ORIGINAL_ARTICLE
Clinical Guideline Adaptation for Treatment of Neonatal Sepsis Based on Frequency of Microbial Agents
Background: Sepsis is one of the most important causes of death in infants. The pattern of bacterial agents responsible for neonatal septicemia changes over time. The main aim of the present study was to provide a clinical guideline adapted for treatment of neonatal sepsis based on the frequency of microbial agents in the Neonatal Intensive Care Unit of Alzahra Hospital, Tabriz, Iran.Methods: The clinical guideline adaptation is conducted based on the ADAPTE Resource Toolkit for Guideline Adaptation (version 2.0) from December 2016 to January 2018. For data collection, the specialized websites were identified, then an internet search method was used for gaining clinical guidelines and medical literature databases. A panel was established with members of multi-specialties and the obtained guidelines were examined and evaluated. In the end, the final guideline was selected and translated.Results: Regarding the guideline, employing antibiotics should start when the neonate is < 35 weeks and premature rupture of membrane (PROM) happened < 18 h. Moreover, it could be employed when the neonate did not receive antibiotics, the gestational age (GA) is < 35 weeks with a PROM < 18 h or a GA < 37 weeks with a PROM ≥ 18 h. Conclusion: Implementation of the neonatal sepsis treatment guideline leads to a unified method of treatment, reduces the risk of antibiotic resistance, and decreases the mortality and morbidity associated with sepsis.
https://ijn.mums.ac.ir/article_13803_1cb3a64f7341f00054b99cc85632ce8a.pdf
2020-01-01
1
11
10.22038/ijn.2019.38426.1605
Antibiotic Treatment
Clinical Guideline
Microbial Agents
Neonatal sepsis
Mohammad Bagher
Hosseini
hosseini.neo@gmail.com
1
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Shahram
Abdoli Oskouei
shahram.oskouei@gmail.com
2
School of Medicine, Department of Community and Family Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Fariba
Heidari
fariba_heidari@hotmail.com
3
School of Medicine, Department of Community and Family Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Amin
Sadat Sharif
4
School of Medicine, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Zakeiye
Salimi
zs.rad2011@yahoo.com
5
Neonatal Intensive Care Unit, Alzahra Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Seyed Amir Abbas
Sharif
amirsharif.md@gmail.com
6
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
1. Annette Enrione A, Powell KR. Sepsis, septic shock and systemic inflammatory response syndrome. In: Kleigman RM, Behrman RE, Jenson HB, Stanton BM, editors. Nelson textbook of pediatrics. 18th ed. Philadelphia: W.B. Saunders; 2008. P. 1094.
1
2. Zaidi AK, Thaver D, Ali SA, Khan TA. Pathogens associated with sepsis in newborns and young infants in developing countries. Pediatr Infect Dis J. 2009; 28(1 Suppl):S10-8.
2
3. Nikpay S, YadegarAzadi A, Mohamadi J, Soleymani A, Badfar G. Epidemiologic Indicators of Neonatal Sepsis in Teaching Hospitals of Ilam, Western Iran during (2012-2017). Int J Pediatr. 2018; 6(7): 7947-58.
3
4. Li Z, Xiao Z, Li Z, Zhong Q, Zhang Y, Xu F. 116 cases of neonatal early-onset or late-onset sepsis: A single center retrospective analysis on pathogenic bacteria species distribution and antimicrobial susceptibility. Int J Clin Exp Med. 2013; 6(8):693-9.
4
5. Rafati MR, Farhadi R, Nemati-Hevelai E, Chabra A. Determination of frequency and antibiotic resistance of common bacteria in late onset sepsis at the neonatal ward in Booali-Sina Hospital of Sari, Iran. J Babol Univ Med Sci. 2014; 16(6):64-71.
5
6. Kliegman R, Behrman RE, Nelson WE. Nelson textbook of pediatrics. New York: Elsevier; 2016.
6
7. Dehghan K, Karimi S, Alilu L. The effect of probiotics on late-onset sepsis in very preterm infants: a randomized clinical trial. Int J Pediatr. 2018; 6(10):8371-9.
7
8. Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr. 2008; 75(3):261-6.
8
9. Wu JH, Chen CY, Tsao PN, Hsieh WS, Chou HC. Neonatal sepsis: a 6-year analysis in a neonatal care unit in Taiwan. Pediatr Neonatol. 2009; 50(3):88-95.
9
10. You D, Hug L, Ejdemyr S, Idele P, Hogan D, Mathers C, et al. Global, regional, and national levels and trends in under-5 mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN inter-agency group for child mortality estimation. Lancet. 2015; 386(10010):2275-86.
10
11. Wang M, Wei H, Zhao Y, Shang L, Di L, Lyu C, Liu J. Analysis of multidrug-resistant bacteria in 3223 patients with hospital-acquired infections (HAI) from a tertiary general hospital in China. Bosnian J Basic Med Sci. 2019; 19(1):86-93.
11
12. Shehab El-Din EM, El-Sokkary MM, Bassiouny MR, Hassan R. Epidemiology of neonatal sepsis and implicated pathogens: a study from Egypt. Biomed Res Int. 2015; 2015:509484.
12
13. Khan SN, Joseph S. Neonatal sepsis: antibiotic sensitivity and resistance pattern of commonly isolated pathogens in a neonatal intensive care unit of a teritiary care hospital, South India. Int J Pharm Bio Sci. 2012; 3(4):802-9.
13
14. Edmond K, Zaidi A. New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med. 2010; 7(3):e1000213.
14
15. Afzalian N. Acute care of at-risk newborns (ACORN).
15
1st ed. Tehran: Publication of Fanohonar; 2011. P. 9-19.
16
16. Resch B, Müller W, Erwa W, Cimenti C, Hofer N, Griesmaier E. Neonatal bacterial infection. In: Tech C, editor. Neonatal bacterial infection. New York: Saunders Book Company; 2013. P. 11-23.
17
17. Stone L. Neonatal bacterial infection (eBook). New York: Hayle Medical; 2015. P. 53-6.
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18. Clinical guideline adaptation. Urogynecology Knowledge Management of Iran. Available at: URL: https://ykmu.tbzmed.ac.ir; 2018.
19
19. Polin RA. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012; 129(5):1006-15.
20
20. Verani JR, McGee L, Schrag SJ. Prevention of perinatal group B streptococcal disease. Morbidity and Mortality Weekly Report (MMWR), Revised Guidelines from CDC. Recommend Rep. 2010; 59(RR10):1-32.
21
21. National Collaborating Centre for Women's and Children's Health (UK). Antibiotics for early-onset neonatal infection: antibiotics for the prevention and treatment of early-onset neonatal infection. London: RCOG Press; 2012.
22
22. Queensland Health. Queensland Maternity and Neonatal Clinical Guidelines Program. Early Onset Group B Streptococcal Disease: Queensland Maternity and Neonatal Clinical Guideline. New York: Queensland Health; 2011.
23
23. Muller-Pebody B, Johnson AP, Heath PT, Gilbert RE, Henderson KL, Sharland M, et al. Empirical treatment of neonatal sepsis: are the current guidelines adequate? Arch Dis Child Fetal Neonatal Ed. 2011; 96(1):F4-8.
24
24. Wilson CB, Nizet V, Maldonado Y, Klein JO, Remington JS. Remington and Klein's infectious diseases of the fetus and newborn infant. 8th ed. New York: Elsevier Health Science; 2015. P. 1048-53.
25
25. Mugglestone MA, Murphy MS, Visintin C, Howe DT, Turner MA. Antibiotics for early‐onset neonatal infection: a summary of the NICE guideline 2012. Obstet Gynaecol. 2014; 16(2):87-92.
26
26. Martin RJ, Fanaroff AA, Walsh MC. Perinatal and Neonatal care in developing countries. fanaroff and martin's neonatal-perinatal medicine: diseases of the fetus and infant. 10th ed. Philadelphia: Mosby Elsevier; 2015.
27
27. Mollarahimi MF, Nojoumi M, Biglari M, Ezoji K. Adaptation of preventive guideline of cardiovascular disease. Razi J Med Sci. 2017; 23(152):46-53.
28
28. Chu A, Hageman JR, Schreiber M, Alexander K. Antimicrobial therapy and late onset sepsis. NeoReviews. 2012; 13(2):e94-102.
29
29. Marchant EA, Boyce GK, Sadarangani M, Lavoie PM. Neonatal sepsis due to coagulase-negative staphylococci. Clin Dev Immunol. 2013; 2013:586076.
30
30. Russell AR. Neonatal sepsis. Paediatr Child Health. 2015; 25(6):271-5 .
31
31. Bhat YR, Lewis LE, Vandana KE. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India. Ital J Pediatr. 2011; 37:32.
32
32. Asgharisana F, Gaibi S. study of the role of common bacterial etiology in neonatal sepsis in Urumiah Shahid. N Cell Mol Biotechnol J. 2011; 1(3):17-21.
33
33. Nahar BS, Afroza S, Roy S, Nahar N, Kundu TN. Neonatal sepsis in a tertiary care hospital: evaluation of causative agents and antimicrobial susceptibilities. Bangladesh J Child Health. 2013; 37(1):14-7.
34
ORIGINAL_ARTICLE
Effect of Massage on Salivary Cortisol Level in Preterm Neonates
Background: Stress in preterm neonates is associated with morbidity and mortality. Preterm newborns who are in need of special care are at risk of experiencing stress because of separation from the mother, ambient noises, lighting intensity, and medical procedures. Massage is believed to reduce stress through touch stimulation, and the cortisol is one of the indicators of the stress response. This study aimed to identify the effects of touch stimulation in the form of massage on salivary cortisol in preterm neonates.Methods: This study was conducted based on a quasi-experimental design. The neonates were divided into intervention and control groups who received massage and standard therapy (n=19) and only the standard therapy (n=20), respectively. The massage was given to the infants three times daily for 15 min. Salivary cortisol was measured after 10 days of intervention.Results: According to the results, the mean salivary cortisol concentration of the control group was higher (0.53±0.73 μg/dL) than that in the intervention group (0.05±0.32 μg/dL). Moreover, there was a significant difference between the groups regarding the salivary cortisol level at pre- and post-test (P=0.001). Based on the pre-test and post-test results, there was a significant decrease in salivary cortisol levels in the intervention group, compared to the control group (P=0.03 versus P=0.53). It should be noted that there were no observable side effects during the intervention.Conclusion: Based on a decrease in salivary cortisol levels, this study suggests that touch stimulation given as a massage may reduce the level of stress in preterm neonates.
https://ijn.mums.ac.ir/article_14175_ba75fa4b1e7ef2aa7252ffabb4c9c69e.pdf
2020-01-01
12
16
10.22038/ijn.2019.40771.1664
Complementary Medicine
Cortisol
Massage
preterm neonate
stress
Rewina
Asmarani
winnyasmarani@yahoo.com
1
Department of Child Health, Faculty of Medicine, Airlangga University, Dr.Soetomo Hospital, Surabaya, Indonesia
AUTHOR
Irwanto
Irwanto
irwanto.idris@gmail.com
2
Department of Child Health, Faculty of Medicine, Airlangga University, Dr.Soetomo Hospital, Surabaya, Indonesia
LEAD_AUTHOR
Ahmad
Suryawan
suryawan.ahmad@gmail.com
3
Department of Child Health, Faculty of Medicine, Airlangga University, Dr.Soetomo Hospital, Surabaya, Indonesia
AUTHOR
Mira
Irmawati
irmawatimira@gmail.com
4
Department of Child Health, Faculty of Medicine, Airlangga University, Dr.Soetomo Hospital, Surabaya, Indonesia
AUTHOR
Martono
Utomo
mrmartono73@gmail.com
5
Department of Child Health, Faculty of Medicine, Airlangga University, Dr.Soetomo Hospital, Surabaya, Indonesia
AUTHOR
1. Gomella T, Cunningham MD, Eyal FG. Intrauterine growth retardation. In: Gomella T, Cunningham MD, Eyal FG, editors. Neonatology. New York: McGraw-Hill Medical Education, LLC; 2013. P. 732-42.
1
2. Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016; 388(10063): 3027-35. 3. Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012; 379(9832):2162-72.
2
4. Montirosso R, Tronick E, Borgatti R. Promoting neuroprotective care in neonatal intensive care units and preterm infant development: insights from the neonatal adequate care for quality of life study. Child Dev Perspect. 2017; 11(1):9-15.
3
5. Cignacco E, Hamers JP, Stoffel L, van Lingen RA, Gessler P, McDougall J, et al. The efficacy of non-pharmacological interventions in the management of procedural pain in preterm and term neonates. A systematic literature review. Eur J Pain. 2007; 11(2):139-52.
4
6. Kugelman A, Colin AA. Late preterm infants: near term but still in a critical developmental time period. Pediatrics. 2013; 132(4):741-51.
5
7. Holsti L, Weinberg J, Whitfield MF, Grunau RE. Relationships between adrenocorticotropic hormone and cortisol are altered during clustered nursing care in preterm infants born at extremely low gestational age. Early Hum Dev. 2007; 83(5):341-8.
6
8. Chen Y, Baram TZ. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology. 2016;
7
41(1):197-206.
8
9. Cabral DM, Antonini SR, Custódio RJ, Martinelli CE Jr, da Silva CA. Measurement of salivary cortisol as a marker of stress in newborns in a neonatal intensive care unit. Horm Res Paediatr. 2013; 79(6):373-8.
