSA. Newborn screening expands: recommendations for pediatricians and medical homes-implications for the system. Pediatrics. 2008;121(1):192-217.
7
9. Debbie Saban, Guidelines for Newborn Blood Spot Sampling. 2015. 10. Harms E, Olgemöller B. Neonatal screening for metabolic and endocrine disorders. Deutsches Ärzteblatt International. 2011;108(1-2):11.
8
ORIGINAL_ARTICLE
Causes of Neonatal Mortality in the Neonatal Intensive Care Unit of Taleghani Hospital
Background: Neonatal survival is one of the most important challenges today. Over 99% of neonatal mortalities occur in the developing countries, and epidemiologic studies emphasize on this issue in the developed countries, as well. In this study, we attempted to investigate the causes of neonatal mortality in Taleghani Hospital, Tabriz, Iran.Methods: In this cross-sectional study, we studied causes of neonatal mortality in neonatal intensive care unit (NICU) of Taleghani Hospital, Tabriz, Iran, during 2013-2014. Data collection was performed by the head nurse and treating physician using a pre-designed questionnaire. Most of the data were extracted from the neonatal records. Information regarding maternal underlying diseases and health care during pregnancy was extracted from mothers' records.Results: A total of 891 neonates were admitted to NICU of Taleghani Hospital of Tabriz, Iran, during 2013-2014, 68 (7.5%) of whom died. Among these cases, 37 (%54.4) were male, 29 (29.4%) were extremely low birth weight, and 16 (23.5%) weighed more than 2.5 kg. The main causes of mortality were congenital anomalies (35.3%), prematurity (26.5%), and sepsis (10.3%), respectively.Conclusion: Congenital anomaly is the most common cause of mortality, and the pattern of death is changing from preventable diseases to unavoidable mortalities
https://ijn.mums.ac.ir/article_9371_f82125b382ff423a3286499362806bf7.pdf
2017-09-01
58
61
10.22038/ijn.2017.25853.1340
causes
Neonatal mortality
NICU
Tabriz
Ali Hossein
Zeinalzadeh
1
Social Determinants of Health Research Center, Preventive and Community Medicine Specialist, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Roghaiyeh
Khodaei
2
Sayed Hamzeh Health Center, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Mohammad
Heidarzadeh
heidarzade_2013@yahoo.com
3
Department of Pediatrics, Tabriz University of Medical Sciences, Director of Department of Neonatal Health, Ministry of Health and Medical Education, Tabriz, Iran
AUTHOR
kayvan
mirnia
kayvanmirnia@yahoo.com
4
Pediatrics Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
1. Gonzalez R, Merialdi M, Lincetto O, Lauer J, Becerra C, Castro R, et al. Reduction in neonatal mortality in Chile between 1990-2000. Pediatrics. 2006; 117(5):e949-54.
1
2. Jehan I, Harris H, Salat S, Zeb A, Mobeen N, Pasha O, et al. Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan. Bull World Health Organ. 2009; 87(2):130-8.
2
3. Javanmardi Z, Beygi M, Ghodousi A. Investigating about the causes of neonates ‘death in the hospitals of Isfahan province. Sci J Forensic Med. 2009; 15(4):229-33 (Persian).
3
4. Sareshtedari M, Shahamat H, Sadegi T. Cause and related factors of neonatal mortality in Qazvin NICU. Hakim Health Syst Res J. 2012; 14(4):227-32 (Persian).
4
5. Lawn JE, Cousens S, Zupan J; Lancet Neonatal Survival Steering Team. 4 million neonatal death: when? where? why? Lancet 2005; 365(9462):891-900.
5
6. Hemmati M, Gheini S. Neonatal mortality rate prevalence in Motazedi hospital of Kermanshah (2002-2003). J Kermanshah Univ Med Sci. 2006; 10(2):130-7 (Persian).
6
7. Goodman DC, Fisher ES, Little GA, Stukel TA, Chang CH, Schoendorf KS. The relation between the availability of neonatal intensive care and neonatal mortality. N Engl J Med 2002; 346(20):1538-44.
7
8. Plug I, Hoffman R, Mackenbach J. Avoidable mortality in the European Union: towards better indicators for the effectiveness of health systems. Rotterdam, Netherlands: Amenable Mortality in the European Union, Towards Better Indicators for the Effectiveness of Health Systems (AMIEHS); 2011.
8
9. Ersdal HL, Mduma E, Svensen E, Perlman J. Birth asphyxia: a major cause of early neonatal mortality in a Tanzanian rural hospital. Pediatrics. 2012; 129(5):e1238-43.
