ORIGINAL_ARTICLE
Cord Blood Serum Ferritin of Infants of Diabetic Mothers
Introduction:Maternal diabetes mellitus is associated with depleted fetal iron stores and this is proportionate to the degree of maternal control, presence or absence of diabetes-related complications, and is not related to maternal iron status. In this study, we aim to assess the effect of maternal diabetes on cord blood serum ferritin. Methods: The present prospective (case-control) study was carried out in AL-Zahraa Teaching Hospital (March 2012-October 2012). Umbilical cord blood samples were collected from 100 newborn infants who were delivered normally or by caesarean section. Fifty infants of diabetic mothers (IDMs) and 50 normal control neonates were randomly recruited. A serum sample was obtained to measure ferritin concentrations by mini VIDAS machine, which compares the results with the standards. Statistical analysis was performed using SPSS (statistical package for social sciences) Version 17. Independent sample t-test was used for data measurement and chi-square test for analyzing the categorical data. Also, Pearson’s correlation coefficient was used to compare two measurement variables. P-valueResults: There was no significant difference between IDMs and infants of healthy mothers, regarding the gestational age at the time of delivery (P=0.31). Also, there was no significant difference between the two groups, regarding their packed cell volume (PCV), mean corpuscular volume (MCV), and red cell distribution width (RDW) (P>0.05). Finally, there was a highly significant difference between the two groups, regarding cord blood serum ferritin (P<0.05). Conclusion: This study shows that IDMs have lower tissue iron stores (S. ferritin) at birth. Also, according to the results, there is a significant association between S. ferritin ,gestational age and birth weight in these neonates.
https://ijn.mums.ac.ir/article_2349_f4be0b6a38350845c6cc4a833c7d43a3.pdf
2014-04-01
1
6
10.22038/ijn.2014.2349
Maternal
Diabetes Mellitus
depleted fetal
iron stores
Jasim
Mohammed Hashim
jasimhashim2000@yahoo.com
1
Consultant Pediatrician, Head of Department of Pediatrics, College of Medicine, Kufa University, Kufa, Iraq
LEAD_AUTHOR
Shamaa
Ameer
2
MBChB , College of Medicine, University of Kufa, Kufa, Iraq
AUTHOR
Kicklighter SD. Infant of diabetic mother. E-medicine October 26, 2001. Available at www.emedicine.com/ped/topic485.html.
1
Widness JA. Fetal risks and neonatal complications of diabetes mellitus and metabolic and endocrine disorders. In: Brody SA, Ueland K, editors. Endocrine disorders in pregnancy. Norwalk (CT): Appleton-Lang; 1989. p. 273– 97.
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Wagner RK, Nielsen PE, Gonik B. Shoulder dystocia. Obstet Gynecol Clin North Am. 1999; 26(2):371– 83.
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Lucas MJ. Medical complications of pregnancy: diabetes complicating pregnancy. Obstet Gynecol Clin North Am. 2001; 28(3):513– 36.
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Milley JR, Papacestas JS, Tabats BD. Effect of insulin on uptake of metabolic substrates by the sheep fetus. Am J Physiol. 1986; 251:E349– 56.
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Philipps AF, Porte PJ, Strabinsky S, Rosenkranz TS, Ray JR. Effects of chronic fetal hyperglycemia upon oxygen consumption in the ovine uterus and conceptus. J Clin Invest. 1984; 74: 279– 87.
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Widness JA, Susa JB, Garcia JF, Singer OB, Sehgal P, Oh W, et al. Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesusfetuses. J Clin Invest. 1981; 67:637– 42.
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Stonestreet BS, Goldstein M, Oh W, Widness JA. Effect of prolonged hyperinsulinemia on erythropoiesis in fetal sheep. Am J Physiol. 1989; 257:R1199– 204.
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Georgieff MK, Widness JA, Mills MM, Stonestreet BS. The effect of prolonged intrauterine hyperinsulinemia on iron utilization in fetal sheep. Pediatr Res. 1989; 26(5):467-9.
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Petry CD, Wobken JD, McKay H, Eaton MA, Seybold VS, Johnson DE, et al. Placental transferring receptor in diabetic pregnancies with increased fetal iron demand. Am J Physiol. 1994; 267:E507– 14.
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Georgieff MK, Petry CD, Mills MM, McKay H, Wobken JD. Increased N-glycosylation and reduced transferrin binding capacity of transferrin receptor isolated from placentas of diabeticmothers. Placenta. 1997; 18:563– 8.
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Petry CD, Eaton MA, Wobken JA, Mills MM, Johnson DE, Georgieff MK. Liver, heart, and brain iron deficiency in newborn infants of diabetic mothers. J Pediatr. 1992; 121:109– 14.
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Georgieff MK, Landon MB, Mills MM, Hedlund BE, Faassen AE, Schmidt RL, et al. Abnormal iron distribution in infants of diabetic mothers: spectrum and maternal antecedents. J Pediatr. 1990; 117:455– 61.
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Sweet DG, Savage GA, Tubman R, Lappin TR, Halliday HL. Cord blood transferrin receptors to assess fetal iron status. Arch Dis Child Fetal Neonatal Ed. 2001; 85:F46–8.
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Rollins MD, Maxwell AP, Afrasiabi M, Halliday HL, Lappin TRJ. Cord blood erythropoietin, pH,PaO2 and haematocrit following caesarean section before labour. Biol Neonate. 1993; 63:147–52.
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Rooney SA. Regulation of surfactant-associated phospholipid synthesis and secretion. In: Polin RA, Fox WW, editors. Fetal and neonatal physiology. 2nd edition. Philadelphia: WB Saunders; 1998. p. 1283–98.
