Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Prevalence of Sensorineural Hearing Loss in Patients with Congenital Hypothyroidism in Qazvin, Iran (2015)
1
5
EN
Fatemeh
Saffari
0000-0002-8366-5205
Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
drfa_saffari@yahoo.com
Mohammad Hassan
Nikpendar
Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
drababaf@gmail.com
Neda
Esmailzadehha
Student Research Committee, School of Health Branch, Iran University of Medical Sciences, Tehran, Iran
dresmailzadehha_neda@yahoo.com
Sonia
Oveisi
Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
soveisi@razi.tums.ac.ir
Ali
Homaei
Shahid Beheshti University of Medical Sciences, Tehran, Iran
ali.homaei2012@gmail.com
Shabnam
Jalilolghadr
0000-0002-8140-9283
Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
shabnam_jalilolgadr@yahoo.com
10.22038/ijn.2018.26901.1356
<strong><em>Background:</em></strong> Congenital hypothyroidism increases the risk of sensorineural hearing loss (SNHL). Children with hearing impairment are prone to communication disorders. The present study aimed to determine the prevalence of SNHL in patients with congenital hypothyroidism in Qazvin, Iran.<br /> <strong><em>Methods:</em></strong> This cross-sectional study was conducted on children with transient or permanent congenital hypothyroidism in Qazvin province, Iran in 2015. The patients were identified through national neonatal thyroid screening during 2006-2011. Hearing loss was assessed using the auditory brainstem response (ABR). A minimum of three years of follow-up was carried out to determine the permanency of congenital hypothyroidism. Data analysis was performed using t-test and Chi-square.<br /> <strong><em>Results</em></strong><strong>:</strong> In total, 155 children with congenital hypothyroidism were enrolled in the study, including 67 females (43.2%) and 151 cases of primary congenital hypothyroidism. Abnormal ABR was observed in 10 patients (6.45%) (6.6% in permanent cases and 6.1% in transient cases), seven of whom were female. In addition, eight patients with primary congenital hypothyroidism and two patients with central congenital hypothyroidism had abnormal ABR (P=0.165). Mean primary thyroid-stimulating hormone levels (52.45±39.91 versus 38.23±28.03 IU/l; P=0.355) and T4 (6.07±4.33 versus 6.98±3.40 µg/dl; P=0.307) had no significant differences in the children with SNHL and other patients. At the beginning of the treatment, mean age of the children with SNHL was 28.50±22.13 days, while it was 28.87±30.34 days in the other subjects (P=0.909).<br /> <strong><em>Conclusion:</em></strong> According to the results, the prevalence of SNHL was lower in the patients with congenital hypothyroidism compared to the reported rates in other countries. However, the assessment of hearing loss should be prioritized in the infants with congenital hypothyroidism.
Communication disorders,Congenital hypothyroidism,Diagnosis,Mass screening,Sensorineural hearing loss
https://ijn.mums.ac.ir/article_11503.html
https://ijn.mums.ac.ir/article_11503_e13450d4accd667897153bdfcdab2abf.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Effectiveness of Kangaroo Mother Care in the Management of Twin Low-Birth-Weight Neonates: A Non-Randomized, Open, Controlled Trial
6
13
EN
Yaswanth
Gonuguntla
0000-0002-9881-6416
Department of Pediatrics, Jawaharlal Nehru Medical College, Nehru Nagar, Belgaum Karnataka, India
dr.yaswanth2010@gmail.com
Tanmaya
Metgud
0000-0003-1685-3772
Department of Pediatrics, Jawaharlal Nehru Medical College, Nehru Nagar, Belgaum, Karnataka, India.
