@article { author = {Gulati, Kartika and Vishnoi, Shree and Choudhary, Sandeep and Jora, Rakesh}, title = {Urinary Uric Acid and Creatinine Ratio as a Marker of Perinatal Asphyxia}, journal = {Iranian Journal of Neonatology}, volume = {13}, number = {1}, pages = {18-24}, year = {2022}, publisher = {Mashhad University of Medical Sciences}, issn = {2251-7510}, eissn = {2322-2158}, doi = {10.22038/ijn.2021.55457.2056}, abstract = {Background: Prediction of the outcome of perinatal asphyxia (PA) is important but formidable. Apgar score has a limited role in predicting the outcome. Urinary uric acid and creatinine ratio (UA/Cr) is an early, noninvasive, and cheap biomarker of PA which may predict its morbidity. This study aimed to determine the urinary UA/Cr in neonates with PA, compare it with UA/Cr in non-asphyxiated neonates, and derive the optimum cut-off value of this ratio to label PA.Methods: This observational cross-sectional study was carried out on 100 term neonates appropriate for gestational age (AGA) with PA (cases) and 100 non-asphyxiated term AGA babies (controls). Urine samples were collected within 24 h of life; moreover, uric acid and creatinine levels were determined by an auto-analyzer.Results: The mean urinary UA/Cr ratio was significantly higher in the cases, compared to the controls (3.41±0.68 vs. 1.99±0.23) (P<0.0001). The cut-off value of this ratio to label PA was>2.5 with sensitivity, specificity, positive predictive value, and negative predictive value of 98%. Urinary UA/Cr ratio and cord blood pH were significantly correlated with each other (correlation coefficient r=-0.8951, P<0.001). Moreover, the urinary UA/Cr ratio and 5-min Apgar score were also significantly correlated with each other (r=-0.8806, P<0.001).Conclusion: Urinary UA/Cr ratio is a non-invasive, cheap, and reliable marker for PA with good predictive value in this study.  }, keywords = {cord blood pH,Perinatal asphyxia,Urinary UA/Cr ratio}, url = {https://ijn.mums.ac.ir/article_19235.html}, eprint = {https://ijn.mums.ac.ir/article_19235_7cd7d0f54d31c4610e357d643b36ac0d.pdf} }