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Metzger BE, Buchanan TA. Diabetes and birth defects: insights from the 1980’s, prevention in the 1990’s. Diabetes Spectrum.1990; 3:149–89
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Georgieff MK. Therapy of infants of diabetic mothers. In: Burg FD, Ingelfinger JR, Wald ER,Polin RA, editors. Current paediatric therapy. 15th edition. Philadelphia: WB Saunders; 1995. p. 793– 803.
18
Chockalingam UM, Murphy E, Ophoven JC, Weisdorf SA, Georgieff MK. Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia. J Pediatr. 1987; 111:283-6.
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Amarnath UM, Ophoven JJ, Mills MM, Murphy EL, Georgieff MK. The relationship between decreased iron stores, serum iron and neonatal hypoglycemia in large-for-date newborn infants. Acta Paediatr Scand. 1989; 78:538-43.
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Murata K, Toyoda N, Ichio T, Ida M, Sugiyama Y. Cord transferrin and ferritin values for erythropoiesis in newborn infants of diabetic mothers. Endocrinol Jpn. 1989; 36:827-32.
21
Georgieff MK, Kassner RJ, Radmer WJ, Berard DJ, Doshi SR, Stonestreet BS. The effect of in utero insulin exposure on tissue iron status in fetal rats. Pediatr Res. 1992; 31:64-7.
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Creasy RK, Resnik R. Intrauterine growth restriction. In: Creasy RK, Resnick R, editors. Maternal-fetal medicine. 4th edition. Philadelphia: WB Saunders; 1999. p. 569– 84.
23
Pilgaard K, Færch K, Carstensen B, Poulsen P, Pisinger C, Pedersen O, et al. Low birth weight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes. Diabetologia. 2010; 53(12): 2526-30.
24
Jensen DM, Damm P, Ovesen P, Mølsted- Pedersen L, Beck-Nielsen H, Westergaard JG, et al. Microalbuminuria, preeclampsia, and preterm delivery in pregnant women with type 1diabetes: results from a nationwide Danish study. Diabetes Care. 2010; 33(1): 90-4.
25
Lundstrom U, Siimes MA, Dallman PR. At what age does iron supplementation become necessary in low-birth-weight infants?. J Pediatr. 1977; 91:878–883.
26
Jansson L, Holmberg L, Ekman R. Variation of serum ferritin in low birth weight infants with maternal ferritin, birth weight and gestational age. Acta Haematol. 1979; 62:273-7.
27
Lott DG, Zimmerman MB, Labbé RF, Kling PJ, Widness JA. Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia. Pediatrics. 2005; 116(2):414-22.
28
ORIGINAL_ARTICLE
Evaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexplained abortions, and 10 women with at least two live births without a miscarriage were analyzed for MTHFR C677T polymorphism using PCR-RFLP (PCR-Restriction Fragment Length Polymorphism) method; the study was carried out on patients referring to Baqiyatallah Hospital and Avicenna Infertility Clinic. The results obtained via estimating the genotype of each polymorphism were analyzed by SPSS version 16. Results: Seventeen women (56.6 %) with recurrent spontaneous abortions and 5 women (50 %) from the control group were heterozygous for MTHFR C677T polymorphism. T-allele frequency in the experiment group was higher than the control group (28.4 % and 25 % for the experiment and control group, respectively). Conclusion: The prevalence of MTHFR C677T polymorphism was slightly higher in RSA patients compared with the controls. This finding failed to support the relationship between this polymorphism and the increasing risk of RSA in the evaluated Iranian women.
https://ijn.mums.ac.ir/article_2350_d41d8cd98f00b204e9800998ecf8427e.pdf
2014-04-01
7
11
10.22038/ijn.2014.2350
Methylenetetrahydrofolate reductase (NADPH2)
Polymorphism (genetics)
Spontaneous abortion
Thrombophilia
Amin
Khaleghparast
keyvan_1878@yahoo.com
1
M.Sc. of Biology-Genetics, Tehran Science and Research Branch of Islamic Azad University, Tehran, IRAN
LEAD_AUTHOR
Sharif
Khaleghparast
2
B.Eng. of Industrial Engineering, Iran University of Science and Technology (IUST), Tehran, IRAN
AUTHOR
Hossein
Khaleghparast
3
Ph.D. of Public Law, Tehran Science and Research Branch of Islamic Azad University, Tehran, IRAN
AUTHOR
Meka A, Reddy BM. Recurrent spontaneous abortions: An overview of the Genetic and Non-Genetic backgrounds. Int J Hum Genet. 2006;6: 109-17.
1
James AH. Venous thromboembolism in pregnancy. Arterioscler Thromb Vasc Biol. 2009; 29(3):326-31.
2
Kupferminc MJ. Thrombophilia and pregnancy Reprod Biol Endocrinol. 2003; 1: 1-23.
3
Kurzawińska G, Seremak-Mrozikiewicz A, Drews K, Barlik M, Mrozikiewicz PM. Genetic conditioned changes in activity of 5,10-methylenetetrahydrofolate reductase (MTHFR) and rec urrent miscarriages. Ginekol Pol. 2009; 80(10):762-7.
4
Spiroski I, Kedev S, Antov S, Arsov T, Krstevska M, Dzhekova-Stojkova S, et al. Methylenetetrahydro-folate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis. Acta Biochim Pol. 2008; 55(3):587-94.
5
Oliveira KC, Bianco B, Verreschi IT, Guedes AD, Galera BB, Galera MF, et al. Prevalence of the polymorphism MTHFR A1298C and not MTHFR C677T is related to chromosomal aneuploidy in Brazilian Turner Syndrome patients. Arq Bras Endocrinol Metabol. 2008; 52(8):1374-81.
6
van der Put NM, van der Molen EF, Kluijtmans LA, Heil SG, Trijbels JM, Eskes TK, et al. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. QJM. 1997; 90(8):511-7.