tanmayametgud@gmail.com
N. S.
Mahantshetti
Department of Pediatrics, Jawaharlal Nehru Medical College, Nehru Nagar, Belgaum Karnataka, India
10.22038/ijn.2018.29036.1391
<strong><em>Background:</em></strong> Twin low-birth-weight (LBW) neonates are exposed to the increased risk of mortality and morbidity due to poor prognosis. The present study aimed to evaluate the effectiveness of kangaroo mother care (KMC) in the management of twin LBW neonates.<br /> <strong><em>Methods:</em></strong> This prospective, observational study was conducted on 150 neonates with the birth weight of <2,200 grams during one year. The neonates were divided into three groups of KMC I (receiving KMC; n=60), KMC II (singletons receiving KMC; n=30), and twins receiving conventional method of care (CMC; n=60). The neonates were assessed before and after the intervention in terms of thermoregulation, growth rate, breastfeeding, and self-confidence of the mothers managing the neonates based on a Likert scale. The subjects were followed-up until reaching the target weight of 2.5 kilograms. Data analysis was performed in SPSS software 20.0.<br /> <strong><em>Results</em></strong><strong><em>:</em></strong> Neonates in the KMC groups were euthermic. Mean weight gain increased in KMC I (13.48±1.76 g/kg/day) and KMC II (13.15±1.66 g/kg/day) compared to the CMC group (11.99±1.20 g/kg/day) (P=0.0014). Length (43.55±1.90, 43.86±1.34, and 43.40 ± 1.94 cm, respectively) (P=0.567) and head circumference (31.13±0.77, 31.43±1.15, and 31.30±1.07 cm, respectively (P=0.498) were comparable in the CMC, KMC I, and KMC II groups. Early initiation of breastfeeding was observed in KMC I (2.68±1.55 days) and KMC II (2.97±2.88 days) compared to the CMC group (5.17±2.65 days) (P<0.0006). In addition, the mothers’ self-confidence to manage the LBW neonates was significantly higher in both the KMC groups compared to the CMC group (P<0.0001).<br /> <strong><em>Conclusion:</em></strong> According to the results, KMC is a cost-effective, humane intervention, which could effectively alleviate the burden of managing twin and singleton LBW neonates in low-income countries.
Kangaroo mother care,Low birth weight,Neonates,Singletons,Twins
https://ijn.mums.ac.ir/article_11504.html
https://ijn.mums.ac.ir/article_11504_7aa3953d1cf3a7890004e5a3cfba97c0.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Maternal Recto-Vaginal Organisms and Surface Skin Colonization in Infants
14
19
EN
Zahra
Akbarian Rad
0000-0003-0668-1137
Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran
z.akbarian@mubabol.ac.ir
Seddigheh
Esmaeilzadeh
Infertility and Health Reproductive Research Center, Babol University of Medical Sciences, Babol, Iran
Mohsen
Haghshenas Mojaveri
Clinical Research Development Unit of Rohani Hospital, Babol University of Medical Sciences, Babol, Iran
Mojgan
Bagherzadeh
Babol University of Medical Sciences, Babol, Iran
mojganbagherzadeh@gmail.com
Mostafa
Javanian
0000-0002-2771-4578
6Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran
7 Department of Statistic and Epidemiology, Babol University of Medical Sciences, Babol, Iran.
mjavanian@gmail.com
10.22038/ijn.2018.28024.1375
<strong><em>Background:</em></strong> Early-onset sepsis is a common cause of neonatal mortality and mainly occurs due to the colonized microorganisms in the maternal recto-vaginal area. The present study aimed to evaluate the effects of maternal risk factors on recto-vaginal colonization and transmission rate of micro-flora from mothers to infants.<br /> <strong><em>Methods:</em></strong> Upon admission, two samples were obtained from the distal third of vagina and rectum of mothers using sterile cotton swabs. Six hours after birth, sterile swab samples were collected from the external ear canal, nose, groin, and umbilicus of the infants. The samples were transferred to the laboratory on Stuart transport medium. Afterwards, the samples were transferred to standard culture media within 24 hours. Transmission rate of organisms was calculated based on the maternal and neonatal findings.<br /> <strong><em>Results</em></strong><strong>:</strong> In total, 13 bacterial and fungal species were detected in the samples. <em>Escherichia coli</em> was the most frequent gram-negative organism in the rectal and vaginal cultures (29.34%) with the transmission rate of 49.4% to the infants. Infants of the mothers with premature rupture of membranes (PROM) had significant <em>Enterobacter cloacae</em>colonization. In addition, frequency of <em>Candida albicans</em> was higher in the mothers with gestational hypertension (21.4%) compared to non-hypertensive women (4.9%). Infants requiring advanced cardiopulmonary resuscitation (CPR) had significantly higher<em> E. coli</em> colonization (45.1%) compared to those not needing CPR (27.6%).<br /> <strong><em>Conclusion:</em></strong> According to the results, gram-negative bacteria (<em>E. coli</em> and <em>Enterobacteriaceae</em> ) were the most frequent organisms in the maternal recto-vaginal area and body surface of the neonates in our clinical setting. Therefore, chemoprophylaxis is recommended for these organisms in prolonged PROM.<br /> <em> </em>
Communication disorders,Congenital hypothyroidism,Diagnosis,Mass screening,Sensorineural hearing loss
https://ijn.mums.ac.ir/article_11507.html
https://ijn.mums.ac.ir/article_11507_776f481692bb7c4c1860e4580b8dcc1d.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Impact of Combined Oral Zinc Sulfate and Phototherapy on Serum Bilirubin Levels in the Term Neonates with Jaundice
20
25
EN
Shourangiz
Beiranvand
0000-0002-3110-3323
School of Nursing, Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
shorangizbiranvand@yahoo.com
Reza
Hosseinabadi
0000-0001-7409-6779
Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
reza_hosseinabadi@yahoo.com
Majid
Firouzi
Department of Pediatrics, Lorestan University of Medical Sciences, Khorramabad, Iran
Mohammad
Almasian
School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
almasian2@gmail.com
Khatereh
Anbari
0000-0002-6468-3053
Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
dr.anbari@gmail.com
10.22038/ijn.2018.27173.1361
<strong><em>Background:</em></strong> Jaundice is a physiological phenomenon and common disorder in the neonatal period. Jaundice occurs in the first month of life in 60% of term and 80% of preterm neonates, leading to hospitalization. The present study aimed to determine the effect of oral zinc sulfate on serum bilirubin levels in the neonates undergoing phototherapy.<br /> <strong><em>Methods:</em></strong> This randomized clinical trial was conducted on 90 normal term neonates aged more than 24 hours with the total serum bilirubin of 14-19 mg/dc, who were admitted to the neonatal ward of Shahid Madani Hospital in Khorramabad, Iran for uncomplicated jaundice. Based on the inclusion criteria, these infants were divided into two groups of experimental (n=45) and control (n=45) via block random allocation. Infants in the control group only received phototherapy, and the experimental group received oral sulfate zinc (5 mg b.i.d.) in addition to phototherapy. Total serum bilirubin levels were measured upon admission and 24 and 48 hours after admission.<br /> <strong><em>Results</em></strong><strong>:</strong> No significant differences were observed between the experimental and control groups in terms of age, gender, birth weight, hemoglobin level, reticulocyte percentage, and total serum bilirubin at the beginning of the study (P>0.05). Comparison of the bilirubin levels using repeated measures ANOVA at different times indicated significant differences in the neonatal serum values and blood cell counts between the study groups (time effect) (F=598.078; P<0.001). However, no significant difference was observed difference in the bilirubin levels between the experimental and control groups (group effect) (F=0.103; P=0.749). Additionally, the interactive time-group effect was not statistically significant.<br /> <strong><em>Conclusion:</em></strong> Although oral zinc salts inhibit the enterohepatic circulation of bilirubin, they might not be effective in the treatment of physiological jaundice in neonates. Due to the lack of human studies on the effect of oral zinc salts, further investigation is recommended.<br /> <em> </em>
Hyperbilirubinemia,Jaundice,Term neonates,Zinc sulfate
https://ijn.mums.ac.ir/article_11517.html
https://ijn.mums.ac.ir/article_11517_2a9b7bbdd7b8b3ab59359e559539e3b6.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Breastfeeding Self-Efficacy as a Predictor of Exclusive Breastfeeding: A Clinical Trial
26
34
EN
Mamak
Shariat
0000-0002-7547-8004
Institute of Family Health, Maternal, Fetal, and Neonatal Health Research Center, Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
mshariat@tums.ac.ir
Nasrin
Abedinia
0000-0002-3337-7109
Institute of Family Health, Maternal, Fetal and Neonatal Health Research Center, Val-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
nasrin.abedinia@gmail.com
Ahmad Ali
Noorbala
Department of Psychiatry, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Jayran
Zebardast
Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Sima
Moradi
Lactation Counseling and Training Center, Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Nasrin
Shahmohammadian
Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Akram
Karimi
General Practitioner, Health Center of Akbar Abad, Tehran, Iran
Mojgan
Abbasi
Institute of Family Health, Maternal, Fetal, and Neonatal Health Research Center, Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
10.22038/ijn.2018.24694.1316
<strong><em>Background:</em></strong> "Exclusive breastfeeding (EBF) is globally promoted as the ideal method of infant feeding during the first six months of life due to its health benefits to both the mother and child" (1). The aim of this study was to examine the effect of the interventions leading to increased awareness, knowledge, and self-efficacy regarding exclusive breastfeeding and duration of breastfeeding.<br /> <strong><em>Methods:</em></strong> This clinical trial was conducted on 129 pregnant women before the gestational age of 21 weeks and 6 days referring to Vali-e-Asr Hospital in Tehran, Iran. The study population was selected using the convenience sampling method. The participants were randomly assigned into two groups of intervention (n=64) and control (n=65). The mothers in the intervention group received one training session on breastfeeding self-efficacy, as well as training and audio packages regarding postpartum care and relationship with neonates. In addition, the women who suffered from anxiety, stress, or depression were provided with psychotherapies. The data collection instruments included the Self-Efficacy Scale, Edinburgh Postnatal Depression Scale, and Spielberger's State-Trait Anxiety Inventory.<br /> <strong><em>Results</em></strong><strong>:</strong> Exclusive breastfeeding was higher in the intervention group than in the control group during the first six months postpartum (P=0.015). The follow-up study showed that there were higher rates of breastfeeding for the two-year-old children in the intervention group (P<0.001). In addition, self-efficacy was associated with anxiety and depression.<br /> <strong><em>Conclusion:</em></strong> As the findings indicated, psychological intervention aimed at increasing self-efficacy had a significant impact on maternal breastfeeding self-efficacy and duration of breastfeeding.
