ORIGINAL_ARTICLE
Correlation between Prolonged Hyperbilirubinemia and Serum Zinc Level in Term Neonates
Background: Prolonged hyperbilirubinemia is defined as jaundice persisting more than two and three weeks of life in term and preterm neonates, respectively. In total, 15-40% of jaundiced neonates became prolonged. The most common causes of prolonged hyperbilirubinemia are breastfeeding, infection, hypothyroidism, and continued hemolysis. Given the fact that no study was conducted on the association between the serums zinc level and prolonged hyperbilirubinemia, this study aimed to compare the healthy neonates with newborns suffering from prolonged hyperbilirubinemia in terms of serum zinc level.Methods: This cross-sectional analytical descriptive study with a control group included all neonates who had a history of hospital admission and phototherapy due to hyperbilirubinemia at Amirkola Children’s Hospital, Babol, Iran. After discharge, on the 14th day of birth, all neonates followed up at the outpatient clinic. The serum bilirubin was checked and the neonates were assigned into the case (with prolonged hyperbilirubinemia) and control (without prolonged hyperbilirubinemia) groups. Both groups were matched regarding confounding factors. Serum zinc level was measured using the colorimetric method and the two groups were compared in this regard.Results: In total, 60 neonates in the case (n=30) and control (n=30) groups were investigated in this study. The serum zinc levels in the case and control groups were 83.7±35.35 and 92.73±38.13 μg/dl, respectively. There was no significant difference between the two groups in terms of the serum zinc level (P=0.34).Conclusion: There is no statistically significant correlation between the serum zinc level and prolonged hyperbilirubinemia in term neonates who had been treated with phototherapy.
https://ijn.mums.ac.ir/article_13801_3aeb52bd3750cc3824856f2e55b349ac.pdf
2019-11-01
1
5
10.22038/ijn.2019.37384.1578
Hyperbilirubinemia
Jaundice
neonate
Term birth
zinc
Mousa
Ahmadpour-kacho
mousa_ahmadpour@hotmail.com
1
Non-Communicable Pediatric Diseases Research Center, Department of Pediatrics, Babol University of Medical Sciences, Babol, Iran.
AUTHOR
Yadollah
Zahedpasha
zypasha@gmail.com
2
Non-Communicable Pediatric Diseases Research Center, Department of Pediatrics, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Soryia
Khafri
khafri@yahoo.com
3
Department of Social Medicine, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Sajedeh
Omidbakhsh-Amiri
omidbakhsh_sajedeh@yahoo.com
4
Department of Pediatrics, Amirkola Children’s Hospital, Babol University of Medical Sciences, Babol, Iran
LEAD_AUTHOR
Sadra
Tehrani
tehranisadra94@gmail.com
5
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
AUTHOR
1. Beiranvand S, Hosseinadadi R, Firuuzi M, Almasian M, Anbari K. Impact of combined oral zinc sulfate and phototherapy on serum bilirubin levels in the term neonates with jaundice. Iran J Neonatal. 2018; 9(3):20-5.
1
2. Terrin G, Berni Canani R, Di Chiara M, Pietravalle A, Aleandri V, Conte F, et al. Zinc in early life: a key element in the fetus and preterm neonate. Nutrients. 2015; 7(12):10427-46.
2
3. King JC. Zinc: an essential but elusive nutrient. Am J Clin Nutr. 2011; 94(2):679S-84S.
3
4. Mendez-Sanchez N, Roldan-Vaadez E, Flores MA, Cardenas-Vazquez R, Uribe M. Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters. Eur J Clin Invest. 2001; 31(9):773-80.
4
5. Hashemian S, Mohammadzadeh A, AtaeeNakhaei A. Efficacy of zinc sulfate in reducing unconjugated hyperbilirubinemia in neonates. Rev Clin Med. 2014; 1(4):229-32.
5
6. Mendez-Sanchez N, Martinez M, Gonzalez V, Roldan-Valadez E, Flores MA, Uribe M. Zinc sulfate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert’s syndrome. Ann Hepatol. 2002; 1(1):40-3.
6
7. Rana N, Mishra S, Bhatnagar S, Paul V, Deorari K, Agarwal R. Efficacy of zinc in reducing hyperbilirubinemia among at-risk neonates: a randomized, double-blind, placebo-controlled trial. Indian J Pediatr. 2011; 78(9):1073-8.
7
8. Vitec L, Munchova L, Zelenka J, Zadinova M, Malina J. The effect of zinc sulfate on serum bilirubin levels in hyperbilirubinemic rats. J Pediatr Gastroenterol Nutr. 2005; 40(2):135-40.
8
9. Hasan EJ. Evaluation of copper, zinc, manganese and magnesium levels in newborn jaundice in Baghdad. IBN Al-Haitham J Pure Appl Sci. 2011; 24(3):800.
9
10. Becker PJ, Carney LN, Corkins MR, Monczka J, Smith E, Smith SE, et al. Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: indicators recommended for the identification and documentation of pediatric malnutrition (under-nutrition). J Acad Nutr Dietetics. 2014; 114(12): 1988-2000.
10
11. El-Mazary AA, Abdel Aziz R, Sayed M, Mahmoud R, Saedii A. Effect of intensive phototherapy and exchange transfusion on copper, zinc and magnesium serum levels in neonates with indirect hyperbilirubinemia. Int J Pediatr. 2017; 5(2): 4371-83.
11
12. Boskabadi H, Maamouri G, Zadeh HM, Shakeri MT, Ghayour-Mobarhan M, Mohammadi S, et al. Comparison of serum zinc level between neonates with jaundice and healthy neonates. Shiraz E Med J. 2015; 16(11-12):e27392.
12
13. Mosayebi Z, Rahmani M, Ardakani SB, Sheikh M, Shariat M, Rezaeizadeh G. Evaluation of serum zinc levels in hyperbilirubinemic neonates before and after phototherapy. Iran J Pediatr. 2016; 26(3):41-6.
13
ORIGINAL_ARTICLE
Correlation between Lead in Maternal Blood, Umbilical Cord Blood, and Breast Milk with Newborn Anthro-pometric Characteristics
Background: Breast milk can be a source of toxic material, along with the transfer of nutrients needed for infant growth. This study was conducted to measure the level of lead in maternal and neonatal blood and breast milk in Tehran, Iran.Methods: In this cross-sectional study, 150 mothers and their infants were studied. Samples of maternal blood, fetal umbilical cord blood, breast milk, and amount of lead measured by atomic absorption method were collected. Correlations between lead levels and demographic characteristics of mother and infants were assessed.Results: The mean levels of lead in maternal and neonatal blood and breast milk were 9.79±4.31, 8.29±4.83, and 8.65±3.67 μg/dl, respectively. The different levels of lead were associated with cord blood, maternal blood, and breast milk. No significant relationship was found between lead levels and neonatal parameters (i.e., weight, height, and head circumference). The Spearman's correlation also showed the association between different levels of lead with cord blood, maternal blood, and breast milk. Linear regression also did not show any relationship between lead levels in cord blood, milk, and mother blood with newborn growth parameters.Conclusion: The present study failed to find a significant correlation between lead and newborn birth parameters. In our study, lead levels in maternal blood, breast milk, and cord blood were lower, compared those of the previous years in Iran; however, it needs to decrease, because lead even at very low concentrations may also have adverse effects.
https://ijn.mums.ac.ir/article_13804_df23be200e66c3c030d60b45d05d18f6.pdf
2019-11-01
6
11
10.22038/ijn.2019.38763.1610
Breast milk
Contaminant
Lead
Maternal Blood
Umbilical cord blood
Hossein
Dalili
hoseindalili@yahoo.com
1
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mamak
Shariat
mshariat@tums.ac.ir
2
Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Zeinab
Kavyani
z_kavyani@yahoo.com
3
Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mojtaba
Fazel
mojtabafazel@yahoo.com
4
Department of Pediatrics, Valiasr Hospital, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Farima
Raji
raji.farima@gmail.com
5
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Fahimeh
Jamali
mfnhrc@tums.ac.ir
6
Department of Midwifery, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Vafa
Ghorban-Sabagh
dr.sabagh@yahoo.com
7
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. Örün E, Yalçın SS, Aykut O, Orhan G, Morgil GK, Yurdakök K, et al. Breast milk lead and cadmium levels from suburban areas of Ankara. SciTotal Environ. 2011;409(13):2467-72.
1
2. Gürbay A, Charehsaz M, Eken A, Sayal A, Girgin G, YurdakökM, et al. Toxic metals in breast milk samples from Ankara, Turkey: assessment of lead, cadmium, nickel, and arsenic levels. Biol Trace Elem Res. 2012;149(1):117-22.
2
3. Dorea JG. Mercury and lead during breast-feeding. Br J Nutr. 2004;92(1):21-40.
3
4. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, Romieu I, Peterson KE, Aro A, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology. 2003; 14(2):206-12.
4
5. Dooyema CA, Neri A, Lo YC, Durant J, Dargan PI, Swarthout T, et al. Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010. Environ Health Perspect. 2011;120(4):601-7.
5
6. Karrari P,Mehrpour O, Abdollahi M. A systematic review on status of lead pollution and toxicity in Iran; Guidance for preventive measures. Daru. 2012;20(1):2.
6
7. Koyashiki GA, Paoliello MM, Tchounwou PB. Lead levels in human milk and children's health risk: a systematic review. Rev Environ Health. 2010; 25(3):243-54.
7
8. Koyashiki GA, Paoliello MM, Matsuo T, de Oliveira MM, Mezzaroba L, Carvalho M, et al. Lead levels in milk and blood from donors to theBreast Milk Bank
8
in Southern Brazil. Environ Res. 2010;110(3): 265-71.
9
9. Mortada WI, Sobh MA, El-Defrawy MM. The exposure to cadmium, lead and mercury from smoking and its impact on renal integrity. Med Sci Monit. 2004;10(3):CR112-6.
10
10. Winiarska-Mieczan A. Cadmium, lead, copper and zinc in breast milk in Poland. Biol Trace Elem Res. 2014;157(1):36-44.
11
11. Soleimani S, Shahverdy MR, Mazhari N, Abdi K, Gerayesh Nejad S, Shams S, et al. Lead concentration in breast milk of lactating women who were living in Tehran, Iran. Acta Med Iran. 2014;52(1):56-9.
12
12. Farhat A, Mohammadzadeh A, Balali-Mood M, Aghajanpoor-Pasha M, Ravanshad Y. Correlation of blood lead level in mothers and exclusively breastfed infants: a study on infants aged less than six months. Asia Pacific J Med Toxicol. 2013; 2(4):150-2.
13
13. Schnur J, John RM. Childhood lead poisoning and the new Centers for Disease Control and Prevention guidelines for lead exposure. J Am Assoc Nurse Pract. 2014;26(5):238-47.
14
14. Ettinger AS, Wengrovitz AM. Guidelines for the identification and management of lead exposure in pregnant and lactating women. Atlanta: National Center for Environmental Health; 2010.
15
14. Ettinger AS, Roy A, Amarasiriwardena CJ, Smith D, Lupoli N, Mercado-García A, et al. Maternal blood, plasma, and breast milk lead: lactational transfer and contribution to infant exposure. Environ Health Perspect. 2013;122(1):87-92.
16
15. Meyer PA, Brown MJ, Falk H. Global approach to reducing lead exposure and poisoning. Mutat Res. 2008;659(1-2):166-75.
17
16. Rahimi E, Hashemi M, Baghbadorani ZT. Determination of cadmium and lead in human milk. Int J Environ Sci Technol. 2009;6(4):671-6.
18
17. Nishioka E, Yokoyama K, Matsukawa T, Vigeh M, Hirayama S, Ueno T, et al. Evidence that birth weight is decreased by maternal lead levels below 5 μg/dl in male newborns. Reprod Toxicol. 2014;47:21-6.
19
18. Atabek ME, Kurtoglu S, Pirgon O, Uzum K, Saraymen R. Relation of in utero lead exposure with insulin-like growth factor-I levels and neonatal anthropometric parameters. Int J Hyg Environ Health. 2007; 210(1):91-5.
20
19. Vigeh M, Yokoyama K, Ramezanzadeh F, Dahaghin M,Sakai T, Morita Y, et al. Lead and other trace metals in preeclampsia: a case–control study in Tehran, Iran. Environ Res. 2006;100(2):268-75.
21
ORIGINAL_ARTICLE
Relationship between Ureaplasma urealyticum Colonization and Bronchopulmonary Dysplasia in Very Low Birth Weight Premature Infants: A Prospective Cohort Study
Background: Bronchopulmonary dysplasia (BPD) is the second prevalent lung disease and one of the care challenges of premature newborns. Different risk factors play an important role in the development of this disease. Therefore, the aim of the present study was to investigate the relationship between colonization with Ureaplasma urealyticum and BPD.Methods: This prospective cohort study was conducted in 2017 in the neonatal intensive care unit of Alzahra Hospital in Tabriz, Iran. The samples included newborns weighing less than 1500 g with the gestational age of less than 32 weeks who required intubation within 72 h after birth. Following recording the initial information, the secretions within the trachea were aspirated and Ureaplasma urealyticum was detected in reference laboratory by polymerase chain reaction. Afterwards, we completed a follow-up of 28 days after birth for BPD.Results: Our findings demonstrated that out of 82 infants, 21 cases (26.3%) were excluded from the study due to discharge from hospital or death before the age of 28 days. Among the rest (61 newborns), three cases (4.3%) were shown to have secretions infected with Ureaplasma and 33 cases (54.1%) suffered from BPD. All the three newborns infected with Ureaplasma had BPD. However, no significant relationship was observed between Ureaplasma infection and BPD (P=0.24).According to the analysis of data, the most important factors contributing to BPD among the patients were the gestational age and birth weight. In other words, for one week increase in the age of pregnancy and for each 100 g increase in birth weight, the likelihood of BPD is reduced by 55% and 1%, respectively. In the present study, no relationship was found between Ureaplasma infection and BPD, which might be due to the low prevalence of this infection. Nonetheless, prematurity and low birth weight could be regarded as the two considerable risk factors for BPD.Conclusion: In order to perfectly determine the role of bacterial colonization within the trachea in BPD, collecting and analyzing various samples for the existence of other bacteria are recommended.
https://ijn.mums.ac.ir/article_13802_28f0c2c8ce161d368759bca58e85d083.pdf
2019-11-01
12
18
10.22038/ijn.2019.38304.1602
Bronchopulmonary dysplasia
Premature Newborn
Ureaplasma urealyticum
very low birth weight infant
Majid
Mahallei
m.mahallei@yahoo.com
1
Pediatric Health Research Center of Tabriz, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Mohmmad Bagher
Hosseini
2
Pediatric Health Research Center of Tabriz, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Heidar
Esmaili
3
Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Golam Reza
Asadi
ofoghahari@gmail.com
4
Department of Pediatric, Tabriz Branch, Islamic Azad University, Tabriz, Iran
LEAD_AUTHOR
1. Carmichael SL, Kan P, Gould JB, Stevenson DK, Shaw GM, Lee HC. Maternal prepregnancy body mass index and risk of bronchopulmonary dysplasia. Pediatric. 2017; 82(1):8-13.