9
10. Diego MA, Field T, Hernandez-Reif M. Preterm infant weight gain is increased by massage therapy and exercise via different underlying mechanisms. Early Hum Dev. 2014; 90(3):137-40.
10
11. Uvnäs-Moberg K, Handlin L, Petersson M. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Front Psychol. 2014; 5:1529.
11
12. Pepino VC, Mezzacappa MA. Application of tactile/ kinesthetic stimulation in preterm infants: a systematic review. J Pediatr (Rio J). 2015; 91(3):213-33.
12
13. Pados BF, McGlothen-Bell K. Benefits of infant massage for infants and parents in the NICU. Nurs Womens Health. 2019; 23(3):265-71.
13
14. Wang L, He JL, Zhang XH. The efficacy of massage on preterm infants: a meta-analysis. Am J Perinatol. 2013; 30(9):731-8.
14
15. Asadollahi M, Jabraeili M, Mahallei M, Asgari Jafarabadi M, Ebrahimi S. Effects of gentle human touch and field massage on urine cortisol level in premature infants: a randomized, controlled clinical trial. J Caring Sci. 2016; 5(3):187-94.
15
16. Forclaz MV, Moratto E, Pennisi A, Falco S, Olsen G, Rodríguez P, et al. Salivary and serum cortisol levels in newborn infants. Arch Argent Pediatr. 2017; 115(3):262-6.
16
17. Okamura H, Kinoshita M, Saitsu H, Kanda H, Iwata S, Maeno Y, et al. Noninvasive surrogate markers for plasma cortisol in newborn infants: utility of urine and saliva samples and caution for venipuncture blood samples. J Clin Endocrinol Metab. 2014; 99(10):E2020-4.
17
18. Provenzi L, Giusti L, Fumagalli M, Tasca H, Ciceri F, Menozzi G, et al. Pain-related stress in the neonatal intensive care unit and salivary cortisol reactivity to socio-emotional stress in 3-month-old very preterm infants. Psychoneuroendocrinology. 2016; 72:161-5.
18
19. Calixto C, Martinez FE, Jorge SM, Moreira AC, Martinelli CE Jr. Correlation between plasma and salivary cortisol levels in preterm infants. J Pediatr. 2002; 140(1):116-8.
19
20. Montero-López E, Santos-Ruiz A, González R,
20
Navarrete-Navarrete N, Ortego-Centeno N, Martínez-Augustín O, et al. Analyses of hair and salivary cortisol for evaluating hypothalamic-pituitary-adrenal axis activation in patients with autoimmune disease. Stress. 2017; 20(6):541-8.
21
21. Gunnar MR. Reactivity of the hypothalamic-pituitary-adrenocortical system to stressors in normal infants and children. Pediatrics. 1992; 90(3 Pt 2):491-7.
22
22. Aliabadi F, Askary RK. Effects of tactile-kinesthetic stimulation on low birth weight neonates. Iran J Pediatr. 2013; 23(3):289-94.
23
23. Irwanto. Strategies of intervention for preterm infants to optimize growth and development. 2nd Symposium & Workshop Update Neonatal. Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga/RSUD Dr Soetomo Surabaya, Indonesia; 2017. P. 25-46.
24
24. Schanberg SM, Field TM. Sensory deprivation stress and supplemental stimulation in the rat pup and preterm human neonate. Child Dev. 1987; 58(6):1431-7.
25
25. Lecuona E, Van Jaarsveld A, Raubenheimer J, Van Heerden R. Sensory integration intervention and the development of the premature infant: a controlled trial. South Afr Med J. 2017; 107(11):976-82.
26
26. Feldman R, Singer M, Zagoory O. Touch attenuates infants’ physiological reactivity to stress. Dev Sci. 2010; 13(2):271-8.
27
27. Neu M, Pan Z, Workman R, Marcheggiani-Howard C, Furuta G, Laudenslager ML. Benefits of massage therapy for infants with symptoms of gastroeso-phageal reflux disease. Biol Res Nurs. 2014; 16(4):387-97.
28
28. Guzzetta A, Baldini S, Bancale A, Baroncelli L, Ciucci F, Ghirri P, et al. Massage accelerates brain development and the maturation of visual function. J Neurosci. 2009; 29(18):6042-51.
29
29. Acolet D, Modi N, Giannakoulopoulos X, Bond C, Weg W, Clow A, et al. Changes in plasma cortisol and catecholamine concentrations in response to massage in preterm infants. Arch Dis Child. 1993; 68(1 Spec No):29-31.
30
30. Im H, Kim E. Effect of Yakson and Gentle Human Touch versus usual care on urine stress hormones and behaviors in preterm infants: a quasi-experimental study. Int J Nurs Stud. 2009; 46(4):450-8.
31
ORIGINAL_ARTICLE
Neonatal Urinary Tract Infection in a Tertiary Care Center in Amman, Jordan
Background: The aim of this study was to describe the prevalence of neonatal urinary tract infection (UTI), demographics, and clinical characteristics in a single referral tertiary neonatal intensive care unit.Methods: The medical records of 118 neonates diagnosed with neonatal UTI were reviewed over a 7-year period.Results: The prevalence of neonatal UTI was 1.5%. The male to female ratio was 1.6:1. In this study, 61% of the neonates were preterm babies. The mean age of diagnosis was 19.55±19.5 days. Pyuria was observed in 20% of the cases, and Escherichia coli was the most common pathogen. Hospital-acquired UTI was observed in 76% of the cases, and community-acquired UTI was noticed in 24% of the subjects. Prolonged jaundice was the most common presenting symptom of UTI followed by sepsis. An abnormal ultrasound was found in 29% of the neonates with hydronephrosis as the most associated anomaly. There was a high rate of extended spectrum-beta lactamase organisms and a high rate of antimicrobial resistance.Conclusion: The occurrence of neonatal UTI was rare in the study population. In addition, hydronephrosis was the most common anomaly. Proper antibiotic stewardship is needed to halt the increasing antimicrobial resistance of uropathogens.
https://ijn.mums.ac.ir/article_14304_3ee260fb8636081984d27bf25bf0c24e.pdf
2020-01-01
17
23
10.22038/ijn.2019.41402.1681
Extended spectrum beta-lactamase producing bacteria
Neonates
Preterm
Urinary tract infection
Jumana
Albaramki
jumanabaramki@hotmail.com
1
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
LEAD_AUTHOR
Manar
Al-lawama
manar_76@hotmail.com
2
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
Manar
Jarra
manarjaara90@gmail.com
3
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
Randa
Alqaisi
alqaisiranda@gmail.com
4
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
Rama
Jadallah
ramai88@hotmail.com
5
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
Asma
AL-Mustafa
asma982@gmail.com
6
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
Eman
Badran
emanfbadran@gmail.com
7
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
Kamal
Akl
kachbl@yahoo.com
8
Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
AUTHOR
1. Bauer S, Eliakim A, Pomeranz A, Regev R, Litmanovits I, Arnon S, et al. Urinary tract infection in very low birth weight preterm infants. Pediatr Infect Dis J. 2003; 22(5):426-30.
1
2. Sastre JBL, Aparicio AR, Cotallo GD, Colomer BF, Hernández MC; Grupo de Hospitales Castrillo. Urinary tract infection in the newborn: clinical and radio imaging studies. Pediatr Nephrol. 2007; 22(10):1735-41.
2
3. Lai A, Rove KO, Amin S, Vricella GJ, Coplen DE. Diagnosis and management of urinary tract infections in premature and term infants. NeoReviews. 2018; 19(6):e337-48.
3
4. Zorc JJ, Levine DA, Platt SL, Dayan PS, Macias CG, Krief W, et al. Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics. 2005; 116(3):644-8.
4
5. Bonadio W, Maida G. Urinary tract infection in outpatient febrile infants younger than 30 days of age: a 10-year evaluation. Pediatr Infect Dis J. 2014; 33(4):342-4.
5
6. Alizadeh Taheri P, Navabi B, Shariat M. Neonatal urinary tract infection: clinical response to empirical therapy versus in vitro susceptibility at Bahrami Children’s Hospital- Neonatal Ward: 2001-2010. Acta Med Iran. 2012; 50(5):348-52.
6
7. Friedman S, Shah V, Ohlsson A, Matlow AG. Neonatal escherichia coli infections: concerns regarding resistance to current therapy. Acta Paediatr. 2000; 89(6):686-9.
7
8. Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management, Roberts KB. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011; 128(3):595-610.
8
9. Vachharajani A, Vricella GJ, Najaf T, Coplen DE. Prevalence of upper urinary tract anomalies in hospitalized premature infants with urinary tract infection. J Perinatol. 2015; 35(5):362-6.
9
10. Biyikli NK, Alpay H, Ozek E, Akman I, Bilgen H. Neonatal urinary tract infections: analysis of the patients and recurrences. Pediatr Int. 2004; 46(1):21-5.
10
11. Weems MF, Wei D, Ramanathan R, Barton L, Vachon L, Sardesai S. Urinary tract infections in a neonatal intensive care unit. Am J Perinatol. 2015; 32(7):695-702.
11
12. Ismaili K, Lolin K, Damry N, Alexander M, Lepage P, Hall M. Febrile urinary tract infections in 0- to 3-month-old infants: a prospective follow-up study. J Pediatr. 2011; 158(1):91-4.
12
13. Kanellopoulos TA, Salakos C, Spiliopoulou I, Ellina A, Nikolakopoulou NM, Papanastasiou DA. First urinary tract infection in neonates, infants and young children: a comparative study. Pediatr Nephrol. 2006; 21(8):1131-7.
13
14. Shaikh N, Morone NE, Bost JE, Farrell MH. Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr Infect Dis J. 2008; 27(4):302-8.
14
15. Han YJ, Yu SL, Tao YZ. Urinary tract infections in the neonatal intensive care unit: clinical analysis of 229 cases. Zhongguo Dang Dai Er Ke Za Zhi. 2012; 14(3):177-80.
15
16. Youssef DM, Elfateh HA, Sedeek R, Seleem S. Epidemiology of urinary tract infection in neonatal intensive care unit: a single center study in Egypt. J Acad Med Sci. 2012; 2(1):25-9.
16
17. Tola HH, Ranjbaran M, Omani-Samani R, Sadeghi M. Prevalence of UTI among Iranian infants with prolonged jaundice, and its main causes: a systematic review and meta-analysis study. J Pediatr Urol. 2018; 14(2):108-15.
17
18. Özcan M, Sarici SÜ, Yurdugül Y, Akpinar M, Altun D, Özcan B, et al. Association between early idiopathic neonatal jaundice and urinary tract infections. Pediatrics. 2017; 11:1179556517701118.
18
19. Mohseny AB, van Velze V, Steggerda SJ, Smits-Wintjens VE, Bekker V, Lopriore E. Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon. Eur J Pediatr. 2018; 177(1):33-8.
19
20. Tamim MM, Alesseh H, Aziz H. Analysis of the efficacy of urine culture as part of sepsis evaluation in the premature infant. Pediatr Infect Dis J. 2003; 22(9):805-8.
20
21. Cleper R, Krause I, Eisenstein B, Davidovits M. Prevalence of vesicoureteral reflux in neonatal urinary tract infection. Clin Pediatr (Phila). 2004; 43(7):619-25.
21
22. Asghar AM, Leong T, Cooper CS, Arlen AM. Hospital-acquired urinary tract infections in neonatal ICU patients: is voiding cystourethrogram necessary? Urology. 2017; 105:163-6.
22
23. Levy I, Comarsca J, Davidovits M, Klinger G, Sirota L, Linder N. Urinary tract infection in preterm infants: the protective role of breastfeeding. Pediatr Nephrol. 2009; 24(3):527-31.
23
24. Foglia EE, Lorch SA. Clinical predictors of urinary tract infection in the neonatal intensive care unit. J Neonatal Perinat Med. 2012; 5(4):327-33.
24
25. Badran EF, Din RA, Shehabi AA. Low intestinal colonization of Escherichia coli clone ST131 producing CTX-M-15 in Jordanian infants. J Med Microbiol. 2016; 65(2):137-41.
25
26. Fan NC, Chen HH, Chen CL, Ou LS, Lin TY, Tsai MH, et al. Rise of community-onset urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli in children. J Microbiol Immunol Infect. 2014; 47(5):399-405.
26
27. Flokas ME, Detsis M, Alevizakos M, Mylonakis E. Prevalence of ESBL-producing Enterobacteriaceae in paediatric urinary tract infections: a systematic review and meta-analysis. J Infect. 2016; 73(6): 547-57.
27
28. Flannery DD, Brandsma E, Saslow J, Mackley AB, Paul DA, Aghai ZH. Do infants in the neonatal intensive care unit diagnosed with urinary tract infection need a routine voiding cystourethrogram? J Matern Fetal Neonatal Med. 2017; 32(11):1749-54.
28
29. Nowell L, Moran C, Smith PB, Seed P, Alexander BD, Cotten CM, et al. Prevalence of renal anomalies after urinary tract infections in hospitalized infants less than 2 months of age. J Perinatol. 2010; 30(4):281-5.