9
10. Nayeri F, Amini E, Yazdi ZO, Naieri AD. Evaluation of the cause and predisposing factors in neonatal mortality by using international coding disease version 10 in Valiasr hospital. Iran J Pediatr. 2007; 17(1):21-6 (Persian).
10
ORIGINAL_ARTICLE
Developing the Principles of Parental Mental Health in the Neonatal Intensive Care Unit (NICU)
Background: Hospitalization of infants in the neonatal intensive care unit (NICU) may disrupt the proper interaction with infants and lead to anxiety and depression, while adversely affecting the role of families. Therefore, it is necessary for healthcare teams to be familiar with the principles of parental mental health in the NICU. The present study aimed to codify the principles of parental mental health in the NICU. Methods: This study was conducted with a triangulation methodology in two steps. In the first step, the principles of mental health care for parents in the NICU were compiled and translated. In the second step, the principles were edited using the Delphi method based on the opinion of experts (physicians, faculty members, and health policymakers). Final principles of parental mental health in the NICU were codified. Results: In total, four general principles of holistic care, relationship with parents in the NICU, special care for establishing communication with families in the NICU, and principles of infants and family care were obtained.Conclusion: Since healthcare teams may not be familiar with the principles of parental mental health in the NICU, the results of the present study could lay the groundwork for promoting the knowledge of healthcare team members in interaction with parents
https://ijn.mums.ac.ir/article_9372_24b160c240c59945fe52af878c968813.pdf
2017-09-01
62
65
10.22038/ijn.2017.19219.1219
Healthcare Team
NICU
Mental Health of Parents
Haydeh
Heidari
1
Faculty of Nursing and Midwifery, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Mohammad
heidarzadeh
heidarzadeh_2013@yahoo.com
2
Department of neonatology, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
1. Noury R, Kelishadi R, Ziaoddini H. Study of common stresses among students in Tehran. J Isfahan Med Sch. 2010; 28(105):1-12.
1
2. Lee SY, Kimble LP. Impaired sleep and well‐being in mothers with low‐birth‐weight infants. J Obstet Gynecol Neonatal Nurs. 2009; 38(6):676-85.
2
3. Walther FJ. Withholding treatment, withdrawing treatment, and palliative care in the neonatal intensive care unit. Early Hum Dev. 2005; 81(12):965-72.
3
4. Hasanpour M, Fooladi M, Awat F. Construction of a questionnaire to assess parental stress in neonatal intensive care unit. Iran J Neonatol. 2015; 6(3):12-6.
4
5. Aliabadi T, Bastani F, Haghani H. Effect of mothers' participation in preterm infants' care in NICU on readmission rates. J Hayat. 2011; 17(2):71-7 (Persian).
5
6. Zelkowitz P, Papageorgiou A, Bardin C, Wang T. Persistent maternal anxiety affects the interaction between mothers and their very low birthweight children at 24 months. Early Hum Dev. 2009; 85(1):51-8.
6
7. Nicolaou M, Glazebrook C. Emotional support for families of sick neonates. Paediatr Child Health. 2008; 18(4):196-9.
7
8. Gavey J. Parental perceptions of neonatal care. J Neonatal Nurs. 2007; 13(5):199-206.
8
9. Bramwell R, Weindling M. Families’ views on ward rounds in neonatal units. Arch Dis Child Fetal Neonatal Ed. 2005; 90(5):F429-31.
9
10. Hollywood M, Hollywood E. The lived experiences of fathers of a premature baby on a neonatal intensive care unit. J Neonatal Nurs. 2011; 17(1):32-40.
10
11. Ambalavanan N, Carlo WA, McDonald SA, Yao Q, Das A, Higgins RD, et al. Identification of extremely premature infants at high risk of rehospitalization. Pediatrics. 2011; 128(5):e1216-25. 12. Parker L. Mothers’ experience of receiving counseling/psychotherapy on a neonatal intensive care unit (NICU). J Neonatal Nurs. 2011; 17(5):182-9.
11
13. Yeasmin S, Rahman KF. Triangulation’ research method as the tool of social science research. BUP J. 2012; 1(1):154-63.
12
14. Ahmadi F, Nasiriani K, Abazari P. Delphi technique: a research tool. Iran J Educ Med Sci. 2008; 8(1):175-85.
13
15. Shin H, White‐Traut R. The conceptual structure of transition to motherhood in the neonatal intensive care unit. J Adv Nurs. 2007; 58(1):90-8.