1
2. Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, et al. Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants. Pediatric. 2012; 71(3):267-73.
2
3. Lundstrøm K, Shaw N, Thomson MA. Chronic lung disease-cracking the condition in the 21st century. Neonatology. 2000; 78(3):233-68.
3
4. Day CL, Ryan RM. Bronchopulmonary dysplasia: old becomes New Again! Pediatr Res. 2016; 81(1-2):210-3.
4
5. Zheng XD, Li D, Yang DH, Xiang X, Mei H, Pu JR, et al. Association of Ureaplasma urealyticum colonization with development of bronchopulmonary dysplasia: a systemic review and meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 2014; 34(2):265-9.
5
6. Soleimani F, Sharifi N, Rasti Borujeni F, Amiri M, Khazaiyan S. Nourodevelopmental follow-up in high-risk infants. Tehran Univ Med J. 2015; 72(11):733-41.
6
7. Rennie JM. Rennie & roberton's textbook of neonatology e-book. New York: Elsevier Health Sciences; 2012.
7
8. Colaizy TT, Morris CD, Lapidus J, Sklar RS, Pillers DA. Detection of ureaplasma DNA in endotracheal samples is associated with bronchopulmonary dysplasia after adjustment for multiple risk factors. Pediatric. 2007; 61(5 Pt 1):578-83.
8
9. Manktelow B, Draper E, Annamalai S, Field D. Factors affecting the incidence of chronic lung
9
disease of prematurity in 1987, 1992, and 1997. Arch Dis Child Fetal Neonatal Ed. 2001; 85(1):F33-5.
10
10. Ng G, da Silva O, Ohlsson A. Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. Cochrane Database Syst Rev. 2016; 12:CD003214.
11
11. Abbott MB, Vlasses CH. Nelson textbook of pediatrics. JAMA. 2011; 306(21):2387-8.
12
12. Davidson LM, Berkelhamer SK. bronchopulmonary dysplasia: chronic lung disease of infancy and long-term pulmonary outcomes. J Clin Med. 2017; 6(1):E4.
13
13. Jobe AH. The new bronchopulmonary dysplasia. Curr Opin Pediatr. 2011; 23(2):167-72.
14
14. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001; 163(7):1723-9.
15
15. Heggie AD, Bar-Shain D, Boxerbaum B, Fanaroff AA, O’riordan MA, Robertson JA. Identification and quantification of ureaplasmas colonizing the respiratory tract and assessment of their role in the development of chronic lung disease in preterm infants. Pediatr Infect Dis J. 2001; 20(9):854-9.
16
16. Northway Jr WH, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease: bronchopulmonary dysplasia. N Engl J Med. 1967; 276(7):357-68.
17
17. Ollikainen J, Korppi M, Heiskanen‐Kosma T, Heinonen K. Chronic lung disease of the newborn is not associated with Ureaplasma urealyticum. Pediatr Pulmonol. 2001; 32(4):303-7.
18
18. Najar Peerayeh S, Samimi R. Detection of ureaplasma urealyticum in clinical samples from infertile women by polymerase chain reaction. Iran J Pharmacol Ther. 2007; 6(1):23.
19
19. Viscardi RM. Ureaplasma species: role in diseases of prematurity. Clin Perinatol. 2010; 37(2):393-409.
20
20. Viscardi RM, Manimtim WM, Sun CC, Duffy L, Cassell GH. Lung pathology in premature infants with Ureaplasma urealyticum infection. Pediatr Dev Pathol. 2002; 5(2):141-50.
21
21. Viscardi RM, Hashmi N, Gross GW, Sun CC, Rodriguez A, Fairchild KD. Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage. J Perinatol. 2008; 28(11):759-65.
22
22. Waites K, Crouse D, Cassell GH. Therapeutic considerations for Ureaplasma urealyticum infections in neonates. Clin Infect Dis. 1993; 17(Suppl 1): S208-14.
23
23. Ollikainen J, Hiekkaniemi H, Korppi M, Sarkkinen H, Heinonen K. Ureaplasma urealyticum infection associated with acute respiratory insufficiency and death in premature infants. J Pediatr. 1993; 122(5 Pt 1):756-60.
24
24. Ollikainen J. Perinatal Ureaplasma urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants. Pediatr Pulmonol. 2000; 30(5):402-5.
25
25. Crouse DT, Odrezin GT, Cutter GR, Reese JM, Hamrick WB, Waites KB, et al. Radiographic changes
26
associated with tracheal isolation of Ureaplasma urealyticum from neonates. Clin Infect Dis. 1993; 17(Suppl 1):S122-30.
27
26. Gancia P, Delogu A, Pomero G. Ureaplasma and bronchopulmonary dysplasia. Early Hum Dev. 2014; 90:S39-41.
28
27. Castro-Alcaraz S, Greenberg EM, Bateman DA, Regan JA. Patterns of colonization with Ureaplasma urealyticum during neonatal intensive care unit hospitalizations of very low birth weight infants and the development of chronic lung disease. Pediatrics. 2002; 110(4):e45.
29
28. Benstein BD, Crouse DT, Shanklin DR, Ourth DD. Ureaplasma in lung. 2. Association with broncho-pulmonary dysplasia in premature newborns. Exp Mol Pathol. 2003; 75(2):171-7.
30
29. Da Silva O, Gregson D, Hammerberg O. Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants. Pediatr Infect Dis J. 1997; 16(4):364-9.
31
30. Hannaford K, Todd DA, Jeffery H, John E, Blyth K, Gilbert GL. Role of Ureaplasma urealyticum in lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed. 1999; 81(3):F162-7.
32
31. Pacifico L, Panero A, Roggini M, Rossi N, Bucci G, Chiesa C. Ureaplasma urealyticum and pulmonary outcome in a neonatal intensive care population. Pediatr Infect Dis J. 1997; 16(6):579-86.
33
32. Couroucli XI, Welty SE, Ramsay PL, Wearden ME, Fuentes-Garcia FJ, Ni J, et al. Detection of microorganisms in the tracheal aspirates of preterm infants by polymerase chain reaction: association of adenovirus infection with bronchopulmonary dysplasia. Pediatr Res. 2000; 47(2):225-32.
34
33. Gien J, Kinsella JP. Pathogenesis and treatment of bronchopulmonary dysplasia. Curr Opin Pediatr. 2011; 23(3):305-13.
35
34. Payne NR, Steinberg SS, Ackerman P, Chrenka BA, Sane SM, Anderson KT, et al. New prospective studies of the association of Ureaplasma urealyticum colonization and chronic lung disease. Clin Infect Dis. 1993; 17(Suppl 1):S117-21.
36
35. Abele-Horn M, Genzel-Boroviczeny O, Uhlig T, Zimmermann A, Peters J, Scholz M. Ureaplasma urealyticum colonization and bronchopulmonary dysplasia: a comparative prospective multicentre study. Eur J Pediatr. 1998; 157(12):1004-11.
37
36. Maksić H, Heljić S, Skokić F, Šumanović-Glamuzina D, Milošević V, Zlatanović A, et al. Predictors and incidence of hospitalization due to respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI) in non-prophylaxed moderate-to-late preterm infants in Bosnia and Herzegovina. Bosnian J Basic Med Sci. 2018; 18(3):279-88.
38
37. Garland SM, Bowman ED. Role of Ureaplasma urealyticum and Chlamydia trachomatis in lung disease in low birth weight infants. Pathology. 1996; 28(3):266-9.
39
ORIGINAL_ARTICLE
Clinical Assessment of Nursing Care Regarding Prevention of Ventilator-associated Pneumonia in Neonates
Background: Ventilator-associated pneumonia (VAP) is the second common nosocomial infection in NICUs leading to some complications. Nurses are one of the main resources in health care that directly influence neonatal health care. Responsibility of most of preventive strategies related to VAP complications lies with nurses; therefore, nursing care should be assessed until the nurses show standard level of performance in hospitals. The aim of this cross-sectional study, conducted within 2015-2016, was to assess nursing care regarding VAP prevention in neonatal intensive care units (NICUs) in selected hospitals affiliated to Shahid Beheshti University of Medical Sciences.Methods: In this descriptive cross-sectional study, 100 observations of nursing care regarding VAP were selected by convenience method in NICUs of Mahdiyeh, Mofid, and Imam Hossein hospitals affiliated to Shahid Beheshti University of Medical Sciences within 2015-2016. The data collection tools included demographic information questionnaire and a developed checklist related to VAP prevention. The observations were assessed and documented with two sampling methods, including time and event sampling. The data were analyzed in SPSS software (version 16).Results: According to the results of the current study, the rate of compliance of nursing care with the standards for prevention of VAP in neonates under mechanical ventilation in NICU with developed standards was estimated at 62.81 percent.Conclusion: Authorities should pay more attention to nursing cares especially incompetent cares explained in this study to increase the health of hospitalized neonates, decrease complications, length of stay, and costs. Moreover, future research is needed to investigate the reasons of this incompetency.
https://ijn.mums.ac.ir/article_13806_31d306f032b76f69eb629da7000aff96.pdf
2019-11-01
19
24
10.22038/ijn.2019.37550.1581
Mechanical Ventilation
neonate
Nursing care
Prevention
Ventilator-associated pneumonia
Leila
Khanali Mojen
zahra.jafari.tums@gmail.com
1
School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Maryam
Rassouli
z.jafari@modares.ac.ir
2
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Saleheh
Tajalli
saleheh_tajalli@yahoo.com
3
Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Ahmad Reza
Baghestani
baghestani.ar@gmail.com
4
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Zahra
Jafari
nurse.jafari@gmail.com
5
School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
1. Wijesooriya LI, Jayaratna HS, Wanasinghe DS. Exploring the cause of an outbreak of neonatal sepsis following ventilator-associated pneumonia in a base hospital, Sri Lanka 2018. 19th Conference on Postgraduate Research, International Postgraduate. University of Kelaniya, Sri Lanka; 2018.
1
2. Malhotra P, Kumar N, Thapar K, Bagga AK. Comparative study of incidence, risk factors, etiological agents and outcome of early and late ventilator associated pneumonia in paediatric intensive care unit at a tertiary care centre. Int J Contemp Pediatr. 2018; 5(3):708-13.
2
3. Gupta S, Sinha S. Care of the ventilated infant. Pediatr Child Health. 2009; 19(12):544-9.
3
4. Said A. Knowledge and practice of intensive care nurses on prevention of ventilator associated pneumonia at muhimbili national Hospital. Dar es Salaam, Tanzania. [Doctoral Dissertation]. Tanzania: Muhimbili University of Health and Allied Science; 2012.
4
5. Yazdani M, Sabetian G, Ra'ofi SH, Roudgari A, Feizi M. A comparative study of teaching clinical guideline for prevention of ventilator-associated pneumonia in two ways: face-to-face and workshop training on the knowledge and practice of nurses in the Intensive Care Unit. J Adv Med Educ Professionalism. 2015; 3(2):68.
5
6. Cernada M, Brugada M, Golombek S, Vento M. Ventilator-associated pneumonia in neonatal patients: an update. Neonatology. 2014; 105(2): 98-107.
6
7. Fallahi M, Dasht AS, Naeempour N, Bassir M, Ghadamli P. Ventilator-associated pneumonia in hospitalized newborns in a neonatal intensive care unit. Arch Pediatr Infect Dis. 2014; 2(3):e16514.
7
8. Garland JS. Strategies to prevent ventilator-associated pneumonia in neonates. Clin Perinatol. 2010; 37(3):629-43.
8
9. Zhou Q, Lee SK, Jiang SY, Chen C, Kamaluddeen M,
9
Hu XJ, et al. Efficacy of an infection control program in reducing ventilator-associated pneumonia in a Chinese neonatal intensive care unit. Am J Infect Control. 2013; 41(11):1059-64.
10
10. Goerens A, Lehnick D, Büttcher M, Daetwyler K, Fontana M, Genet P, et al. Neonatal ventilator associated pneumonia: a quality improvement initiative focusing on antimicrobial stewardship. Front Pediatr. 2018; 6:262.
11
11. Sodhi MK, Kumar GA, Singh K, Kumar A, Malhotra S, Neki N. Incidence, clinical and microbiological pattern of ventilator associated pneumonia (VAP) in neonatal intensive care unit in Amritsar, India. Int J Curr Res Med Sci. 2018; 4(2):21-30.
12
12. Afjeh SA, Sabzehei MK, Karimi A, Shiva F, Shamshiri AR. Surveillance of ventilator-associated pneumonia in a neonatal intensive care unit: characteristics, risk factors, and outcome. Arch Iran Med. 2012; 15(9):567-71.
13
13. Moradi M, Nili F, Nayeri F, Amini E, Esmaeilnia T. Study of characteristics, risk factors and outcome for Ventilator Associated Pneumonia in Neonatal Intensive Care Unit patient. Tehran Univ Med J. 2013; 71(6):373-81.
