TY - JOUR ID - 6147 TI - Etiologies of Prolonged Unconjugated Hyperbilirubinemia in Neonates Admitted to Neonatal Wards JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Kazem Sabzehei, Mohammad AU - Basiri, Behnaz AU - Gohari, Zahra AU - Bazmamoun, Hassan AD - Department of Pediatrics, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran AD - General Practitioner, Hamadan University of Medical Sciences, Hamadan, Iran Y1 - 2015 PY - 2015 VL - 6 IS - 4 SP - 37 EP - 42 KW - Prolonged Unconjugated Hyperbilirubinemia KW - cholestasis KW - neonate DO - 10.22038/ijn.2015.6147 N2 - Background: Jaundice is a common condition among neonates. Prolonged unconjugated hyperbilirubinemia occurs when jaundice persists beyond two weeks in term neonates and three weeks in preterm neonates. This study aimed to determine the etiologies of prolonged unconjugated hyperbilirubinemia in infants admitted to the neonatal ward of Besat Hospital in Hamadan, Iran. Methods: This study was conducted on all infants diagnosed with prolonged unconjugated hyperbilirubinemia during 2007-2012 in the neonatal ward of Besat Hospital in Hamadan, Iran. Demographic characteristics of infants, physical examination and laboratory findings were collected and analyzed to determine the etiologies of neonatal hyperbilirubinemia. Results: In total, 100 infants diagnosed with neonatal hyperbilirubinemia were enrolled in this study, including 49 male and 51 female neonates with mean age of 20±1 days and mean bilirubin level of 17.5±4.0 mg/dL. Main causes of hyperbilirubinemia were urinary tract infection, ABO incompatibility, hypothyroidism and glucose-6-phosphate dehydrogenase deficiency in 14%, 5%, 6% and 5% of neonates, respectively. Moreover, unknown etiologies, such as breastfeeding, were detected in 70% of the studied infants. Conclusion: According to the results of this study, determining the main causes of prolonged unconjugated hyperbilirubinemia in neonates is of paramount importance. In the majority of cases, neonatal hyperbilirubinemia is associated with physiological factors, such as breastfeeding. UR - https://ijn.mums.ac.ir/article_6147.html L1 - https://ijn.mums.ac.ir/article_6147_181fa83f16586f8776ae7958109c8072.pdf ER -