14
16. Black BP, Holditch‐Davis D, Miles MS. Life course theory as a framework to examine becoming a mother of a medically fragile preterm infant. Res Nurs Health. 2009; 32(1):38-49.
15
17. Kohan M, Borhani F, Abbaszadeh A, Soltan Ahmadi J, Khajehpoor M. Experience of mothers with premature infants in neonatal intensive care unit. J Qual Res Health Sci. 2012; 1(1):41-51 (Persian).
16
18. Rasti M, Aliabadi F, Shafarodi N, Rafiee F, Kalani M. Specification of the educational needs of parents with premature infants admitted to neonatal intensive care unit. J Modern Rehabilit. 2014; 8(4):21-9 (Persian).
17
19. Bastani F, Aliabadi T, Haghani H. The effectiveness of participatory care program in neonatal intensive care unit on state anxiety of mothers of preterm newborns. J Babol Univ Med Sci. 2012; 14(3):59-65 (Persian).
18
20. Alderson P, Hawthorne J, Killen M. Parents’ experiences of sharing neonatal information and decisions: Consent, cost and risk. Soc Sci Med. 2006; 62(6):1319-29.
19
21. Schlittenhart JM. Preparing parents to care for their NICU infant: an evidence based discharge teaching tool. [Master Dissertation]. Washington: Washington State University College of Nursing; 2011.
20
22. Black BP, Holditch‐Davis D, Miles MS. Life course theory as a framework to examine becoming a mother of a medically fragile preterm infant. Res Nurs Health. 2009; 32(1):38-49
21
ORIGINAL_ARTICLE
Effect of Probiotics on Infantile Colic Using the Quadratic Inference Functions
Background: Infantile colic is defined as episodes of extreme and excessive crying due to unknown causes. Various results have been reported regarding the management of colic with probiotics in terms of effectiveness, with no side effects or health risks in the infants. The present study aimed to evaluate the effect of probiotics on the infants with colic using the quadratic inference functions (QIF).Methods: This single-blind, randomized, clinical trial was conducted on 98 infants admitted to the pediatric gastroenterology clinic of Bu Ali Sina Hospital in Sari, Iran. The neonates were diagnosed with infantile colic by a pediatric gastroenterologist. Patients were randomly divided into two groups (49 subjects per each). In the control group, the infants received placebo, and in the case group, the neonates were administrated with BioGaia probiotic oral drops for 21 days. The QIF method was fitted to analyze the influential factors in the improvement of infantile colic.Results: According to the QIF results in data analysis, mean duration of crying had a significant difference between the infants in the case and control groups (P<0.001). Moreover, time (first, second, and third week) was determined as a leading variable in the improvement of infantile colic (P=0.001).Conclusion: According to the results of longitudinal data analysis, use of probiotics in the evolving gut could reduce infantile colic and improve the quality of life in the studied neonates
https://ijn.mums.ac.ir/article_9373_e2123bfdbb4c9d68b78a097be8898c4b.pdf
2017-09-01
66
71
10.22038/ijn.2017.19901.1225
Infantile colic
Probiotics
Quadratic inference functions
Maryam
Tatari
1
Department of Biostatistics, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
jamshid
Yazdani-charati
jamshid.charati@gmail.com
2
Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
LEAD_AUTHOR
Hassan
Karami
karamiha@mums.ac.ir
3
Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Hamed
Rouhanizadeh
4
Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
1. Anabrees J, Indrio F, Paes B, AlFaleh K. Probiotics for infantile colic: a systematic review. BMC Pediatr. 2013; 13:186.
1
2. Brazelton TB. Crying in infancy. Pediatrics. 1962; 29(4):579-88.
2
3. Illingworth RS. Crying in infants and children. Br Med J. 1955; 1(4905):75-8.
3
4. Savino F. Focus on infantile colic. Acta Paediatr. 2007; 96(9):1259-64.
4
5. Wessel MA, Cobb JC, Jackson EB, Harris GS Jr, Detwiler AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics. 1954; 14(5):421-35.
5
6. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007; 119(1):e124-30.
6
7. Barr RG, Kramer MS, Boisjoly C, McVey-White L, Pless IB. Parental diary of infant cry and fuss behaviour. Arch Dis Child. 1988; 63(4):380-7.
7
8. Barr RG. Colic and crying syndromes in infants. Pediatrics. 1998; 102(5 Suppl E):1282-6.
8
9. de Weerth C, Fuentes S, Puylaert P, de Vos WM. Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics. 2013; 131(2):e550-8.