Exclusive breastfeeding,Psychiatric disorder,Psychological therapies,Self-efficacy
https://ijn.mums.ac.ir/article_11518.html
https://ijn.mums.ac.ir/article_11518_84a0cfe2a066124176a55c85872d617e.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Correlations of Handling Procedures and Sleep Patterns of the Infants Admitted to the Neonatal Intensive Care Unit
35
41
EN
zahra
godarzi
0000-0002-4198-6879
Department of Pediatric and Neonatal Intensive Care Faculty of Nursing & Midwifery Tehran Univesity of Medical Scienses, Tehran/Iran
godarzi.zahra@gmail.com
Khadijeh
Zarei
Department of Pediatrics and NICU Nursing Education, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
Mamak
Shariat
0000-0002-7547-8004
Maternal & Child Health Specialist, Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
mshariat@tums.ac.ir
khosro
Sadeghniat
Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
Niko
Nikafs
Maternal, Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
Hamideh
Sepaseh
Logman Hospital Shahid Beheshti University of Medical Sciences, Tehran, Iran
10.22038/ijn.2018.23783.1299
<strong><em>Background:</em></strong> The present study aimed to assess handling procedures and their effects on the sleep-wake time in the preterm infants admitted to the neonatal intensive care unit (NICU).<br /> <strong><em>Methods:</em></strong> This observationalcross-sectional study was conducted in the NICU ofVali-e-Asr Teaching Hospital affiliated to Tehran University of Medical Sciences (TUMS), Iran in 2016. Sample population consisted of 15 preterm infants, and duration of the handling procedures was considered to be 15 days or 360 hours. Handling procedures were recorded within an uninterrupted 24-hours period. Sleep patterns of the infants were checked at 8 AM-8 PM using Als’ behavioral states scale of Newborn Individualized Developmental Care and Assessment Program (NIDCAP sheet).<br /> <strong><em>Results</em></strong><strong>:</strong> Mean frequency of the handling procedures during 24 hours was 59.93±15.86. Within 12 hours, mean frequency of the care/monitoring, therapeutic, and supportive procedures was 41.20±12.14 during the day, while it was 18.73±5.43 at night. Mean handling procedures in minutes was 18.73±5.43 for care/monitoring procedures, 13.60±13.28for therapeutic procedures, and 76.21±93.08 for supportive procedures. In therapeutic and care/monitoring handling procedures, sleep duration decreased in the infants, while it increased in the supportive procedure. Mean total oxygen saturation was 94.80±2.81, and mean total heart rate was 147.30±16.76.<br /> <strong><em>Conclusion:</em></strong> According to the results, supportive handling could increase sleep duration in preterm infants. Therefore, it is recommended that this technique be applied for the comfort of preterm infants in the presence of parents.
Handling,Neonatal intensive care unit (NICU),Preterm infant,Sleep
https://ijn.mums.ac.ir/article_11520.html
https://ijn.mums.ac.ir/article_11520_44da540483fa6dfc3e3d34fdf69ee1be.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Effect of Blood Sampling Site on the Changes in the Physiological Indices of Preterm Infants: A Crossover Clinical Trial
42
48
EN
Zahra
Pourashoori
0000-0002-6104-2269
Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Iran
zpourashori@yahoo.com
Keyvan
Mirnia
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Fatemeh
Ghorbani
0000-0002-2807-6344
Department of Pediatric Nursing, Tabriz University of Medical Sciences, Tabriz, Iran
f.ghorbani2006@gmail.com
Abdolrasoul
Safaiyan
Road Traffic Center, Department of Biostatistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran
arsafaiyan@gmail.com
Mohammad Ali
Nematzadeh
Nurse in Asadabadi Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
mnemat299@yahoo.com
Mohammad
Arshadi Bostanabad
0000-0001-5091-9590
Department of Pediatric Nursing, Tabriz University of Medical Sciences, Tabriz, Iran
arshadi_m@yahoo.com
10.22038/ijn.2018.27487.1366
