eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
1
6
10.22038/ijn.2014.2633
2633
تحقیقی اصیل
The Relationship between Maternal Serum Magnesium Level and Infant Low Birth Weight in Hafez Hospital, Shiraz, Iran
Shahnaz Pourarian
porarish@sums.ac.ir
1
Bahia Namavar Jahromi
namavar@yahoo.com
2
Faranak Takmil
takmi@yahoo.com
3
Neonatal Research Center, Department of Pediatrics, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pediatrics, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Introduction: There is a great deal of controversy regarding the effect of gestational magnesium (Mg) deficiency on fetal growth and the incidence of low birth weight (LBW) in infants. Therefore, this study aimed to delineate the possible relationship between maternal Mg level and infant LBW. Methods: This case-control study was conducted on 180 mothers in Shiraz, Iran. Fasting blood samples were obtained for magnesium after delivery. Maternal and neonatal demographic data were recorded, and the mothers were divided into two groups: the control group including mothers with normal-weight infants (≥2500 g), and the case group consisting of mothers with LBW infants (
https://ijn.mums.ac.ir/article_2633_69ab9617d7df6a83eebb95ccbab56fc6.pdf
Low birth weight
Maternal magnesium
neonate
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
7
11
10.22038/ijn.2014.2640
2640
تحقیقی اصیل
Association between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Amin Khaleghparast
keyvan_1878@yahoo.com
1
Sharif Khaleghparast
2
Hossein Khaleghparast
3
M.Sc. of Biology - Genetics, Science and Research Branch of Islamic Azad University, Tehran, Iran
B. Eng. of Industrial Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
Ph.D. in Public Law, Science and Research Branch of Islamic Azad University, Tehran, Iran
Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortions and 10 women with at least two live births without a miscarriage, who referred to Baqiyatallah Hospital and Avicenna Infertility Clinic, were analyzed for MTHFR A1298C polymorphism using PCR-RFLP method. The results obtained via estimating the genotype of each polymorphism were analyzed using SPSS v16. Results: Thirteen subjects (43.3 %) with RPL and 6 women (20 %) in the control group were heterozygous for MTHFR A1298C polymorphism. C allele frequency in the patient group was higher than the control group (41.7% and 40% for the patient and control groups, respectively). Conclusion: The prevalence of MTHFR A1298C polymorphism was slightly higher in RPL patients compared to the controls. This finding failed to support the relationship between this polymorphism and the increasing risk of RPL in the evaluated Iranian women.
https://ijn.mums.ac.ir/article_2640_e159383851af3419fc92de21972a3ed8.pdf
Methylenetetrahydrofolate reductase (NADPH2)
Polymorphism (genetic)
Spontaneous abortion
Thrombophilia
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
12
16
10.22038/ijn.2014.2641
2641
تحقیقی اصیل
Prevalence of Breastfeeding–associated Hypernatremia among Hospitalized Hyperbilirubinemic Neonates
Mitra Basiratnia
1
Narjes Pishva
pishvan@sums.ac.ir
2
Azimeh Dehghani
a_dehghani313@yahoo.com
3
Shiraz Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Introduction: This study aimed to assess the incidence of breastfeeding-associated hypernatremia and related risk factors among hospitalized hyperbilirubinemic neonates. Methods: This prospective study was conducted at Nemazee Hospital affiliated to Shiraz University of Medical Sciences during one year to determine the association between hypernatremia (serum sodium concentration of >150 mEq/L) and exclusive breastfeeding of the neonates. During the study period, 122 neonates were recruited and the patients’ history was taken through using the medical records (regarding child delivery) and asking the mother. Laboratory data including total and direct bilirubin levels, serum sodium level and blood urea nitrogen (BUN) were recorded. P-valueResults: The study was carried out on 86 exclusively breastfed neonates (EBFN) and 36 neonates with mixed type of feeding. The incidence of hypernatremia among the EBFN and non-exclusively breastfed neonates (non-EBFN) was 9.3% and 2.7%, respectively. Moreover, 55% of the neonates with hypernatremia had a significant weight loss (>10% cummulative weight loss). A significant correlation was observed between hypernatremia and weight loss (P=0.008). Also, in spring and autumn, no hypernatremia was observed among 53 cases, and during summer and winter, 9 out of 69 neonates (13%) presented with hypernatremia (P=0.042). Conclusion: Hypernatremic dehydration is relatively common among EBFN. Regular weight monitoring, proper breastfeeding and environmental temperature control should be encouraged for preventing breastfeeding-associated hypernatremia.