9
10. Lehtonen L, Korvenranta H, Eerola E. Intestinal microflora in colicky and noncolicky infants: bacterial cultures and gas-liquid chromatography. J Pediatr Gastroenterol Nutr. 1994; 19(3):310-4.
10
11. Savino F, Bailo E, Oggero R, Tullio V, Roana J, Carlone N, et al. Bacterial counts of intestinal Lactobacillus species in infants with colic. Pediatr Allergy Immunol. 2005; 16(1):72-5.
11
12. Hotel AC, Cordoba A. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Prevention. 2001; 5(1):1-59.
12
13. Connolly E, Mollstam B. Use of selected lactic acid bacteria for reducing infantile colic. Washington: United States Patent US; 2015.
13
14. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007; 119(1):e124-30.
14
15. Diggle P, Heagerty P, Liang KY, Zeger S. Analysis of longitudinal data. 2nd ed. New York, USA: Oxford University Press; 2002.
15
16. Fitzmaurice G, Davidian M, Verbeke G, Molenberghs G. Longitudinal data analysis. Florida: CRC Press; 2008.
16
17. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986; 73(1):13-22.
17
18. Crowder M. On consistency and inconsistency of estimating equations. Econometr Theor. 1986; 2(3):305-30.
18
19. Crowder M. On the use of a working correlation matrix in using generalized linear models for repeated measures. Biometrika. 1995; 82(2):407-10.
19
20. Qu A, Lindsay BG, Li B. Improving generalised estimating equations using quadratic inference functions. Biometrika. 2000; 87(4):823-36.
20
21. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, doubleblind, placebo-controlled trial. J Pediatr. 2013; 162(2):257-62.
21
22. Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, doubleblind, placebo-controlled trial. Pediatrics. 2010; 126(3):e526-33.
22
23. Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014; 348:g2107.
23
24. Chau K, Lau E, Greenberg S, Jacobson S, YazdaniBrojeni P, Verma N, et al. Probiotics for infantile colic: a randomized, double-blind, placebocontrolled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr. 2015; 166(1):74-8.
24
25. Fallani M, Young D, Scott J, Norin E, Amarri S, Adam R, et al. Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics. J Pediatr Gastroenterol Nutr. 2010; 51(1):77-84.
25
26. Marques TM, Wall R, Ross RP, Fitzgerald GF, Ryan CA, Stanton C. Programming infant gut microbiota: influence of dietary and environmental factors. Curr Opin Biotechnol. 2010; 21(2):149-56.
26
27. Akbarian Rad Z, Haghshenas Mojaveri M, Zahed Pasha Y, Ahmadpour-kacho M, Hajian K, Taghipoor Y. The effect of probiotic lactobacillus reuteri on reducing the period of restlessness in infants with colic. J Babol Univ Med Sci. 2015; 17(5):7-11.
27
ORIGINAL_ARTICLE
A Classic Case of Maple Syrup Urine Disease and a Novel Mutation in the BCKDHA Gene
Background: Maple syrup urine disease (MSUD) is an inherited branched-chain amino acid metabolic disorder caused by the deficiency in the branched-chain alpha-keto acid dehydrogenase (BCKD) complex. In MSUD, elevation of the branched-chain amino acids, such as alpha-keto acid and alpha-hydroxy acid, occurs due to the BCKDC gene deficiency, appearing in the blood, urine, and cerebrospinal fluid, which leads to neurological damage and mental retardation. MSUD phenotypically penetrates due to the mutations in the coding genes of four subunits of the BCKD complex, including the BCKDHA, BCKDHB, DBT, and DLD genes.Case report: We aimed to report the cases of three families whose children were affected by MSUD and presented with symptomatic features during the first week of birth, which were identified by mass spectrometry. DNA study was performed as a diagnosis panel containing four encoded BCKDC subunit genes.Conclusion: In the current study, DNA analysis and phenotypic manifestations indicated a novel mutation of c.143delT, p.L48Rfs*15 in the BCKDHA gene in a homozygous state, which is a causative mutation for the classic MSUD phenotype. Early diagnosis and neonatal screening are recommended for the accurate and effective treatment of this disease
https://ijn.mums.ac.ir/article_9374_32e072f96fdca8beb34d8107c06b4910.pdf
2017-09-01
72
74
10.22038/ijn.2017.18533.1212
BCKD deficiency
DNA mutational analysis
Maple syrup urine disease
Alieh
Mirzaee
1
Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Narges
Pishva
2
Neonatology Research Center, Department of Pediatrics, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Zohreh
Karamizadeh
zkaramizadeh@yahoo.com
3
Department of Pediatric Endocrinology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Jurgen
Kohlhase
jkohlhase@humangenetik-freiburg.de
4
Center for Human Genetics, Freiburg, Germany
AUTHOR
Shahnaz
Purarian
5
Neonatology Research Center, Department of Pediatrics, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Fariba
Hemmati
hemmati@sums.ac.ir
6
Neonatology Research Center, Department of Pediatrics, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mostajab
Razavi
7
Neonatology Research Center, Department of Pediatrics, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Shiva
Nasirabadi
nasirabadi@sums.ac.ir
8
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
1. Harris RA, Zhang B, Goodwin GW, Kuntz MJ, Shimomura Y, Rougraff P, et al. Regulation of the branched-chain alpha-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. Adv Enzyme Regul. 1990; 30:245-63.