29
30. Pauchard JY, Chehade H, Kies CZ, Girardin E, Cachat F, Gehri M. Avoidance of voiding cystourethrography in infants younger than 3 months with Escherichia coli urinary tract infection and normal renal ultrasound. Arch Dis Child. 2017; 102(9):804-8.
30
31. Hasvold J, Bradford L, Nelson C, Harrison C, Attar M, Stillwell T. Gentamicin resistance among Escherichia coli strains isolated in neonatal sepsis. J Neonatal Perinatal Med. 2013; 6(2):173-7.
31
ORIGINAL_ARTICLE
Assessment of the Relationship between Hyperglycemia during the First 24 Hours Post-surgery and the Type of Calorie Intake in the Neonatal Intensive Care Unit
Background: The present study aimed to determine the mean blood glucose during the first 24 h post-surgery and its relation with the source of calorie intake.Methods: The data of the current observational retrospective study was collected from hospital medical records. A total of 45 neonates suffering from atresia in different parts of the gastrointestinal tract, who were candidates for open abdominal surgery from September to October 2016 were selected. Blood glucose within 24 h after the surgery were taken four times using a glucometer. Moreover, the mean blood glucose during this period was calculated. Independent Student's t-test, chi-square test, and logistic regression model were performed to assess the association of post-operative blood glucose with calorie and macronutrient intakes.Results: In one third of neonates, the mean blood glucose of the samples during the first day after the surgery was ≥180 mg/dl and the rest of them had mean blood glucose of 40-179 mg/dl. There was a significant relationship between blood glucose BG≥180 mg/dl and calorie (P=0.001), macronutrient (carbohydrate (P<0.001), and fat (P=0.04)) intakes. After adjustment of confounding variables, carbohydrate intake was found as an independent factor in increasing BG≥180 mg/dl during the first 24 h after the surgery (P=0.01). In addition, fat intake was observed as an effective factor in decreasing BG≥180 mg/dl during this time (P=0.04).Conclusion: The present study revealed that there was a significant relationship between mean blood glucose during the first 24 h after the surgery and intake of macronutrients (carbohydrate and fat).
https://ijn.mums.ac.ir/article_14296_5584d40ae5c6b41538a00b59528eead0.pdf
2020-01-01
24
30
10.22038/ijn.2019.35551.1541
Hyperglycemia
Macronutrients Intake
NICU
Post-surgery
Vahideh
Banazadeh
banazadehv931@maums.ac.ir
1
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Farkhondeh
Razmpour
razmpourf921@mums.ac.ir
2
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Majid
Sezavar
sezavardm@mums.ac.ir
3
Pediatric intensive care specialist, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Nooshin
Abdollahpour
nooshin.ap@gmail.com
4
Département of Biology, Faculty of Sciences, Young Researchers and Elite Club, Islamic Azad University-Mashhad Branch, Mashhad, Iran
AUTHOR
Gholamreza
Khademi
khademigh@mums.ac.ir
5
Neonatal Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001; 17(1):107-24.
1
2. Kao LS, Morris BH, Lally KP, Stewart CD, Huseby V, Kennedy KA. Hyperglycemia and morbidity and mortality in extremely low birth weight infants. J Perinatol. 2006; 26(12):730-6.
2
3. van der Griend BF, Lister NA, McKenzie IM, Martin N, Ragg PG, Sheppard SJ, et al. Postoperative mortality in children after 101,885 anesthetics at a tertiary pediatric hospital. Anesth Analg. 2011; 112(6):1440-7.
3
4. Catre D, Lopes MF, Madrigal A, Oliveiros B, Viana JS, Cabrita AS. Early mortality after neonatal surgery: analysis of risk factors in an optimized health care system for the surgical newborn. Rev Bras Epidemiol. 2013; 16:943-52.
4
5. Hays SP, Smith EB, Sunehag AL. Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants. Pediatrics. 2006; 118(5):1811-8.
5
6. Klein GW, Hojsak JM, Schmeidler J, Rapaport R. Hyperglycemia and outcome in the pediatric intensive care unit. J Pediatr. 2008; 153(3):379-84.
6
7. Hall NJ, Peters M, Eaton S, Pierro A. Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis. J Pediatr Surg. 2004; 39(6):898-901.
7
8. Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology. 2015; 123(6): 1455-72.
8
9. Adler A. Prediction of feeding difficulties in post-operative neonates. Connecticut: Yale University School of Medicine; 2014.
9
10. Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R, Parenteral Nutrition Guidelines Working Group. 1. Guidelines on paediatric parenteral nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr. 2005; 41:S1-4.
10
11. Letton RW, Chwals WJ, Jamie A, Charles B. Early postoperative alterations in infant energy use increase the risk of overfeeding. J Pediatr Surg. 1995; 30(7):988-93.
11
12. Thureen PJ. Neonatal nutrition and metabolism. Cambridge: Cambridge University Press; 2012.
12
13. Rennie JM, Kendall G. A manual of neonatal intensive care. 15th ed. Florida: CRC Press; 2013.
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14. Adler A. Prediction of feeding difficulties in post-operative neonates. Connecticut: Yale University School of Medicine; 2014.
14
15. Pierro A. Metabolism and nutritional support in the surgical neonate. J Pediatr Surg. 2002; 37(6):811-22.
15
16. Pierro A, Carnielli V, Filler RM, Smith J, Heim T. Metabolism of intravenous fat emulsion in the surgical newborn. J Pediatr Surg. 1989; 24(1):95-102.
16
17. Herman R, Btaiche I, Teitelbaum DH. Nutrition support in the pediatric surgical patient. Surg Clin. 2011; 91(3):511-41.
17
18. Bajwa SJ, Baruah MP, Kalra S, Kapoor MC.
18
Interdisciplinary position statement on management of hyperglycemia in peri-operative and intensive care. J Anaesthesiol Clin Pharmacol. 2015; 31(2):155.
19
19. Wu Y, Lai W, Pei J, Zhao Y, Wang Q, Xiang B. Hyperglycemia and its association with clinical outcomes in postsurgical neonates and small infants in the intensive care unit. J Pediatr Surg. 2016; 51(7):1142-5.
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20. Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Books; 1988.
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21. Nuntnarumit P, Chittamma A, Pongmee P, Tangnoo A, Goonthon S. Clinical performance of the new glucometer in the nursery and neonatal intensive care unit. Pediatr Int. 2011; 53(2):218-23.
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22. Khajavi L, Khademi G, Mehramiz M, Norouzy A, Safarian M. Association of dysglycemia with mortality in children receiving parenteral nutrition in pediatric intensive care unit. Turkish J Pediatr. 2018; 60(2):134-41.
23
23. Bajwa SS, Baruah MP, Kalra S, Kapoor MC. Guidelines on Inpatient Management of Hyperglycemia. Med Update. 2010; 23:164-9.
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24. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. New Engl J Med. 2001; 345(19):1359-67.
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25. Wu Y, Pei J, Yang XD, Zhao YY, Xiang B. Hyperglycemia and its association with clinical outcomes for patients in the pediatric intensive care unit after abdominal surgery. J Pediatr Surg. 2013; 48(4):801-5.
26
26. Hawdon JM, Aynsley-Green A. Disorders of blood glucose homeostasis in the neonate. London: Churchill Livingstone; 1992. P. 777-96.
27
27. Hemachandra AH, Cowett RM. Neonatal
28
hyperglycemia. New York: Pediatrics Review American Academy of Pediatrics; 1999. P. 16.
29
28. Srinivasa G, Jain R, Pildes RS, Kannan CR. Glucose homeostasis during anesthesia and surgery in infants. J Pediatr Surg. 1986; 21(8):718-21.
30
29. Anand KJ, Brown MJ, Bloom SR, Aynsley-Green A. Studies on the hormonal regulation of fuel metabolism in the human newborn infant undergoing anaesthesia and surgery. Hormone Res Paediatr. 1985; 22(1-2):115-28.
31
30. Jaksic T, Shew SB, Keshen TH, Dzakovic A, Jahoor F. Do critically ill surgical neonates have increased energy expenditure? J Pediatr Surg. 2001; 36(1):63-7.
32
31. Mehta NM, Bechard LJ, Dolan M, Ariagno K, Jiang H, Duggan C. Energy imbalance and the risk of overfeeding in critically ill children. Pediatr Crit Care Med. 2011; 12(4):398.
33
32. Jones MO, Pierro A, Hammond P, Nunn A, Lloyd DA. Glucose utilization in the surgical newborn infant receiving total parenteral nutrition. J Pediatr Surg. 1993; 28(9):1121-5.
34
33. Pierro A, Eaton S. Metabolism and nutrition in the surgical neonate. Semin Pediatr Surg. 2008; 17(4): 276-84.
35
34. Das JB, Joshi ID, Philippart AI. Depression of glucose utilization by Intralipid in the post-traumatic period: An experimental study. J Pediatr Surg. 1980; 15(6):739-45.
36
35. Ainsworth S, McGuire W. Percutaneous central venous catheters versus peripheral cannulae for delivery of parenteral nutrition in neonates. Cochrane Database Syst Rev. 2015; 10:CD004219.
37
36. Khan AI, Vasquez Y, Gray J, Wians Jr FH, Kroll MH. The variability of results between point-of-care testing glucose meters and the central laboratory analyzer. Arch Pathol Lab Med. 2006; 130(10): 1527-32.
38
ORIGINAL_ARTICLE
Intravenous Paracetamol and Patent Ductus Arteriosus Closure
Background: Standard medical treatments for patent ductus arteriosus (PDA) closure are, including indomethacin/ibuprofen and surgical ligation. Nowadays, a new strategy to close PDA is the use of paracetamol. The present study aimed to describe the use of intravenous (IV) paracetamol for PDA closure in neonates who present a contraindication to ibuprofen or ibuprofen failure with no possibility to perform surgical ligation due to major instability.Methods: The present study was conducted from January to December 2017 in the neonatal intensive care unit of Dr. Zainoel Abidin Hospital and Harapan Bunda Hospital, Banda Aceh, Indonesia, on neonates with hemodynamic significant PDA (hsPDA). All the subjects received IV paracetamol (15 mg/kg every 6 h) for 3 days. Thereafter, the ductus was evaluated by echocardiography on the 5th day after the regiment.Results: A total of 72 neonates were diagnosed with hsPDA and their average of gestational age was 34.26 weeks and their average of birth weight was 1945.69 g for 39 (54.2%) female neonates, 33 (45.8%) male neonates, 45 (62.5%) premature infants, and 27 (37.5%) full-term infants. About 26 (36.1%) infants had a closed PDAs on the 5th days of evaluation, 11 (15.3%) infants had regiment twice for closed PDA at the 10th days of evaluation, and 35 (48.6%) neonates had more closed PDA after three or four regiments. Successful closure with paracetamol was achieved in 51(70.8%) neonates, while 21 (29.2%) neonates failed the PDA closure.Conclusion: Based on the findings of the present study, IV paracetamol appears to be reasonably effective for PDA closure in both preterm and term infants. This should be the first-line of therapy choice when there are contraindications for the treatment with ibuprofen.
https://ijn.mums.ac.ir/article_14601_4d982847bd34561288ee771d218b9094.pdf
2020-01-01
31
35
10.22038/ijn.2020.39771.1636
effective choice
Paracetamol
Patent Ductus Arteriosus
Herlina
Dimiati
herlinadimiati@yahoo.com
1
Pediatric Cardiology Division, Department of Child Health, Medical School, Syiah Kuala University, Zainoel Abidin Hospital, Banda Aceh, Indonesia
LEAD_AUTHOR
Dora
Darussalam
herlinadimiati@gmail.com
2
Neonatology Division, Department of Child Health, Medical School, Syiah Kuala University, Zainoel Abidin Hospital, Banda Aceh, Indonesia .
AUTHOR
Isra
Firmansyah
herlinadimiati@unsyiah.ac.id
3
Neonatology Division, Department of Child Health, Medical School, Syiah Kuala University, Zainoel Abidin Hospital, Banda Aceh, Indonesia
AUTHOR
1. Agarwal R, Deorari AK, Paul VK. Patent ductus arteriosus in preterm neonates. Indian J Pediatr. 2008; 75(3):277.
1
2. Allegaert K, Anderson B, Simons S, van Overmeire B. Paracetamol to induce ductus arteriosus closure: is it valid? Arch Dis Child. 2013; 98(6):462-6.
2
3. Brunner B, Hoeck M, Schermer E, Streif W, Kiechl-Kohlendorfer U. Patent ductus arteriosus low platelets, cyclooxygenase inhibitors and intraventricular hemorrhage in very low birth weight preterm infants. J Pediatr. 2013; 163(1):23-8.
3
4. Weisz DE, More K, McNamara PJ, Shah PS. PDA ligation and health outcomes: a meta-analysis. Pediatrics. 2014; 133(4):e1024-46.
4
5. Hammerman C, Bin-Nun A, Markovitch E, Schimmel MS, Kaplan M, Fink D. Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics. 2011; 128(6):e1618-21.
5
6. Dani C, Poggi CH, Mosca F, Schena F, Lista G, Ramenghi L, et al. Efficacy and safety of IV paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial. Trials. 2016; 17:182.
6
7. El-Khuffash A, Amish J, Corcoran D, Shah P, Hooper CH, Brown N, et al. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr Res. 2014; 76(3):238-44.