https://ijn.mums.ac.ir/article_2641_118bd769c41eecb24221f551afffeb0e.pdf
Dehydration
Exclusively breast-fed
Hyperbilirubinemia
Hypernatremia
neonate
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
17
20
10.22038/ijn.2014.2642
2642
تحقیقی اصیل
Assessment of the Prevalence of Hearing Impairment in Neonates Born in Imam Reza, Ghaem and OM-Albanin Hospitals of Mashhad
Ahmad Shah Farhat
farhatah@mums.ac.ir
1
Mohammad Mahdi Ghasemi
2
Javad Akhondian
3
Ashraf Mohamadzadeh
mohamadzadeha@mums.ac.ir
4
Habibollah Esmaeili
5
Rana Amiri
6
Mohammad Reza Tale
7
Faezeh Madani Sani
8
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ear-Nose-Throat Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Pediatrics Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Health Science Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Pejvak Auditory Steady-State Responses, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mashhad University of Medical Sciences, Mashhad, Iran
Introduction: The prevalence of hearing loss in neonates is 2-5 out of every 1,000 live births. Global Health Committee, American Academy of Otolaryngology, and American Academy of Pediatrics have recommended that hearing loss in infants be identified, and treated when possible, prior to 6 months of age. This study was designed with the aim to screen the hearing of neonates in Mashhad, Iran. Methods: All neonates born in Imam Reza, Om-Albanin and Ghaem Hospitals from November 2008 to November 2010 were screened by Otoacoustic Emission (OAE) test at the time of discharge, followed by a secondary OAE test in case of the failure of the first test; also, a confirmatory Auditory Steady State Response (ASSR) test was performed in 3 weeks to evaluate the type of hearing loss. After data analysis, the frequency of hearing loss in neonates and different risk factors were assessed. Results: In the present study, 8,987 neonates were analyzed. Thirty one neonates (3.5 per 1000) failed the ASSR test; among these neonates, 6.5%, 25.8%, 25.8% and 19.2% had slight, mild, moderate, and moderate to severe hearing loss, respectively. Also, 16.1% had profound deafness and 6.5% presented with sensorineural involvement. Positive family history of hearing impairments, craniofacial anomalies, hyperbilirubinemia and different hearing syndromes were significantly different between the case and control groups (P<0.05). Conclusion: In this study, 3.5 neonates out of 1,000 live births had different types of hearing impairments; therefore, it is recommended that screening be performed before discharge.
https://ijn.mums.ac.ir/article_2642_a9feccfa4857685419de04dde60655b1.pdf
Auditory Steady State Response
Hearing Impairment
Neonates
Otoacoustic emission
Prevalence
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
21
24
10.22038/ijn.2014.2643
2643
تحقیقی اصیل
Assessment of the Recorded Causes of Neonatal Hospitalization and the Related Factors in Neonatal Wards and NICUs in Bojnord
Maryam Hassanzadeh Bashtian
1
Mohammad Reza Armat
2
Ali Khakshour
khakshoura@mums.ac.ir
3
Student Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
North Khorasan University of Medical Sciences, Bojnord, Iran
School of Medicine, North Khorasan University of Medical Sciences, Bojnord, Iran
Introduction: According to Millennium Development Goal (MDG) number 4, child mortality should be reduced by two thirds by 2015. The focus has been on decreasing neonatal deaths in high-mortality countries. In this study, we assessed the recorded causes of neonatal hospitalization in the neonatal intensive care unit (NICU) and infant care wards. Methods: The present cross-sectional study was carried out in two hospitals (Bentolhoda hospital and Emam Reza hospital) of North Khorasan University of Medical Sciences, Bojnord in 2011-2012. We assessed different variables such as maternal age at infant’s birth, gestational age, first and fifth minute Apgar scores, and hospitalization etiology. Chi-square and Kruskal-Wallis tests were used for the statistical analysis. Results: In this study, the most common cause of neonatal admission was icterus. Most of the infants' birth weight was higher than 2,500 gr.There was a relationship between Apgar score in the first and fifth minutes and causes of hospitalization (P<0.001). Infants' gender and maternal mode of delivery had no significant relationship with the cause hospitalization (P<0.06). However, birth weight and gestational age were significantly related to the causes of admission in hospitals (P<0.0001). Conclusion: Identifying the factors which influence the hospitalization of infants can help control these risk factors.It can also lead to the decrease of neonatal mortality, which is a reflection of nations’ socio-economic status.