14
14. Ceballos K, Waterman K, Hulett T, Makic MB. Nurse-driven quality improvement interventions to reduce hospital-acquired infection in the NICU. Adv Neonatal Care. 2013; 13(3):154-63.
15
15. Iosifidis E, Pitsava G, Roilides E. Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention. Future Microbiol. 2018; 13(12):1431-46.
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16. Foglia E, Meier MD, Elward A. Ventilator-associated pneumonia in neonatal and pediatric intensive care unit patients. Clin Microbiol Rev. 2007; 20(3):409-25.
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17. Brito DV, Brito CS, Resende DS, Moreira do Ó J, Abdallah VO, Gontijo Filho PP. Nosocomial infections in a Brazilian neonatal intensive care unit: a 4-year surveillance study. Rev Soc Bras Med Trop. 2010; 43(6):633-7.
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18. Chawla R. Epidemiology, etiology, and diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia in Asian countries. Am J Infect Control. 2008; 36(4 Suppl):S93-100.
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19. Goldsmith JP, Karotkin E, Suresh G, Keszler M. Assisted ventilation of the neonate e-book: evidence-based approach to newborn respiratory care. New York: Elsevier Health Sciences; 2016.
20
20. Aelami MH, Lotfi M, Zingg W. Ventilator-associated pneumonia in neonates, infants and children.
21
Antimicrob Resist Infect Control. 2014; 3(1):30.
22
21. Lucas A. The effect of a nurse-respiratory therapist weaning protocol on the duration of mechanical ventilation and the incidence of ventilator-associated pneumonia. Huntington, United States: The Graduate School of Marshall University; 2008.
23
22. McBeth CL, Montes RS, Powne A, North SE, Natale JE. Interprofessional approach to the sustained reduction in ventilator-associated pneumonia in a pediatric intensive care unit. Crit Care Nurse. 2018; 38(6):36-45.
24
23. Zolfaghari M, Aeen FB, Noghabi AA, Mehran A. Effects of active and passive implementation of ventilator associated pneumonia guideline on nurses’ performance in critical care units: a controlled clinical trial. Nurs Pract Today. 2015; 1(3):126-34.
25
24. Thelan LA. Critical care nursing: diagnosis and management. Missouri: Mosby Inc: CV Mosby; 1994.
26
25. Aeen FB, Zolfaghari M, Asadi Noghabi AA, Mehran A. Nurses' performance in prevention of ventilator associated pneumonia. Hayat. 2013; 19(3):17-27.
27
26. Gonçalves FA, Brasil VV, Ribeiro LC, Tipple AF. Nursing actions for the prevention of ventilator-associated pneumonia. Acta Paulista Enfermagem. 2012; 25:101-7.
28
27. Ali NS. Critical Care Nurses' knowledge and compliance with ventilator associated pneumonia bundle at Cairo university hospitals. Crit Care. 2013; 4(15):66-78.
29
28. Tajalli S, Nourian M, Rassouli M, Baghestani AR. Clinical assessment of nursing care regarding hemovigilance in neonatal wards and neonatal intensive care units in selected hospitals affiliated to Shahid Beheshti University of Medical Sciences (2013-2014). Iran Red Crescent Med J. 2015; 17(7):e19987.
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29. Jiang K, Wang C, Sun C, Zhong H, Yan S, Zhou S. Ventilator-associated pneumonia in premature newborns admitted to the intensive care unit. Int J Clin Exp Med. 2018; 11(5):4695-701.
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30. Geslain G, Guellec I, Guedj R, Guilbert J, Jean S, Valentin C, et al. Incidence and risk factors of ventilator-associated pneumonia in neonatal intensive care unit: a first French study. Minerva Anestesiol. 2018; 84(7):829-35.
32
31. Tolentino-DelosReyes AF, Ruppert SD, Shiao SY. Evidence-based practice: use of the ventilator bundle to prevent ventilator-associated pneumonia. Am J Crit Care. 2007; 16(1):20-7.
33
ORIGINAL_ARTICLE
Comparison of the Effect of Yakson Touch and Oral Glucose on the Severity of Phlebotomy Pain in Preterm Infants
Background: Infants are exposed to different painful procedures during hospitalization in the neonatal intensive care unit (NICU). Due to the harmful effects of pain on infants, NICUs require methods by the aid of which the pain in infants can be controlled. Yakson touch and oral glucose are among non-pharmacological methods for pain relief in infants. In this regard, the present study was conducted to compare the effect of Yakson touch and oral glucose on the severity of phlebotomy pain in preterm infants.Methods: In this randomized clinical trial, 99 preterm infants hospitalized in NICU were randomly allocated to three groups, including Yakson touch (n=33), oral glucose (n=33), and control (n=33). In the oral glucose group, 1 cc of 50% glucose was orally given to the infants 1 min before phlebotomy. In the Yakson touch group, touching was performed for 5 min, and then the phlebotomy was performed. The infants in the control group did not receive a specific treatment. Infant pain level was determined before and after the phlebotomy using video recording based on Neonatal Infant Pain Scale. The data were analyzed using the analytical statistical tests, including the analysis of variance, Chi-square, Wilcoxon, and Kruskal-Wallis, in SPSS software (version 20).Results: The mean scores of pain in the two experimental groups were significantly lower than that of the control group (P=0.001), but there was no significant difference between the two experimental groups (P>0.05).Conclusion: According to our findings, both two methods (i.e., Yakson touch and oral glucose) can reduce phlebotomy pain in preterm infants hospitalized in intensive care unit. It is recommended to use Yakson touch in case of lack of access to glucose.
https://ijn.mums.ac.ir/article_13805_dca8697f25fa2f01e8b20a855846307e.pdf
2019-11-01
25
32
10.22038/ijn.2019.38769.1614
oral glucose
Pain
Phlebotomy
Preterm infant
Yakson touch
Khadijeh
Dehghani
shadehghani@gmail.com
1
Faculty of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
LEAD_AUTHOR
Akram
Bagheri Ahmadabadi
2
Neonatal Intensive Care, Faculty of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Hossein
Fallahzade
3
Research Center of Prevention and Epidemiology, Health Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Tahere
Salimi
4
Faculty of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
1. Salmani N, Karjoo Z, Dehghani K, Sadeghnia A. Effect of facilitated tucking created with simulated hands on physiological pain indicators during venipuncture in premature infants. Iran J Neonatol. 2017; 8(4): 7-12.
1
2. Obeidat H, Kahalaf I, Callister CL, Froelicher ES. Use of facilitated tucking for nonpharmacological pain management in preterm infants. J Perinat Neonatal Nurs. 2009; 23(4):372-7.
2
3. Axelin A, Salanterä S, Lehtonen L. ‘Facilitated tucking by parents’ in pain management of preterm infants-a randomized crossover trial. Early Hum Dev. 2006; 82(4):241-7.
3
4. Carbajal R, Rousset A, Danan C, Coquery S, Nolent P, Ducrocq S, et al. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008; 300(1):60-70.
4
5. Sohrabimb MB, Aghayan SM, Zolfaghari P, Delmoradi F, Amerian F, Ghasemian Aghmashhadi
5
M. Studying on signs of pain in neonates. Knowl Health. 2012; 6(3):50-3 (Persian).
6
6. Rihani T, Mohebbi T, Boskabadi H, Gholami H, Ghavami Ghanbarabadi V. The effect of facilitated tucking during venipuncture on pain and physiological parameters in preterm infants. Evid Based Care. 2012; 2(2):47-56 (Persian).
7
7. Sheikhbahaeddinzadeh E. Examination, diagnosis and nursing care in the NICU. Tehran: Boshra; 2012.
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8. Hartley KA, Miller CS, Gephart SM. Facilitated tucking to reduce pain in neonates: evidence for best practice. Adv Neonatal Care. 2015; 15(3):201-8.
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9. Nicholson JM, Berthelsen D, Abad V, Williams K, Bradley J. Impact of music therapy to promote positive parenting and child development. J Health Psychol. 2008; 13(2):226-38.
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10. Saeedi R, Asnaashari Z, Amirinejad M, Esmaili H. The effect of Kangaroo care method on the pain intensity of vaccination in newborns. J Sabzevar Univ Med Sci. 2007; 13(4):172-8.
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11. Tarhani F, Moumennasab M. A survey: glucose sedative effect in neonates during Venus blood sampling. Yafteh. 2004; 6(21):47-50 (Persian).
12
12. Nishitani S, Miyamura T, Tagawa M, Sumi M, Takase R, Doi H, et al. The calming effect of a maternal breast milk odor on the human newborn infant. Neurosci Res. 2009; 63(1):66-71.
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13. Gibbins S, Stevens B, McGrath PJ. Comparison of pain-responses in infants of different gestational ages. Neonatology. 2008; 93(1):10-8.
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14. Cloherty JP. Manual of neonatal care. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2004. P. 703-4.
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15. Gibbins BS. Pain management; what is the right outcome? Newborn Infant Nurs Rev. 2007; 7(1):47-8.
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16. Bueno M, Kimura AF, Diniz CS. Scientific evidences for managing pain in the neonatal population. Acta Paulista Enfermagem. 2009; 22(6):828-32.
17
17. Liaw JJ, Yang L, Katherine Wang KW, Chen CM, Chang YC, Yin T. Non-nutritive sucking and facilitated tucking relieve preterm infant pain during heel-stick procedures: a prospective, randomised controlled crossover trial. Int J Nurs Stud. 2012; 49(3):300-9.
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18. Porter FL, Wolf CM, Gold J, Lotsoff D, Miller JP. Pain and pain management in newborn infants: a survey of physicians and nurses. Pediatrics. 1997; 100(4): 626-32.
19
19. Kucukoglu S, Kurt S, Aytekin A. The effect of the facilitated tucking position in reducing vaccination-induced pain in newborns. Ital J Pediatr. 2015; 41(1):61.
20
20. Tsao JC, Evans S, Meldrum M, Altman T, Zeltzer LK. A review of CAM for procedural pain in infancy: part II. Other interventions. Evid Based Complement Alternat Med. 2008; 5(4):399-407.
21
21. Larsson BA, Tannfeldt G, Lagercrant H, Olsson GL. Venipuncture is more effective and less painful than heel lancing for blood tests in neonates. Pediatric.1998; 101(5):882-6.
22
22. Skogsdal Y, Eriksson M, Schollin J. Analgesia in newborn had given oral glucose. Acta Paediatr. 1997; 86(2):217-20.
23
23. Stevens B, Taddio A, Ohlsson A, Einarson T. The efficacy of sucrose for relieving procedural pain in neonat–a systematic review and meta-analysis. Acta Paediatr. 1997; 86(8):837-42.
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24. Johnston C, Stremler R, Horton L, Friedman A. Effects of repeated doses of sucrose during heel stick procedures in preterm neonates. Biol Neonate. 1999; 75(3):160-6.
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25. Blass E, Fitzgerald E, Kehoe P. Interactions between sucrose, pain and isolation distress. Pharamacol Biochem Behav. 1987; 26(3):483-9.
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26. Barr RG, Que VS, Cousineau D, Oberlander TF, Brian JA, Young SN. Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborns and six-week-old infants. Dev Med Child Neurol. 1994; 36(7):608-18.
27
27. Meek J, Huertas A. Cochrane review: non-nutritive sucking, kangaroo care and swaddling/facilitated tucking are observed to reduce procedural pain in infants and young children. Evid Based Nurs. 2012; 15(3):84-5.
28
28. Stevens B, Yamada J, Lee GY, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2013; 1:CD001069.
29
29. Bahman Bijari B, Iranmanesh S, Eshghi F, Baneshi MR. Gentle human touch and Yakson: the effect on Preterm's behavioral reactions. ISRN Nurs. 2012; 2012:750363.
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30. Im H, Kim E, Park E, Sung K, Oh W. Pain reduction of heel stick in neonates: Yakson compared to non-nutritive sucking. J Trop Pediatr. 2008; 54(1):31-5.
31
31. Eshghi F, Iranmanesh S, Bahman Bijari B, Borhani F, Motamed Jahromi M. Effects of Yakson therapeutic touch on the behavioral response of premature infants. J Babol Univ Med Sci. 2015; 17(10):15-21.
32
32. Park ES, Sung KS, Oh WO, Im HS, Kim ES, Kim YA, et al. Pain relieving effect of Yakson therapy for infants. Taehan Kanho Hakhoe Chi. 2006; 36(6): 897-904.
33
33. Parashar P, Samuel AJ, Bansal A, Aranka VP. Yakson touch as a part of early intervention in the Neonatal Intensive Care Unit: A systematic narrative review. Ind J Crit Care Med. 2016; 20(6):349-52.
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34. Mitchell A, Waltman PA. Oral sucrose and pain relief for preterm infants. Pain Manag Nurs. 2003; 4(2):62-9.
35
35. Hatfield LA, Chang K, Bittle M, Deluca J, Polomano RC. The analgesic properties of intraoral sucrose: an integrative review. Adv Neonatal Care. 2011; 11(2):83-92.
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36. Lawrence J, Alcock D, McGrath P, Kay J, MacMurray SB, Dulberg C. The development of a tool to assess neonatal pain. Neonatal Netw. 1993; 12(6):59-66.
37
37. Boroumandfar K, Khodaei F, Abdeyazdan Z, Maroufi M. Comparison of vaccination-related pain in infants who receive vapocoolant spray and breastfeeding during injection. Iran J Nurs Midwifery Res. 2013;
38
38. Rafati S, Rejeh N, Tadrisi SD, Karimi M, Molodi A. Effect of massage on physiological pain responses of blood sampling in infant. Iran J Nurs Res. 2015; 10(2):45-53 (Persian).
39
39. Abbasi Z, Salari E, Rashidi F, Taherpour M. The effect of massage on the intensity of pain caused by vaccination in infants. J North Khorasan Univ Med Sci. 2011; 3(3):51-6 (Persian).
