TY - JOUR ID - 1748 TI - Comparison of the efficacy of Clofibrate with Phenobarbital in decreasing neonatal hyperbilirubinemia JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Ahadi, A AU - Mirzarahimi, M AU - Ahmadabadi, F AU - Tavasoli, A AU - Parvaneh, N AD - Department of Pediatric, Bouali Hospital, School of Medicine , Ardabil University of Medical Sciences, Ardabil, Iran. AD - Department of Pediatric, School of Medicine , Tehran University of Medical Sciences, Tehran, Iran Y1 - 2013 PY - 2013 VL - 4 IS - 3 SP - 13 EP - 19 KW - Clofibrate KW - Phenobarbital KW - hyperbillirubinemia KW - Neonatal Jaundice DO - 10.22038/ijn.2013.1748 N2 - Background: Hyperbilirubinemiais a common problem in newborn infants. It can progress to kernicterus in severe forms, unless an intervention is initiated. The objective of this study was to compare the efficacy of Clofibrate with Phenobarbital in full-term neonates with nonhemolytic jaundice. Methods: this double blind clinical trial study was performed on 60 neonate who were divided randomly in two groups of full-term jaundiced neonates: the clofibrate-treated group (n = 30) and the Phenobarbital group (n = 30). Infants in the clofibrate group received a single oral dose of 100 mg/kg clofibrate while the neonates in the Phenobarbital group received a single oral dose of 5 mg/kg Phenobarbital; both groups received phototherapy. Total serum and direct bilirubin levels were measured at the beginning, 12 and 24 hours after the initiation of treatment. Results: The mean ± SD total serum bilirubin level of the Phenobarbital group and clofibrate groups at enrollment was 17.84 ± 1.017 and 18.04 ±0.852 mg/dL, respectively. The mean ± SD total serum bilirubin in Phenobarbital group and clofibrate groups after 24 hours was 11.11 ± 1.273 and 12.55 ± 1.008 mg/dL, respectively (P = 0.000). After 72 hours of intervention, 25 (83%) neonates of the Phenobarbital group and 23 (76%) of the clofibrate group were discharged with a total serum bilirubin of P = 0.000). No side-effect was observed on serial examination during hospitalization, and on the first and seventh day after discharge. Conclusion: Phenobarbital in the compared with clofibrate results in a faster decline in total serum bilirubin, shorter duration of hospitalization and had no side effects in jaundiced full-term neonates. UR - https://ijn.mums.ac.ir/article_1748.html L1 - https://ijn.mums.ac.ir/article_1748_eb28722b7dfc51a9261b2eb915fa4b8b.pdf ER -