<strong><em>Background:</em></strong> Venipuncture is one of the most painful and common interventions in Neonatal ward. A preterm infant can not cope long-lasting physiologic stresses; therefore, the pain caused by blood sampling may change the infant’s physiologic responses to the stress. This present study aim is to investigated and compare physiologic changes (pulse rate and oxygen saturation) in two sites of blood sampling in preterm infants.<br /> <strong><em>Methods:</em></strong> This crossover clinical trial was performed on 105 preterm infants of 28-32 weeks’ gestational age in Tabriz Alzahra teaching hospital. Infants were selected through convenient sampling method and were allocated to two groups using doubleblock. In group 1(53 infants): the blood was first drawn from head veins and after a 24-hour interval, it was repeated at the back of the hand. In group 2 (52 infants): this procedure was implemented conversely.Infants' demographic variables and physiologic values(pulse rate and oxygen saturation) were measured in both sampling methods. The data were analyzed using SPSS.13, Paired t-test and Friedman test. P˂ 0.05 was considered as significant.<br /> <strong><em>Results</em></strong><strong>:</strong> There was a significant difference between two groups considering infants’ age and various assessing timeswhen pulse rate changeswere investigated (Pv≤0.001);however, no significant difference was found regarding toblood sampling sites(head & back of the hand)).In addition, no significant difference was found in oxygen saturation changes in terms of age and blood sampling sites(head& back of the hand); however, these changes were significantly different in terms of different blood sampling times (PvTIME≤ 0.001).<br /> <strong><em>Conclusion:</em></strong> Pulse rate and oxygen saturation changingwas not significantly different in two methods of blood sampling from head veins and back of the hand veins in preterm infants; therefore, both sites can be used for drawing blood. During blood sampling in preterm infants of lower gestational age, the rate of pulse increased;however, the level of oxygen saturation decreased. As a result, since infants of lower gestational age are more vulnerable, drawing blood is required to be performed at the first attempt and no more attempts should be made
Blood,Hand,Head,Infant,Physiologic,Venipuncture
https://ijn.mums.ac.ir/article_11523.html
https://ijn.mums.ac.ir/article_11523_ba751c9060431a44aca9681c91e28785.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Effect of Protein Supplementation on the Growth of Infants Weighing Less than 1,000 Grams Hospitalized on the Neonatal Intensive Care Unit of Akbar Abadi Hospital in Tehran, Iran (2015-2016)
49
56
EN
Mandana
Kashaki
0000-0002-5070-8600
Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
kashakimd@gmail.com
Ali
Mazouri
Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
mazouriali@gmail.com
Arash
Bordbar
Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
Maryam
Saboute
0000-0003-2146-3752
Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
saboutem@yahoo.com
zahra
behnamfar
0000-0002-8923-836X
Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran.
z_behnamfar@yahoo.com
Atefeh
Talebi
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
atalebi@yahoo.com
10.22038/ijn.2018.27558.1368
<strong><em>Background:</em></strong> Breast milk provides adequate protein to facilitate growth for term infants. Appropriate nutrition is necessary for the growth of preterm infants. Extremely-low-birth-weight (ELBW) infants require higher protein intakes to achieve adequate growth.<br /> The present study aimed to evaluate the effect of protein supplements on the physical growth of infants weighing less than 1,000 grams through the serial measurement of their anthropometric indices (weight, height, and head circumference) during admission at the neonatal intensive care unit (NICU).<br /> <strong><em>Methods:</em></strong> This triple-blind, randomized clinical trial was conducted on 64 infants weighing less than 1,000 grams, who were admitted to the NICU of Akbar Abadi Hospital in Tehran, Iran during 2015-2016. Data on the daily nutritional intake of the subjects were recorded until discharge from the hospital. Data analysis was performed in SPSS version 24.<br /> <strong><em>Results</em></strong><strong>:</strong> In total, 63 infants were enrolled in the study. Mean daily weight gain of the infants was 55.92±36.90 and 30.80±13.91 grams in the case and control groups, respectively (P=0.001). Mean weekly linear growth in the case and control groups was 0.77±0.67 and 0.76±0.29 centimeter, respectively (P=0.939). Mean weekly head circumference growth in the case and control groups was 0.51±0.10 and 0.34±0.16 centimeter, respectively (P<0.001).<br /> <strong><em>Conclusion:</em></strong> According to the results, protein therapy in the premature, extremely-low-birth-weight (ELBW) infants could improve the rate of weight gain and head circumference growth. Given the importance of weight gain in premature ELBW infants, it is recommended that protein therapy be employed in these newborns. Various studies have denoted the few side-effects of protein therapy, which indicates the safety of this method to resolve the lack of weight gain in these infants.
