@article { author = {Khosravi, Mohammad and Khazaeel, Kaveh and Khaksary Mahabady, Mahmoud and Behmanesh, Mohammad Amin}, title = {Effects of Maternal Immune System Status on Neonate’s Immune System}, journal = {Iranian Journal of Neonatology}, volume = {11}, number = {3}, pages = {31-37}, year = {2020}, publisher = {Mashhad University of Medical Sciences}, issn = {2251-7510}, eissn = {2322-2158}, doi = {10.22038/ijn.2020.41505.1682}, abstract = {Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate’s humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study.Results: The spleen’s mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P≤0.05) in the anti-sheep red blood cells antibody titer.Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate’s immune responses, spleen, liver, and thymus development.}, keywords = {Immune response,Maternal,neonate,Rat}, url = {https://ijn.mums.ac.ir/article_15708.html}, eprint = {https://ijn.mums.ac.ir/article_15708_f6ddae5637b0fbf69c7ca3f66d6b091a.pdf} }