7
Goyette P, Pai A, Milos R, Frosst P, Tran P, Chen Z, et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome. 1998; 9(8):652-6.
8
Bailey LB, Gregory JF. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr. 1999; 129(5):919-22.
9
Nishio K, Goto Y, Kondo T, Ito S, Ishida Y, Kawai S, et al. Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake. J Epidemiol. 2008; 18(3):125-31.
10
Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol. 2003; 157(7):571-82.
11
Etienne MC, Ilc K, Formento JL, Laurent-Puig P, Formento P, Cheradame S, et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity. Br J Cancer. 2004; 90(2):526-34.
12
Bakker RC, Brandjes DP. Hyperhomocysteinaemia and associated disease. Pharm World Sci. 1997; 19(3):126-32.
13
Tamura T, Picciano MF. Folate and human reproduction. Am J Clin Nutr. 2006; 83(5):993-1016.
14
Wang XP, Lin QD, Ma ZW, Zhao AM. C677T and A1298C mutation of the methylenetetrahydrofolate reductase gene in unexplained recurrent spontaneous abortion. Zhonghua Fu Chan Ke Za Zhi. 2004; 39(4):238-41.
15
Mtiraoui N, Zammiti W, Ghazouani L, Braham NJ, Saidi S, Finan RR, et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses. Reproduction. 2006; 131(2):395-401.
16
Carp H, Salomon O, Seidman D, Dardik R, Rosenberg N, Inbal A. Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. Hum Reprod. 2002; 17(6):1633-7.
17
Morales-Machin A, Borjas-Fajardo L, Quintero JM, Zabala W, Alvarez F, Delgado W, et al. C677T polymorphism of the methylentetrahydrofolate reductase gene as risk factor in women with recurrent abortion. Invest Clin. 2009; 50(3):327-33.
18
Unfried G, Hohlagschwandtner M, Heinze G, Huber JC, Nagele F, Tempfer C. Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage. Fertil Steril. 2003; 79(5):1141-8.
19
Esfahani ST, Cogger EA, Caudill MA. Heterogeneity in the prevalence of methylenetetrahydrofolate reductase gene polymorphisms in women of different ethnic groups. J Am Diet Assoc. 2003; 103(2):200-7.
20
ORIGINAL_ARTICLE
Investigating causes of infant mortality in hospital of children during 2010-2011 in Bandar Abbas
Introduction: Infant mortality index is an important health indicator. This index has a direct impact on infant mortality and mortality of children less than five years. The present study aimed to investigate causes of infant deaths during 2010-2011 in Bandar Abbas hospital of children. Methods: In this cross - sectional retrospective study profiles of all dead newborns who aged from 0 to 28 days in Children's Hospital of Bandar Abbas zero to 28 days during the past two years were considered as the sample of this study. The necessary information were collected through answering to a predesigned checklist, telephone interviews, if necessary, the data were gathered from visiting people in person. Then the data were analyzed by using SPSS software version 16. Results: In the present study, prematurity was the most common cause of infant death (25 percent). 62 percent of newborns aged less than 7 days so two-thirds of the deaths occurred in the first week of their life, variables such as the infant`s age, the RAM or pre-term, birth weight, type of birth, father's education, and mother's education all showed a statistically significant relationship with infant mortality. Conclusion: In this regard paying particular attention to low birth weight infants, increasing the health awareness of mothers and families, providing the standard care before and during pregnancy can be effective in reducing infant mortality.
https://ijn.mums.ac.ir/article_2351_9ecb826827704a71df5792c23dc58f6d.pdf
2014-04-01
12
18
10.22038/ijn.2014.2351
Infants
Mortality
Prematurity
Sakineh
Dadipoor
mdadipoor@yahoo.com
1
Master Student in Health Education, Mother & Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
AUTHOR
Minoo
Rajaei
minoo.raja@yahoo.com
2
Gynecologist, Associate Professor, Hormozgan Research Center For Reproduction, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
AUTHOR
Selma
Naderi
selma.naderi@yahoo.com
3
Babies Specialist, Assistant Professor, Pediatric Clinical Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
AUTHOR
Amin
Ghanbarnejad
amin.ghanbarnejad@yahoo.com
4
MS in Biostatistics, Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
AUTHOR
Ali
Safari Moradabadi
alisafari_31@yahoo.com
5
Master Student in Health Education, student research committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
LEAD_AUTHOR
1.fatemeh tabatabai, dakhili, ghasemzadeh. Factors affecting infant mortality in ardabil in the 2005-2006. Islamic azad university of ardebil (clinical laboratory science conference findings). 2006.
1
2. nayeri f, amini e, yazdi zo, naieri ad. Evaluation of the cause and predisposing factors in neonatal mortality by using international coding diseases version 10 in valiasr hospital. Iranian journal of pediatrics. 2007;17(suppl 1).
2
3. javanmardi z, beygi marjan ga. Investigating about the causes of neonates’death in the hospitals of isfahan province. Scientific journal of forensic medicine. 2010.
3
4. Farah ashrafzadeh, pourabasi k. Causes and risk factors of mortality in children under one year of mashhad. Medical journal of mashhad. 1997;21:40.
4
5. hamedi a, lotfi n, kharazmi a. The causes of infant mortality and comparison of two 5-year periods. Journal of sabzevar school of medical sciences. 2001.
5
6. Lawn je, wilczynska-ketende k, cousens sn. Estimating the causes of 4 million neonatal deaths in the year 2000. International journal of epidemiology. 2006; 35(3):706-18.
6
7. boskabadi h, maamouri g, afshari j, mobarhan m, shakeri m-t. Serum interleukin 8 level as a diagnostic marker in late neonatal sepsis. Iranian journal of pediatrics. 2010;20(1).
7
8. hamidehazizkhan, sozani a. Examine factors associated with infant mortality at the social security hospital in yazd. International congress of pediatrics. 2009.