7
8. Oncel MY, Yurttutan S, Uras N, Altug N, Ozdemir R, Ekmen S, et al. An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants. Arch Dis Child Fetal Neonatal Ed. 2013; 98(1):F94.
8
9. Oncel MY, Yurttutan S, Degirmencioglu H, Uras N, Altug N, Erdeve O, et al. IV paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants. Neonatology. 2013; 103(3):166-9.
9
10. Sinha R, Negi V, Dalal SS. An interesting observation of PDA closure with oral paracetamol in preterm neonates. J Clin Neonatol. 2013; 2(1):30-2.
10
11. Roofthooft DW, van Beynum IM, Helbing WA, Reiss IK, Simons SH. Paracetamol for ductus arteriosus closure: not always a success story. Concerning the article by M.Y. Oncel et al: IV paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants [Neonatology
11
2013;103:166-169]. Neonatology. 2013; 104(3):170.
12
12. Tekgündüz KS, Ceviz N, Caner I, Olgun H, Demirelli Y, Yolcu C, et al. IV paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. Cardiol Young. 2015; 25(6):1060-4.
13
13. Oncel MY, Eras Z, Uras N, Canpolat FE, Erdeve O, Oguz SS. Neurodevelopmental outcomes of preterm infants treated with oral paracetamol versus ibuprofen for patent ductus arteriosus. Am J Perinatol. 2017; 34(12):1185-9.
14
14. Hermes-DeSantis ER, Clyman RI. Patent ductus arteriosus: pathophysiology and management. J Perinatol. 2006; 26(Suppl 1):14-8.
15
ORIGINAL_ARTICLE
Assessment of Umbilical Cord Nucleated Red Blood Cell Count in Discharged and Dead Very Low Birth Weight Infants
Background: Predictive value of the umbilical nucleated red blood cells (NRBCs) at birth for neonatal outcomes has been assessed. Hence, the present study was conducted to compare NRBC between discharged and dead neonates.Methods: This cross-sectional study was performed on preterm newborns with a birth weight of < 1,500 g admitted to the Neonatal Intensive Care Unit of Ghaem Hospital, Mashhad, Iran, within 2012-2018. The subjects were divided into two groups of discharged and dead. Data collection tool was a researcher-made questionnaire containing three sections, namely maternal demographic information, neonatal data, and blood tests (measuring white blood cell [WBC], absolute NRBC, NRBC/100 WBC and blood gas). The collected data were analyzed in SPSS software (version 20), using t-test, Chi-square test, receiver operating characteristic curve, and regression models.Results: A total of 205 neonates, including 136 discharged neonates (66.03%) and 69 dead neonates (33.7%), were examined in the present study. The results demonstrated a significant difference between the two groups in terms of the first minute Apgar score (P=0.023), fifth minute Apgar score (P=0.010), gestational age (P=0.000), birth weight (P=0.000), WBC (P=0.020), absolute NRBC (P=0.004), NRBC percentage (P=0.001), duration of mechanical ventilation (P=0.029), duration of oxygen therapy (P=0.012).Moreover, mechanical ventilation (P=0.036), type of oxygen therapy (P=0.000), NRBC percentage (P=0.001), and absolute NRBC count (P=0.001) showed a statistically significant relationship with neonatal survival rate.Conclusion: As the findings indicated, mechanical ventilation, type of oxygen therapy, absolute NRBC count, and NRBC percentage can be used as markers for predicting neonatal mortality rate.
https://ijn.mums.ac.ir/article_14305_6da3f621d71be9a6c6446d19c665ba89.pdf
2020-01-01
36
42
10.22038/ijn.2019.38344.1603
death
Discharged
Neonates
NRBC
Prediction
Hassan
Boskabadi
boskabadih@mums.ac.ir
1
Department of Pediatrics, Faculty of Medicine, Mashhad University o Medical Sciences, Mashhad, Iran
AUTHOR
Forough
Rakhshanizadeh
rakhshanizadehf@mums.ac.ir
2
Department of Pediatrics, Faculty of Medicine, Mashhad University o Medical Sciences, Mashhad, Iran
AUTHOR
Maryam
Zakerihamidi
maryamzakerihamidi@yahoo.co.nz
3
Department of Midwifery, Faculty of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
LEAD_AUTHOR
1. Cunha AD, Fernandes DD, Melo PF, Guedes MH. Fatores associados à asfixia perinatal Factors associated with perinatal asphyxia. Rev Bras Ginecol Obstet. 2004; 26(10):799-805.
1
2. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? Where? Why? Lancet. 2005; 365(9462):891-900.
2
3. Boskabadi H, Omidian M, Mafinejad S. Neonatal Complications Related with Prolonged Rupture of Membranes .Macedonian Journal of Medical Sciences. 2011;4(1):93-8.
3
4. Boskabad H, Moudi A, Parvini Z, Barati T. Evaluation of the cause and related factors of neonatal mortality in Qaem hospital 2009-2010. Iran J Obstet Gynecol Infertil. 2012; 14(7):21-6.
4
5. Boskabadi H, Zakerihamidi M, Sadeghian MH, Avan A, Ghayour-Mobarhan M, Ferns GA. Nucleated red blood cells count as a prognostic biomarker in predicting the complications of asphyxia in neonates. J Maternal Fetal Neonatal Med. 2017; 30(21):2551-6.
5
6. Boskabadi H, Navaee Boroujeni A, Mostafavi-Toroghi H, Hosseini G, Ghayour-Mobarhan M, Hamidi Alamdari D, et al. Prooxidant-antioxidant balance in perinatal asphyxia. Indian J Pediatr. 2014;81(3):248-53.
6
7. Hermansen MC. Nucleated red bloodcells in the fetus and newborn. Arch Dis Child Fetal Neonatal Ed. 2001; 84(3):F211-5.
7
8. Ravishankar V, Buhimschi CS, Booth CJ, Bhandari V, Norwitz E, Copel J, et al. Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition. Am J Obstet Gynecol. 2007;
8
196(5):482.e1-8.
9
9. Stachon A, Bolulu O, Holland-Letz T, Krieg M. Association between nucleated red blood cells in bloodand the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70. Shock. 2005; 24(1):34-9.
10
10. Boskabadi H, Maamouri G, Afshari JT, Mafinejad S, Hosseini G, Mostafavi-Toroghi H, et al. Evaluation of serum interleukins-6, 8 and 10 levels as diagnostic markers of neonatal infection and possibility of mortality. Iran J Basic Med Sci. 2013; 16(12):1232.
11
11. Boskabadi H, Sadeghian MH. Investigation of changes in nucleated red blood cells in neonatal infection. Iran J Neonatol. 2017; 8(4):26-32.
12
12. Perrone S, Vezzosi P, Longini M, Marzocchi B, Tanganelli D, Testa M, et al. Nucleated red blood cell count in term and preterm newborns: reference values at birth. Arch Dis Child Fetal Neonatal Ed. 2005; 90(2):F174-5.
13
13. Bahman Bijari B, Farahmandinia Z, Hazeghi A. Predictive value of nucleated red blood cell counts in cord and peripheral blood of asphyxiated term neonates in the first week of life. J Shahid Sadoughi Univ Med Sci. 2010; 17(5):330-6.
14
14. Schaer C, Schmugge M, Frey B. Prognostic value of nucleated red blood cells in critically ill children. Swiss Med Wkly. 2014; 144:w13944.
15
15. Marchant T, Willey B, Katz J, Clarke S, Kariuki S, Ter Kuile F, et al. Neonatal mortality risk associated with preterm birth in East Africa, adjusted by weight for gestational age: individual participant level meta-analysis. PLoS Med. 2012; 9(8):e1001292.
16
16. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010; 375(9730):1969-87.
17
17. International development, poverty. World Bank Group. Available at: URL: http://www.worldbank. org; 2015.
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18. Simmons LE, Rubens CE, Darmstadt GL, Gravett MG. Preventingpreterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions. Semin Perinatol. 2010; 34(6):408-15.
19
19. Oliveira TG, Freire PV, Moreira FT, Moraes JD, Arrelaro RC, Rossi S, et al. Apgar score and neonatal mortality in a hospital located in the southern area of São Paulo City, Brazil. Einstein (São Paulo). 2012; 10(1):22-8.
20
20. Boskabadi H, Ashrafzadeh F, Doosti H, Zakerihamidi M. Assessment of risk factors and prognosis in asphyxiated infants. Iran J Pediatr. 2015; 25(4):1-6.
21
21. Casey BM, McIntire DD, Leveno KJ. The continuing value of the Apgar score for the assessment of newborn infants. N Engl J Med. 2001; 344(7): 467-71.
22
22. Hagen EW, Sadek-Badawi M, Carlton DP, Palta M. Permissive hypercapnia and risk for braininjury and developmental impairment. Pediatrics. 2008; 122(3):e583-9.
23
23. Msall ME. Neurodevelopmental surveillance in the first 2 years after extremely preterm birth:evidence, challenges, and guidelines. Early Hum Dev. 2006; 82(3):157-66.
24
24. Christensen RD, Henry E, Andres RL, Bennett ST. Reference ranges for blood concentrations of nucleated red blood cells in neonates. Neonatology. 2011; 99(4):289-94.
25
25. Green DW, Hendon B, Mimouni FB. Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates. Pediatrics. 1995; 96(3):475-8.
26
26. Krajewski P, Welfel E, Kalinka J, Pokrzywnicka M, Kwiatkowska M. Evaluation of the relationship between circulating nucleated red blood cells count and inborn infection in neonates. Ginekologia Polska. 2008; 79(1):17-22.
27
27. Boskabadi H, Maamouri G, Sadeghian MH, Ghayour-Mobarhan M, Heidarzade M. Early diagnosis of perinatal asphyxia by nucleated red blood cell count: a case-control study. Arch Iran Med. 2010;
28
13(4):275.
29
28. Goel M, Dwivedi R, Gohiya P, Hegde D. Nucleated redblood cell in cord blood as a marker of perinatal asphyxia. J Clin Neonatol. 2013; 2(4):179.
30
29. Widness JA, Clemons GK, Garcia JF, Oh W, Schwartz R. Increased immunoreactive erythropoietin in cord serum after labor. Am J Obstet Gynecol. 1984; 148(2):194-7.
31
30. Elveđi Gašparović V, Gverić Ahmetašević S, Čolić A. Nucleated red blood cells count as first prognostic marker for adverse neonatal outcome in severe preeclamptic pregnancies. Collegium Antropol. 2012; 36(3):853-7.
32
31. Bakhshaee M, Boskabadi H, Hassanzadeh M, Nourizadeh N, Ghassemi MM, Khazaeni K, et al. Hearing impairment in the neonate of preeclamptic women. Otolaryngol Head Neck Surg. 2008; 139(6):846-9.
33
ORIGINAL_ARTICLE
Evaluation of Pulse Oximetry in the Early Diagnosis of Cardiac and NonCardiac Diseases in Healthy Newborns
Background: Critical congenital heart diseases (CCHDs) are among the most common birth malformations. This study aimed to determine the cardiac and noncardiac diseases in the Iranian healthy newborns using pulse oximetry (POX) as a suggested screening method.Methods: In this cross-sectional study, healthy term and near term neonates who were born from October 2017 to March 2018 were evaluated. Preductal and postductal POX was performed in all asymptomatic healthy newborns after 24 hours of life or at any time before discharge from the nursery. Oxygen saturation (SPO2) was considered normal if SPO2 was 95%, and the difference between preductal O2 saturation and postductal POX was obtained at ≤ 3%. The POX was repeated after 2 hours for abnormal patients. In the case of the same results in both repeated measures, echocardiography, chest X-ray, sepsis screening, and blood glucose were conducted.Results: A total of 413 asymptomatic healthy term and near term neonates underwent the pulse oximetry screening (POX). The mean birth weight and gestational age of the neonates were 3256.31±509.62 gr and 38.2 weeks, respectively. The POX was performed averagely 19.5 hours after birth. Finally, a total of 10 cases were detected with abnormal POX. Among these 10 patients, three cases had cardiac diseases (i.e., transposition of the great arteries, ventricular septal defect/pulmonary atresia, and ventricular septal defect/pulmonary hypertension), three cases had noncardiac diseases (i.e., esophageal stenosis, hypoglycemia, and persistent pulmonary hypertension/sepsis), and four subjects were healthy.Conclusion: The obtained findings showed that routine pox, along with clinical examinations could be applied, especially in developing countries for the early detection of cardiac and noncardiac diseases in asymptomatic newborns.
https://ijn.mums.ac.ir/article_14172_75761589f632fac10a74e608015046d8.pdf
2020-01-01
43
50
10.22038/ijn.2019.38511.1608
Cardiac and noncardiac diseases
Critical Congenital Heart Disease
Newborns
Pulse Oximetry
Pre and Postductal Saturation
Ziba
Mosayebi
mosayebiir@gmail.com
1
Department of Neonatal Care Unit, Children’s Medical Center, Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Amir Hossein
Movahedian
movahedian.ah@gmail.com
2
Pediatric Department, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Elaheh
Amini
amini_el88@yahoo.com
3
Pediatric Department, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Parvin
Akbari Asbagh
parvin.akbariasbagh@yahoo.com
4
Pediatric Department, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Vafa
GhorbanSabagh
dr.sabagh@yahoo.com
5
Pediatric Department, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mamak
Shariat
mshariat@tums.ac.ir
6
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Hossein
Dalili
hoseindalili@yahoo.com
7
Pediatric Department, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Maryam
Saeedi
m_saidi52@yahoo.com
8
Department of Neonatal Care Unit, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. Shahzad M, Waqar T, Waheed KAI, Gul R, Fatima ST. Pulse oximetry as a screening tool for critical congenital heart defects in newborns. J Pak Med Assoc. 2017; 67(8):1220-3.