40
40. Herrington CJ, Chiodo LM. Human touch effectively and safely reduces pain in the newborn intensive care unit. Pain Manag Nurs. 2014; 15(1):107-15.
41
41. Im H, Kim E. Effect of Yakson and Gentle Human Touch versus usual care on urine stress hormones and behaviors in preterm infants: a quasi-experimental study. Int J Nurs Stud. 2009; 46(4): 450-8.
42
42. Harrison LL. The use of comforting touch and massage to reduce stress for preterm infants in the neonatal intensive care unit. Newborn Infant Nurs Rev. 2001; 1(4):235-41.
43
43. Eghbalian F, Shalchi Z. Comparing the efficacy of oral glucose 50%, acetaminophen and breast-feeding on reducing neonatal pain. J Urmia Univ Med Sci. 2014; 25(7):578-85 (Persian).
44
44. Khodam H, Sabzi Z. Effectiveness of oral sucrose on pain severity in term newborn undergoing heel prick. Iran J Nurs Res. 2011; 5(19):45-51 (Persian).
45
45. NooriShadkam M, Behjati M, Fallahzadeh H. Comparison of topical EMLA cream with oral glucose on pain reduction at venipuncture in Ichteric newborns. J Rafsanjan Univ Med Sci. 2005; 4(4):294-9 (Persian).
46
ORIGINAL_ARTICLE
Determination of the Frequency of Microbial Agents and Drug Susceptibility Pattern of the Neonatal Sepsis in the Neonatal Intensive Care Unit at Alzahra Hospital, Tabriz, Iran
Background: Neonatal sepsis is one of the most important causes of infant mortality in developing countries. The causative organisms for sepsis are various in different regions across the world. The aim of this study was to determine the frequency of microbial agents and drug resistance pattern of the neonatal sepsis in newborns admitted to the neonatal intensive care unit (NICU) at Alzahra Hospital Tabriz, Iran.Methods: This descriptive cross-sectional study was carried out from December 2016 to January 2018 in the NICU at Alzahra Hospital Tabriz, Iran. The medical records of all neonates admitted to the NICU were investigated using the convenience sampling method. The data were collected using a two-part demographic form. Subsequently, the data were analyzed in SPSS software (version 22.0).Results: Out of 174 positive blood culture, 52.4% (n=92) and 46.6% (n=82) of Gram-negative (G) and Gram-positive (G) bacteria accounted for the cause of sepsis, respectively. The most common cause of early- and late-onset sepsis was Coagulase-Negative Staphylococci (CoNS), and the most common G-negative and G-positive bacteria were Acinetobacter and CoNS, respectively. The G-positive bacteria showed the most antibiotic susceptibility to Vancomycin (81.45%), Ampicillin (52.15%), and Imipenem (47.32%). On the other hand, the highest drug susceptibility in G-negative bacteria was related to antibiotics, such as Amikacin (73.64%), Imipenem (56.36%), and Ciprofloxacin (52.44%). Moreover, the most antibiotic resistance was associated with Oxacillin (100%), Tetracycline (100%), and Ciprofloxacin (44.4%).Conclusion: The CoNS is the main cause of early- and late-onset sepsis among the neonates admitted to the NICU at Alzahra Hospital, Tabriz, Iran. G-positive and G-negative as causative agents of sepsis showed the highest susceptibility to Vancomycin and Amikacin, respectively.
https://ijn.mums.ac.ir/article_13807_07681d4422b01be6c637940034403542.pdf
2019-11-01
33
40
10.22038/ijn.2019.37288.1574
Antibiotic Treatment
Drug resistance
Microbial Agents
Neonatal sepsis
Mohammad Bagher
Hosseini
hosseini.neo@gmail.com
1
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Shahram
Abdoli Oskouei
shahram.oskouei@gmail.com
2
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Fariba
Heidari
fariba_heidari@hotmail.com
3
School of Medicine, Department of Community and Family Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Amin
Sadat Sharif
4
School of Medicine, Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Zakeiye
Salimi
zs.rad2011@yahoo.com
5
Neonatal Intensive Care Unit, Alzahra Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Seyed Amir Abbas
Sharif
amirsharif.md@gmail.com
6
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
1. Martin RJ, Fanaroff AA, Walsh MC. Perinatal and
1
Neonatal care in developing countries. fanaroff and martin's neonatal-perinatal medicine: diseases of the fetus and infant. 10th ed. Philadelphia: Mosby Elsevier; 2015.
2
2. Stone L. Neonatal bacterial infection (eBook). New York: Publisher Hayle Medical; 2015. P. 53-6.
3
3. Kliegman RM, Behrman RE, Nelson WE. Nelson textbook of pediatrics E-Book. New York: Elsevier Health Sciences; 2016.
4
4. Dehghan K, Karimi S, Alilu L. The effect of probiotics on late-onset sepsis in very preterm infants: a randomized clinical trial. Int J Pediatr. 2018; 6(10):8371-9.
5
5. West B, Tabansi P. Prevalence of neonatal septicaemia in the University of Port Harcourt Teaching Hospital, Nigeria. Niger J Paed. 2014; 41(1):33-7.
6
6. Abdullah ST, Moustafa AN, Mohsen Anwar A. Prognostic validity of red cell distribution width in neonatal sepsis. Int J Pediatr. 2018; 6(11):8579-86.
7
7. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017; 390(10104):1770-80.
8
8. Sharma CM, Agrawal RP, Sharan H, Kumar B, Sharma D, Bhatia SS. “Neonatal sepsis”: bacteria & their susceptibility pattern towards antibiotics in neonatal intensive care unit. J Clin Diagn Res. 2013; 7(11):2511.
9
9. Rafati M, Farhadi R, Nemati-Hevelai E, Chabra A. Determination of frequency and antibiotic resistance of common bacteria in late onset sepsis at the neonatal ward in Booali-Sina Hospital of Sari, Iran. J Babol Univ Med Sci. 2014; 16(6):64-71.
10
10. El-Din S, Rabie EM, El-Sokkary MM, Bassiouny MR, Hassan R. Epidemiology of neonatal sepsis and implicated pathogens: a study from Egypt. Biomed Res Int. 2015; 2015:509484.
11
11. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014; 27(1):21-47.
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12. Nikpay S, YadegarAzadi A, Mohamadi J, Soleymani A, Badfar G. Epidemiologic indicators of neonatal sepsis in teaching hospitals of Ilam, Western Iran during (2012-2017). Int J Pediatr. 2018; 6(7): 7947-58.
13
13. Hornik CP, Fort P, Clark RH, Watt K, Benjamin D, Smith PB, et al. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2012; 88:S69-74.
14
14. Gheibi SH, Fakoor Z, Karamyyar M, Khashabi J, Ilkhanizadeh B, Asghari-Sana F, et al. Coagulase negative staphylococcus; the most common cause of neonatal septicemia in Urmia, Iran. Iran J Pediatr. 2008; 18(3):237-43.
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15. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013; 60(2):367.
16
16. Edmond K, Zaidi A. New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med. 2010; 7(3):e1000213.
17
17. Schulman J, Dimand RJ, Lee HC, Duenas GV, Bennett
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MV, Gould JB. Neonatal intensive care unit antibiotic use. Pediatrics. 2015; 135(5):826-33.
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18. Cantey JB, Wozniak PS, Pruszynski JE, Sánchez PJ. Reducing unnecessary antibiotic use in the neonatal intensive care unit (SCOUT): a prospective interrupted time-series study. Lancet Infect Dis. 2016; 16(10):1178-84.
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19. Perna E. The use and misuse of antibiotics in the neonatal intensive care unit. J Neonatal Nurs. 2016; 22(2):64-7.
21
20. Novitsky A, Tuttle D, Locke RG, Saiman L, Mackley A, Paul DA. Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants. Am J Perinatol. 2015; 32(1):43-8.
22
21. Tsai MH, Chu SM, Hsu JF, Lien R, Huang HR, Chiang MC, et al. Risk factors and outcomes for multidrug-resistant Gram-negative bacteremia in the NICU. Pediatrics. 2014; 133(2):e322-9.
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22. Marchant EA, Boyce GK, Sadarangani M, Lavoie PM. Neonatal sepsis due to coagulase-negative staphylococci. Clin Dev Immunol. 2013; 2013:586076.
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23. World Health Organization. WHO guidelines on drawing blood: best practices in phlebotomy. Geneva: World Health Organization; 2010.
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24. Cloherty JP, Eichenwald EC, Stark AR. Manual of neonatal care. Philadelphia: Lippincott Williams & Wilkins; 2008.
26
25. Ghotaslou R, Soltani Ahari H, Ghorashi S. Study of the microbial etiologies and resistance pattern of neonatal septicemia in Tabriz Pediatric Hospital. J Ardabil Univ Med Sci. 2007; 7(2):155-9.
27
26. Khalilimatinzadeh Z, Amirsalari S, Kavehmanesh Z, Afsharpaiman S, Torkaman M. Study of the most common clinical and laboratory symptoms in suspected infants with sepsis in Baqiyatallah and Najmieh hospitals from 2001 to 2005. Sci Inform Database. 2007; 9(3):233-40.
28
27. Zhale D, Mohammad Rasoul T, Fatemeh D, Afshin A. Prevalence of bacterial and antibiotic sensitivity in septicemia of neonates admitted to Kermanshah Imam Reza Hospital (2007-2008). J Kermanshah Univ Med Sci. 2011; 15:2.
29
28. Forouzandeh Z, Soltani Banavandi M, Kheyrkhah B. Molecular identification and evaluation of antibiotic resistance of coagulase negative Staphylococcus isolated from Neonatal Sepsis hospitalized at Gharazi Hospital in Sirjan, Kerman. J Shahrekord Univ Med Sci. 2017; 19(1):117-25.
30
29. Aoyagi Y, Adderson EE, Rubens CE, Bohnsack JF, Min JG, Matsushita M, et al. L-ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway. Infect Immunity. 2008; 76(1):179-88.
31
30. Savoia D, Gottimer C, Crocilla C, Zucca M. Streptococcus agalactiae in pregnant women: phenotypic and genotypic characters. J Infect. 2008; 56(2):120-5.
32
31. Li Z, Xiao Z, Li Z, Zhong Q, Zhang Y, Xu F. 116 cases of neonatal early-onset or late-onset sepsis: A single
33
center retrospective analysis on pathogenic bacteria species distribution and antimicrobial susceptibility. Int J Clin Exp Med. 2013; 6(8):693.
34
32. Leal YA, Álvarez-Nemegyei J, Velázquez JR, Rosado-Quiab U, Diego-Rodríguez N, Paz-Baeza E, et al. Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up. BMC Pregnancy Childbirth. 2012; 12(1):48.
35
33. Kohli-Kochhar R, Omuse G, Revathi G. A ten-year review of neonatal bloodstream infections in a tertiary private hospital in Kenya. J Infect Dev Ctries. 2011; 5(11):799-803.
36
34. Fernandes C, Pammi M, Katakam L. Guidelines for acute care of the neonate 25th edition (2017–2018). Texas: Department of Pediatrics Baylor College of Medicine Houston; 2017.
37
ORIGINAL_ARTICLE
Pattern and Outcome of Newborn Emergencies in a Tertiary Center, Lagos, Nigeria
Background: Neonatal mortality had not changed significantly in the last decade in African countries particularly in Nigeria; however, under-five mortality had reduced significantly. Nigeria with a quarter of maternal and under-five mortality is among ten countries with the highest neonatal mortality. Previous studies had shown patterns of newborn morbidity and mortality; however, no study has been conducted in this regard recently. The present study aimed to ascertain the current patterns of newborn morbidity and mortality.Methods: A retrospective review of records of all newborn admissions over a period of one year was carried out. Extracted data include age, gender, diagnosis on admission outcome, and cause of mortality. The frequency of morbidity and outcome variables were analyzed and then calculated.Results: The major reason for admission was jaundice 29.6% followed by asphyxia 25%, sepsis 16.1%, and prematurity 9%. The neonatal mortality rate was 12.5% with more than half of the deaths occurring within 24 hours and almost all within 72 hours. Causes of death were asphyxia 58.2%, jaundice 16.4%, sepsis 10 .4%, and prematurity 3%. More than half of the neonates with asphyxia were likely to die within 24 hours.Conclusion: Asphyxia, jaundice, sepsis, and prematurity were the major causes of morbidity. In addition, asphyxia is still a major cause of preventable death in newborns in Nigeria.
https://ijn.mums.ac.ir/article_14099_72288698bac086884912865a0c65168e.pdf
2019-11-01
41
46
10.22038/ijn.2019.38272.1612
Asphyxia
Jaundice
Newborn
Preterm
Sepsis
Patricia
Akintan
akintanpatricia@gmail.com
1
Lagos University Teaching Hospital, Lagos, Nigeria/ University of Lagos, College of Medicine, Lagos, Nigeria
LEAD_AUTHOR
Iretiola
Fajolu
iretifaj@yahoo.co.uk
2
Lagos University Teaching Hospital, Lagos, Nigeria/ University of Lagos, College of Medicine, Lagos, Nigeria
AUTHOR
Babyemi
Osinaike
drosinaike@gmail.com
3
Lagos University Teaching Hospital, Lagos, Nigeria
AUTHOR
Beatrice
Ezenwa
beatriceezenwa@yahoo.com
4
Lagos University Teaching Hospital, Lagos, Nigeria/University of Lagos, College of Medicine, Lagos, Nigeria
AUTHOR
Chinyere
Ezeaka
ezeakac@yahoo.com
5
Lagos University Teaching Hospital, Lagos, Nigeria/University of Lagos, College of Medicine, Lagos, Nigeria
AUTHOR
1. Save the Children International. State of the world’s mothers: surviving the first day. London: Save the Children; 2013.
1
2. Alkema L, New JR, Pedersen J, You D. Child mortality estimation 2013: an overview of updates in estimation methods by the United Nations Interagency Group for Child Mortality Estimation. PloS One. 2014; 9(7):e101112.
