TY - JOUR ID - 15708 TI - Effects of Maternal Immune System Status on Neonate’s Immune System JO - Iranian Journal of Neonatology JA - IJN LA - en SN - 2251-7510 AU - Khosravi, Mohammad AU - Khazaeel, Kaveh AU - Khaksary Mahabady, Mahmoud AU - Behmanesh, Mohammad Amin AD - Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz,Ahvaz, Iran AD - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz,Ahvaz, Iran AD - Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz ,Iran. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran AD - Department of Histology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran Y1 - 2020 PY - 2020 VL - 11 IS - 3 SP - 31 EP - 37 KW - Immune response KW - Maternal KW - neonate KW - Rat DO - 10.22038/ijn.2020.41505.1682 N2 - Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate’s humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study.Results: The spleen’s mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P≤0.05) in the anti-sheep red blood cells antibody titer.Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate’s immune responses, spleen, liver, and thymus development. UR - https://ijn.mums.ac.ir/article_15708.html L1 - https://ijn.mums.ac.ir/article_15708_f6ddae5637b0fbf69c7ca3f66d6b091a.pdf ER -