1
2. Plana MN, Zamora J, Suresh G, Fernandez‐Pineda L, Thangaratinam S, Ewer AK. Pulse oximetry screening for critical congenital heart defects. Cochrane Database Syst Rev. 2018; 3:CD011912.
2
3. Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK. Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis. Lancet. 2012; 379(9835):2459-64.
3
4. Tsao PC, Shiau YS, Chiang SH, Ho HC, Liu YL, Chung YF, et al. Development of a newborn screening program for critical congenital heart disease (CCHD) in Taipei. PloS One. 2016; 11(4):e0153407.
4
5. Jawin V, Ang H-L, Omar A, Thong M-K. Beyond critical congenital heart disease: newborn screening using pulse oximetry for neonatal sepsis and respiratory diseases in a middle-income country. PloS oneOne. 2015; 10(9):e0137580
5
6. Narayen IC, Blom NA, van Geloven N, Blankman EI, van den Broek AJ, Bruijn M, et al. Accuracy of pulse oximetry screening for critical congenital heart defects after home birth and early postnatal
6
discharge. J Pediatr. 2018; 197:29-35.e1.
7
7. Narayen IC, Blom NA, Ewer AK, Vento M, Manzoni P, te Pas AB. Aspects of pulse oximetry screening for critical congenital heart defects: when, how and why? Arch Dis Child Fetal Neonatal Ed. 2015; 101(2):F162-7.
8
8. Ewer AK. Pulse oximetry screening for critical congenital heart defects in newborn infants: Should it be routine? Arch Dis Child Fetal Neonatal Ed. 2014; 99(1):F93-5.
9
9. Movahedian AH, Mosayebi Z, Sagheb S. Evaluation of pulse oximetry in the early detection of cyanotic congenital heart disease in newborns. J Tehran Univ Heart Center. 2016; 11(2):73.
10
10. Ismail AQT, Cawsey M, Ewer AK. Newborn pulse oximetry screening in practice. Arch Dis Child Educ Pract Ed. 2017; 102(3):155-61.
11
11. Mahle WT, Newburger JW, Matherne GP, Smith FC, Hoke TR, Koppel R, et al. Role of pulse oximetry in examining newborns for congenital heart disease: a scientific statement from the American Heart Association and American Academy of Pediatrics. Circulation. 2009; 120(5):447-58.
12
12. Ewer AK, Martin GR. Newborn pulse oximetry screening: which algorithm is best? Pediatrics. 2016; 138(5):e20161206.
13
13. Johnson LC, Lieberman E, O’Leary E, Geggel RL. Prenatal and newborn screening for critical congenital heart disease: findings from a nursery. Pediatrics. 2014; 134(5):916-22.
14
14. Mosayebi Z, Movahedin AH, Safari A, Akbari H. Evaluation of the result of hand and foot pulse oximetry in the early detection of cyanotic congenital heart diseases in newborns delivered at Kashan Shabihkhani hospital during the first 6 months of 2006. Razi J Med Sci. 2012; 19(101):15-22.
15
ORIGINAL_ARTICLE
Relationship between Mothers’ Spiritual Health Scores with Newborns’ Physical Development Indices and Physiologic Parameters in Hazrat Zeinab Training Hospital
Background: Spiritual health is one of the important factors predicting human health. This study aimed to determine the relationship between mothers’ spiritual health with newborns’ physical development indices and other physiologic parameters.Methods: In this cross-sectional study, 155 mothers giving birth to newborns were selected from Hazrat Zeinab hospital during 2017-2018. The data were gathered through a checklist containing all mothers’ and babies’ demographic information. Moreover, we used Palutzian and Ellison’s scale to measure the mothers’ spiritual health score. To analyze the data, we used SPSS software (version 18).Results: The mothers’ mean age was reported as 27.84±6.67 years. Moreover, 71.6% of the mothers’ educational level was under diploma, and 65.2% of them were not employed (did not have any jobs). The mean score of the mothers’ spiritual health was 75.96±8.75. In this regard, 97.4% of the subjects had a moderate level of spiritual health, and 2.6% of them had a high level of spiritual health. There was a significant negative correlation between the mothers’ spiritual health score and neonates’ physical development scores. However, this correlation was significant (height: r=-0.1, P=0.21; weight r=-0.058, P=0.47; size of head: r=-0.033, P=0.6; size of belly: r=0.047, P=0.56), and there were positive correlations between the mothers’ spiritual health scores (heart beats: r=-0.034, P=0.66; percentage of saturated oxygen: r=-0.034, P=0.90; degree of heat: r=0.047, P=0.96). However, none of these correlations were statistically significant.Conclusion: In general, the results of this study showed that most of the mothers had a normal and high level of spiritual health, but a higher percentage of moderate level of spiritual health was observed in mothers, compared to those of other levels. Moreover, no significant correlations were found between mothers’ spiritual health scores with newborns’ physical development indices and other physiologic factors.
https://ijn.mums.ac.ir/article_14173_aa3c1f680bf25f09de3269ddf22b3412.pdf
2020-01-01
51
59
10.22038/ijn.2019.38835.1615
mothers
Newborns
physical development indices
physiologic indices
Spiritual health
Sedigheh
Tayebi
sedigetayebi@gmail.com
1
Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Zohreh
Montaseri
montaseriz@sums.ac.ir
2
Community-Based Psychiatric Care Research Center, Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mitra
Edraki
edrakim@sums.ac.ir
3
Community Based Psychiatric Care Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Marzieh
Akbarzadeh
akbarzadm@sums.ac.ir
4
Maternal-Fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
1. Haji A, Mahmoud Fh, Karimi Q, Abbasi A. The relationship between psychological profile of pregnant women with weight, height and head circumference of infants at birth. J Health Breeze. 2016; 5(1):18-26.
1
2. Howland LC. Preterm birth: implications for family
2
stress and coping. Newborn Infant Nurs Rev. 2007; 7(1):14-9.
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3. Burke KC, Burke JD, Rae DS, Regier DA. Comparing age at onset of major depression and other psychiatric disorders by birth cohorts in five US community populations. Arch Gen Psychiatry. 1991; 48(9):789-95.
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4. Selman L, Harding R, Gysels M, Speck P, Higginson IJ. The measurement of spirituality in palliative care and the content of tools validated cross-culturally: a systematic review. J Pain Symptom Manage. 2011; 41(4):728-53.
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5. Cooper KL, Chang E, Sheehan A, Johnson A. The impact of spiritual care education upon preparing undergraduate nursing students to provide spiritual care. Nurse Educ Today. 2013; 33(9):1057-61.
6
6. Rahimi N, Nouhi E, Nakhaee N. Spiritual well-being and attitude toward spirituality and spiritual care in nursing and midwifery students. Iran J Nurs. 2013; 26(85):55-65.
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7. Pickner WJ, Puumala SE, Chaudhary KR, Burgess KM, Payne NR, Kharbanda AB. Emergency department utilization for mental health in American Indian children. J Pediatr. 2016; 174:226-31.e3.
8
8. Jadidi A, Farahaninia M, Janmohammadi S, Haghani H. Spiritual well being of elderly people resident in nursing home. J Geriatr Nurs. 2015; 1(2):22-30.
9
9. Tajvidi M, Dehghan Nayeri N. Experiencing spirituality in pregnancy: a phenomenological study. J Urmia Nurs Midwifery Facul. 2016; 14(8):674-81.
10
10. Callister LC, Khalaf I. Spirituality in childbearing women. J Perinat Educ. 2010; 19(2):16-24.
11
11. Avaznejad N, Ravanipour M, Bahreyni M, Motamed N. Comparison of spiritual health in mothers with healthy children and mothers of children with chronic disease in Kerman 2015-2016. Nurs Vulnerables. 2016; 3(8):13-25.
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12. Burkhardt MA, Nagai-Jacobson MG. Spirituality: living our connectedness. Massachusetts: Cengage Learning; 2002.
13
13. Sayyed Fatemi N, Rezai M, Givari A, Hosseini F. Impact of prayer on spiritual health of patients with cancer. Payesh. 2006; 5(4):295-304.
14
14. Mann JR, Mannan J, Quiñones LA, Palmer AA, Torres M. Religion, spirituality, social support, and perceived stress in pregnant and postpartum Hispanic women. J Obstet Gynecol Neonatal Nurs. 2010; 39(6):645-57.
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15. Kadivar M, Seyedfatemi N, Jeshvaghanee SS, Cheraghi MA, Haghani H. Exploring the relationship between spiritual well-being and stress and coping strategies in the mothers of infants hospitalized in the neonatal intensive care units. Daneshvar Med. 2015; 22(118):67-76.
16
16. Vafaei Fooladi A, Rassouli M, Yaghmaie F, Shakeri N. Assessing correlation between spiritual wellbeing and stress of mothers of hospitalized newborns in neonatal intensive care units. Iran J Nurs. 2015; 28(95):54-62.
17
17. Haji Rafiei E, Tork Zahrani S, Alavi Majd H, Nayebi
18
Nia As. Spiritual health and its related factors in pregnant women presenting to health centers In Qazvin, Iran, In 2015. J Nurs Midwifery Urmia Univ Med Sci. 2018; 16(4):225-33.
19
18. Narimani M, Rostami M. Role of religious attitudes, spiritual well-being and social support in predicting the life satisfaction in mothers of mental retardation children. Islam Health J. 2014; 1(3):41-9.
20
19. Rezaei M, Adib-Hajbaghery M, Seyedfatemi N, Hoseini F. Prayer in Iranian cancer patients undergoing chemotherapy. Complement Ther Clin Prac. 2008; 14(2):90-7.
21
20. Domar AD, Penzias A, Dusek JA, Magna A, Merarim D, Nielsen B, et al. The stress and distress of infertility: does religion help women cope? Sex Reprod Menopause. 2005; 3(2):45-51.
22
21. McCoubrie RC, Davies AN. Is there a correlation between spirituality and anxiety and depression in patients with advanced cancer? Support Care Cancer. 2006; 14(4):379-85.
23
22. Nelson CJ, Rosenfeld B, Breitbart W, Galietta M. Spirituality, religion, and depression in the terminally ill. Psychosomatics. 2002; 43(3):213-20.
24
23. Kabiry B, Shahri P, Azarnosh S, Haghighizadeh M, Mirfathi S. The relationship between mother’s general health and growth of below-6-month-old infants referred to health centers of west of Ahvaz. Sadra Med Sci J. 2015; 3(3):227-34.
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24. Underwood LG, Teresi JA. The daily spiritual experience scale: development, theoretical description, reliability, exploratory factor analysis, and preliminary construct validity using health-related data. Ann Behav Med. 2002; 24(1):22-33.
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25. Liou SR, Wang P, Cheng CY. Effects of prenatal maternal mental distress on birth outcomes. Women Birth. 2016; 29(4):376-80.
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26. Bazrafshan MR, Rad AM. The effect of pregnant women’s anxiety on apgar score and birth weight of newborns (2009). Sci J Hamadan Nurs Midwifery Facul. 2009; 17(12):58-68.
28
27. Dehestani H, Moshfeghy Z, Ghodrati F, Akbarzadeh M. The relationship of spiritual health and mother’s forgiveness with her anxiety in the labor of the pregnant women. Int J Womens Health Reprod Sci. 2018; 7(2):174-9.
29
28. Akbarzadeh M, Masoudi Z, Zare N, Vaziri F. Comparison of the effects of doula supportive care and acupressure at the BL32 point on the mother’s anxiety level and delivery outcome. Iran J Nurs Midwifery Res. 2015; 20(2):239.
30
29. Akbarzadeh M, Masoudi Z, Hadianfard MJ, Kasraeian M, Zare N. Comparison of the effects of maternal supportive care and acupressure (BL32 acupoint) on pregnant women’s pain intensity and delivery outcome. J Pregnancy. 2014; 2014:129208.
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30. Adanikin AI, Onwudiegwu U, Akintayo AA. Reshaping maternal services in Nigeria: any need for spiritual care? BMC Pregnancy Childbirth. 2014; 14(1):196.
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31. Abiodun OA, Adetoro OO, Ogunbode OO. Psychiatric morbidity in a pregnant population in Nigeria. Gen
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Hosp Psychiatry. 1993; 15(2):125-8.
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32. Carmichael SL, Shaw GM, Yang W, Abrams B, Lammer EJ. Maternal stressful life events and risks of birth defects. Epidemiology. 2007; 18(3):356-61.
35
33. Sable MR, Wilkinson DS. Impact of perceived stress, major life events and pregnancy attitudes on low birth weight. Fam Plann Perspect. 2000; 32(6):288-94.
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34. Williamson JH, LeFevre M. Tangible assistance: a simple measure of social support predicts pregnancy outcome. Fam Pract Res J. 1992; 12(3):289-95.