1
2. Strauss KA, Puffenberger EG, Morton DH. Maple Syrup urine disease. Washington: GeneReviews; 2013.
2
3. Nellis MM, Kasinski A, Carlson M, Allen R, Schaefer AM, Schwartz EM, et al. Relationship of causative genetic mutations in maple syrup urine disease with their clinical expression. Mol Genet Metab. 2003; 80(1-2):189-95.
3
4. Howell RR; Advisory Committee on Heri Disorders and Genetic Diseases in Newborns and Children. Advisory committee on heri disorders and genetic diseases in newborns and children. Ment Retard Dev Disabil Res Rev. 2006; 12(4):313-5.
4
5. Imtiaz F, Al-Mostafa A, Allam R, Ramzan K, AlTassan N, Tahir AI, et al. Twenty novel mutations in BCKDHA, BCKDHB and DBT genes in a cohort of 52 Saudi Arabian patients with maple syrup urine disease. Mol Genet Metab Rep. 2017; 11:17-23.
5
6. Ellaway CJ, Wilcken B, Christodoulou J. Clinical approach to inborn errors of metabolism presenting in the newborn period. J Paediatr Child Health. 2002; 38(5):511-7.
6
7. Miryounesi M, Ghafouri-Fard S, Goodarzi H, Fardaei M. A new missense mutation in the BCKDHB gene causes the classic form of maple syrup urine disease (MSUD). J Pediatr Endocrinol Metab. 2015; 28(5- 6):673-5.
7
8. Menkes JH, Hurst PL, Craig JM. A new syndrome: progressive familial infantile cerebral dysfunction associated with an unusual urinary substance. Pediatrics. 1954; 14(5):462-7.
8
9. Chuang DT. Maple syrup urine disease (branchedchain ketoaciduria). In: Scriver CR, editor. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill; 2001. P. 1971-2005.
9
10. Gupta D, Bijarnia-Mahay S, Saxena R, Kohli S, DuaPuri R, Verma J, et al. Identification of mutations, genotype-phenotype correlation and prenatal diagnosis of maple syrup urine disease in Indian patients. Eur J Med Genet. 2015; 58(9):471-8.
10
11. Morton DH, Strauss KA, Robinson DL, Puffenberger EG, Kelley RI. Diagnosis and treatment of maple syrup disease: a study of 36 patients. Pediatrics. 2002; 109(6):999-1008.
11
12. Rodriguez-Pombo P, Navarrete R, Merinero B, Gomez-Puertas P, Ugarte M. Mutational spectrum of maple syrup urine disease in Spain. Hum Mutat. 2006; 27(7):715.
12
ORIGINAL_ARTICLE
Subcutaneous Emphysema in a Healthy Child: An Unusual Clue for the Diagnosis of Foreign Body Aspiration
Background: Spontaneous pneumomediastinum (SPM) and subcutaneous emphysema are rare findings in children. Various etiologies have been reported for SPM, such as foreign body aspiration in infants, especially in those aged less than three years. In addition to the complications associated with foreign body aspiration, SPM may also become a life-threatening condition if left untreated. In the present report, we discussed a case of subcutaneous emphysema, pneumothorax, and pneumomediastinum in a 13-month-old infant previously treated for pneumonia.Case report: The infant was initially presented with subcutaneous emphysema of the neck, without respiratory distress following pneumonia. In the chest radiography, mediastinal shift and possible pneumothorax were reported, and a chest tube was inserted as the respiratory condition deteriorated. Emergency bronchoscopy showed a foreign body logged in the left respiratory tract, which was removed. Three days later, the chest tube was detached, and the patient was discharged in healthy conditions within the next two days.Conclusion: Pediatricians constantly need to consider the risk of foreign body aspiration, particularly in the presence of respiratory complications, such as SPM, even in the infants with an unreliable history of foreign body aspiration
https://ijn.mums.ac.ir/article_9375_ea33458c4c3e2eb859697832e89c7ddb.pdf
2017-09-01
75
77
10.22038/ijn.2017.15072.1164
Foreign Bodies
Pneumothorax
Subcutaneous Emphysema
Seied Mohsen
Emami
mohsenemami007@gmail.com
1
Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Mohammad
Shurideh Yazdi
2
Department of Otorhinolaryngology, Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Reza
Jafarzadeh Esfehani
drrezajafarzadeh@yahoo.com
3
Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. Moghadam HM, Jafarzadeh M, Meimaneh A. Foreign body aspiration in children. Iran J Pediatr. 2007; 17(Suppl 2):281-4.