https://ijn.mums.ac.ir/article_2643_23d03ca97ab19e5bb4e380f1a086f86b.pdf
Disease
Etiology
Infant
Maternal
Neonatal hospitalization
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
25
28
10.22038/ijn.2014.2644
2644
تحقیقی اصیل
Effects of Delivery Mode on Short-term Neonatal Outcomes
Minoo fallahi
1
Gelavizh Keshtmand
2
Mahta Fatemeh Bassir
3
Neonatal Health Research Center (NHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Neonatal Health Research Center (NHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Neonatal Health Research Center (NHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: The risk of morbidity and mortality increases in neonates admitted to the neonatal intensive care units (NICUs). Various factors contribute to the prognosis of these newborns. In the current study, we aimed to investigate the role of mode of delivery on short-term neonatal outcomes. Methods: This retrospective study was conducted on 215 neonates admitted to the NICU of Shohada-e-Tajrish Hospital in 2007 and 2008. The respiratory distress syndrome (RDS), mortality, birth weight, gestational age, and Apgar score were compared between two groups born via natural vaginal delivery (NVD) and c-section (CS), respectively. Results: In the current study, of 126 CS cases, 46.8% had a gestational age of more than 37 weeks, 52.4% were low birth weight (LBW) infants, 29.3% had severe RDS, 17.7% had an Apgar score less than 7, and 9.7% of the infants passed away. Of 89 NVD cases, 44.9% had a gestational age of more than 37 weeks, 48.3% were LBW infants, 18.4% had an Apgar score less than 7, 27.9% had severe RDS, and 10.1% of the infants passed away. The mean length of hospital stay was 8.39 and 7.84 days in CS and NVD groups, respectively. In CS and NVD groups, 27.8% and 22.5% had markers of infection. These factors had no significant association with the mode of delivery. Conclusion: Mode of delivery has no impact on the Apgar score, mortality, length of hospital stay, RDS, and infection markers in neonates admitted to the NICU.
https://ijn.mums.ac.ir/article_2644_cc1858c7e9d04315eabd909c98961266.pdf
CS
Mode of Delivery
Neonates
NVD
RDS
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
29
32
10.22038/ijn.2014.2645
2645
تحقیقی اصیل
Lumbar Puncture in Neonates with Sepsis
Reza Saeidi
saeedir@mums.ac.ir
1
Gholamali Mamori
2
Simin Maghrebi
3
Maryam Ziadi LotfAbadi
4
Department of Pediatrics, Associate Professor of Neonatology, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pediatrics, Professor of Neonatology, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pediatrics, Resident of Neonatology, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Health, MD-MPH,Mashhad University of Medical Sciences, Mashhad, Iran
Introduction: Infections are one of the main causes of death during childhood. Epidemiologic studies in Iran showed that the incidence of neonatal sepsis was 1.8% in 1995. Moreover, the incidence of neonatal meningitis is 0.2 to 0.4 in per 1,000 live births. The aim of this study was to determine the necessity of lumbar puncture (LP) in early neonatal sepsis. Methods: In a retrospective study, after obtaining ethical approval, we evaluated the records of 1,100 neonates, younger than 7 days, who were admitted to the hospital between 2001 and 2007. They were suspected of sepsis and thus, LP was performed. Statistical analyses were performed by SPSS version 16. Nominal variables were compared using Chi-square or Fisher’s exact test. Other parametric and non-parametric tests were used as required. Results: In our study, 1,100 neonates, suspected of sepsis, were evaluated. Of all neonates, 28.3% and 71.7% were older and younger than 3 days, respectively. Male-to-female ratio was 1:5 in 115 neonates. Sepsis was confirmed by positive blood culture, and 21 neonates (2.1%) had positive cerebrospinal fluid (CSF), which was significantly associated with blood culture results. Conclusion: There was a significant relationship between blood culture and CSF culture results. However, regarding the low incidence of positive CSF, LP should be performed for each case, based on clinical manifestations and clinical opinion.