ELBW infants,Growth,Protein
https://ijn.mums.ac.ir/article_11524.html
https://ijn.mums.ac.ir/article_11524_ff2426f4487546edad50c6cef7c75db0.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Effect of the Sound of the Holy Quran on the Physiological Responses and Pain Caused by Blood Sampling from the Heels of Hospitalized Neonates at the Neonatal Intensive Care Unit
57
63
EN
Maryam
Marofi
0000-0002-0993-2774
MSc in Nursing, School of Nursing and Midwifery, Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
marofi@nm.mui.ac.ir
Fatemeh
Abedini
MSc in Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Maryam
Shirazi
0000-0003-0116-8772
School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
m_shirazi@nm.mui.ac.ir
Zohreh
Badiei
PhD, Department of Pediatrics, School of Medicine, Child Growth and Development Center, Isfahan University of Medical Sciences, Isfahan, Iran
Zahra
Baghersad
MSc in Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
Farzaneh
Nikobakht
MSc in Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
10.22038/ijn.2018.28102.1376
<strong><em>Background:</em></strong> Invasive procedures could change the physiological responses of neonates. The present study aimed to evaluate the effect of the sound of the Holy Quran on the physiological responses and pain caused by heel stick blood sampling in neonates.<br /> <strong><em>Methods:</em></strong> This three-stage, two-group, clinical trial was conducted on 72 hospitalized term neonates at the neonatal intensive care unit (NICU) of Al-Zahra Hospital in Isfahan, Iran during 2013-2014. Subjects were selected via simple random sampling and allocated to two groups of intervention and control. Data were collected using a questionnaire consisting of the demographic characteristics, physiological responses, and pain of the neonates. Data analysis was performed in SPSS version 18.<br /> <strong><em>Results</em></strong><strong><em>:</em></strong> Post-hoc LSD test indicated that the mean respiratory and heart rates were significantly higher in the intervention group (sound of the Holy Quran) during blood sampling compared to before and three minutes after the procedure (P<0.001). In addition, the results of post-hoc LSD test showed that oxygen saturation was significantly lower during blood sampling compared to before (P=0.001) and three minutes after the procedure (P=0.002) in the intervention group. However, the difference was not statistically significant (P=0.54).<br /> <strong><em>Conclusion:</em></strong> According to the results, playing the sound of the Holy Quran during painful procedures could positively influence the stabilization of the physiological responses in the hospitalized neonates, thereby reducing their exposure to the risk of decreased oxygen saturation and the associated complications.<br /> <em> </em>
Holy quran,Intensive Care Unit,neonate,Physiological responses
https://ijn.mums.ac.ir/article_11525.html
https://ijn.mums.ac.ir/article_11525_f93a8a70ddf2e81991c894d28619e529.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Therapeutic Potency of Cord Blood Stem Cells in Patients with Cerebral Palsy: A Systemic Literature Review
64
69
EN
Ahmadshah
Farhat
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
farhatah@mums.ac.ir
Anahita
Majma
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
majmaaa911@mums.ac.ir
Farah
Ashrafzadeh
Qaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Javad
Akhondian
Qaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ashraf
Mohammadzadeh
0000-0001-2345-6789
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
mohamadzadeha@mums.ac.ir
ali
ghasemi
Department of Oncology and Stem Cell, Mashhad University of Medical Sciences, Mashhad, Iran. .
ghasemial@mums.ac.ir
10.22038/ijn.2018.29711.1402
<strong><em>Background:</em></strong> The main objective of this study was to systematically review the reported potency of cord blood stem cells in treating patients with neurological disorders such as cerebral palsy. <br /> <strong><em>Methods:</em></strong> PubMed, Scopus, and Cochrane were searched thoroughly on September 2016 using the following search terms: “Umbilical cord blood stem cells” AND “development” AND “cerebral palsy” to find articles in which the umbilical cord blood stem cells were used to treat patients with cerebral palsy. Only English-language studies conducted on patients with cerebral palsy were included and used for data extraction. <br /> <strong><em>Results</em></strong><strong>:</strong> Of a total of 77 articles found in the database search, only 6 papers fully met the inclusion criteria. The results showed successful treatment with cord blood stem cells in 165 patients with cerebral palsy.<br /> <strong><em>Conclusion:</em></strong> Studies on both human and animal models have shown the beneficial effects of stem cell therapy in the treatment of various neurological diseases. Data presented that cord blood stem cells can be considered as a main therapeutic strategy to treat patients with cerebral palsy. In addition, it is shown that cord blood stem cells significantly improve motor function, cognition, and memory in patients with cerebral palsy.