1
2. Anantasit N, Manuyakorn W, Anantasit N, Choong K, Preuthipan A. Spontaneous pneumomediastinum in non-asthmatic children with exercise-induced bronchoconstriction. Am J Case Rep. 2015; 16:648-51.
2
3. Chiu CY, Wong KS, Yao TC, Huang JL. Asthmatic versus non-asthmatic spontaneous pneumomediastinum in children. Asian Pac J Allergy Immunol. 2005; 23(1):19-22.
3
4. Lee CY, Wu CC, Lin CY. Etiologies of spontaneous pneumomediastinum in children in middle Taiwan. Pediatr Pulmonol. 2010; 45(9):869-73.
4
5. Lee CY, Wu CC, Lin CY. Etiologies of spontaneous pneumomediastinum in children of different ages. Pediatr Neonatol. 2009; 50(5):190-5.
5
6. Hu M, Green R, Gungor A. Pneumomediastinum and subcutaneous emphysema from bronchial foreign body aspiration. Am J Otolaryngol. 2013; 34(1):85-8.
6
7. Oncel M, Sunam GS, Ceran S. Tracheobronchial aspiration of foreign bodies and rigid bronchoscopy in children. Pediatr Int. 2012; 54(4):532-5.
7
8. Chapin MM, Rochette LM, Annest JL, Haileyesus T, Conner KA, Smith GA. Nonfatal choking on food among children 14 years or younger in the United States, 2001-2009. Pediatrics. 2013; 132(2):275-81.
8
9. Mirza B, Saleem M, Sheikh A. Broken piece of silicone suction catheter in upper alimentary tract of a neonate. APSP J Case Rep. 2010; 1(1):8.
9
10. Pokharel R, Adhikari P, Bhusal CL, Guragain RP. Oesophageal foreign bodies in children. JNMA J Nepal Med Assoc. 2008; 47(172):186-8.
10
11. Boufersaoui A, Smati L, Benhalla KN, Boukari R, Smail S, Anik K, et al. Foreign body aspiration in children: experience from 2624 patients. Int J Pediatr Otorhinolaryngol. 2013; 77(10):1683-8. 12. Bonin MM. Hamman's syndrome (spontaneous pneumomediastinum) in a parturient: a case report. J Obstet Gynaecol Can. 2006; 28(2):128-31.
11
13. Soysal O, Kuzucu A, Ulutas H. Tracheobronchial foreign body aspiration: a continuing challenge. Otolaryngol Head Neck Surg. 2006; 135(2):223-6.
12
14. Zerella JT, Dimler M, McGill LC, Pippus KJ. Foreign body aspiration in children: value of radiography and complications of bronchoscopy. J Pediatr Surg. 1998; 33(11):1651-4.
13
ORIGINAL_ARTICLE
New Insight into the Effect of Phototherapy on Serum Magnesium Level
Background: Jaundice is one of the most common findings in the neonatal period. In almost all the cases, neonatal jaundice occurs due to the elevated level of unconjugated bilirubin. Evidence is scarce regarding the association between magnesium and bilirubin levels in neonatal hyperbilirubinemia. The present study aimed to investigate serum magnesium levels before and after phototherapy.Methods: This observational study was conducted on 65 neonates with jaundice, who were admitted to 17 Shahrivar Hospital of Rasht, Iran during September 2011-2012. Neonates with total serum bilirubin level of >20 mg/dL underwent phototherapy with 12 lamps. Magnesium levels were measured before and 24 hours after phototherapy. Data analysis was performed in SPSS version 19 using descriptive statistics (mean and standard deviation) and paired t-test at 95% confidence interval, and P-value of less than 0.05 was considered statistically significant.Results: In total, 65 neonates, including 37 boys (56.9%) and 28 girls (43.1%), were enrolled in the study. Mean magnesium level was significantly higher before phototherapy (2.07±0.33) compared to after phototherapy (1.81±0.27) (P<0.0001).Conclusion: According to the results, mean magnesium level was significantly higher before phototherapy compared to after phototherapy. However, physiological characteristics of magnesium were not assessed. It seems that the findings of the present study could lay the groundwork for further investigation in this regard.