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35. Hasanjanzadeh P, Faramarzi M. Relationship between maternal general and specific-pregnancy stress, anxiety, and depressionsymptoms and pregnancy outcome. J Clin Diagn Res. 2017; 11(4):VC04-7.
38
36. Aslami E, Alipour A, Aghayusefi A, Najib F. Assessing the effectiveness of mindfulness-based islamic–spiritual schemas on anxiety of mothers pregnancy and infants physiological health. J Health Psychol. 2015; 4(14):5-16.
39
37. Toosi M, Akbarzadeh M, Zare N, Sharif F. The role of relaxation training in health index of infants in pregnant mothers. J Jahrom Univ Med Sci. 2013; 11(1):14.
40
38. Akbarzadeh M, Dokuhaki S, Joker A, Pishva N, Zared N. Teaching attachment behaviors to pregnant women: a randomized controlled trial of effects on infant mental health from birth to the age of three months. Ann Saudi Med. 2016; 36(3):175-83.
41
39. Dokuhaki A, Akbarzadeh M, Pishva N, Zare N. A study of the effect of training pregnant women
42
about attachment skills on infants motor development indices at birth to four months. Fam Med Prim Care Rev. 2017; 19(2):114-22.
43
40. Dokuhaki S, Heidary M, Akbarzadeh M. Investigation of the effect of training attachment behaviors to pregnant mothers on some physical indicators of their infants from birth to three months based on the separation of male and female infants. Pediatr Neonatol. 2018; 60(3):324-31.
44
41. Akbarzadeh M , Bahmani N, Moatari M, PourAhmad S, Zare N .The effects of training based on BASNEF model and acupressure at GB21 point on the infants’ physical growth indicators. Iran J Neonatol. 2014; 5(4):18-24.
45
42. Akbarzadeh M, Moattari M, Bahmani N, Bonyadpour B, Pour Ahmad S. Comparison of the effects of educational programs on the development of infants aged 1-3 months based on the BASNEF model and application of acupressure on the GB-21 point. Iran J Neonatol. 2016; 7(2):20.
46
43. Setodeh S, Sharif F, Akbarzadeh M. The impact of paternal attachment training skills on the extent of maternal neonatal attachment in primiparous women: a clinical trial. Fam Med Prim Care Rev. 2018; 20(1):47-54.
47
44. Edraki M, Zendeh-Zaban S, Beheshti PN, Hemati F, Haghpanah S. The effect of maternal attachment behaviors program on physiological indicators of preterm infants: a clinical trial. Sadra Med Sci J. 2017; 4(1):1-10.
48
ORIGINAL_ARTICLE
Specific Ultrasound Pattern of Perinatal Torsioned Ovarian Cysts: Sonographic-pathologic Correlation
Background: The accurate differentiation of perinatal torsioned ovarian cysts (PTOCs) in neonates is of utmost importance. This importance is due to the fact that if PTOCs are diagnosed properly, minimally invasive or conservative management approaches can be offered. The present study aimed to describe the ultrasound findings of PTOCs and compare the results with pathological findings.Methods: This prospective cross-sectional study was conducted in Mashhad University of Medical Sciences, Mashhad, Iran, within 2014-2019. All infants with an intra-peritoneal cyst underwent meticulous ultrasound examination. Patients were followed up until reaching the final diagnosis. In surgically approved PTOCs, the correlation between sonographic and pathologic findings was examined.Results: Twenty two cases (aged 2 days to 6 months, mean age = 6 weeks) with PTOC were diagnosed during this time. Cysts were mainly on the right side (86%) with mean diameter of 51 mm (27-73mm). The ultrasonogrphic signs of fluid debris level, triple-layer wall and wrinkled inner layer were observed in almost all of patients.The pathologic triple-layer of perinatal torsioned ovarian cysts included necrotic content with granulation, stroma, and epithelium layers was observed by ultrasound as a uni-locular cyst containing fluid debris level with an echogenic wrinkled inner layer, a hypoechoic uneven non-uniform middle layer and echogenic outer epithelial surface.Conclusion: Sonographically detected triple-layered pattern for PTOCs was completely in agreement with pathologic results. Then, this specific ultrasound pattern is pathognomonic for PTOC.
https://ijn.mums.ac.ir/article_14602_23b6cef4ac3798245b655a739b081c65.pdf
2020-01-01
60
66
10.22038/ijn.2020.39619.1629
Pathology
Perinatal ovarian cyst
Ultrasound
sensitivity
specificity
Torsion
Seyed Ali
Alamdaran
alamdarana@mums.ac.ir
1
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Nona
Zabolinejad
ijn@mums.ac.ir
2
Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Lida
Jarahi
jarahil@mums.ac.ir
3
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Maryam
Tavakoli
tavakolimnf@gmail.com
4
Department of Radiology, Faculty of medicine, North khorasan University of Medical Sciences, Bojnurd, Iran
AUTHOR
Fariborz
Azizi
azizif941@mums.ac.ir
5
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad
Yekta
ijn1389@gmail.com
6
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ali
Feyzi
feyzila@mums.ac.ir
7
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. Luis JD, Ricardo PÃ, Pomares A, Bravo C, Francisco GÃ, Aguar Ã, et al. Congenital ovarian cyst: diagnosis and perinatal management. J Gynecol Neonatal Biol. 2015; 1(1):1-5.
1
2. Spence JE, Domingo M, Pike C, Wenning J. The resolution of fetal and neonatal ovarian cysts. Adolesc Pediatr Gynecol. 1992; 5(1):27-31.
2
3. Akın MA, Akın L, Özbek S, Tireli G, Kavuncuoğlu S, Sander S, et al. Fetal-neonatal ovarian cysts--their monitoring and management: retrospective evaluation of 20 cases and review of the literature. J Clin Res Pediatr Endocrinol. 2010; 2(1):28-33. 4. Catania VD, Briganti V, Di Giacomo V, Miele V, Signore F, de Waure C, et al. Fetal intra-abdominal cysts: accuracy and predictive value of prenatal ultrasound. J Matern Fetal Neonatal Med. 2016; 29(10):1691-9.
3
5. Bagolan P, Giorlandino C, Nahom A, Bilancioni E, Trucchi A, Gatti C, et al. The management of fetal ovarian cysts. J Pediatr Surg. 2002; 37(1):25-30.
4
6. Mostofian E, Ornvold K, Latchaw L, Harris RD. Prenatal sonographic diagnosis of abdominal
5
mesenteric lymphangioma. J Ultrasound Med. 2004; 23(1):129-32.
6
7. Tseng D, Curran TJ, Silen ML. Minimally invasive management of the prenatally torsed ovarian cyst. J Pediatr Surg. 2002; 37(10):1467-9.
7
8. Aziz D, Davis V, Allen L, Langer JC. Ovarian torsion in children: is oophorectomy necessary? J Pediatr Surg. 2004; 39(5):750-3.
8
9. Foley PT, Ford WD, McEwing R, Furness M. Is conservative management of prenatal and neonatal ovarian cysts justifiable? Fetal Diagn Ther. 2005; 20(5):454-8. 10. Nussbaum AR, Sanders RC, Hartman DS, Dudgeon DL, Parmley TH. Neonatal ovarian cysts: sonographic-pathologic correlation. Radiology. 1988; 168(3): 817-21.
9
11. Godfrey H, Abernethy L, Boothroyd A. Torsion of an ovarian cyst mimicking enteric duplication cyst on transabdominal ultrasound: two cases. Pediatr Radiol. 1998; 28(3):171-3.
10
12. Kim HS, Yoo SY, Cha MJ, Kim JH, Jeon TY, Kim WK. Diagnosis of neonatal ovarian torsion: emphasis on prenatal and postnatal sonographic findings. J Clin Ultrasound. 2016; 44(5):290-7.
11
13. Vitezica I, Czernik C, Rothe K, Hinkson L, Ladendorf B, Henrich W. Prenatal diagnosis and management of a massive fetal ovarian hemorrhagic cyst torsion with secondary fetal anemia. J Clin Ultrasound. 2014; 42(4).219-22.
12
14. Ozcan HN, Balci S, Ekinci S, Gunes A, Oguz B, Ciftci AO, et al. Imaging findings of fetal-neonatal ovarian cysts complicated with ovarian torsion and auto-amputation. Am J Reontgenol. 2015; 205(1):185-9.
13
15. Brandt ML, Helmrath MA. Ovarian cysts in infants and children. Semin Pediatr Surg. 2005; 14(2):78-85.
14
16. Cheng G, Soboleski D, Daneman A, Poenaru D, Hurlbut D. Sonographic pitfalls in the diagnosis of enteric duplication cysts. AJR Am J Roentgenol. 2005; 184(2):521-5.
15
17. Trinh TW, Kennedy AM. Fetal ovarian cysts: review of imaging spectrum, differential diagnosis, management, and outcome. Radiographics. 2015; 35(2):621-35. 18. Llorens Salvador R, Sangüesa Nebot C, Pacheco Usmayo A, Picó Aliaga S, Garcés Iñigo E. Neonatal ovarian cysts: ultrasound assessment and differential diagnosis. Radiologia. 2017; 59(1):31-9.
16
19. Giorlandino C, Bilancioni E, Bagolan P, Muzii L, Rivosecchi M, Nahom A. Antenatal ultrasonographic diagnosis and management of fetal ovarian cysts. Int J Gynaecol Obstet. 1994; 44(1):27-31.
17
20. Monnery-Noché ME, Auber F, Jouannic JM, Bénifla JL, Carbonne B, Dommergues M, et al. Fetal and neonatal ovarian cysts: is surgery indicated? Prenat Diagn. 2008; 28(1):15-20.
18
21. Chinchure D, Ong CL, Loh AH, Rajadurai VS. Neonatal ovarian cysts: role of sonography in diagnosing torsion. Ann Acad Med Singapore. 2011; 40(6):291-5.
19
22. Ogul H, Havan N, Pirimoglu B, Guvendi B, Kisaoglu A, Kantarci M. Prenatal and postnatal ultrasonographic findings of the torsioned ovarian cyst: a case report and brief literature review. Int Surg. 2015; 100(3):514-7.
20
23. McKenzie AS, Dyer RB. The “fishnet” appearance. Abdom Imaging. 2015; 40(6):2058-9.
21
24. Koike Y, Inoue M, Uchida K, Kawamoto A, Yasuda H, Okugawa Y, et al. Ovarian autoamputation in a neonate: a case report with literature review. Pediatr Surg Int. 2009; 25(7):655-8.
22
ORIGINAL_ARTICLE
A Study of the Relationship between Job Satisfaction and Burnout among Neonatal Intensive Care Unit Staff
Background: Considering the importance of job satisfaction and occupational burnout among nurses, the present study aimed to determine the prevalence of occupational burnout and the degree of job satisfaction among neonatal intensive care unit (NICU) nurses.Methods: The current research was a cross-sectional study in which the Job Descriptive Index and Maslach Burnout Inventory were distributed among the NICU nurses. The collected data were analyzed using SPSS software.Results: A total of 30 NICU nurses working in two public and private hospitals participated in the present study. The mean age of the participants was measured at 37.46±6.93 years, most of them (73.3%) held a Bachelor’s degree and more than 60% were married. No significant relationship between job satisfaction and burnout was observed among the nurses. Both variables were moderate among the NICU nurses as representatives of the staff working in special units.Conclusion: It is widely believed that people who are exposed to extreme stress for a long time are more likely to suffer from occupational burnout. Moreover, considering the importance of this issue in healthcare environments for the provision of services that physically and mentally affect patients, it is recommended to pay greater attention to employee satisfaction and burnout process in hospital settings.
https://ijn.mums.ac.ir/article_14684_d954678484f27ce7fc78e7cfcf22a47c.pdf
2020-01-01
67
70
10.22038/ijn.2019.39744.1634
Burnout
Job satisfaction
NICU
Reza
Saeidi
saeedir@mums.ac.ir
1
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Azra
Izanloo
a.izanloo64@gmail.com
2
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
AUTHOR
Sara
Izanlou
izanlous2@yahoo.com
3
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
LEAD_AUTHOR
1. Saeidi R, Sadeghi V. Equity in health: Comparison of children health indices in poor and rich zones. Iran J Neonatol. 2015; 5(4):15-18. 2. Alkahthani N, Allam Z. A comparative study of job burnout, job involvement, locus of control and job satisfaction among banking employees of kingdom of Saudi Arabia. Life Sci J. 2013; 10(4):2135-44. 3. Naz S, Rehman S, Saqib H. The relationship between job satisfaction and personality trait among bank employees. Far East J Psychol Busin. 2013; 11(5):57-72.
1
4. Rosales RA, Labrague LJ, Rosales GL. Nurses' Job satisfaction and Burnout: is there a connection? Int J Adv Nurs Stud. 2013; 2(1):1. 5. Lackritz JR. Exploring burnout among university faculty: incidence, performance, and demographic issues. Teach Teacher Educ. 2004; 20(7):713-29.
2
6. Shakeri MT. The relationship between job satisfaction and job performance among midwives working in healthcare centers of Mashhad, Iran. Reprod Health. 2014; 2(3):157-64.
3
7. Zandi A, Kohandel M, Kiaye A. Effects of exercise on the rate of job burnout and job satisfaction staff Islamic Azad University Shahr Quds Branch. Ann Biol Res. 2013; 4(6):29-35.