8
9. fanarrof neonatal septicemia in : textbook of neonatal principle disease. 1992: 61 - 634.
9
1 10.bahman-bijari b, niknafs p. Causes of neonatal mortality in kerman province in 1387-(2008-2009).Urmia medical journal. 2012; 22(6):501-6.
10
11. esmail nasab n, majidzadeh s, nadim a. An epidemiologic study of neonatal mortality and fetal death and risk factors in kordestan.Hakim research journal (pesian). 2001; 4(4):272-7.
11
12. taghavi m. Factors affecting infant mortality in fifteen city of the eastern province khorasan and azarbaijan in 1995. Proceedings of the first conference on health research network. 2000.
12
13.agha s. The determinants of infant mortality in pakistan. Social science & medicine. 2000; 51(2):199-208.
13
14. firoz amani, mahnocher berak, nayereh amini sani, dehghan mh. Factors associated with infant mortality at hospitals affiliated with the university
14
Medical sciences in 2002-2003. Journal of ardabil university of medical sciences. 2005;5(4):305-10.
15
15.15.heydarian f, lotfi n, khakshour a, hasanpour k, hosseini s. Clinical and laboratory evaluation of neonatal sepsis at ghaem hospitals in mashhad. Journal of north khorasan university of medical sciences. 2012.
16
ORIGINAL_ARTICLE
Effect of foot reflexology on physiologic index of neonates
Introduction: The traditional view that neonates are not capable of perceiving pain has been refuted and there is now no doubt those neonates feel pain. Although babies cannot express their pain as older children, but capable to show in response the pain a set of measures as observable behavioral responses. The aim of this study was to determine Effect of foot reflexology on physiologic index of neonates. Methods: This investigation was a quasi-experimental study on 30 neonates admitted to NICU. The questionnaires were composed of socio-demographic status and NIPS scale test. Measurements of HR and SaO2 were taken twice, before and then again after completion of the intervention, and foot reflexology was codified to measure and evaluate them. PResults: The study showed that there was significant difference between before and after the intervention on physiologic index(O2 saturation, heart rate) in neonates (P=0.003). Nonetheless, we suggest doing more studies in related subjects. Conclusion: Our investigation shows that foot reflexology can improve the physiologic index and decrease O2 saturation, heart rate (toward normal range), and can inspirited relaxation in neonates. Nonetheless, we suggest to doing more studies to this subjects.
https://ijn.mums.ac.ir/article_2352_e5d7d0c80a2c1b388dba65a9ddc74cea.pdf
2014-04-01
19
22
10.22038/ijn.2014.2352
Reflexology
physiological index
Neonates
Nasrin
Samadi
1
MSC of Nursing, Ardabil University of Medical Sciences, Ardabil, Iran.
AUTHOR
Irandokht
Allahyari
2
MSC of Nursing, Ardabil University of Medical Sciences, Ardabil, Iran
LEAD_AUTHOR
Effat
Mazaheri
3
MSC of Nursing, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Masoumeh
Rostamnejad
4
MSC of Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Nasrin
Mehrnoush
5
MSC of Nursing, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Maryam
Namadi
6
MSC of Nursing, Islamic Azad University, Ardabil Medical Branch, Ardabil, Iran
AUTHOR
Rogaie
Naseri
7
MSC of Nursing, Islamic Azad University, Ardabil Medical Branch, Ardabil, Iran.
AUTHOR
Mina
Nahamin
8
MSC of Nursing, Ardabil University of Medical Sciences, Ardabil, Iran.
AUTHOR
1. Hyesang Im, Eunjung Kim, Eunsook Park, Kyungsuk Sung, and Wonoak Oh. Pain Reduction of Heel Stick in Neonates: Yakson Compared to Non-nutritive Sucking, Journal of Tropical Pediatrics Vol. 54, No. 1, and pp.31-35
1
2. Mats Eriksson, Hanne Storm, Asbjo¨ rnFremming, Jens Schollin, Skin conductance compared to a combined behavioural and physiological pain measure in newborn infants,ActaPædiatrica 2008 97, pp. 27–30
2
3. Jen-Jiuan Liaw, Wen-Ping Zeng, Luke Yang, Yeong-Seng Yuh, Ti Yin and Meei-Horng Yang. Nonnutritive Sucking and Oral Sucrose Relieve Neonatal Pain during Intramuscular Injection of Hepatitis Vaccine, Journal of Pain and Symptom Management Vol. 42 No. 6 December 2011
3
4.Aurimery Gomes Chermont, Luis FábioMagnoFalcão, Eduardo Henrique Laurindo de Souza Silva, Rita de Cássia Xavier Balda and Ruth Guinsburg, Skin-to-Skin Contact and/or Oral 25% Dextrose for Procedural Pain Relief for Term Newborn Infants, Pediatrics 2009;124;e1101
4
5. ANJALI KULKARNI, *JAYA SHANKAR KAUSHIK, *PIYUSH GUPTA, HARSH SHARMA AND †RK AGRAWAL.2010. Massage and Touch Therapy in Neonates:The Current Evidence. INDIAN pediatrics. 47 (10). 771- 777.
5
6. Tiffany Field, Miguel Diego, Maria Hernandez-Reif,Massage therapy research.Developmental Review 27 (2007) 75–89
6
7. Sunil jain, Praveen Kumar and Douglas D McMillan. Prior leg massage decreases pain responses to heel stick in
7
8. Preterm babies, Journal of Paediatrics and Child Health 42 (2006) 505–508
8
9. Luigi Codipietro, Manuela Ceccarelli and Alberto Ponzone, Breastfeeding or Oral Sucrose Solution in Term Neonates Receiving Heel Lance: A Randomized, Controlled Trial. Pediatrics 2008; 122; e716-e721
9
10.Vickers A, Ohlsson A, Lacy J, Horsley A. Massagefor promoting growth and development of pretermand/or low birth weight infants. Cochrane DatabaseSystem Rev 2004; 2: CD000390.