https://ijn.mums.ac.ir/article_9380_e982efc4ab304c26caee2c1dc67d5502.pdf
2017-09-01
44
47
10.22038/ijn.2017.20603.1233
Jaundice
neonate
magnesium
Phototherapy
Mohammad Mahdi
Karambin
1
Pediatric Growth Disorders Research Center, Department of Pediatrics, School of Medicine, 17 Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Abtin
Heidarzadeh
heidarzadeh@gums.ac.ir
2
School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Hadi
Norouzi
3
Pediatric Growth Disorders Research Center, Department of Pediatrics, School of Medicine, 17 Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Setila
Dalili
setiladalili1346@gums.ac.ir
4
Pediatric Growth Disorders Research Center, Department of Pediatrics, School of Medicine, 17 Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, Iran
LEAD_AUTHOR
1. Badeli HR, Sharafi R, Sajedi SA. The effect of clofibrate on neonatal hyperbilirubinemia in uncomplicated jaundice. Iranian Journal of Pediatrics. 2008;18(1):20-4.
1
2. Qaisiya MAH. Unconjugated Bilirubin mediated oxidative stress, ER stress, and activation of Nrf2 pathway. 2014.
2
3. Mehta Y, Shitole C, Setia MS. Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis. Iranian journal of pediatrics. 2016;26(1).
3
4. Khosravi N, Aminian A, Taghipour R. Total serum magnesium level in icteric neonates before and after phototherapy. Tehran University of Medical Sciences. 2011;69(7).
4
5. Imamoglu E, Gursoy T, Karatekin G, Ovali F. Effects of antenatal magnesium sulfate treatment on cerebral blood flow velocities in preterm neonates. Journal of Perinatology. 2014;34(3):192-6.
5
6. Dalili S, Rezvany SM, Medghalchi A, Mohammadi H, Dalili H, Mirzanejad M, Gholamnezhad H, Amirhakimi A. Congenital hypothyroidism: a review of the risk factors. Acta Medica Iranica. 2012 Nov 1;50(11):735.
6
7. Karamizadeh Z, Dalili S, Sanei-far H, Karamifard H, Mohammadi H, Amirhakimi G. Does congenital hypothyroidism have different etiologies in Iran?. Iranian journal of pediatrics. 2011 Jun;21(2):188.
7
8. Karamifar H, Dalili S, Karamizadeh Z, Amirhakimi G, Dalili H. Autoimmune polyglandular syndrome type 2: an unusual presentation. Acta Medica Iranica. 2010;48(3):196-7.
8
9. Dalili S, Mohtasham-Amiri Z, Rezvani SM, Dadashi A, Medghalchi A, Hoseini S, Gholami-Nezhad H, Amirhaki A. The prevalence of Iodine Deficiency Disorder in two different populations in Northern Province of Iran: a comparison using different indicators recommended by WHO. Acta Medica Iranica. 2012 Dec 1;50(12):822.
9
10. Ilves P, Kiisk M, Soopold T, Talvik T. Serum total magnesium and ionized calcium concentrations in asphyxiated term newborn infants with hypoxic‐ ischaemic encephalopathy. Acta Paediatrica. 2000;89(6):680-5.
10
11. Engel RR, Elin RJ. Hypermagnesemia from birth asphyxia. The Journal of pediatrics. 1970;77(4):631-7. 12. Sarici SU, Serdar MA, Erdem G, Alpay F. Evaluation of plasma ionized magnesium levels in neonatal hyperbilirubinemia. Pediatric research. 2004;55(2):243-7.
11
13. Okhravi T, Eslami ST, Ahmadi AH, Nassirian H, Najibpour R. Evaluation of Auditory Brain Stems Evoked Response in Newborns With Pathologic Hyperbilirubinemia in Mashhad, Iran. Iranian Red Crescent medical journal. 2015;17(2).
12
14. Naylor DE, Liu H, Niquet J, Wasterlain CG. Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiology of disease. 2013;54:225-38.
13
15. Wong RJ, Stevenson DK, editors. Neonatal hemolysis and risk of bilirubin-induced neurologic dysfunction. Seminars in Fetal and Neonatal Medicine; 2015: Elsevier.