2
3. World Health Organization. Levels and trends for maternal mortality: 1990 to 2013. Geneva: World Health Organization; 2014.
3
4. Lawn JE, Blencowe H, Oza S, You D, Lee AC, Waiswa P, et al. Every Newborn: progress, priorities, and potential beyond survival. Lancet. 2014; 384(9938): 189-205.
4
5. Wang H, Liddell CA, Coates MM, Mooney MD, Levitz CE, Schumacher AE, et al. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384(9947):957-79.
5
6. Shackman G, Wang X, Liu YL. Basic guide to the world: trends in infant mortality rates. Wisconsin: University of Wisconsin-Madison; 2014.
6
7. Akinyemi JO, Bamgboye EA, Ayeni O. Trends in neonatal mortality in Nigeria and effects of bio-demographic and maternal characteristics. BMC Pediatr. 2015; 15(1):36.
7
8. Ugwu GI, Okperi BO, Chinemelu UC. Pattern and outcome of presentation at the children emergency unit of a tertiary institution in the Niger Delta region of Nigeria: a one year prospective study. J Med. 2012; 13(2):170-3.
8
9. Owa JA, Osinaike AI. Neonatal morbidity and mortality in Nigeria. Indian J Pediatr. 1998; 65(3):441-9. 10. Ezeaka VC, Ogunbase AO, Awongbemi OT, Grange AO. Why our children die: a review of paediatric mortality in a tertiary centre in Lagos, Nigeria. Nigerian Quart J Hosp Med. 2003; 13(1):17-21.
9
11. Omoigberale AI, Sadoh WE, Nwaneri DU. A 4 year review of neonatal outcome at the University of Benin Teaching Hospital, Benin City. Niger J Clin Pract. 2010; 13(3):321-5.
10
12. Mukhtar-Yola M, Iliyasu Z. A review of neonatal morbidity and mortality in Aminu Kano Teaching Hospital, northern Nigeria. Trop Doctor. 2007; 37(3):130-2.
11
13. Toma BO, Ige OO, Abok II, Onwuanaku C, Abah RO, Donli A. Pattern of neonatal admissions and outcome in a tertiary institution in north central Nigeria. Nigeria J Med Trop. 2013; 15(2):121-5.
12
14. Ekwochi U, Ndu IK, Nwokoye IC, Ezenwosu OU, Amadi OF, Osuorah DI. Pattern of morbidity and mortality of newborns admitted into the sick and special care baby unit of Enugu State University Teaching Hospital, Enugu state. Niger J Clin Pract. 2014; 17(3):346-51.
13
15. Mmbaga BT, Lie RT, Olomi R, Mahande MJ, Kvåle G, Daltveit AK. Cause-specific neonatal mortality in a neonatal care unit in Northern Tanzania: a registry based cohort study. BMC Pediatr. 2012; 12(1):116.
14
16. Kumar MK, Thakur S, Singh B. Study of the morbidity and the mortality patterns in the neonatal intensive care unit at a tertiary care teaching Hospital in Rohtas District, Bihar, India. J Clin Diagnostic Res. 2012; 6(2):282-5.
15
17. Ersdal HL, Mduma E, Svensen E, Perlman J. Birth asphyxia: a major cause of early neonatal mortality in a Tanzanian rural hospital. Pediatrics. 2012; 129(5):e1238-43.
16
18. Ravikumar SA, Elangovan H, Elayaraja K, Sunderavel AKK. Morbidity and mortality profile of neonates in a tertiary care centre in Tamil Nadu: a study from South India. Int J Contemp Pediatr 2018;5:377-82.
17
19. Ralkia A, Khan M, Memon AA, Daher SA. Pattern and outcome of neonatal ailments in a tertiary care hospital. Par J Med Res. 2014; 53(1):14.
18
20. Walana W, Acquah Ekuban KS, Abdul-Mumin A, Naafu B, Aruk E, et al. Pattern, causes and treatment outcomes of neonatal admission in the tamale teaching hospital. Clinics Mother Child Health. 2016; 13:(252):2.
19
21. Ali SR, Ahmed S, Lohana H. Disease patterns and outcomes of neonatal admissions at a secondary care hospital in Pakistan. Sultan Qaboos Univ Med J. 2013; 13(3):424.
20
22. Hoque MS, Alam S, Ahmed AS. Pattern of neonatal admissions and outcome in an intensive care unit (ICU) of a tertiary care paediatric hospital in Bangladesh a one-year analysis. J Bangladesh Coll Physic Surg. 2013; 31(3):134-9.
21
23. Demisse AG, Alemu F, Gizaw MA, Tigabu Z. Patterns of admission and factors associated with neonatal mortality among neonates admitted to the neonatal intensive care unit of University of Gondar Hospital, Northwest Ethiopia. Pediatr Health Med Ther. 2017; 8:57.
22
24. Devpura B, Bhadesia P, Nimbalkar S, Desai S, Phatak A. Discharge against medical advice at neonatal intensive care unit in Gujarat, India. . International Journal of Pediatrics. 2016; 2016:1897039.
23
25. Al-Turkistani HK. Discharge against medical advice from Neonatal Intensive Care Unit: 10 years experience at a University Hospital. J Fam Community Med. 2013; 20(2):113-115.
24
ORIGINAL_ARTICLE
Assement Efficacy and Complication of the Distance between Phototherapy Lamps and Neonate’s Body Level on Serum Bilirubin Decrease and Phototherapy Complications in Neonatal Hyperbilirubinemia
Background: Jaundice is one of the most leading causes of neonate hospitalization (51.8%) during the first four weeks of life, and phototherapy is one of the most common and safest methods for the treatment of jaundice. Different results have been obtained from the studies conducted on the investigation of factors affecting increased phototherapy effect on the reduction of neonatal jaundice. However, there still exist many questions concerning the methods that maximize the effect of phototherapy.The current research aimed to determine the effect of the distance between phototherapy lamps and neonate's body on the reduction of serum bilirubin and phototherapy complications in the neonates with physiologic jaundice.Methods: The study was carried out on 60 newborns with jaundice. The neonates in the intervention group were put under phototherapy within a distance of 20 cm, and the ones in the control group underwent phototherapy within a distance of 40 cm. Daily bilirubin was measured at times 0, 12, and 24, and the neonates were examined in terms of serum bilirubin reduction and phototherapy complications.Results: The obtained results revealed that phototherapy within the distance of 20 cm causes more reduction in the total bilirubin 12 and 24 hours after phototherapy. However, there was no significant difference between bilirubin 48 hours after phototherapy and phototherapy duration and the complications between the two groups.Conclusion: Based on the results, the method of phototherapy distance reduction could be used as a safe and effective way for the quicker reduction of serum bilirubin level, prevention of hyperbilirubinemia complications and complications of blood transfusion in neonates with physiologic jaundice.
https://ijn.mums.ac.ir/article_14035_cb0c6f9cc13d9754dbf84324fc202358.pdf
2019-11-01
47
52
10.22038/ijn.2019.38470.1607
Jaundice
neonate
phototherapy distance
Roghayeh
Zardosht
rozardosht@yahoo.com
1
Department of Operative Room and Anesthetics, Iranian Research Center on Healthy Aging. School of paramedical, Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Ahmad
Shah Farhat
farhata@mums.ac.ir
2
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Reza
Saeidi
saeedir@mums.ac.ir
3
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Fatemeh
Parvin
parvinf1@mums.ac.ir
4
Nursing and Midwifery School, Sabzevar University of Medical Sciences, Sabzevar, Iran
LEAD_AUTHOR
1. Aouthmany MM. Phototherapy increases hemoglobin degradation and bilirubin production in preterm neonates. J Perinatol. 1999; 19(4):271-4.
1
2. Escobar GJ, Greene JD, Hulac P, Kincannon E, Bischoff K, Gardner M, et al. Rehospitalisation after birth hospitalisation: patterns among neonates of all gestations. Arch Dis Child. 2005; 90(2):125-31.
2
3. Lin CH, Yang HC, Cheng CS, Yen CE. Effects of neonate massage on jaundiced neonates undergoing phototherapy. Ital J Pediatr. 2015; 41(1):94.
3
4. Ehsanipour F, Khosravi N, Jalali S. The effect of hat on phototherapy-induced hypocalcemia in icteric newborns. Razi J Med Sci. 2008; 15(58):25-9.
4
5. Zauk AM. Phototherapy: a simple and safe treatment for neonatal jaundice. J Pediatr Neonat Care. 2015; 2(3):8-10.
5
6. Melton K, Akinbi HT. Neonatal jaundice: strategies to reduce bilirubin-induced complications. Postgrad Med. 1999; 106(6):167-78.
6
7. Farhat AS, Mohammadzadeh A. Assesment, diagnosis and treatment of pediatrics. 14th ed. Mashhad: Mashhad University of Medical Science; 2007.
7
8. Eghbalian F, Monsef AR. Comparison of the efficacy and complications between two dimensional phototherapy (cylindrical) and uni dimensional phototherapy (double) in neonatal unconjugated hyperbilirubinemia. J Urmia Univ Med Sci. 2010; 20(4):254-60.
8
9. Mohammady M, Janani L. Randomization in randomized clinical trials: from theory to practice. J Hayat. 2016; 22(2):102-14.
9
10. Boonyarittipong P, Kriangburapa W, Booranavanich K. Effectiveness of double-surface intensive phototherapy versus single-surface intensive phototherapy for neonatal hyperbilirubinemia. Med J Med Assoc Thai. 2008; 91(1):50-5.
10
11. Djokomuljanto S, Quah BS, Surini Y, Noraida R, Ismail N, Hansen TW, et al. Efficacy of phototherapy for neonatal jaundice is increased by the use of low-cost white reflecting curtains. Arch Dis Child Fetal and Neonatal Ed. 2006; 91(6):F439-42.
11
12. Salehzadeh F, Mirza Rahimi M, Janhangiri S, Habibzadeh S, Amini Sani N, Samshirgara M, et al. Mirror covered tunnel phototherapy increases the efficacy of phototherapy for neonatal jaundice. Iran J Neonatol. 2011; 1(1):20-3.
12
13. Naderi SA, Safdarian F, Jahanlou AR, Mazloomi D. Comparison of triple and double phototherapy in neonatal hyperbilirubinemia. Hormozgan Med Sci. 2009; 13(1):13-6.
13
14. Ek-isariyaphorn R, Maneenut R, Kardreunkaew J, Khobkhun W, Saenphrom S. The efficacy of the in-house light-emitting diode phototherapy equipment compare to conventional phototherapy equipment on the treatment of neonatal hyperbilirubinemia. J Med Assoc Thai. 2013; 96(12):1536-41.
14
15. Babaei H, Alipour AA, Hemmati M, Ghaderi M, Rezaei M. Effect of white plastic cover around the phototherapy unit on hyperbilirubinemia in full term neonates. Iran J Pediatr. 2013; 23(2):143-8.
15
16. Goodarzi R, Khamesan B, Hamedi Y, Yousefi F, Houshmandi MM. Comparing the effects of continuous and intermittent phototherapy in reducing bilirubin levels of neonates. J Urmia Univ Med Sci. 2013; 24(6):423-9.
16
17. Behjati S, Ghotbi H. Evaluation of efficacy and complication between three mode of phototherapy. Iran J Pediatr. 2006; 16(2):23-33.
17
ORIGINAL_ARTICLE
Neonatal Respiratory Distress in Misan: Causes, Risk Factors, and Outcomes
Background: Respiratory distress is considered one of the most frequent causes of admission in the neonatal unit. Additionally, it is the leading cause of neonatal morbidity and mortality. This study aimed to determine the incidence of neonatal respiratory distress and its causes, risk factors, and outcomes to have a baseline data about the magnitude of respiratory distress with a further step toward the development of the neonatal field.Methods: This cross-sectional study was conducted in the neonatal care unit of Misan Hospital for Child and Maternity in Misan, Iraq, during one year. All the neonates who developed respiratory distress were included in this study according to the World Health Organization criteria.Results: The total number of neonatal admission during the study period was 870 cases among whom 738 (84.8%) subjects developed respiratory distress. The fatality rate was 21%, and the majority of deaths were found in respiratory distress syndrome (RDS) (67.1%). The RDS, transient tachypnea, and birth asphyxia were the major causes of neonatal respiratory distress. Statistically, prematurity, type of delivery, and number of babies at the delivery time were significantly associated with respiratory distress development.Conclusion: The incidence rate of neonatal respiratory distress was apparently high in Misan forming the most common cause of neonatal admission associated with a high mortality rate. Efforts toward preventing the causes and risk factors for neonatal respiratory distress, as well as, improving the efficacy of neonatal care unit are the significant challenges to improve the neonatal care and outcome.
https://ijn.mums.ac.ir/article_13799_d5c8d076e545360c2e292bb0bb7d23fd.pdf
2019-11-01
53
60
10.22038/ijn.2019.39348.1626
Misan
neonatal care unit
Neonates
Preterm
respiratory distress
Hussein Fadhil Musa
Aljawadi
husseinaljawadi.mcm@uomisan.edu.iq
1
Pediatrics Department, College of Medicine, Misan University, Misan, Iraq
LEAD_AUTHOR
Esraa Abd Al-Muhsen
Ali
esraa.ali@uomisan.edu.iq
2
Pediatrics Department, College of Medicine, Misan University, Misan, Iraq
AUTHOR
1. Baeckert P, Ackermann-Liebrich U, Duc G. Neonatal respiratory distress syndrome in Switzerland. Data for 1984 and comparison with 1974. Schweiz Med Wochenschr. 1987; 117(27-28):1021-7.
1
2. McCormick M, Cooper P. Managing newborn problems: a guide for doctors, nurses, and midwives. Geneva: World Health Organization; 2003.
2
3. Swarnkar K, Swarnkar M. Neonatal respiratory distress in early neonatal period and its outcome. Int J Biomed Adv Res. 2015;6(09):643-7.
3
4. Pramanik AK, Rangaswamy N, Gates T. Neonatal respiratory distress: a practical approach to its diagnosis and management. Pediatr Clin North Am. 2015; 62(2):453-69.