10
11. Hernandez-Reif M, Field T, Diego M, Beutler J.Evidence-based medicine and massage. Pediatrics2001; 108: 1053.
11
12. Lawrence J: The development of a tool to assess neonatalpain. Neonatal Netw 12:59-66, 1993
12
13. Lawrence J Alcock D et al.The development of a tool to assess neonatal pain.Neonatal Network. 1993; 12 (6 September): 59-66.
13
14. Jonsdottir RB, Kristjansdottir G. The sensitivity of the premature infant pain profile: PIPP to measure pain in hospitalized neonates.J EvalClinPract. 2005; 11(6):598–605
14
15. Jones JE, Kassity N: Varieties of alternative experience: complementary care in the neonatal intensive care unit. ClinObstetGynecol 44:750- 768, 2001
15
16. Bellieni CV, Bagnoli F, Perrone S et al. Effect of multisensory stimulation on analgesia in term neonates: a randomized controlled trial. Pediatr.Res. 2002; 51: 460–3.
16
17. Jain S, Kumar P, McMillan DD. Prior leg massagedecreases pain responses to heel stick in pretermbabies. J Paediatr Child Health 2006; 42: 505-508.
17
18. Céline Catelin, Sylvie Tordjman, Vincent Morin, Emmanuel Oger, andJacques Sizun.2005. Clinical, Physiologic, and Biologic Impact of Environmental andBehavioral Interventions in Neonates During aRoutine Nursing Procedure. Journal of Pain. 6(12); 791-797.
18
ORIGINAL_ARTICLE
A survey on the prevalence of group B Streptococcus in pregnant women referred to the obstetrics and Gynecology ward at babol Ayatollah Rouhani hospital
OBJECTIVES:Prenatal infections are one of the fundamental causes of early puerperal complications in mothers and neonates. These infections are mostly due to colonized organisms in pregnant woman's genitor-urinary system. The aim of this study was to determine the incidence of streptococcus group B (GBS) colonization in parturient women and the rate of pathogen transmission to the newborn. METHODS: Totally 400 pregnant women (gravid one and nuliparity and gestational age 35-37 weeks) applied for this study.Vaginal and rectal samples was given from all mothers and skin samples were given from their child, and if the neonates become symptomatic and admission accord the blood samples were given to evaluate blood culture. After sample culturing on the specific environment data analyzed by SPSS software. Results: GBS colonization was seen in 15.2% of mothers and 7.75%oh their child. Vertical transmission rate was 49.2%. Also it was significant relation between organism colonization prevalence and prolonged ruptured of membrane more than 18 hours. (P=0) Discussion: According to high prevalence of GBS colonization and vertical transmissions rate in our city and ,it seems that prophylaxis for GBS is necessary to protect neonates .
https://ijn.mums.ac.ir/article_2353_0e1dc5bb408e69efe2f09ab98e1a4ad4.pdf
2014-04-01
23
27
10.22038/ijn.2014.2353
neonatal infection
prenatal infection
GBS
Colonization
Mohsen
Haghshenas Mojaveri
1
Neonatologist, Non- Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
LEAD_AUTHOR
Yadollah
Zahedpasha
2
Neonatologist, Non- Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
AUTHOR
Nesa
Asnafi
3
Infertility and Reproductive Health Research Center,Babol University of Medical Sciences, Babol, Iran.
AUTHOR
Javad
Farhadi
4
Babol University of Medical Sciences, Babol, Iran
AUTHOR
Ghamar
Haddad
5
Babol University of Medical Sciences, Babol, Iran
AUTHOR
1.Jones FS. Studies in Bovine Mastitis: Iv. The Sources of Infection in Streptococcic Mastitis. J Exp Med.1918;28(6):735-48.
1
2.Gladstone IM, Ehrenkranz RA, Edberg SC, Baltimore RS. A ten-year review of neonatal sepsis and comparison with the previous fifty-year experience. Pediatr Infect Dis J. 1990;9(11):819-25.
2
3.Baker CJ, Barrett FF. Transmission of group B streptococci among parturient women and their neonates. J Pediatr. 1973;83(6):919-25.
3
4.Baker CJ. Group B streptococcal infections. Clin Perinatol. 1997;24(1):59-70.
4
5.Burman LG, Christensen P, Christensen K, Fryklund B, Helgesson AM, Svenningsen NW, et al. Prevention of excess neonatal morbidity associated with group B streptococci by vaginal chlorhexidine disinfection during labour. The Swedish Chlorhexidine Study Group. Lancet. 1992 11;340(8811):65-9.
5
6.Baker CJ, Goroff DK, Alpert S, et al. Vaginal colonization with group B streptococcus: a study in college women. J Infect Dis. 1977;135(3):392-7.
6
7.Namavar Jahromi B, Poorarian S, Poorbarfehee S. The prevalence and adverse effects of group B streptococcal colonization during pregnancy. Arch Iran Med. 2008;11(6):654-7.
7
8. Nomura ML, Passini Junior R, Oliveira UM, Calil R. Group B streptococcus maternal and neonatal colonization in preterm rupture of membranes and preterm labor. Rev Bras Ginecol Obstet. 2009;31(8):397-403.
8
9.Eren A, Kucukercan M, Oguzoglu N, Unal N, Karateke A. The carriage of group B streptococci in Turkish pregnant women and its transmission rate in newborns and serotype distribution. Turk J Pediatr. 2005;47(1):28-33.
