TY - JOUR ID - 2640 TI - Association between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Khaleghparast, Amin AU - Khaleghparast, Sharif AU - Khaleghparast, Hossein AD - M.Sc. of Biology - Genetics, Science and Research Branch of Islamic Azad University, Tehran, Iran AD - B. Eng. of Industrial Engineering, Iran University of Science and Technology (IUST), Tehran, Iran AD - Ph.D. in Public Law, Science and Research Branch of Islamic Azad University, Tehran, Iran Y1 - 2014 PY - 2014 VL - 5 IS - 2 SP - 7 EP - 11 KW - Methylenetetrahydrofolate reductase (NADPH2) KW - Polymorphism (genetic) KW - Spontaneous abortion KW - Thrombophilia DO - 10.22038/ijn.2014.2640 N2 - Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortions and 10 women with at least two live births without a miscarriage, who  referred to Baqiyatallah Hospital and Avicenna Infertility Clinic, were analyzed for MTHFR A1298C polymorphism using PCR-RFLP method. The results obtained via estimating the genotype of each polymorphism were analyzed using SPSS v16.   Results: Thirteen subjects (43.3 %) with RPL and 6 women (20 %) in the control group were heterozygous for MTHFR A1298C polymorphism. C allele frequency in the patient group was higher than the control group (41.7% and 40% for the patient and control groups, respectively). Conclusion: The prevalence of MTHFR A1298C polymorphism was slightly higher in RPL patients compared to the controls. This finding failed to support the relationship between this polymorphism and the increasing risk of RPL in the evaluated Iranian women. UR - https://ijn.mums.ac.ir/article_2640.html L1 - https://ijn.mums.ac.ir/article_2640_e159383851af3419fc92de21972a3ed8.pdf ER -