4
5. Edwards MO, Kotecha SJ, Kotecha S. Respiratory distress of the term newborn infant. Paediatr Respir Rev. 2013; 14(1):29-36.
5
6. Hermansen CL, Mahajan A. Newborn respiratory distress. Am Fam Physician. 2015; 92(11):994-1002.
6
7. John EB, Carlo WA. Respiratory distress syndrome in VLBW infants: changes in management and outcomes observed by the NICHD Neonatal Research Network. Semin Perinatol. 2003; 27(4):288-92.
7
8. Crowley P. Withdrawn: prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev. 2006; 3:CD000065.
8
9. Sinn JK, Ward MC, Henderson‐Smart DJ. Developmental outcome of preterm infants after surfactant therapy: systematic review of randomized controlled trials. J Paediatr Child Health. 2002; 38(6):597-600.
9
10. American Academy of Pediatrics Committee on Fetus and Newborn. Levels neonatal care. Pediatrics. 2012; 130(3):587-97.
10
11. Oestergaard MZ, Inoue M, Yoshida S, Mahanani WR, Gore FM, Cousens S, et al. Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of progress, projections, and priorities. PLoS Med. 2011; 8(8):e1001080.
11
12. Hameed NN, Abdul Jaleel RK, Saugstad OD. The use of continuous positive airway pressure in preterm babies with respiratory distress syndrome: a report from Baghdad, Iraq. J Matern Neonatal Med. 2014; 27(6):629-32.
12
13. Ali EA. Neonatal mortality rate in aseptic neonatal care unit of Al-Sadder teaching hospital in missan province from 2011 to 2014. Eur Sci J. 2016; 12(27):55-62.
13
14. Ballard JL, Khoury JC, Wedig KL, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr. 1991; 119(3):417-23.
14
15. Ersch J, Roth-Kleiner M, Baeckert P, Bucher HU. Increasing incidence of respiratory distress in neonates. Acta Paediatr. 2007; 96(11):1577-81.
15
16. Tochie JN, Choukem SP, Langmia RN, Barla E, Koki-Ndombo P. Neonatal respiratory distress in a reference neonatal unit in Cameroon: An analysis of prevalence, predictors, etiologies and outcomes. Pan Afr Med J. 2016; 24:152.
16
17. Jasso-Gutiérrez L, Durán-Arenas L, Flores-Huerta S, Cortés-Gallo G. Recommendations to improve healthcare of neonates with respiratory insufficiency beneficiaries of Seguro Popular. Salud Publica Mex. 2012; 54:S57-64.
17
18. Qari SA, Alsufyani AA, Muathin SH, El Margoushy NM. Prevalence of respiratory distress syndrome in neonates. Egypt J Hosp Med. 2018; 70(1):257-64.
18
19. Fedakar A, Aydoğdu C. Clinical features of neonates treated in the intensive care unit for respiratory distress. Turk J Pediatr. 2011; 53(2):173-9.
19
20. Abdelrahman SM, Hamed SM, Nasr A. Neonatal respiratory distress in Omdurman Maternity Hospital, Sudan. Sudan J Paediatr. 2014; 14(1):65-70.
20
21. Sabzehei M, Basiri B, Shokouhi M, Fayyazi A. Causes and outcomes of respiratory distress in neonates hospitalized in the neonatal intensive care unit of Beâ sat hospital in Hamadan, Iran. Int J Pediatr. 2017; 5(12):6253-60.
21
22. Palod PH, Lawate BB, Sonar MN, Bajaj SP. A study of clinical profile of neonates with respiratory distress and predictors of their survival admitted in neonatal intensive care unit of tertiary care hospital. Int J Contemp Pediatr. 2017; 4(6):2027-31.
22
23. Saboute M, Kashaki M, Bordbar A, Khalessi N, Farahani Z. The incidence of respiratory distress syndrome among preterm infants admitted to neonatal intensive care unit: a retrospective study. Open J Pediatr. 2011; 5(4):285-9.
23
24. Santosh S, Kushal KK, Adarsha E. A clinical study of respiratory distress in newborn and its outcome. Indian J Neonatal Med Res. 2013; 1(1):2-4.
24
25. Hibbard JU, Wilkins I, Sun L, Gregory K, Haberman S, Hoffman M, et al. Respiratory morbidity in late preterm births. JAMA. 2010; 304(4):419.
25
26. Levine EM, Ghai V, Barton JJ, Strom CM. Mode of delivery and risk of respiratory diseases in newborns. Obstet Gynecol. 2001; 97(3):439-42.
26
27. American College of Obstetricians and Gynecologists; Society for Maternal-Fetal Medicine. Obstetric care consensus no. 1. safe prevention of the primary cesarean delivery. Obstet Gynecol. 2014; 123(3): 693-711.
27
28. Hameed NN, Al-janabi MK, Al-reda YI. Respiratory distress in full term newborns. Iraqi Postgraduate J. 2007; 6(3):233-9.
28
29. Ross MG, Beall MH. Cesarean section and transient tachypnea of the newborn. Am J Obstet Gynecol. 2006; 195(5):1496-7.
29
30. Gouyon JB, Ribakovsky C, Ferdynus C, Quantin C, Sagot P, Gouyon B, et al. Severe respiratory disorders in term neonates. Paediatr Perinat Epidemiol. 2008; 22(1):22-30.
30
31. Stutchfield P, Whitaker R, Russell I. Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial. BMJ. 2005; 331(7518):662.
31
32. Chandrasekhar R, Mohan MM, Lakshmi BV. Clinical study of respiratory distress in newborn. Int J Contemp Pediatr. 2016; 10:2349-91.
32
33. Anadkat JS, Kuzniewicz MW, Chaudhari BP, Cole FS,
33
Hamvas A. Increased risk for respiratory distress among white, male, late preterm and term infants. J Perinatol. 2012; 32(10):780-5.
34
34. Oyelese Y, Culin A, Ananth CV, Kaminsky LM, Vintzileos A, Smulian JC. Meconium-stained amniotic fluid across gestation and neonatal acid-base status. Obstet Gynecol. 2006; 108(2):345-9.
35
35. Dargaville PA, Copnell B. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics. 2006; 117(5):1712-21.
36
36. Arafa MA, Alshehri MA. Predictors of neonatal mortality in the intensive care unit in Abha, Saudi Arabia. Saudi Med J. 2003; 24(12):1374-6.
37
37. Assembly OG. Road map towards the implementation of the United Nations millennium declaration: report of the secretary-general. In: Road Map Towards The Implementation of The United Nations Millennium Declaration: Report of the Secretary-General, New York, United Nations; 2001.
38
ORIGINAL_ARTICLE
Knowledge, Attitude and Practice of Mothers about Exclusively Breastfeeding in Sabzevar in 2017
Background: Exclusive breastfeeding is one of the most important issues for public health and Pediatricians in developing countries. Despite the importance of exclusive breastfeeding, only 39% of children in the world are breastfed during the first six months of life.Methods: This study was a Cross-sectional descriptive-analysis conducted on a total number of 396 breastfeeding mothers in 2017.The data collection tool was a structured questionnaire, including demographic information, questions about knowledge and attitude, and performance. We collected the data through face-to-face interview.Results: Based on our results mean and standard deviation of knowledge score of exclusive breastfeeding, attitude, and performance were reported as 7.6±2.4, 43.1±3.3, and 5.1±0.9, respectively.Frequency rates of participants who had high performance, knowledge, and attitude level were, 93.4 % (370), 26 % (103), and 98.5 % (390), respectively.Conclusion: The present study indicated that the majority of mothers had a positive attitude and practice desired however knowledge score was low. Maternal education and relatives was one of the important determinants of exclusive breastfeeding. Health care professionals have important roles in providing suitable fields for these interventions. Using open and extensive questions in other studies can help in finding the causes of breastfeeding cessation during infancy.
https://ijn.mums.ac.ir/article_13800_e0bb8923eed7b939d6494af7b642bb25.pdf
2019-11-01
61
66
10.22038/ijn.2019.35597.1543
Attitude
Exclusive breastfeeding
Infants
Knowledge
Performance
Aghil
Keykhosravi
drakeykhosravi@yahoo.com
1
Department of Pediatrics, Nephrology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Bita
Barghamadi
bitakiyavash@gmail.com
2
Department of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Rozita
Sabzevari
rozita56@yahoo.com
3
Department of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Mohammad
Neamatshahi
9151737407mn@gmail.com
4
Department of Anesthesia, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
AUTHOR
Mahboubeh
Neamatshahi
mahneamatshahi@yahoo.com
5
Department of Community Medicine, Faculty of Medicine, Research Center Social Determinants Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
LEAD_AUTHOR
1. Fincham R, Harrison D, Khosa M, Le Roux I. Nutrition and health in South Africa: the state of nutrition and the development of nutrition policy. South Africa: Southern Africa Labour and Development Research Unit; 1993.
1
2. Unicef. Breastfeeding and family nutrition with affection and hygiene/giving other foods while breastfeeding continues. New York: Press Release, Breastfeeding Week; 2005. P. 1-7.
2
3. Organisation Mondiale De La Santé, World Health Organisation Staff, World Health Organization, UNICEF, UNAIDS. Global strategy for infant and young child feeding. Geneva: World Health Organization; 2003.
3
4. Rasania SK, Singh SK, Pathi S, Bhalla S, Sachdev TR. Breast feeding practices in a maternal and child health centre in Delhi. Health Popul Perspect Issues. 2003; 26(110):15.
4
5. World Health Organization. The WHO Global data bank on infant and young child feeding. Geneva: World Health Organization; 2001.
5
6. Vijayalakshmi P, Susheela T, Mythili D. Knowledge, attitudes, and breast feeding practices of postnatal mothers: A cross sectional survey. Int J Health Sci. 2015; 9(4):364.
6
7. Grummer-Strawn LM, Reinold CM, Krebs NF, Control CfD, Prevention. Use of World Health Organization and CDC growth charts for children aged 0-59 months in the United States. Atlanta: Department of Health and Human Services, Centers for Disease Control and Prevention; 2010.
7
8. Agunbiade OM, Ogunleye OV. Constraints to exclusive breastfeeding practice among breastfeeding mothers in Southwest Nigeria: implications for scaling up. Int Breastfeed J. 2012; 7(1):5.
8
9. Steyn NP, Badenhorst CJ, Nel JH, Ladzani R. Breast-feeding and weaning practices of Pedi mothers and the dietary intakes of their preschool children. South Afr J Food Sci Nutr. 1993; 5(1):10-3.
9
10. Richter LM. The early introduction of solids: an
10
analysis of belief and practices among African women in Soweto. South Africa: University of the Witwatersrand; 1987.
11
11. Lawrence RA. A review of the medical benefits and contraindications to breastfeeding in the United States. Washington, DC: National Center for Education in Maternal and Child Health; 1997.
12
12. Issaka AI, Agho KE, Page AN, Burns P, Stevens GJ, Dibley MJ. Determinants of early introduction of solid, semi-solid or soft foods among infants aged 3–5 months in four Anglophone West African countries. Nutrients. 2014; 6(7):2602-18.
13
13. Okolo SN, Adewunmi YB, Okonji MC. Current breastfeeding knowledge, attitude, and practices of mothers in five rural communities in the Savannah region of Nigeria. J Trop Pediatr. 1999; 45(6):323-6.
14
14. Mogre V, Dery M, Gaa PK. Knowledge, attitudes and determinants of exclusive breastfeeding practice among Ghanaian rural lactating mothers. Int Breastfeed J. 2016; 11(1):12.
15
15. Oche M, Umar A, Ahmed H. Knowledge and practice of exclusive breastfeeding in Kware, Nigeria. Afr Health Sci. 2011; 11(3):518-23.
16
16. Chaudhary R, Shah T, Raja S. Knowledge and practice of mothers regarding breast feeding: a hospital based study. Health Renaissance. 2011;
17
9(3):194-200.
18
17. Onah S, Osuorah DI, Ebenebe J, Ezechukwu C, Ekwochi U, Ndukwu I. Infant feeding practices and maternal socio-demographic factors that influence practice of exclusive breastfeeding among mothers in Nnewi South-East Nigeria: a cross-sectional and analytical study. Int Breastfeed J. 2014; 9(1):6.
19
18. Abasiattai AM, Etukumana EA, Nyong E, Eyo UE. Knowledge and practice of exclusive breastfeeding among antenatal attendees in Uyo, Southern Nigeria. Gaziantep Med J. 2014; 20(2):130-5.
20
19. Apanga PA. A review on facilitators and barriers to exclusive breastfeeding in West Africa. Benefits. 2014; 4(24):1-15.
21
20. Khassawneh M, Khader Y, Amarin Z, Alkafajei A. Knowledge, attitude and practice of breastfeeding in the north of Jordan: a cross-sectional study. Int Breastfeed J. 2006; 1(1):17.
22
21. Hurley KM, Black MM, Papas MA, Quigg AM. Variation in breastfeeding behaviours, perceptions, and experiences by race/ethnicity among a low‐income statewide sample of Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) participants in the United States. Matern Child Nutr. 2008; 4(2):95-105.