9
10.Bakhtiari R, Soltan Dallal M, Zaemi Yazdi J, Fallah J, Amir Mozaffari N, Pourmand M et al . Evaluation of PCR method for diagnosis of Group B Streptococcuscarriage in pregnant women. Iranian J Med Microbiology. 2007; 1(2):1-8.[persian]
10
11.Kubota. T, Jinushi. M, Sato. T, Machida. M. Colonization by group B streptococci and preterm birth. Contemp Rev Obstet Gynaecol. 1999;11(2):99-104.
11
12.Orrett FA. Colonization with Group B streptococci in pregnancy and outcome of infected neonates in Trinidad. Pediatr Int. 2003;45(3):319-23.
12
13.Kadanali A, Altoparlak U, Kadanali S. Maternal carriage and neonatal colonisation of group B streptococcus in eastern Turkey: prevalence, risk factors and antimicrobial resistance. Int J Clin Pract. 2005;59(4);437-440
13
14.Kunze M, Ziegler A, Fluegge K, Hentschel R, Proempeler H, Berner R. Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany. J Perinat Med. 2011;39(4):417-22.
14
15.Chaudhry BY, Akhtar N, Balouch AH. Vaginal carriage rate of group B Streptococcus in pregnant women and its transmission to neonates. J Ayub Med Coll Abbottabad. 2010 Oct;22(4):167-70.
15
ORIGINAL_ARTICLE
Comparison of CSF parameters between traumatic and nontraumatic puncture in term versus preterm neonates
Introduction: Evaluation of the cerebrospinal fluid (CSF) white blood cell (WBC) count and glucose and protein concentrations is used to assess the probability of the presence of central nervous system (CNS) infection. Although normal values are well established for CSF cell counts and protein and glucose contents in children and adults, this is not the case for neonates. The purpose of this study was to evaluate the composition of noninfected CSF obtained by nontraumatic lumbar puncture in neonates (age < 28 days), specifically distinguishing CSF profiles of those term babies compared with those premature infants. Materials& Methods: The CSF samples obtained by lumbar puncture from 120 neonates were examined by routine procedures.Results: By comparing CSF parameters between term gestation neonate group with premature neonate one, nontraumatic puncture, there was no statistically significant difference(p<0.05) in the mean WBC (p=0.6 )The mean protein concentration was significantly greater in those premature neonates ( p <0.04). The mean glucose concentration was also analogous in both groups (p=0.5) Conclusion: a prospective study using mortality under developmental follow up will better define the utility of CSF parameters in the premature neonate
https://ijn.mums.ac.ir/article_2354_e42790081d595cf53396092ed862676a.pdf
2014-04-01
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30
10.22038/ijn.2014.2354
neonatal CSF
term vs. preterm
traumatic vs. nontraumatic
Arijit
majumdar
1
Dr. bcroypgips, Dr. B.C. Roy Post Graduate Institute of Paediatric Sciences, Kolkata, India.
LEAD_AUTHOR
Anshuman
Jana
angshuforu@gmail.com
2
IPGMER Kolkata, Dr. B.C.Roy Post Graduate Institute of Pediatric Sciences,Kolkata, India
AUTHOR
anir
banjana
3
BSMC Bankura, Dr. B.C. Roy Post Graduate Institute of Paediatric Sciences, Kolkata, India.
AUTHOR
Soumali
Biswas
drsoumali.biswas26@gmail.com
4
CMC, Kolkata, Dr. B.C. Roy Post Graduate Institute of Paediatric Sciences, Kolkata, India.
AUTHOR
1.Overall JC., Jr. Neonatal bacterial meningitis. Analysis of predisposing factors and outcome compared with matched control subjects. J Pediatr. 1970; 76:499– 51.
1
2.Fishman RA. CSF findings in diseases of the nervous system. In Fishman RA . Cerebrospinal fluid in diseases of the nervous system. 2Ed. Philadelphia: W.B. Saunders, 1992:253-255.
2
3.Sarff LD, Platt LH, McCracken GH. Cerebrospinal fluid evaluation in neonates: comparison of high-risk infants with and without meningitis. J Pediatr 1976;88:473 -477.
3
4. Robertson J, Shilkofski N. The Harriet Lane Handbook. 17th ed. Mosby; Philadelphia: 2005.p.557.
4
5. Bonadio WA, Smith D. CBC differential profile in distinguishing etiology of neonatal meningitis. Pediatr Emerg Care 1989;5:94-96.
5
6.Portnoy JM, Olson LC. Normal cerebrospinal fluid values in children: another look. Pediatrics 1985; 75:484- 487.
6
7.Visser VE, Hall RT. Lumbar puncture in the evaluation of suspected neonatal sepsis. J Pediatr 1980; 96:1063- 1067.
7
8.Wyers HJG, Bakker JCW. De liquor cerebrospinalis van normale, a terme geboren neonat. Maandschrift Kindergenceskunde 1954; 22:253-256.
8
9.Luz BR. Contribuição para o estudo da xantocromia do líquido cefalorraqueano de recém-nascidos normais. Tese. Faculdade de Medicina da Universidade de São Paulo. São Paulo, 1972.
9
10. Diniz EMA, Spina-França A, Livramento JA, et al. Líquido cefalorraquídeo de recién nacidos pretérmino durante el período neonatal III. Estudio proteínico. Bol Méd Hosp Infant Méx 1982;39:473-476.
10
11.Vaz FAC, Livramento JA, Spina-França A .Líquido cefalorraqueano no recém-nascido pré-termo sadio. Arq Neuropsiquiatr 1977;35:183-188.