14
16. Imani M, Rezaee-pour M, Mohamdi M, Shiri M, Noroozifar M, Mahmodi N. Study of relationship between total Magnesium and total bilirubin levels in neonates' sera before and after phototherapy. Razi Journal of Medical Sciences. 2012;19(100):54-61.
15
ORIGINAL_ARTICLE
Partial Ectopia Cordis: A Case Report
Background: One-third of all major congenital anomalies are Congenital heart disease (CHD) and Reported CHD prevalence increased over time and in Asian countries is more than western countries. Ectopia cordis (EC) is a rare congenital anomaly with an estimated incidence of 1:100 000 live births in developed countries. EC is characterized by abnormal heart placement outside the thorax, mostly on the thoracoabdominal side. This form is often associated with pentalogy of Cantrell.Case report: We report one cases of the ectopia cordis at the Emam Reza Hospital in Mashhad. In this report, a rare case with incomplete pentalogy of Cantrell are described. It was a boy with a large omphalocele with evisceration of the heart. He had normal capillary refill and responded to stimuli. This patient was a male fetus with ectopia cordis with intracardiac anomalies; a large omphalocele with evisceration of the heart; a hypoplastic sternum and rib cage.Conclusion: Prognosis seems to be poorer in patients with the complete form of pentalogy of Cantrell, EC, and patients with associated anomalies. Intracardial defects do not seem to be a prognostic factor
https://ijn.mums.ac.ir/article_9383_439221eb22268f23b030573fbaff115b.pdf
2017-09-01
78
81
10.22038/ijn.2017.26082.1348
congenital heart disease
Ectopia cordis
neonate
Reza
Saeidi
saeedir@mums.ac.ir
1
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ashraf
Mohammadzadeh
mohamadzadeha@mums.ac.ir
2
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ahmadshah
Farhat
farhatah@mums.ac.ir
3
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammadreza
Naghibi
naghibimr@mums.ac.ir
4
Department of Pediatric and Congenital Cardiology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hassan
Birjandi
5
Department of Pediatric and Congenital Cardiology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Saeedreza
Lotfi
srlotfi2007@yahoo.com
6
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ, et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011; 58(21):2241-7.
1
2. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002; 39(12): 1890-900.
2
3. Leca F, Thibert M, Khoury W, Fermont L, Laborde F, Dumez Y. Extrathoracic heart (ectopia cordis). Report of two cases and review of the literature. Int J Cardiol. 1989; 22(2):221-8.
3
4. Carmi R, Boughman JA. Pentalogy of Cantrell and associated midline anomalies: a possible ventral midline developmental field. Am J Med Genet. 1992; 42(1):90-5.
4
5. Cantrell JR, Haller JA, Ravitch MM. A syndrome of congenital defects involving the abdominal wall, sternum, diaphragm, pericardium, and heart. Surg Gynecol Obstet. 1958; 107(5):602-14.
5
6. Morales JM, Patel SG, Duff JA, Villareal RL, Simpson JW. Ectopia cordis and other midline defects. Ann Thorac Surg. 2000; 70(1):111-4.
6
7. Correa-Rivas MS, Matos-Llovet I, Garcia-Fragoso L. Pentalogy of Cantrell: a case report with pathologic findings. Pediatr Dev Pathol. 2004; 7(6):649-52.
7
8. Polat I, Gul A, Aslan H, Cebeci A, Ozseker B, Caglar B, et al. Prenatal diagnosis of pentalogy of Cantrell in three cases, two with craniorachischisis. J Clin Ultrasound. 2005; 33(6):308-11
8
9. Pivnick EK, Kaufman RA, Velagaleti GV, Gunther WM, Abramovici D. Infant with midline thoracoabdominal schisis and limb defects. Teratology. 1998; 58(5): 205-8.
9
10. Uygur D, Kis S, Sener E, Gunce S, Semerci N. An infant with pentalogy of Cantrell and limb defects diagnosed prenatally. Clin Dysmorphol. 2004; 13(1):57-8.
10
11. Bittmann S, Ulus H, Springer A. Combined pentalogy of Cantrell with tetralogy of Fallot, gallbladder agenesis, and polysplenia: a case report. J Pediatr Surg. 2004; 39(1):107-9
11
12. Toyama WM. Combined congenital defects of the anterior abdominal wall, sternum, diaphragm, pericardium, and heart: a case report and review of the syndrome. Pediatrics. 1972; 50(5):778-92.
12