23
ORIGINAL_ARTICLE
Assessing the Performance of Nurses in the Proper Adjustment of Monitoring Instruments in the Neonatal Intensive Care Unit
Background: Monitoring serves to maintain physiologic variables within normal limits and when a parameter crosses a set threshold, an alarm is triggered. Therefore, this study aimed to determine whether alarm limits are properly adjusted in the neonatal intensive care unit (NICU) by nursing staff or not.Methods: The data concerning alarm limits corresponding to the three shifts of nursing work were recorded for the newborns with cardiorespiratory problems, such as hyaline membrane disease, transient tachypnea of the newborns, and pneumonia, who were admitted to the NICU of Imam Reza Hospital, Mashhad, Iran during March 2016-December 2016.Results: The findings of this study showed that 75.1% of the 95 subjects of this study were preterm infants, while the others were cases with a gestational age of more than 37 weeks. The mean birth weight of the neonates was 1939.15±899.2 g. The upper alarm limit of pulse oximetry (95%) had been set correctly just in almost 26% of the patients. On the other hand, only at about 21% of all the cases, a normal lower alarm limit (85%) was observed for this variable. Compliance with the normal lower and upper limits of alarm for heart rate (i.e., 90 and 180 beats/min, respectively) was reported only in 10.46% and 18.6% of the infants, respectively.Conclusion: This study revealed that the alarm limits in NICU for unstable neonates were frequently set outside the normal range.
https://ijn.mums.ac.ir/article_13295_0ca47b90119bb509c98c5825a17a89cb.pdf
2019-11-01
67
70
10.22038/ijn.2019.32615.1458
Alarm limits
Monitoring tools
Nursing staff
preterm infants
Ahmad
Shah Farhat
farhata@mums.ac.ir
1
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ashraf
Mohammadzadeh
mohamadzadeha@mums.ac.ir
2
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Reza
Saeidi
saeedir@mums.ac.ir
3
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Fatemeh
Chitgar Rahimi
chitgarrahimif@mums.ac.ir
4
Head Nurse of Neonatal Intensive Care Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Abdul Raouf
Forough
nrc@mums.ac.ir
5
Abu Ali Sina Hospital, Mazarsharif, Afghanistan
AUTHOR
Azra
Izanloo
a.izanloo@gmail.com
6
Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
AUTHOR
1. Tin W, Gupta S. Optimum oxygen therapy in preterm babies. Arch Dis Child Fetal Neonatal Ed. 2007; 92(2):F143-7.
1
2. Armbruster J, Schmidt B, Poets C, Bassler D. Nurses’
2
compliance with alarm limits for pulse oximetry: qualitative study. J Perinatol. 2010; 30(8):531-4.
3
3. Sola A, Golombek SG, Montes Bueno MT, Lemus‐Varela L, Zuluaga C, Domínguez F, et al. Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia? Acta Paediatr. 2014; 103(10):1009-18.
4
4. Hay WW, Rodden DJ, Collins SM, Melara DL, Hale KA, Fashaw LM. Reliability of conventional and new pulse oximetry in neonatal patients. J Perinatol. 2002; 22(5):360-6.
5
5. Drew BJ, Harris P, Zègre-Hemsey JK, Mammone T, Schindler D, Salas-Boni R, et al. Insights into the problem of alarm fatigue with physiologic monitor devices: a comprehensive observational study of consecutive intensive care unit patients. PloS One. 2014; 9(10):e110274.
6
6. Imhoff M, Kuhls S. Alarm algorithms in critical care monitoring. Anesth Analg. 2006; 102(5):1525-37.
7
7. Chambrin MC. Alarms in the intensive care unit: how can the number of false alarms be reduced? Crit Care. 2001; 5(4):184-8.
8
8. Görges M, Markewitz BA, Westenskow DR. Improving alarm performance in the medical intensive care unit using delays and clinical context. Anesth Analg. 2009; 108(5):1546-52.
9
9. Chow LC, Wright KW, Sola A; CSMC Oxygen Administration Study Group. Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics. 2003; 111(2):339-45.
10
10. Clucas L, Doyle LW, Dawson J, Donath S, Davis PG. Compliance with alarm limits for pulse oximetry in very preterm infants. Pediatrics. 2007; 119(6): 1056-60.
11
11. Solsona JF, Altaba C, Maúll E, Rodríguez L, Bosqué C, Mulero A. Are auditory warnings in the intensive care unit properly adjusted? J Adv Nurs. 2001; 35(3):402-6.
12
12. van der Eijk AC, Dankelman J, Schutte S, Simonsz HJ, Smit BJ. An observational study to quantify manual adjustments of the inspired oxygen fraction in extremely low birth weight infants. Acta Paediatr. 2012; 101(3):e97-104.
13
13. Hagadorn JI, Furey AM, Nghiem TH, Schmid CH, Phelps DL, Pillers DA, et al. Achieved versus intended pulse oximeter saturation in infants born less than 28 weeks' gestation: the AVIOx study. Pediatrics. 2006; 118(4):1574-82.
14
ORIGINAL_ARTICLE
Prediction of Respiratory Morbidities in Late Preterm Neonates Using Cord Blood Arterial Lactate and Base Excess
Background: Late preterm neonates may have the external appearance and behavior similar to their counterparts.However, they are susceptible to various neonatal morbidities , due to their physiological and metabolical immaturity.To assess the correlation between cord blood arterial lactate levels and base excess with the development ofrespiratory distress in late preterm neonates.Methods: All inborn neonates born at Kasturba hospital Manipal, satisfying the criteria of late preterm infants (34 -366/7 weeks) were included in this prospective observational study.The data recorded included gender, birth weight,multiple births, presence of major congenital anomalies, mode of delivery, APGAR score at minute 5, need forresuscitation, admission to the neonatal intensive care unit (NICU), and days of hospitalization. Lactate and base excesswere estimated using blood obtained from umbilical artery sampling. The primary outcome assessed was therequirement of delivery room resuscitation. The secondary outcomes assessed were the development of respiratorydistress, requirement of invasive/non- invasive ventilation, and respiratory support.Results: Cord blood base excess levels were significantly higher in late preterm neonates requiring delivery roomresuscitation compared to those who did not require resuscitation (median: -8 vs -4mEq/L, p-value: 0.002).In terms ofrespiratory morbidities, cord blood base excess levels were significantly higher in neonates with respiratory distresssyndrome (RDS)(median: -8.5 vs -3.4 mEq/L, p-value 0.001), and transient tachypnea of newborn (TTNB) (median: -8vs -3.4 mEq/L, p-value 0.004), compared to those without RDS and TTNB.However,there was no signi icant associationbetween cord blood lactate levels and the outcomes assessed.Conclusion: Estimation of arterial base excess levels obtained from umbilical cord blood sampling during delivery mayserve as a sensitive marker for predicting respiratory morbidities in late preterm neonates.
https://ijn.mums.ac.ir/article_13798_22145d514d9a18ecd9e5ea87949e2b4d.pdf
2019-11-01
71
75
10.22038/ijn.2019.39551.1628
base excess
Cord blood
Lactate
Late preterm
respiratory morbidities
Farooq
Syed
drysr1949@gmail.com
1
Department of Paediatrics, Kodagu Institute of Medical Sciences and Teaching Hospital, Madikeri, Karnataka, India
AUTHOR
Sandesh
Kini
sandesh.kini@manipal.edu
2
Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
LEAD_AUTHOR
Leslie
Edward Lewis
leslie.lewis@manipal.edu
3
Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
Ramesh
Bhat Y
ramesh.bhaty@manipal.edu
4
Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
Jayashree
Purkaystha
jaya.p@manipal.edu
5
Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
AUTHOR
1. Abu-Salah O. Unfavourable outcomes associated with late preterm birth: observations from Jordan. J Pak Med Assoc. 2011; 61(8):769-72.
1
2. Raju TN. The “Late Preterm” birth-ten years later. Pediatrics. 2017; 139(3):e20163331.
2
3. Deshpande SA, Platt MP. Association between blood lactate and acid-base status and mortality in ventilated babies. Arch Dis Child Fetal Neonatal Ed. 1997; 76(1):F15-20.
3
4. Fuyama Y, Shima Y, Shindo F, Nakajima M, Urashima M. Clinical significance of measuring lactate levels in cord blood to predict development of respiratory distress syndrome in neonates. Japan Med Assoc J. 2005; 48(6):268.
4
5. Mathai SS, Raju U, Kanitkar M. Management of respiratory distress in the newborn. Med J Armed
5
Forces India. 2007; 63(3):269-72.
6
6. Shapiro-mendoza CK, Lackritz EM. Epidemiology of late and moderate preterm birth. Semin Fetal Neonatal Med. 2015; 17(3):120-5.
7
7. Engle WA, Tomashek KM, Wallman C, Care P; Committee on Fetus and Newborn, American Academy of Pediatrics. “Late-Preterm” infants : a population at risk. Pediatrics. 2007; 120(6):1390-401.
8
8. Consortium on Safe Labor, Hibbard JU, Wilkins I, Sun L, Gregory K, Haberman S, et al. Respiratory morbidity in late preterm births. JAMA. 2010; 304(4):419-25.
9
9. Wang L, Chen L, Li R, Zhao J, Wu X, Li X, et al. Efficacy of surfactant at different gestational ages for infants with respiratory distress syndrome. Int J Clin Exp Med. 2015; 8(8):13783-9.
10
10. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S, et al. Births : final data for 2005. Natl Vital Stat Rep. 2007; 56(6):1-103.
11
11. Roth-Kleiner M, Wagner BP, Bachmann D, Pfenninger J. Respiratory distress syndrome in near-term babies after caesarean section. Swiss Med Wkly. 2003; 133(19-20):283-8.
12
12. Bastek JA, Langmuir H, Kondapalli LA, Par E, Adamczak JE, Srinivas SK. Antenatal corticosteroids for late-preterm infants : a decision-analytic and economic analysis. ISRN Obstet Gynecol. 2012; 2012:491595.
13
13. Patil SS, Rath SR, George CE. Study on umbilical cord arterial blood gas analysis and cord blood lactate levels as predictors for adverse neonatal outcome : an observational study. Int J Reprod Contracept Obstet Gynecol. 2018; 7(4):1494-500.
14
14. Zamzami TY, Al-Saedi SA, Marzouki AM, Nasrat HA. Prediction of perinatal hypoxic encephalopathy: proximal risk factors and short-term complications. J Clin Gynecol Obstet. 2014; 3(3):97-104.
15
15. Victory R, Penava D, Da Silva O, Natale R, Richardson B. Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term. Am J Obstet Gynecol. 2004; 191(6):2021-8.
16
16. Andres RL, Saade G, Gilstrap LC, Wilkins I, Witlin A, Zlatnik F. Association between umbilical blood gas parameters and neonatal morbidity and death in neonates with pathologic fetal acidemia. Am J Obstet Gynecol. 1999; 181(4):867-71.
17
17. Begum LN, Ahmed F, Haq K, Mallick LL. Clinical outcome of the late preterm infants. Bangabandhu Sheikh Mujib Med Univ J. 2017; 10(3):132-4.
18
18. Machado Júnior LC, Passini Júnior R, Rodrigues Machado Rosa I. Late prematurity : a systematic review. J Pediatr (Rio J). 2014; 90(3):221-31.
19
ORIGINAL_ARTICLE
The Incidence and Risk Factors Associated with Posttraumatic Stress Disorders among Parents of NICU Hospitalized Preterm Neonates
Background: Parents of preterm neonates are exposed to great stress that can lead to posttraumatic stress disorder. The current study aimed to assess the incidence of posttraumatic stress disorders (PTSD) in both mothers and fathers of preterm infants.Methods: A prospective cohort study was done at two Iranian hospitals in 2016. One hundred and sixty parents of preterm neonates entered the study. A questionnaire related to acute stress disorder (ASD) was completed for parents at days 3-5 after birth. One month later, the parents were asked for the second interview. Prenatal posttraumatic stress questionnaire (PPQ) for mothers and posttraumatic stress disorder checklist (PCL) for fathers were completed. Prevalence of PTSD among the mothers and fathers was compared.Results: According to the results, 32.5% of all mothers and 4% of all fathers showed ASD. After a month, 40% of the mothers and 21.5% of the fathers showed PTSD. A significant correlation was seen between PPQ and PCL scores (P<0.001). There were also significant correlations between both father’s and mother’s ASD scores with mother’s PPQ score (P=0.019, P<0.001). The PPQ scores among employed mothers and mothers with unemployed husbands were significantly higher than others (P=0.038, OR=2.46; P=0.02, OR=0.436). A history of an accident during recent years for mother could change both mother's ASD and PPQ scores (P=0.002, OR=0.133; P=0.002, OR=0.15). Both PPQ and PCL scores also increased by father's history of an accident during recent years (P=0.02, OR=0.541; P=0.01, OR=0.325).Conclusion: The ASD and PTSD among mothers were more frequent than in fathers. Fathers indicated delayed onset of PTSD in comparison with mothers.
https://ijn.mums.ac.ir/article_13808_2916ca311eeff93fd2a352c4f7f3a1bf.pdf
2019-11-01
76
82
10.22038/ijn.2019.38135.1597
Acute
Intensive Care Units
Neonatal
parents
Premature birth
Stress disorders
Traumatic
Azam
Tofighi Naeem
azamtofighinaeem@tums.ac.ir
1
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mamak
Shariat
mshariat@tums.ac.ir
2
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammad Reza
Zarkesh
zarkesh@tums.ac.ir
3
Department of Neonatology, Yas Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Nasrin
Abedinia
mfnhrc@tums.ac.ir
4
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Sara
Teimoory bakhsh
teimoorybakhsh@yahoo.com
5
Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Fatemeh
Nayeri
fsnayeri@sina.ac.ir
6
Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
1. Ghorbani M, Dolatian M, Shams J, Alavi-Majd H. Anxiety, post-traumatic stress disorder and social supports among parents of premature and full-term infants. Iran Red Crescent Med J. 2014; 16(3): e13461.
1
2. Ghorbani M, Dolatian M, Shams J, Alavi-Majd H, Tavakolian S. Factors associated with posttraumatic stress disorder and its coping styles in parents of preterm and full-term infants. Glob J Health Sci. 2014; 6(3):65-73.
2
3. Mandy GT. Incidence and mortality of the preterm infant. Massachusetts: UpToDate; 2017.
3
4. Wilson-Costello D, Payne A. Long-term neurodevelo-pmental outcome of preterm infants: epidemiology and risk factors. Massachusetts: UpToDate; 2017.
4
5. Holditch-Davis D, Santos H, Levy J, White-Traut R, O'Shea TM, Geraldo V, et al. Patterns of psychological distress in mothers of preterm infants. Infant Behav Dev. 2015; 41:154-63.