4
8. Maslach C, Jackson S, Leiter MP. Maslach burnout inventory manual. 3rd ed. California: Consulting Psychologists Press Inc; 1997.
5
9. Moghimi SM. Organization and management research approach. Tehran: Terme Publisher; 2001. P. 315-20. (Persian)
6
10. Filian E. Evaluation of burnout and its correlation with coping mechanisms in nurses of educational hospitals of Tehran. [Dissertation]. Tehran: Tehran University of Medical Sciences; 1993. (Persian)
7
11. Talaei A, Mohammadnejad M, Samari AA. Burnout in staffs of health care centers in Mashhad. J Fund Mental Health. 2007; 36:133-42.
8
12. Kilfedder CJ, Power KG, Wells TJ. Burnout in psychiatric nursing. J Adv Nurs. 2001; 34(3):383-96.
9
13. Keller KL, Koenig WJ. Management of stress and prevention of burnout in emergency physicians. Ann Emerg Med. 1989; 18(1):42-7.
10
14. Ozyurt A, Hayran O, Sur H. Predictors of burnout and job satisfaction among Turkish physicians. J Assoc Phys. 2006; 99(3):161-9.
11
15. Sharma A, Sharp DM, Walker LG, Monson JR. Stress and burnout among colorectal surgeons and colorectal nurse specialists working in the National Health Service. Colorectal Dis. 2008; 10(4):397-406.
12
ORIGINAL_ARTICLE
Effect of Enteral Administration of Granulocyte-Colony Stimulating Factor (G-CSF) on Feeding Tolerance in Very Low Birth Weight and Extremely Low Birth Weight Neonates; a Historical-Controlled Clinical Trial
Background: The current study aimed to investigate the effect of enteral Granulocyte-Colony Stimulating G-CSF(Factor) on feeding tolerance in very low birth weight (VLBW) and extremely low birth weight (ELBW) neonates.Methods: This historical-controlled clinical trial was conducted on VLBW and ELBW neonates admitted to MahdiehHospital, affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran, between July 2016 and March 2017.In the intervention group, 81 neonates with birth weights of 710-1480 were given enteral 5 μg/kg/day of G-CSF (whichhas been approved by the US FDA) for 7 consecutive days. On the other hand, the control group included 191 neonateswho did not receive G-CSF with birth weights of 600-1490 admitted during 24 months prior to the study. The twogroups were compared in terms of adverse effects of treatment, primary and secondary outcomes.Results: The mean of gestational age and birth weight in the G-CSF group were reported as 29.96±2.47 weeks and1204.81±201.68 grams, and these values in the control group were measured at 29.77±2.13 weeks and1189.47±207.89 grams, respectively. Neonates who received G-CSF demonstrated better feeding tolerance, asreflected by the earlier achievement of 50, 75, 100, full enteral feeding of 150, and maximal enteral feeding of 180mL/kg/day (p < 0.05), with earlier weight gain and a shorter hospital stay. The rate of necrotizing enteroc olitis(NEC) in the G-CSF group was measured at 3.7% that was significantly lower, as compared to the control group(P=0.005). Approximately 8.9% of the neonates in the control group expired which was higher than the G-CSFgroup (P=0.06). All neonates tolerated the treatment and there was no statistically significant difference betweenthe two groups.Conclusion: As evidenced by the obtained results, the enteral administration of G-CSF to VLBW and ELBW neonatesimproved feeding tolerance and it was well tolerated without any associated side effects.
https://ijn.mums.ac.ir/article_14174_b79ef45196d18004dacb69e0a9159677.pdf
2020-01-01
71
79
10.22038/ijn.2019.39838.1639
Granulocyte colony-stimulating factor
Feeding tolerance
neonate
Very low birth weight
Mahmoud
Soltani
soltani.m@iums.ac.ir
1
Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Seyyed Abolfazl
Afjeh
a_afjeh@sbmu.ac.ir
2
Mahdieh Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Ahmad Reza
Shamshiri
arshamshiri@tums.ac.ir
3
Epidemiology Department, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Leila
Allahqoli
lallahqoli@gmail.com
4
Endometriosis Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
AUTHOR
Nasrin
Khalesi
khalesi.n@iums.ac.ir
5
Department of Pediatrics, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. ChristineAG, SherinU. Avery's disease of the newborn. Philadelphia, PA: Elsevier; 2012.
1
2. Fanaro S. Feeding intolerance in the preterm infant. Early Hum Dev. 2013;89 Suppl 2:S13-20.
2
3. Khashana A, Moussa R. Incidence of feeding intolerance in preterm neonates in neonatal intensive care units, Port Said, Egypt. Journal of Clinical Neonatology. 2016;5(4):230.
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4. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book: Diseases of the Fetus and Infant: Elsevier Health Sciences; 2016.
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5. Rowland KJ, Choi PM, Warner BW. The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis. Seminars in pediatric surgery. 2013;22(2):101-11.
5
6. MohanKumar K, Namachivayam K, Ho TT, Torres BA, Ohls RK, Maheshwari A. Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis. Seminars in perinatology. 2017;41(1):52-60.
6
7. Nair RR, Warner BB, Warner BW. Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. Seminars in perinatology. 2008;32(2):107-13.
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8. Juul S, Felderhoff-Mueser U. Epo and other hematopoietic factors. Seminars in fetal & neonatal medicine. 2007;12(4):250-8.
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9. Chousterman BG, Arnaud M. Is There a Role for
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Hematopoietic Growth Factors During Sepsis? Frontiers in immunology. 2018;9:1015.
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10. Shin YK, Cho SR. Exploring Erythropoietin and G-CSF Combination Therapy in Chronic Stroke Patients. International journal of molecular sciences. 2016;17(4):463.
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11. Liu SP, Lee SD, Lee HT, Liu DD, Wang HJ, Liu RS, et al. Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity. PloS one. 2010; 5(4):e10093.
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12. Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatric clinics of North America. 2013;60(1):49-74.
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13. Calhoun DA RB, Gersting JA, Sullivan SE, Christensen RD. Stability of granulocyte colony-stimulating factor and erythropoietin in human and synthetic amniotic fluid after in vitro simulations of digestion. J Pharm Technol 2002;18:310-5.
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14. DarleneA. Calhoun AM, Robert D. Christensen Granulocyte Recombinant Granulocyte Colony-Stimulating Factor Administered Enterally to Neonates Is Not Absorbed. Pediatrics. 2003; 112:421-3.
15
15. Christensen RD HT, Gerstmann DR, Calhoun DA Enteral administration of a simulated amniotic fluid to very low birth weight neonates. Perinatol 2005;25:380-5.
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16. Barney C K LDK, Alder S C , Scoffield S H , Schmutz N and Christensen R D Treating feeding intolerance with an enteral solution patterned after human amniotic fluid: a randomized, controlled, masked trial Journal of Perinatology 2007;27:28-31.
17
17. Canpolat FE YM, Korkmaz A, Yigit S, Tekinalp G Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study. PediatrSurg 2006;41:1134-8.
18
18. El-Ganzoury MM, Awad HA, El-Farrash RA, El-Gammasy TM, Ismail EA, Mohamed HE, et al. Enteral granulocyte-colony stimulating factor and erythropoietin early in life improves feeding tolerance in preterm infants: a randomized controlled trial. The Journal of pediatrics. 2014; 165(6):1140-5.e1.
19
19. Price TH, Chatta GS, Dale DC. Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans. Blood. 1996;88(1):335-40.
20
20. Canpolat FE, Yurdakok M, Korkmaz A, Yigit S, Tekinalp G. Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study. Journal of pediatric surgery. 2006;41(6):1134-8.
21
21. Barney CK, Purser N, Christensen RD. A phase 1 trial testing an enteral solution patterned after human amniotic fluid to treat feeding intolerance. Advances in neonatal care : official journal of the National Association of Neonatal Nurses. 2006;6(2):89-95.
22
22. Gad G, El-Farrash R, Abdelkader H, Fahmy S, editors. Granulocyte colony stimulating factor and
23
erythropoietin enterally given for neonates recovering from GIT surgeries: randomized controlled trial Haematologica 2017: Ferrata strorti foundation via giuseppe belli 4, 27100 pavia, Italy.
24
23. Lima-Rogel V, Ojeda MA, Villegas C, Torres-Montes A, Medrano S, Calhoun DA, et al. Tolerance of an enterally administered simulated amniotic fluid-like solution by neonates recovering from surgery for congenital bowel abnormalities. Journal of perinatology : official journal of the California Perinatal Association. 2004;24(5):295-8.
25
24. Calhoun DA, Maheshwari A, Christensen RD. Recombinant granulocyte colony-stimulating factor administered enterally to neonates is not absorbed. Pediatrics. 2003;112(2):421-3.
26
25. Borjianyazdi L, Froomandi M, Noori Shadkam M, Hashemi A, Fallah R. The effect of granulocyte colony stimulating factor administration on preterm infant with neutropenia and clinical sepsis: a randomized clinical trial. Iranian journal of pediatric hematology and oncology. 2013;3(2):64-8.
27
26. El-Farrash RA, Gad GI, Abdelkader HM, Salem DAD, Fahmy SA. Simulated amniotic fluid-like solution given enterally to neonates after obstructive bowel surgeries: A randomized controlled trial. Nutrition (Burbank, Los Angeles County, Calif). 2019;66:187-91.
28
27. Calhoun DA, Lunoe M, Du Y, Christensen RD. Granulocyte colony-stimulating factor is present in
29
human milk and its receptor is present in human fetal intestine. Pediatrics. 2000;105(1):e7.
30
28. Juul SE, Yachnis AT, Christensen RD. Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus. Early human development. 1998;52(3):235-49.
31
29. Calhoun DA, Murthy SN, Bryant BG, Luedtke SA, Bhatt-Mehta V. Recent advances in neonatal pharmacotherapy. Annals of Pharmacotherapy. 2006;40(4):710-9.
32
30. Gathwala G, Walia M, Bala H, Singh S. Recombinant human granulocyte colony-stimulating factor in preterm neonates with sepsis and relative neutropenia: a randomized, single-blind, non-placebo-controlled trial. Journal of tropical pediatrics. 2012;58(1):12-8.
33
31. Bedford Russell AR, Emmerson AJ, Wilkinson N, Chant T, Sweet DG, Halliday HL, et al. A trial of recombinant human granulocyte colony stimulating factor for the treatment of very low birthweight infants with presumed sepsis and neutropenia. Archives of disease in childhood Fetal and neonatal edition. 2001;84(3):F172-6.
34
32. Molaee M, Karbandi S, Boskabadi H, Esmaeily H. The effects of massage on intra ventricular hemorrhage in preterm infants in the neonatal intensive care unit. Scientific Journal of Kurdistan University of Medical Sciences. 2016;21(1).
35
ORIGINAL_ARTICLE
Postnatal Preventive Effect of Magnesium Sulfate on Intraventricular Hemorrhage of Preterm Infants
Background: Germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH) are among the causes of morbidity and mortality in very low birth weight (VLBW) neonates. The aim of this study was to determine the postnatal prophylactic effect of magnesium sulfate on GMH-IVH.Methods: In this double-blind clinical trial, 140 VLBW newborns were selected. The babies with birth weight ≤ 1500 g and gestational age ≤ 32 weeks were included. The babies with major malformation, infection, hemostatic disorders, severe cardio-respiratory failure, as well as asphyxia and resuscitation in the delivery room were excluded. They were randomly divided into two groups using a coin. The case group received 50% magnesium sulfate 4 mg/kg/day as a single dose via intravenous injection over 15-20 min for 3 days. All babies had a head ultrasound (HUS) in 24 to 48 h after birth, and if it was normal they were included in the study. The HUS was repeated in 1, 2, and 3 weeks after birth by a radiologist who did not know about the intervention. The control group received placebo sterile water in a dose similar to magnesium sulfate. The magnesium level was measured on day 4 at the end of the treatment.Results: Although GMH-IVH was two times more in the control group, the difference was not statistically significant between the two groups (P>0.05). The difference in the grading of IVH was not also significant between the two groups (P=0.25). The level of magnesium sulfate was significantly higher in the case group (P=0.04).Conclusion: The results of this study showed that the postnatal administration of magnesium sulfate has no effect on the prevention of IVH.
https://ijn.mums.ac.ir/article_14603_f970e3ed5c2c331bd0f635f14abbc684.pdf
2020-01-01
80
85
10.22038/ijn.2020.39711.1633
Germinal matrix hemorrhage and intraventricular hemorrhage
Magnesium sulfate
very low birth weight neonate
Ashraf
Mohammadzadeh
mohamadzadeha@mums.ac.ir
1
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Ahmad Shah
Farhat
farhata@mums.ac.ir
2
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Reza
Saeidi
saeedir@mums.ac.ir
3
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Marziyeh
Roshandel
rooshandelm@mums.ac.ir
4
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Azin
Vaezi
vaezia@mums.ac.ir
5
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1. Saeidi R, Izanloo A. Probiotics and retinopathy of premature: systemic review: P449. Arch Dis Childhood. 2019; 104:A1-428.
1
2. Chevallier M, Debillon T, Pierrat V, Delorme P, Kayem G, Durox M, et al. Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study. Am J Obstetr Gynecol. 2017; 216(5):518.e1-12.