11
ORIGINAL_ARTICLE
Neonatal Tetanus in Mashhad (North East of Iran) over a 17 Year period
Introduction: Neonatal tetanus is a highly fatal disease that can be prevented by immunization and improvement in obstetric practices. The aim of the present study was to assess the characteristics of cases of neonatal tetanus in two large tertiary hospitals (Ghaem and Imam Reza hospitals) of Mashhad -North East of Iran between 1984- 2001. Methods: all cases whose epidemiological and clinical characteristics were compatible with neonatal tetanus and were admitted into the NICU’s of these two hospitals between July 1984 to June 2001 were analyzed from their hospital records. Results: A total of 60 patients had been hospitalized with the diagnosis of neonatal tetanus during the study period. All of them were delivered out of hospital by untrained birth attendants and none of the mothers had been immunized against tetanus during pregnancy. 74% of infants died. Age younger than 7 days at the time of admission was associated with a high mortality rate. Conclusion: Although neonatal tetanus is a highly fatal disease yet. It can be prevented with appropriate health care practices and tetanus immunization of pregnant women
https://ijn.mums.ac.ir/article_2355_d46d137f82f0909e5b33a77d77e13bd9.pdf
2014-04-01
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33
10.22038/ijn.2014.2355
Neonatal
tetanus
Tetanus toxoid
Immunization
Hasan Mottaghi
Moghaddam
1
Department of pediatrics, Mashhad University of medical sciences, Mashhad, Iran
AUTHOR
Ashraf
Mohammad Zadeh
mohamadzadeha@mums.ac.ir
2
Neonatal reserch center , Mashhad University of medical sciences, Mashhad, Iran
AUTHOR
Sepideh
Bagheri
md314@yahoo.com
3
Department of pediatrics, Mashhad University of medical sciences, Mashhad, Iran
LEAD_AUTHOR
Moslem
Moosafarkhani
4
Department of pediatrics, Mashhad University of medical sciences, Mashhad, Iran
AUTHOR
1- Roper MH, Vandelaer JH, Gasse FL. Maternal and neonatal tetanus. Lancet 2007; 370:1947-59.
1
2- WHO: “the global burden of disease 2004 update”. Available at: http://www.who.int/healthinfo/ global-burden-disease/ 2004-report-update/en/index.html.
2
3- Schofield F. Selective primary health care: strategies for control of disease in developing world. Xxii. Tetanus: a preventable problem. Rev Infect dis 1986; 8:144-56.
3
4- Lawn JE, Wilczynska-Kelende K, Consens SN .Estimating the causes of 4 million neonatal deaths in the year 2000. Int J Epidemiol 2006; 35:706-18.
4
5- WHO vaccine preventable diseases: monitoring system 2012 global summary.Last updated: 14 Jul 2012.
5
6- Dikici B, Uzun H, Yilmaz-Keskin E, Tas T, Gunes A, Kocamaz H, et al. Neonatal tetanus in turkey; what has changed in the last decade? BMC infect dis 2008; 8: 12.
6
7- Ertem M, Cakmak A, Saka G, Ceylan A. Neonatal tetanus in South-Eastern region of Turkey: Changes in prognostic aspects by better healthcare .J tropic pediatr 2004; 50: 297-300.
7
8- Vandelaer J, Birmingham M, Gasse F, Kurian M, Shaw C, Garnier S. Tetanus in developing countries: an update of maternal and neonatal tetanus elimination initiative. Vaccine 2003; 21: 3442-5.
8
9- Expanded program on immunization. The “high-risk” approach: the WHO recommended strategy to accelerated elimination of neonatal tetanus.WKLY Epidemiol Rec 1996; 71:33-6.
9
10- Aylward RB, Mansour E, Oon EA, et al. the role of surveillance in a high risk approach to the elimination of neonatal tetanus in Egypt. Int J Epidemiol 1996; 25: 1286 -91.
10
11- Davies-Adetugbo AA, Torimiro SE, Ako-Nai KA. Prognostic factors in neonatal tetanus .Tropic Med Int Health1998; 3: 9-13.
11
12- Daud S, Mohammad T, Ahmad A. Tetanus neonatarum (a preliminary report of assessment of different therapeutic regimens).J Tropi pediatr 1981; 27: 308-11.
12
13- Quddus A, Luby S, Rahbar M, Perviz Y. Neonatal tetanus: Mortality rate and risk factors in Loralai District, Pakistan. Int J Epidemiol 2001; 31: 648-53.
13
14- Chai F, Prevots DR, Wang X, Birmingham M, Zhang R. Neonatal tetanus incidence in china, 1996-2001 and risk factors for neonatal tetanus. Guangxi Province, China. Int J Epidemiol 2001; 33: 551-7.
14
15- Oruamabo RS. Neonatal tetanus in Nigeria: Does it still pose a major threat to neonatal survival? Arch Dis Child 2007; 92: 9-10.
15
16- Ergie CO, Ofovwe G. Cluster survey on neonatal tetanus mortality in Nigeria: observation on some clinical aspects.J tropic Pediatr 1993; 39: 372-3.
16
ORIGINAL_ARTICLE
Neonatal Purpura Fulminans
Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (protein C) deficiency,the management includes an acute phase of replacement therapy with fresh frozen plasma (FFP) or protein C concentrate and a maintenance therapy that includes anticoagulation with Warfarin or low molecular weight heparin. Here we report a case of neonatal purpura fulminans due to suspected protein C deficiency.
https://ijn.mums.ac.ir/article_2356_3d8486b0ca9d29f7dcf3f0bd4d2c72e4.pdf
2014-04-01
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37
10.22038/ijn.2014.2356
protein C
purpura fulmonis
Reza
Saeidi
saeedir@mums.ac.ir
1
Department of pediatrics, Associate Professor of Neonatology, Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
Reza
Gharaee
gharaeijr1@mums.ac.ir
2
Department of pediatrics, Fellow of neonatology, Mashhad University of Medical Sciences , Mashhad, Iran
LEAD_AUTHOR
Zohreh
Nobakht
3
Rheumatologist, Mashhad University of Medical Sciences , Mashhad, Iran
AUTHOR
1. Marlar RA, Montgomery RR, Broekmans AW. Diagnosis and treatment of homozygous protein C deficiency.Report of the working party on homozygous protein C deficiency of the Subcommittee on Protein C and Protein S, International Committee on Thrombosis and Haemostasis. J Pediatr 1989;114:528-34.