Cerebral palsy,Stem cell therapy,Umbilical cord blood cells
https://ijn.mums.ac.ir/article_11526.html
https://ijn.mums.ac.ir/article_11526_d8a8fbcb03f5bb8131ec1e3404db2d8b.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Relationship between Hypnosis for Pain Management in Labor and Adverse Neonatal Outcomes: A Systematic Review
70
75
EN
Majid
Khadem Rezaiyan
0000-0003-2698-176X
Community Medicine Specialist, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
khademrm921@mums.ac.ir
Reza
Saeidi
0000-0002-0075-5732
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
saeedir@mums.ac.ir
Masumeh
Ghazanfarpour
Razi School of Nursing and Midwifery, Kerman University of Medical Science, Kerman, Iran
Mohamadghasem
Etemadi Mashhadi
Anesthesiologist, Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
mona
najaf najafi
0000-0002-2646-7720
community medicine
najafnm@mums.ac.ir
10.22038/ijn.2018.30047.1407
<strong><em>Background:</em></strong> Many techniques have been proposed to relieve labor pain, one of which is hypnotherapy, which can be defined as the usage of hypnosis during labor to alleviate pain or anxiety. The aim of this systematic review was to examine the possible relationship between hypnosis and neonatal outcomes based on the available reports.<br /> <strong><em>Methods:</em></strong> Major databases, including PubMed, Web of Science, Scopus, and Cochrane CENTRAL, were systematically searched up to February 6, 2018. In the next stage, the titles and abstracts of the retrieved articles were reviewed to identify the relevant studies. The quality of the studies was evaluated using the Jadad scale. Study appraisal and data extraction were carried out by one of the authors, and then double-checked by another researcher. Finally, the search process resulted in the inclusion of 10 trials.<br /> <strong><em>Results</em></strong><strong>:</strong> Based on eight studies, hypnosis for pain management during labor had no effect on Apgar score in neonates. No significant difference was reported between hypnosis and non-hypnosis groups in terms of the number of admission to the Neonatal Intensive Care Unit (NICU). Furthermore, the short-term effect of hypnosis on the continuation of exclusive breastfeeding was indicated in three studies. However, the duration of neonatal admission to nursery or NICU was not reported in any of the studies. Only one study reported that there was no significant difference between hypnosis and control groups concerning the frequency of hospital readmission.<br /> <strong><em>Conclusion:</em></strong> Based on the evidence reported in the literature, it could be concluded that hypnosis can be regarded as a safe approach for pain management during the labor. Moreover, this intervention did not show to exert any adverse effects on neonatal health status.
Apgar score,Hypnosis,Labor pain,Neonatal outcome
https://ijn.mums.ac.ir/article_11527.html
https://ijn.mums.ac.ir/article_11527_717d1eaf88191d0878702b3b39325b14.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Reciprocal Effects of Multiple Sclerosis, Childbirth, and Postpartum
76
82
EN
Mahboubeh
Valiani
0000-0003-3955-4628
Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
valiani@nm.mui.ac.ir
Freshteh
Ashtari
Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
f_ashtari@med.mui.ac.ir
fatemeh
mokhtari
0000-0002-8293-1831
Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
f.mokhtary@ymail.com
10.22038/ijn.2018.28749.1384
<strong><em>Background:</em></strong> Multiple sclerosis (MS) is a chronic disease of the central nervous system, which is more prevalent in women than men. Considering the onset of MS in the women of reproductive age, the present study aimed to investigate the reciprocal effects of MS, childbirth, and postpartum.<br /> <strong><em>Methods:</em></strong> This retrospective, descriptive-analytical study was conducted on 110 women diagnosed with MS during pregnancy in Isfahan, Iran during 2016-2017. The subjects had become pregnant within the recent decade and were selected via random sampling. Data on the demographic characteristics, pregnancy and postpartum profile, medicinal changes, symptoms, severity, and attack rates of MS were collected. Data analysis was performed in SPSS version 16.<br /> <strong><em>Results</em></strong><strong><em>:</em></strong> Mean age at the completion of pregnancy was 38.13 weeks. In total, 63.9% of the deliveries were accomplished via caesarean and 35.1% of the women had natural vaginal delivery. Mean pain intensity at childbirth was 7.11. No symptoms of MS attacks were reported in 86.7% of the subjects during delivery and 90.7% of the women within the first six weeks of childbirth. All the neonates were healthy, and 66.3% of the mothers had no psychological and emotional postpartum complications. In addition, 40.3% of the women started their MS medication within the first six months after childbirth.<br /> <strong><em>Conclusion:</em></strong> According to the results, MS was not associated with the increased risk of preterm or post-term delivery. Moreover, it did not increase the severity of labor pain in the mothers. On the other hand, the rate of elective cesarean section was higher in MS patients compared to the general population, especially in the cases with disabilities. According to the Friedman curve, MS caused no substantial changes in the progression of delivery, and most of the neonates were healthy males with an Apgar score of 10. However, the severity of limb numbness and blurred vision increased in the women with MS in the postpartum period.