2
3. Vries LS. Intracranial hemorrhage and vascular lesions. Fanaroff and Martin’s neonatal-perinatal medicine. 10th ed. St Lois: Mosby. 2015.
3
4. Shafik AN, Khattab MA, Osman AH. Magnesium sulfate versus esomeprazole impact on the neonates of preeclamptic rats. Eur J Obstet Gynecol Reprod Biol. 2018; 225:236-42.
4
5. Ballard J, Khoury JC, Wedig KL, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr. 1991; 119(3):417-23.
5
6. Volpe JJ. Intracranial hemorrhage: germinal matrix - intraventricular hemorrhage of the premature infant. Neurology of the newborn. 5th ed. Philadelphia: Saunders Elsevier; 2008.
6
7. McCrea HJ, Ment LR. The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate. Clin Perinatol. 2008; 35(4):777-92.
7
8. Smit E, Odd D, Whitelaw A. Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants. Cochrane Database Syst Rev. 2013; 8:CD001691.
8
9. Bandstra ES, Montalvo BM, Goldberg RN, Pacheco I, Ferrer PL, Flynn J, et al. Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants. Pediatrics. 1988; 82(4):533-42.
9
10. Ment LR, Oh W, Ehrenkranz RA, Philip AG, Vohr B, Allan W, et al. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics. 1994; 93(4):543-50.
10
11. Aranda J, Thomas R. Systematic review: intravenous ibuprofen in preterm newborns. Semin Perinatol. 2006; 30(3):114-20.
11
12. Mittendorf R, Pryde PG. An overview of the possible relationship between antenatal pharmacologic magnesium and cerebral palsy. J Perinatal Med. 2000; 28(4):286-93.
12
13. Di Renzo GC, Mignosa M, Gerli S, Burnelli L, Luzi G, Clerici G, et al. The combined maternal
13
administration of magnesium sulfate and aminophylline reduces intraventricular hemorrhage in very preterm neonates. Am J Obstet Gynecol. 2005; 192(2):433-8.
14
14. Garnier Y, Middelanis J, Jensen A, Berger R. Neuroprotective effects of magnesium on metabolic disturbance in fetal hippocampal slices after oxygen-glucose deprivation: mediation by nitric oxide system. J Soc Gynecol Investig. 2002; 9(2):86-92.
15
15. Elimian A, Verma R, Ogburn P, Wiencek V, Spitzer A, Quirk J. Magnesium sulfate and neonatal outcomes of preterm neonates. J Matern Fetal Neonatal Med. 2002; 12(2):118-22.
16
16. Petrova A, Mehta R. Magnesium sulfate tocolysis and intraventricular hemorrhage in very preterm infants. Indian J Pediatr. 2012; 79(1):43-7.
17
17. Parashi S, Bordbar A, Mahmoodi Y, Jafari MR. The survey of magnesium sulfate in prevention of intraventricular hemorrhage in premature infants: a randomized clinical trial. Shiraz E Med J. 2017; 18(11):e55094.
18
18. The American college of Obstetricians and gynecologist. Committee opinion No 652: magnesium sulfate use in obstetrics. Obstet Gynecol. 2016; 127(1):e52-3.
19
19. Kent AL,Wright IM, Abdel-Latif ME. Mortality and adverse neurologic outcomes are greater in preterm male infants. Pediatrics. 2012; 129(1):124-31.
20
20. Mohammed MA, Aly H. Male gender is associated with intraventricular hemorrhage. Pediatrics. 2010; 125(2):e333-9.
21
ORIGINAL_ARTICLE
Efficacy of Fluconazole Prophylaxis on Invasive Candidiasis Infection in Extremely Low Birth Weight Neonates
Background: Invasive candidiasis infection is one of the main life-threatening problems for extremely low birth weight (ELBW) neonates who are in the neonatal intensive care unit (NICU). Candidiasis can cause mortality, short-term morbidity, and long-term neurodevelopmental outcome in infected infants who survive. Therefore, since several years ago fluconazole prophylaxis has begun for premature newborns who were admitted to NICUs in some parts of the world.Methods: In this retrospective cohort, the population study was all the infants of less than 1,000 gram admitted to Valiasr Hospital during the years 2011-2016. The subjects were divided into two groups of control and intervention. The control group did not receive any fluconazole prophylaxis, while for the test group, intravenous fluconazole was administered. Finally, we compared the incidence of candidiasis between the two groups.Results: Fluconazole was administered to 70 out of 167 neonates. Our findings showed that two infants of the prophylaxis group (2.9%) and two (1.2%) of the non-prophylaxis group were infected with Candida species. The difference between the two groups was not statistically significant (P=0.501). Among the risk factors, bacterial sepsis, the duration of central catheter installation, total parenteral nutrition, meropenem or vancomycin administration, and hospitalization costs were significantly related to the incidence of invasive candidiasis infection.Conclusion: The incidence of candidiasis in our study was 2.39% and fluconazole prophylaxis has not been effective in reducing fungal infections. Consequently, further investigations in larger sample sizes with different study settings and a variety of methodologies are needed to evaluate the efficacy of fluconazole prophylaxis on invasive candidiasis infection in ELBW neonates.
https://ijn.mums.ac.ir/article_13810_1151af0d4f3dbef5b24bc92b7ebffc74.pdf
2020-01-01
86
91
10.22038/ijn.2019.39564.1635
Extremely low birth weight
Fluconazole
Invasive Candidiasis Infection
prophylaxis
Hosein
Dalili
hoseindalili@yahoo.com
1
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Nikoo
Niknafs
nikoo.niknafs@gmail.com
2
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mamak
Shariat
mshariat@tums.ac.ir
3
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Raheleh
Moradi
rahele.moradi1987@gmail.com
4
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Hasti
Charousaei
hastich97@gmail.com
5
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Elaheh
Amini
amini_el88@yahoo.com
6
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Roksana
Moeini
roksanamoeini@yahoo.com
7
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Afsaneh
Akhondzadeh
afsan_akhondzadeh@yahoo.com
8
Department of Pediatrics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
AUTHOR
Amir
Naddaf
dr.amirnaddaf@gmail.com
9
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine e-book: diseases of the fetus and infant. 10th ed. New York: Elsevier Health Sciences; 2015. P. 751-71.
1
2. Benjamin DK, Hudak ML, Duara S, Randolph DA, Bidegain M, Mundakel GT, et al. Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial. JAMA. 2014; 311(17):1742-49.
2
3. Lee J, Kim H, Shin SH, Choi CW, Kim EK, Choi EH, et al. Efficacy and safety of fluconazole prophylaxis in extremely low birth weight infants: multicenter pre-post cohort study. BMC Pediatr. 2016; 16:67.
3
4. Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G, et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med. 2007; 356(24):2483-95.
4
5. Healy CM, Baker C, Zaccaria E, Campbell JR. Impact of fluconazole prophylaxis on incidence and outcome of invasive candidiasis in a neonatal intensive care unit. J Pediatr. 2005; 147(2):166-71.
5
6. Ericson JE, Benjamin DK. Fluconazole prophylaxis for prevention of invasive candidiasis in infants. Curr Opin Pediatr. 2014; 26(2):151-6.
6
7. Hope WW, Castagnola E, Groll AH, Roilides E, Akova M, Arendrup MC, et al. European Society of Clinical Microbiology and Infectious Diseases guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp. Clin Microbiol Infect. 2012; 18(Suppl 7):38-52.
7
8. Aliaga S, Clark RH, Laughon M, Walsh TJ, Hope WW, Benjamin DK, et al. Changes in the incidence of
8
candidiasis in neonatal intensive care units. Pediatrics. 2014; 133(2):236-42.
9
9. Aziz M, Patel AL, Losavio J, Iyengar A, Berven M, Schloemer N, et al. Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants. Pediatr Infect Dis J. 2010; 29(4):352-6.
10
10. Kaufman D, Boyl R, Hazen K, Patrie JT, Robinson M, Grossman LB. Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weight. J Pediatr. 2005; 147(2):172-9.
11
11. Kaufman D, Boyl R, Hazen K, Patrie JT, Robinson M, Donowitz LG. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med. 2001; 345(23):1660-6.
12
ORIGINAL_ARTICLE
A Case Report of Neonatal Atrial Flutter with Poor Feeding and Tachypnea
Background: Arrhythmias in neonates are not common and usually affect newborns with a normal heart or those that suffer from structural heart disease. A malignant type of arrhythmias is supraventricular tachycardia. Meanwhile, one uncommon type of supraventricular arrhythmias is atrial flutter (AFL), which is founded upon reentry mechanisms in the atrium. The AFL may result in heart failure or even death, but the majority of its cases have revealed favorable prognosis in the event of early prenatal diagnosis and immediate treatment.Case report: A four-day term male newborn with a birth weight of 4,560 g born to a 43-year-old multiparous mother was delivered through cesarean section. The patient’s admission to the hospital was on account of her poor feeding and tachypnea. The results of physical checkup exhibited tachycardia with 210 beats/min, and electrocardiogram (ECG) indicated a narrow QRS complex tachycardia with P-waves in the leads II and III that showed AFL. The adenosine injection revealed atrioventricular conduction 2.1. Therefore, oral propranolol therapy with a dosage of 3 mg/kg/day was prescribed for the patient. Given the recurrence of AFL, cardioversion was conducted with 0.25 joule/kg until the rhythm was restored to normal. Later, the normal sinus rhythm was observed on ECG. Fifteen days after birth, the patient was discharged with a perfect general state. The results of a 6-month follow-up did not show any AFL.Conclusion: Despite its rare occurrence, AFL must be considered in the differential diagnosis of newborns with poor feeding with tachypnea and tachycardia.
https://ijn.mums.ac.ir/article_14604_8bd9e8b0da79bbc6d0e4c2729fcbf2a8.pdf
2020-01-01
92
96
10.22038/ijn.2020.43455.1721
Arrhythmias
Atrial Flutter
neonate
Supraventricular Tachycardia
Yazdan
Ghandi
drghandi1351@gmail.com
1
Department of Pediatrics, School of Medicine, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran
LEAD_AUTHOR
Saeed
Alinejad
alinejad.s@yahoo.com
2
Department of Pediatrics, School of Medicine, Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran
AUTHOR
1. Kundak AA, Dilli D, Karagol B, Karadag N, Zenciroglu A, Okumus N, et al. Non benign neonatal arrhythmias observed in a tertiary neonatal intensive care unit. Indian J Pediatr. 2013; 80(7):555-9.
1
2. Tunaoğlu FS, Yıldırım A, Akça A. Atriyal flattere neden olan hamak mitral kapak: Üç aylık bebek olgu. Türk Pediatri Arşivi. 2013; 48(3):244-7.
2
3. Özdemir R, Altug N, Dizdae E, Yurttutan S, Öncel MY, Erdeve Ö, et al. Prematüre bir yenidoğanda kardiyoversiyon ile tedavi edilen atriyal flatter
3
olgusu. Türkiye Çocuk Hastalıkları Dergisi. 2013; 7(1):47-9.
4
4. Southall D, Johnson A, Shinebourne E, Johnston P, Vulliamy D. Frequency and outcome of disorders of cardiac rhythm and conduction in a population of newborn infants. Pediatrics. 1981; 68(1):58-66.
5
5. Wanamaker B, Cascino T, McLaughlin V, Oral H, Latchamsetty R, Siontis KC. Atrial Arrhythmias in pulmonary hypertension: pathogenesis, prognosis and management. Arrhythm Electrophysiol Rev. 2018; 7(1):43-8.
6
6. Pike JI, Krishnan A, Kaltman J, Donofrio MT. Fetal and neonatal atrial arrhythmias: an association with maternal diabetes and neonatal macrosomia. Prenat Diagn. 2013; 33(12):1152-7.
7
7. Gad A, Morelli P, Decristofaro J. Perinatal isolated atrial flutter associated with maternal cocaine and opiate use in a late preterm infant. J Matem Fetal Neonatal Med. 2010; 23(9):1062-5.
8
8. Wilson N, Forfar JD, Godman MJ. Atrial flutter in the newborn resulting from maternal lithium ingestion. Arch Dis Child. 1983; 58(7):538-9.
9
9. Texter KM, Kertesz NJ, Friedman RA, Fenrich AL Jr. Atrial flutter in infants. J Am Coll Cardiol. 2006; 48(5):1040-6.
10
10. Gulletta S, Rovelli R, Fiori R, Bella PD. Multiple external electrical cardioversions for refractory neonatal atrial flutter. Pediatr Cardiol. 2012; 33(2):354-6.
11
11. Lulic Jurjevic R, Podnar T, Vesel S. Diagnosis, clinical features, management, and post-natal follow-up of fetal tachycardias. Cardiol Young. 2009; 19(5):486-93.
12
12. Ceresnak SR, Starc TJ, Hordof AJ, Pass RH, Bonney WJ, Liberman L. Elevated impedance during cardioversion in neonates with atrial flutter. Pediatr Cardiol. 2009; 30(4):436-40.
13
13. Roumiantsev S, Settle MD. Atrial flutter in the neonate: a case study. Neonatal Netw. 2017; 36(5):313-7.
14
14. Yilmaz-Semerci S, Bornaun H, Kurnaz D, Cebeci B, Babayigit A, Buyukkale G, et al. Neonatal atrial flutter: three cases and review of the literature. Turk J Pediatr. 2018; 60(3):306-9.
15