1
2. Manco-Johnson MJ, Abshire TC, Jacobson LJ, Marlar RA. Severe neonatal protein C deficiency: prevalence and thrombotic risk. J Pediatr 1991;119:7938.
2
3. Price VE, ledinghamdl ,Krumpel A ,Chan AK. Diagnosis and management of neonatal purpurafulminans. Fetal and Neonatal Medicine 2011;30:1-5
3
4. Hattenbach LO, Beeg T, Kreuz W, Zubcov A. Ophthalmic manifestation of congenital protein C deficiency. J AAPOS 1999;3:188-90.
4
5. Seligsohn U, Berger A, Abend M, et al. Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med 1984; 310:559-62.
5
6. Kirkinen P, Salonvaara M, Nikolajev K, Vanninen R, Heinonen K. Antepartum findings in fetal protein C deficiency. Prenatdiagn 2000; 20:746-9.
6
7. Monagle P, Chalmers E, Chan A, et al. Antithrombotic therapy in neonates and children: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008; 133:887S-968S.
7
8. Ten Kate MK, van der Meer J. Protein S deficiency: a clinical perspective. Haemophilia 2008; 14:1222-8.
8
9. Goldenberg NA, Manco-Johnson MJ. Protein C deficiency.Haemophilia 2008; 14:1214-21.
9
10. Zenciroglu A, Karagol BS, Ipek MS, Okumus N, Yarali N, Aydin M. Neonatal purpurafulminans secondary to group B streptococcal infection. Pediatrhematoloncol 2010;27:620-5.
10
11. Issacman SH, Heroman WM, Lightsey AL. Purpurafulminans following lateonset
11
Group B beta-hemolytic streptococcal sepsis. Am J Dis Child 1984;138:915-6.
12
12. Branson HE, Katz J, Marble R, Griffin JH. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpurafulminans in a newborn infant. Lancet 1983; 2:1165-8.
13
13. Estelles A, Garcia-Plaza I, Dasi A, et al. Severe inherited "homozygous" protein C deficiency in a newborn infant. Thrombhaemost 1984;52:53-6.
14
14. Andrew M, Paes B, Milner R, et al. Development of the human coagulation system in the healthy premature infant. Blood 1988;72:1651-7.
15
15. Lee MJ, Kim KM, Kim JS, Kim YJ, Lee YJ, Ghim TT. Long-term survival of a child with homozygous protein C deficiency successfully treated with living donor liver transplantation. Pediatr Transplant 2009;13:251-4.
16
ORIGINAL_ARTICLE
Fetus nasal injury after maternal blunt trauma during pregnancy, a case report
Introduction: Neonatal period damages occur due to mechanical forces (compression, stretching) during the birth process are classified as birth trauma. Various maternofetal factors, such as maternal diabetes, breech or other noncephalic presentations and birth weight might have been effective in developing prenatal trauma. Shoulder dystocia, which is common in neonates` of diabetic mothers, usually occurs in term neonates and associated with birth trauma and complications such as brachial plexus palsy. A higher rate of trauma was reported in neonates with birth weight more than 4500 gram. Recently, incidence of birth trauma was decreased, because of better prenatal care. Fetus face trauma might happen due to maternal blunt trauma. Although this type of fetus injuries are rare, they could be life threatening. In this article we report a neonate with nasal trauma.
https://ijn.mums.ac.ir/article_2358_7f45e0e3264e55e297981bd516457906.pdf
2014-04-01
38
40
10.22038/ijn.2014.2358
fetus
nasal injury
blunt truma
Ahmad
Shah Farhat
farhata@mums.ac.ir
1
Neonatologist, assistant professor, Mashhad university of medical Science, Mashhad, Iran
AUTHOR
Simin
Maghrebi
2
Resident of neonatology, Mashhad university of medical Science, Mashhad, Iran
LEAD_AUTHOR
1. Martin R, Avroy F, Fanaroff MBCH, Walsh M. Fanaroff and Martin's Neonatal-Perinatal Medicine, 9th Edition.2008. 2. Borna H, Rad SM, Borna S, Mohseni SM. Incidence of and risk factors for birth trauma in Iran.Taiwan J Obstet Gynecol. 2010 Jun; 49(2):170-3. 3. Stoksted P, Schønsted-Madsen U.Traumatology of the newborn's nose.Rhinology. 1979 Jun; 17(2):77-82.
1
4. Pirsig W. The injured nose of the newborn. A review (author's transl)MonatsschrKinderheilkd. 1979 Jan; 127(1):14-9
2
5. Bednaríková L, Brízová M. Injuries of the nose in neonates.CasLekCesk. 1990 Jun29; 129(26):815-9.
3
6. Quante M, Franzen G, Strauss P. The correlation between permanent septal deformities and nasal trauma during birth. Rhinology. 1976 Sep; 14(3):141-6.
4
7. Melamed N, Aviram A, Silver M, Peled Y, Wiznitzer A, Glezerman M, Yogev Y. Pregnancy course and outcome following blunt trauma. J Matern Fetal Neonatal Med. 2012 Sep; 25(9):1612-7.
5
8. Weintraub AY, Levy A, Holcberg G, Sheiner E. The outcome of blunt abdominal trauma preceding birth. Int J FertilWomens Med. 2006 Nov-Dec; 51(6):275-9.
6
9. tarvonen M, Ulander VM, Süvari L, Teramo K. Minor trauma during pregnancy can cause severe fetomaternal hemorrhage Duodecim. 2011; 127(16):1727-31
7