Childbirth,Multiple Sclerosis,Postpartum,pregnancy
https://ijn.mums.ac.ir/article_11528.html
https://ijn.mums.ac.ir/article_11528_54661df5a82a5ca63450081624800b1f.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Co-existence of Two Rare Conditions: Oculo-Palato-Cerebral Syndrome and Congenital Chylothorax
83
87
EN
Seyhan
Erisir Oygucu
0000-0003-4990-8290
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, University of Kyrenia, Sehit Yahya Bakır Sokak, Karakum, Kyrenia, North Cyprus
seoygucu@hotmail.com
Gonul
Tezel
0000-0002-1054-535X
Division of Neonatology, Department of Pediatrics, Antalya Training and Research Hospital, Antalya, Turkey
tezelgonul@hotmail.com
Muhammet
Kazim Erol
.Department of Ophthalmology, Antalya Training and Research Hospital, Antalya, Turkey
Ozgur
Erkal
0000-0003-1059-8774
Division of Medical Genetics, Department of Pediatrics, Antalya Training and Research Hospital, Antalya, Turkey
ozgurerkal2@hotmail.com
10.22038/ijn.2018.30368.1415
<strong><em>Background:</em></strong> Oculo-palato-cerebral syndrome is an extremely rare condition characterized by various features, including low-birth weight, microcephaly, cerebral atrophy, mild-to-severe developmental delay, cleft palate, persistent hyperplastic primary vitreous, microphthalmia, small hands and feet, joint laxity, and large ears with thick helices. Diagnosis of this syndrome is based on the clinical manifestations, particularly the presence of persistent hyperplastic primary vitreous in association with other malformations. Congenital chylothorax is also a rare condition in the neonatal period, which is caused by the abnormal accumulation of the lymphatic fluid within the pleural space. This condition may be detected prenatally or during the neonatal period. <br /> <strong><em>Case report:</em></strong> We presented the case of a patient with oculo-palato-cerebral syndrome and congenital chylothorax based on a literature review.<br /> <strong><em>Conclusion:</em></strong> Oculo-palato-cerebral syndrome and congenital chylothorax are both rare conditions. To the best of our knowledge, this was the first case report on congenital chylothorax in association with oculo-palato-cerebral syndrome in the available literature. Since there have only been five case reports on these patients, further evidence is required to confirm the possible association between these rare conditions.
Congenital chylothorax,Oculo-palato-cerebral syndrome,Persistent hyperplastic primary vitreous
https://ijn.mums.ac.ir/article_11529.html
https://ijn.mums.ac.ir/article_11529_f8a5c3633d8078be53bb0b4aabc9f38d.pdf
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
9
3
2018
09
01
Myocarditis and Meningitis during Early Sepsis in a Neonate with Streptococcus pseudopneumoniae: A Case Report
88
91
EN
yazdan
ghandi
0000-0002-8825-7163
1. Amirkabir Hospital, School of Medicine, Department of Pediatrics, Pediatric Cardiology, Arak University of Medical Sciences, Arak, Iran
drghandi1351@gmail.com
Vahab
Ghanbari sheldareh
Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran
Saeed
Alinejad
0000-0002-7861-4155
Department of Neonatology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
s.alinejad@arakmu.ac.ir
Danial
Habibi
Department of Biostatistics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
10.22038/ijn.2018.30299.1414
Although myocarditis is uncommon in neonates, a wide variety of infectious pathogens can result in myocarditis, including viruses, bacteria, rickettsia, fungi, and protozoa. Viruses are most often the infectious disease found to cause acute myocarditis. On the other hand, bacterial myocarditis (BM) is an unusual cause of infectious myocarditis. BM is commonly seen in the context of sepsis or as part of a bacterial syndrome.<br /> <em>Streptococcus pseudopneumoniae</em> has mostly been isolated from the respiratory tract specimens. This infection is not prevalent in neonates. In this case report, a 5-day-old male neonate was admitted with the signs of fever, jaundice, and poor feeding. Moreover, he was lethargic and hypotonic with reduced neonatal reflexes and obvious tachycardia.<br /> Clinical and physical examinations were performed in addition to chest X-rays, echocardiography, cerebrospinal fluid (CSF) analysis, and other laboratory tests. The final diagnosis was confirmed as myocarditis and meningitis. The patient was treated with antibiotics and intravenous immunoglobulin (IVIG).<br /> On the sixth day of hospitalization, fever of the neonate fever resolved. On the 24th day, the CSF analysis was normal and the CSF, as well as blood culture were negative. The patient was discharged on the 30th day in good general and physical condition. The subsequent echocardiography performed four months’ post-hospitalization was normal.
Early sepsis,Meningitis,Myocarditis,neonate,Streptococcus pseudopneumoniae
https://ijn.mums.ac.ir/article_11530.html
https://ijn.mums.ac.ir/article_11530_12ef3e9207fe7d840c4fe5c9e26e8866.pdf