5
6. Gondwe KW, Holditch-Davis D. Posttraumatic stress symptoms in mothers of preterm infants. Int J Afr Nurs Sci. 2015; 3:8-17.
6
7. Shaw RJ, Lilo EA, Storfer-Isser A, Ball MB, Proud MS, Vierhaus NS, et al. Screening for symptoms of postpartum traumatic stress in a sample of mothers with preterm infants. Issues Ment Health Nurs. 2014; 35(3):198-207.
7
8. Misund AR, Nerdrum P, Diseth TH. Mental health in women experiencing preterm birth. BMC Pregnancy Childbirth. 2014; 14:263.
8
9. Greene MM, Rossman B, Patra K, Kratovil AL, Janes JE, Meier PP. Depression, anxiety, and perinatal-specific posttraumatic distress in mothers of very low birth weight infants in the neonatal intensive care unit. J Dev Behav Pediatr. 2015; 36(5):362-70.
9
10. Habersaat S, Borghini A, Nessi J, Pierrehumbert B, Forcada-Guex M, Ansermet F, et al. Posttraumatic stress symptoms and cortisol regulation in mothers of very preterm infants. Stress Health. 2014; 30(2):134-41.
10
11. Gangi S, Dente D, Bacchio E, Giampietro S, Terrin G, De Curtis M. Posttraumatic stress disorder in parents of premature birth neonates. Proc Soc Behav Sci. 2013; 82:882-5.
11
12. Borghini A, Habersaat S, Forcada-Guex M, Nessi J, Pierrehumbert B, Ansermet F, et al. Effects of an early intervention on maternal post-traumatic stress symptoms and the quality of mother-infant interaction: the case of preterm birth. Infant Behav Dev. 2014; 37(4):624-31.
12
13. The Australian Psychological Society, The Royal Australian College of General Practitioners, The Royal Australian and New Zealand College of Psychiatrists. Australian guidelines for the treatment of acute stress disorder & posttraumatic stress disorder. Australia: National Health and Medical Research Council; 2015. 14. Shaw RJ, St John J, Lilo EA, Jo B, Benitz W, Stevenson DK, et al. Prevention of traumatic stress in mothers with preterm infants: a randomized controlled trial. Pediatrics. 2013, 132(4):886-94.
13
15. Aftyka A, Rybojad B, Rosa W, Wróbel A, Karakuła-Juchnowicz H. Risk factors for the development of post-traumatic stress disorder and coping strategies in mothers and fathers following infant hospitalisation in the neonatal intensive care unit. J Clin Nurs. 2017; 26(23-24):4436-45.
14
16. Chang HP, Chen JY, Huang YH, Yeh CJ, Huang JY, Su PH, et al. Factors associated with post-traumatic symptoms in mothers of preterm infants. Arch Psychiatr Nurs. 2016; 30(1):96-101.
15
17. Feeley N, Hayton B, Gold I, Zelkowitz P. A comparative prospective cohort study of women following childbirth: mothers of low birth weight infants at risk for elevated PTSD symptoms. J Psychosom Res. 2017; 101:24-30.
16
18. Van Vliet IM, De Beurs E. The MINI-International Neuropsychiatric Interview. A brief structured diagnostic psychiatric interview for DSM-IV en ICD-10 psychiatric disorders. Tijdschr Psychiatr. 2007; 49(6):393-7.
17
19. Santana MR, Zatti C, Spader ML, Malgarim BG, Salle E, Piltcher R. Acute stress disorder and defense mechanisms: a study of physical trauma patients admitted to an emergency hospital. Trends Psychiatry Psychother. 2017; 39(4):247-56.
18
20. Shelby RA, Golden-Kreutz DM, Andersen BL. Mismatch of posttraumatic stress disorder (PTSD) symptoms and DSM-IV symptom clusters in a cancer sample: exploratory factor analysis of the PTSD checklist-civilian version. J Trauma Stress. 2005; 18(4):347-57.
19
21. Abedian Z, Soltani N, Mokhber N, Esmaily H. Comparing post-traumatic stress disorder in primiparous and multiparous women with preeclampsia. J Midwifery Reprod Health. 2013; 1(1):13-8.
20
22. Mirzamani M, Mohammadi MR, Besharat MA. Application of the PTSD symptoms scale (PSS) for Iranian PTSD patients. Med J Islamic Republic Iran. 2006; 19(4):345-8.
21
23. Goutaudier N, Lopez A, Séjourné N, Denis A, Chabrol H. Premature birth: subjective and psychological experiences in the first weeks following childbirth, a mixed-methods study. J Reprod Infant Psychol. 2011; 29(4):364-73.
22
24. Shaw RJ, Bernard RS, Deblois T, Ikuta LM, Ginzburg K, Koopman C. The relationship between acute stress disorder and posttraumatic stress disorder in the neonatal intensive care unit. Psychosomatics. 2009; 50(2):131-7.
23
25. Lefkowitz DS, Baxt C, Evans JR. Prevalence and correlates of posttraumatic stress and postpartum depression in parents of infants in the Neonatal Intensive Care Unit (NICU). J Clin Psychol Med Settings. 2010; 17(3):230-7.
24
26. Le Gouëz M, Alvarez L, Rousseau V, Hubert P, Abadie V, Lapillonne A, et al. Posttraumatic stress reactions in parents of children esophageal atresia. PloS One. 2016; 11(3):e0150760.
25
27. Shaw RJ, Deblois T, Ikuta L, Ginzburg K, Flisher B, Koopman C. Acute stress disorder among parents of infants in the neonatal intensive care nursery. Psychosomatics. 2006; 47(3):206-12.
26
28. Candelori C, Trumello C, Babore A, Keren M, Romanelli R. The experience of premature birth for fathers: the application of the Clinical Interview for Parents of High-Risk Infants (CLIP) to an Italian sample. Front Psychol. 2015; 6:1444.
27
29. Carter JD, Mulder RT, Bartram AF, Darlow BA. Infants in a neonatal intensive care unit: parental response. Arch Dis Child Fetal Neonatal Ed. 2005; 90(2):109-13.
28
30. Brandon DH, Tully KP, Silva SG, Malcolm WF, Murtha AP, Turner BS, et al. Emotional responses of mothers of late‐preterm and term infants. J Obstet Gynecol Neonatal Nurs. 2011; 40(6):719-31.
29
31. Verreault N, Da Costa D, Marchand A, Ireland K, Banack H, Dritsa M, et al. PTSD following childbirth: a prospective study of incidence and risk factors in Canadian women. J Psychosom Res. 2012; 73(4):257-63. 32. Shaban Z, Dolatian M, Shams J, Alavi-Majd H, Mahmoodi Z, Sajjadim H. Post-traumatic stress disorder (PTSD) following childbirth: prevalence and contributing factors. Iran Red Crescent Med J. 2013; 15(3):177-82.
30
ORIGINAL_ARTICLE
Coarse Tremor as the Only Sign of Perinatal Hemorrhagic Stroke: A Case Report
Background: Tremor which is the most common abnormal movement in the neonatal period might be a benign condition or the result of pathologic events and is divided into two subtypes, namely fine tremor and coarse tremor. Fine tremor is usually benign and results from some metabolic disturbance, such as hypoglycemia. On the other hand, coarse tremor is an indicator of brain insult and should be regarded as a central pathology comparable to intracranial hemorrhage and hypoxic-ischemic encephalopathy and requires further evaluations. Stroke is one of the most important associated pathologies that are readily missed in the neonatal period. The possibility of stroke should be suspected in all newborns in the presence of coarse tremor.Case report: Here, we will present a newborn with perinatal hemorrhagic stroke who was in good condition after birth with Apgar score of 9 and normal vital signs, birth weight, head circumference, length, and primitive reflexes; however, he had coarse tremor in both upper extremities in physical examination as the only sign of the hemorrhagic stroke.Conclusion: It is recommended that neonates with coarse tremor be investigated more carefully to rule out the structural brain pathology.
https://ijn.mums.ac.ir/article_14100_ea70b3ea698ca8dc5390d6e4533c42be.pdf
2019-11-01
83
86
10.22038/ijn.2019.37692.1583
Hemorrhagic stroke
Ischemic stroke
jitteriness
Prenatal stroke
tremor
Sina
Karamimagham
s_karamimagham@sums.ac.ir
1
Neonatal Research Center, Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
Maryam
Poursadeghfard
poursadegh@sums.ac.ir
2
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
1. Paddock M, Demetriou A, Nicholl R. Are we considering neonatal stroke early enough in our differential diagnosis? J Neonatal Perinatal Med. 2014; 7(4):293-9.
1
2. Huntsman RJ, Lowry NJ, Sankaran K. Nonepileptic motor phenomena in the neonate. Paediatr Child Health. 2008; 13(8):680-4.
2
3. Armentrout DC, Caple J. The jittery newborn. J Pediatr Health Care. 2001; 15(3):147-9.
3
4. Gelfand AA, Glass HC, Marco EJ, Ferriero DM. Focal clonic seizures suggest stroke in a newborn. Neurol Bull. 2010; 2(1):7-11.
4
5. Gleason CA, Juul SE. Avery's diseases of the newborn e-book. New York: Elsevier Health Sciences; 2017.
5
6. Hagberg H, Edwards AD, Groenendaal F. Perinatal brain damage: the term infant. Neurobiol Dis. 2016; 92:102-12.
6
7. Joseph S, Angelis D, Bennett R, Kola B, Hughes A. Variability in clinical presentation of neonatal stroke: report of four cases. Case Rep Neurol Med. 2017; 2017:5215686.
7
8. Pulver M, Juhkami K, Loorits D, Ilves P, Kuld J, Õiglane-Šlik E, et al. Symptomatic neonatal arterial ischemic stroke with prenatal and postnatal neuroimaging. Child Neurol Open. 2017; 4:23290 48X17730460.
8
9. Gacio S, Muñoz Giacomelli F, Klein F. Presumed perinatal ischemic stroke: a review. Arch Argent Pediatr. 2015; 113(5):449-55.
9
10. Wang LW, Huang CC, Yeh TF. Major brain lesions detected on sonographic screening of apparently normal term neonates. Neuroradiology. 2004; 46(5):368-73.
10
11. Chang YC, Lee CY, Chen CH, Ku YC, Wang JD. Cyanosis as a signal of perinatal stroke: findings at ultrasound and MRI. Iran J Pediatr. 2015; 25(3):e533.
11
12. Walkinshaw SA. Fetal choroid plexus cysts: are we there yet? Prenat Diagn. 2000; 20(8):657-62.
12
13. Demasio K, Canterino J, Ananth C, Fernandez C, Smulian J, Vintzileos A. Isolated choroid plexus cyst in low-risk women less than 35 years old. Am J Obstet Gynecol. 2002; 187(5):1246-9.
13
ORIGINAL_ARTICLE
Sacrococcygeal Teratoma: A Case Report
Background: Neonatal tumors are usually prenatally diagnosed or within the irst 30 days of life. The true incidence ofneonatal tumors is unknown as a great number of pregnancies with a prenatally diagnosed mass result in stillbirth ormiscarriage. Most solid neonatal tumors are benign whereas less than 50% of neonatal neoplasms are malignant;however, some tumors with malignant patterns may histologically show benign behaviors. The incidence of malignanttumors is 1 in every 12,500-27,500 live births, accounting for 2% of all childhood cancers. Teratomas are the mostcommon perinatal neoplasms, accounting for 25-33% of the cases. Around two-thirds of all sacrococcygeal teratomas(SCTs) are reported in the neonatal period but with a small risk of malignancy.Case report: Herein, we reported a case of SCT in a newborn leading to a complicated cesarean delivery.Conclusion: In general, teratomas are embryonic typically benign tumors arising from germ cells. They usually consistof various tissues originating from two or more embryonic layers. These tumors are believed to be the most commonneonatal germ cell tumors. The sacrococcygeal region is the most common site for extragonadal teratomas formation.
https://ijn.mums.ac.ir/article_14101_fea98a2382bf3ff14ed02f80ae9debb4.pdf
2019-11-01
87
89
10.22038/ijn.2019.40339.1656
Neonatal tumors
Neoplasm
Teratoma
Reza
Saeidi
saeedir@mums.ac.ir
1
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Farnaz
Kalani-Moghaddam
farnaz.kalani@gmail.com
2
Department of Neonatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Gholamali
Mamouri
maamourigh@mums.ac.ir
3
Department of Neonatology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1. Kumar A, Gupta N, Prasad S, Sharma JB.Sacrococcygeal teratoma: a case report. J Indian Med Assoc. 2002; 100(9):575-6.
1
2. Martin RJ, Fanaroff AA, Walsh MC. Neonatal perinatal medicine. 10th ed. New York: Mosby; 2015.
2
3. Lee H. Sacrococcygeal teratoma (SCT). UCSF Fetal Treatment Center. Available at: URL: https://fetus.ucsf.edu/sct; 2018.
3
4. Legbo JN, Opara WE, Legbo JF. Mature sacrococcygeal teratoma: case report. Afr Health Sci.2008; 8(1):54-7.
4
5. Szyllo K, Lesnik N. Sacrococcygeal teratoma–case report and review of the literature. Am J Case Rep.2013; 14:1.
5
6. Yoon HM, Byeon SJ, Hwang JY, Kim JR, Jung AY, Lee JS, et al. Sacrococcygeal teratomas in newborns: comprehensive review for the radiologists. Acta Radiol. 2018; 59(2):236-46.
6
7. Girwalkar-Bagle A, Thatte WS, Gulia P.Sacrococcygeal teratoma: a case report and review of literature. Anaesth Pain Intensive Care. 2014;18(4):449-51.
7
8. Sinha S, Sarin YK, Deshpande VP. Neonatal sacrococcygeal teratoma: our experience with 10 cases. J Neonatal Surg. 2013; 2(1):4.
8
9. Cheikh D, Ibrahima D, Samba F, Oumar N, Omar S,Gabriel N. Giant sacrococcygeal teratoma in newborns: management of two cases in an underdeveloped country. Ann Surg Perioperat Med.2018; 1(1):1.
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