https://ijn.mums.ac.ir/article_2645_e86d78668cdd2c5e96ecb4db9af8279e.pdf
Lumbar puncture
Neonatal sepsis
neonate
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
33
36
10.22038/ijn.2014.2646
2646
گزارش موارد نادر
Kernicterus in Two Generations: A Need for More Aggressive Preventive Measures
Kuti Bankole Peter
kutitherapy@yahoo.com
1
Ogundele Tolulope
2
Adeniyi Adewuyi Temidayo
3
Kuti Demilade Kehinde
4
Department of Paediatrics and Child Health, Obafemi Awolowo University/Wesley Guild Hospital Unit of the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria
Department of Paediatrics Wesley Guild Hospital, Ilesa, Nigeria
Department of Paediatrics Wesley Guild Hospital, Ilesa, Nigeria
Department of Paediatrics, Wesley Guild Hospital, Ilesa, Nigeria
Bilirubin induced brain damage is still a common cause of morbidity and mortality in Nigerian infants. No much success has been recorded in decades despite the fact that brain damage from bilirubin toxicity in the newborn is easily preventable with affordable and effective means. We report a case of a newborn with acute bilirubin encephalopathy. This case was considered of interest because the mother of the baby herself had kernicterus as a newborn now manifesting with features of choreoathetoid cerebral palsy. The baby was brought to our facility late just as how the mother was presented late to a health facility 30 years ago. The unfortunate occurence of brain damage from bilirubin toxicity in two successive generations calls for urgent attention. We advocate more aggressive and all-embracing preventive measures including routine home visit of newborns, awareness creation and health education and involvement of all stakeholders to nip this problem in the bud.
https://ijn.mums.ac.ir/article_2646_fbb484047d47a463c234566dbcb56ba9.pdf
Kernicterus
Neonatal Jaundice
Preventive Measures
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
37
39
10.22038/ijn.2014.2647
2647
گزارش موارد نادر
An Unusual Size of Neonatal Ovarian Cyst
Reza Sharafi
1
Setila Dalili
2
Afagh Hassanzadeh Rad
3
Department of Neonatology, Al-Zahra Hospital, Gilan University of Medical Sciences, Gilan, Iran
Department of Pediatric Endocrinology, 17th Shahrivar Hospital, School of Medicine, Gilan University of Medical Sciences, Rasht, Iran
Pediatric Growth Disorders Research Center, 17th Shahrivar Hospital, School of Medicine, Gilan University of Medical Sciences, Rasht, Iran
Neonatal ovarian cysts (NOC) are usually self-limiting structures, however, large or complex cysts may lead to severe complications. Unfortunately, no standard guidelines have been introduced for the management, treatment and follow-up of these cysts. In this report, we aimed to introduce a very large NOC without any pre- and post-natal complications. A 30 year-old mother, gravida 2, para 2, with an unremarkable prenatal course until the 36th week of gestation, delivered an infant. The routine fetal ultrasound revealed a 140x 60 mm echogenic cyst, with debris in the lower fetal abdomen (it may be due to hemorrhage). A healthy female infant, weighing 3,200 gr was born through vaginal delivery at 38 weeks’ gestation. On the first day after birth, the laboratory results showed normal serum concentrations of hormones. Repeated sonography after birth showed a neonatal ovarian cyst which had remained unchanged in size; therefore, clinicians performed an early surgery.
https://ijn.mums.ac.ir/article_2647_16c81ed8b18f96fc31c6dd1a00d1f7c9.pdf
Infant
Ovarian cyst
Prenatal diagnosis
Ultrasound
eng
Mashhad University of Medical Sciences
Iranian Journal of Neonatology
2251-7510
2322-2158
2014-07-01
5
2
40
42
10.22038/ijn.2014.2648
2648
گزارش موارد نادر
A Newborn with a Congenital Chylothorax
Mehrdad Mirzarahimi
mmirzarahimi.@arums.ac.ir
1
Maryam Hosseini Khotbesara
hosseini.maryam67@yahoo.com
2
Mahsa Hosseini Khotbesara
hosseini.mahsa@yahoo.com
3
Amin Bagheri
smr_mtn@yahoo.com
4
Department of Pediatrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Department of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran
Department of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Department of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Congenital chylothorax is an uncommon cause of respiratory distress and a life-threatening condition in newborns. It is identified by abnormal accumulation of chyle in the pleural space. Herein, we report a male infant who was born by a successful vaginal delivery. After the first three days of life, he had feeding difficulties and cyanotic episodes during breastfeeding. On admission, physical examination showed decreased breath sounds on the right side of the chest and the plain chest X-ray indicated right-sided pleural effusion. This patient was diagnosed with congenital chylothorax, based on the evaluation of pleural fluid via diagnostic and therapeutic thoracentesis and postnatal diagnostic X-rays. Since the effusion was persistent after drainage of pleural space, total parenteral nutrition (TPN) and surgical pleurodesis (on the right side of lung) were performed on the patient. Due to the fact that congenital chylothorax is a life-threatening condition, reporting these cases could be a great assistance to physicians for managing the disease; it can also help with reducing the resultant morbidity and mortality.
https://ijn.mums.ac.ir/article_2648_c9a121bb124feebd49ba96ab541fab82.pdf
Congenital chylothorax
Enteral Nutrition
Newborn
Pleurodesis