@article { author = {Abd Almonaem, Eman and Dabour, Ahmed and Elawady, Mona and Abdel Haie, Omima}, title = {Clinco-etiological Profile and Predictors of Outcome of Neonatal Seizures: A Prospective Observational Study from Egypt}, journal = {Iranian Journal of Neonatology}, volume = {13}, number = {2}, pages = {22-31}, year = {2022}, publisher = {Mashhad University of Medical Sciences}, issn = {2251-7510}, eissn = {2322-2158}, doi = {10.22038/ijn.2022.60558.2152}, abstract = {Background: Neonatal seizures are the most prevalent neurological disorders. In Egypt,  the characteristics and neurodevelopmental outcomes of neonatal seizures have not been sufficiently explored. Methods: The present study was conducted on 120 full-term and preterm newborns from  October 2016 and October 2020.  The adverse outcomes of cerebral palsy, mortality, developmental delay, and/or epilepsy have been considered. The associations between adverse outcomes and 13 variables were analyzed. Results: Hypoxic-ischemic encephalopathy (HIE) (34.2%) was the most common etiology for neonatal seizures, followed by intracranial hemorrhage (25.8%). The predominant seizure type was subtle (57.5%), preceded by clonic seizure (16.7%). Moreover,  72 neonates had a normal outcome, 14 (60%) cases had minor functional disabilities, and 27 (22.5%) newborns survived with one or more neurodevelopmental abnormalities (6 cases had cerebral palsy, and 21 newborns had global developmental delay), with a 17.5 % mortality rate. Based on the univariate analysis, 10 variables were associated with an unfavorable outcome; nonetheless, only three variables, namely metabolic acidosis, abnormal cranial ultrasonography findings, and the presence of congenital heart disease, were independent predictors as illustrated by multivariate logistics. Conclusion: As evidenced by the obtained results, HIE and intracranial hemorrhage were the most common causes of neonatal seizures. Perinatal insult, prematurity, seizure onset <24 hours, low Apgar score at 1 min, myoclonic or mixed seizure, the efficacy of the anticonvulsant therapy, abnormal cranial U/S, metabolic acidosis, abnormal electroencephalography (EEG)  pattern, and the presence of congenital heart disease were the most reliable predictors of adverse outcome.    }, keywords = {Infants,neonate,Preterm,Outcome,Seizure}, url = {https://ijn.mums.ac.ir/article_20180.html}, eprint = {https://ijn.mums.ac.ir/article_20180_550be0d5f3efb558fc924e9a73197906.pdf} }